A non-human primate model for the study of oral iron chelators.

abstract：:Acute graft-versus-host disease (GvHD) is an important complication of bone marrow transplantation in humans. Risk factors are imprecisely defined and controversial. We analysed data from 2036 recipients of HLA-identical sibling transplants for leukaemia or aplastic anaemia to identify risk factors for GvHD. Analyses ...

journal_title：British journal of haematology

authors： Gale RP,Bortin MM,van Bekkum DW,Biggs JC,Dicke KA,Gluckman E,Good RA,Hoffmann RG,Kay HE,Kersey JH

更新日期：1987-12-01 00:00:00

abstract：:Although the beta thalassaemia trait affects millions of people worldwide, there have been no controlled studies to determine whether it is associated with any clinical disability or abnormal physical signs. To address this question, 402 individuals were studied: 217 with beta thalassaemia trait, of whom 154 were awar...

journal_title：British journal of haematology

authors： Premawardhena A,Arambepola M,Katugaha N,Weatherall DJ

更新日期：2008-05-01 00:00:00

abstract：:It has been suggested that the iron storage protein ferritin has a number of physiological functions not directly related to iron metabolism and a number of these relate to lymphocyte and macrophage activity. The present study demonstrates a selective distribution of ferritin on lymphocyte and macrophage surface membr...

journal_title：British journal of haematology

authors： Cragg SJ,Hoy TG,Jacobs A

更新日期：1984-08-01 00:00:00

abstract：:There is evidence for increased factor VII turnover and the associated increased thrombin generation and fibrinolytic activities in sickle cell disease (SCD) that may affect in vivo platelet and endothelial cell reactivity. We studied the release of specific eicosanoids that are indicative of in vivo platelet activati...

journal_title：British journal of haematology

authors： Kurantsin-Mills J,Ibe BO,Natta CL,Raj JU,Siegel RS,Lessin LS

更新日期：1994-07-01 00:00:00

abstract：:In a 61-year-old man with glucose-6-phosphate dehydrogenase (G6PD) deficiency and poorly controlled non-insulin-dependent diabetes mellitus, an episode of acute haemolysis occurred after the administration of glyburide (glibenclamide). Erythrocyte fragmentation, with haemoglobin condensation zones next to clear zones,...

journal_title：British journal of haematology

authors： Meloni G,Meloni T

更新日期：1996-01-01 00:00:00

abstract：:The reasons why some patients with multiple myeloma (MM) do not develop severe bone loss, or even develop sclerotic bone lesions, remain unclear. In order to answer this question at the cellular and tissue level, we evaluated the histological bone condition of 10 patients with MM who never developed lytic bone lesions...

journal_title：British journal of haematology

authors： Bataille R,Chappard D,Marcelli C,Rossi JF,Dessauw P,Baldet P,Sany J,Alexandre C

更新日期：1990-12-01 00:00:00

abstract：:Panobinostat in combination with bortezomib and dexamethasone demonstrated a significant and clinically meaningful progression-free survival benefit compared with placebo, bortezomib and dexamethasone in the phase 3 PANORAMA 1 (Panobinostat Oral in Multiple Myeloma 1) trial. Despite this benefit, patients in the panob...

journal_title：British journal of haematology

authors： San-Miguel JF,Hungria VTM,Yoon SS,Beksac M,Dimopoulos MA,Elghandour A,Jedrzejczak WW,Guenther A,Na Nakorn T,Siritanaratkul N,Schlossman RL,Hou J,Moreau P,Lonial S,Lee JH,Einsele H,Salwender H,Sopala M,Redhu S,Paul S

更新日期：2017-10-01 00:00:00

abstract：:Second primary malignancies have long been associated with chronic lymphocytic leukaemia (CLL). We assessed secondary tumour samples from CLL and control patients for the presence of human papilloma virus (HPV). 132 CLL patients with 44 second malignancies were compared to a matched randomly-identified control populat...

journal_title：British journal of haematology

authors： Flynn JM,Andritsos L,Lucas D,Byrd JC

更新日期：2010-05-01 00:00:00

abstract：:Erythrocytes from elderly donors (> 70 years), but not young donors (18-35 years), are shown to undergo sequestration in an in vitro erythrophagocytosis assay. Comparable levels of sequestration are observed for high density erythrocytes from young individuals and both low density and high density erythrocytes from el...

journal_title：British journal of haematology

authors： Shapiro S,Kohn D,Gershon H

更新日期：1993-04-01 00:00:00

abstract：:Coagulation factor concentrates are known to inhibit a variety of immune reactions when assessed in vitro. This study assessed the immunomodulatory activity of a wide range of coagulation factor concentrates by measuring their inhibition of PHA-stimulated lymphocyte proliferation and reduction in IL-2 secretion. The h...

journal_title：British journal of haematology

authors： Pearson HJ,Stirling D,Ludlam CA,Steel CM

更新日期：1999-09-01 00:00:00

abstract：:High-dose dexamethasone (HD-Dex) has been reported to benefit AL amyloidosis patients with varying response rates. Our preliminary experience with the usual HD-Dex schedule indicated that the induction phase was rather toxic in AL patients. We therefore adopted a milder schedule consisting of dexamethasone 40 mg on d ...

journal_title：British journal of haematology

authors： Palladini G,Anesi E,Perfetti V,Obici L,Invernizzi R,Balduini C,Ascari E,Merlini G

更新日期：2001-06-01 00:00:00

abstract：:Primary ocular lymphoma (POL), a lymphoma of the globe, is a restricted form of primary central nervous system lymphoma (PCNSL) that often progresses to the brain and meninges; frequently it is misdiagnosed until central nervous system (CNS) lymphoma develops. The optimal treatment has not yet been identified. We retr...

journal_title：British journal of haematology

authors： Hormigo A,Abrey L,Heinemann MH,DeAngelis LM

更新日期：2004-07-01 00:00:00

abstract：:A simple technique to separate erythrocytes from bone marrow by sedimentation under gravity after addition of hydroxyethyl starch is described. This method of removing red blood cells from the donor marrow was evaluated in 23 consecutive allogeneic bone marrow transplants between ABH-incompatible individuals. Infusion...

journal_title：British journal of haematology

authors： Ho WG,Champlin RE,Feig SA,Gale RP

更新日期：1984-05-01 00:00:00

abstract：:The level of minimal residual disease (MRD) in marrow early in treatment strongly predicts outcome in childhood acute lymphoblastic leukaemia (ALL). Using PCR we studied 30 pairs of aspirates and trephines taken during induction treatment. Consensus PCR primers showed a monoclonal gene rearrangement in eight pairs, po...

journal_title：British journal of haematology

authors： Sykes PJ,Brisco MJ,Hughes E,Snell LE,Dolman G,Neoh SH,Peng LM,Toogood I,Venables WN,Morley AA

更新日期：1998-10-01 00:00:00

abstract：:In whole blood from splenectomized subjects (n = 20), red cells showed a significant increase of mean surface area (MSA), mean cell volume (MCV), MSA/MCV-ratio and osmotic resistance, with the mean cell haemoglobin concentration (MCHC) being decreased. Studies on red cell populations of different cell age revealed tha...

journal_title：British journal of haematology

authors： de Haan LD,Werre JM,Ruben AM,Huls HA,de Gier J,Staal GE

更新日期：1988-05-01 00:00:00

abstract：:Enlarged lymph nodes may be a marker of occult cancer, but accurate data on cancer risk are limited. We used population-based Danish medical registries to assess cancer risk in a cohort of patients with a first-time inpatient or outpatient hospital contact for enlarged lymph nodes during 1994-2008. Observed cancer inc...

journal_title：British journal of haematology

authors： Frederiksen H,Svaerke C,Thomsen RW,Farkas DK,Pedersen L,Weiss NS,Sørensen HT

更新日期：2013-03-01 00:00:00

abstract：:The relationship between the three measurable components of the factor VIII complex, procoagulant activity (VIII:C), Ristocetin cofactor (VIIIR:WF) and factor VIII related antigen (VIIR:AG), has been investigated using a solid phase immunoadsorption system in which homologous antibodies specific for VIII:C are insolu...

journal_title：British journal of haematology

authors： Koutts J,Lavergne JM,Meyer D

更新日期：1977-11-01 00:00:00

abstract：:We report a high incidence of subacute, chronic and sometimes occult intracranial subdural haematoma (SDH) occurring during intensive chemotherapy for acute myeloid leukaemia (AML) with a monoblastic component. Between March 1990 and January 1993, 86 AML patients from our institution were randomized in the multicentri...

journal_title：British journal of haematology

authors： Jourdan E,Dombret H,Glaisner S,Micléa JM,Castaigne S,Degos L

更新日期：1995-03-01 00:00:00

abstract：:It has been shown that granulocyte/macrophage colony stimulating factor (GM-CSF) is able to support myeloma cell propagation in cooperation with interleukin (IL)-6, the major growth factor for malignant plasma cells, although the biological mechanisms involved remain unknown. Therefore we investigated (i) the expressi...

journal_title：British journal of haematology

authors： Villunger A,Egle A,Kos M,Egle D,Tinhofer I,Henn T,Uberall F,Maly K,Greil R

更新日期：1998-09-01 00:00:00

abstract：:Eleven patients are described in whom myelomatosis was complicated by the laboratory and clinical features of the hyperviscosity syndrome (HVS). The myeloma type was IgA in nine and IgG3 in two. In those patients with IgA myeloma the HVS was related to the presence of high molecular weight complexes in the serum. Remi...

journal_title：British journal of haematology

authors： Preston FE,Cooke KB,Foster ME,Winfield DA,Lee D

更新日期：1978-04-01 00:00:00

abstract：:The response to 0.8 ml of D-positive (ccDEE) red cells injected i.v., together with 1 microgram anti-D i.m., was studied in 13 D-negative male volunteers (test subjects); the red cells were labelled with 51Cr and were found to have a mean survival time of 24 d, after correction for Cr elution. Within the following 5 m...

journal_title：British journal of haematology

authors： Contreras M,Mollison PL

更新日期：1983-01-01 00:00:00

abstract：:Comparative data on immunochemotherapy regimens for Waldenström macroglobulinaemia/lymphoplasmacytic lymphoma (WM/LPL) are lacking. We analysed overall survival (OS), risk of hospitalizations, transfusions and plasmapheresis in a population-based cohort of patients ≥65 years old initiating WM/LPL therapy in 1999-2013....

journal_title：British journal of haematology

authors： Olszewski AJ,Chen C,Gutman R,Treon SP,Castillo JJ

更新日期：2017-10-01 00:00:00

abstract：:Distinguishing Burkitt lymphoma (BL) from B cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma (DLBCL) and BL (DLBCL/BL), and DLBCL is challenging. We propose an immunohistochemistry and fluorescent in situ hybridization (FISH) based scoring system that is employed in three ...

journal_title：British journal of haematology

authors： Naresh KN,Ibrahim HA,Lazzi S,Rince P,Onorati M,Ambrosio MR,Bilhou-Nabera C,Amen F,Reid A,Mawanda M,Calbi V,Ogwang M,Rogena E,Byakika B,Sayed S,Moshi E,Mwakigonja A,Raphael M,Magrath I,Leoncini L

更新日期：2011-09-01 00:00:00

abstract：:We report the data of CD34+ cell immunoselection from peripheral blood after G-CSF-alone mobilization (10 micrograms/kg/d s.c.) in nine children with neuroblastoma (median age 4-5 years (2-8), median body weight 16 kg (10-20). Leukaphereses were carried out on a Cobe Spectra separator and two consecutive harvests (4 b...

journal_title：British journal of haematology

authors： Kanold J,Berger M,Rapatel C,de Lumley L,Lutz P,Plantaz D,Vannier JP,Bergeron C,Mechinaud F,Favrot M

更新日期：1995-10-01 00:00:00

abstract：:Studies have shown that familial risk contributes to aetiology of lymphomas. Using large population registries from Sweden, we evaluated risk of lymphoma subtypes among first-degree relatives of 2668 follicular lymphoma (FL) patients, 2517 diffuse large B-cell lymphoma (DLBCL) patients, and 6963 Hodgkin lymphoma (HL) ...

journal_title：British journal of haematology

authors： Goldin LR,Björkholm M,Kristinsson SY,Turesson I,Landgren O

更新日期：2009-06-01 00:00:00

abstract：:The records of 121 children presenting with acute lymphoblastic leukaemia between 1969 and 1982 were reviewed. The overall relapse free survival rate was 50%. However, girls presenting with a total white blood cell count of 20 X 10(9)/l or less (35% of all patients) had a particularly favourable prognosis with an 80% ...

journal_title：British journal of haematology

authors： Stockley RJ,Ahlquist PY,Mott MG

更新日期：1983-10-01 00:00:00

abstract：:The dependence of survival time on a set of prognostic factors was explored by means of Cox's regression model in 137 cases of myelofibrosis with myeloid metaplasia (MMM). The following parameters recorded at diagnosis proved to be important independent indicators of a poor prognosis: a higher value for age, a lower v...

journal_title：British journal of haematology

authors： Barosi G,Berzuini C,Liberato LN,Costa A,Polino G,Ascari E

更新日期：1988-12-01 00:00:00

abstract：:The levels of platelet-associated Igs (PAIgs) and plasma circulating antiplatelet antibodies were evaluated by a flow cytometric immunofluorescence assay (FCIFA), an enzyme-linked immunoassay (ELISA), and a platelet radioactive antiglobulin test (PRAT), in a group of 45 human immunodeficiency virus (HIV)-infected intr...

journal_title：British journal of haematology

authors： Gonzalez-Conejero R,Rivera J,Rosillo MC,Cano A,Rodriguez T,Vicente V

更新日期：1996-05-01 00:00:00

abstract：:Venesection of 10% of whole blood volume or plateletpheresis was performed in nine patients with chronic myeloproliferative disorders and in five normal control subjects. Before venesection, the patients showed impaired platelet aggregation in 33% of tests, most often in response to stimulation with 9 mumol adrenaline...

journal_title：British journal of haematology

authors： Boughton BJ

更新日期：1978-08-01 00:00:00

abstract：:We have studied the surface expression of the Toll-like receptor family member CD 180 on cells from 78 patients with B-chronic lymphocytic leukaemia (B-CLL). B-CLL cells had variable levels of CD 180 expression, but this was always less than that expressed by normal blood B cells and was stable for 24 months. Signific...

journal_title：British journal of haematology

authors： Porakishvili N,Kulikova N,Jewell AP,Youinou PY,Yong K,Nathwani A,Heelan B,Duke V,Hamblin TJ,Wallace P,Ely P,Clark EA,Lydyard PM

更新日期：2005-11-01 00:00:00