Abstract:
:Glycosylation is a common post-translational protein modification, in which glycans are built onto proteins through the sequential addition of monosaccharide units, in reactions catalysed by glycosyltransferases. Glycosylation influences the physicochemical and biological properties of proteins, with subsequent effects on subcellular and extracellular protein trafficking, cell-cell recognition, and ligand-receptor interactions. Glycan structures can be complex, as is the regulation of their biosynthesis, and it is only recently that the systems biology of metabolic flux control and glycosyltransferase networks has become a study in its own right. We review various models of glycosylation that have been proposed to date, based on current knowledge of Golgi structure and function, and consider how metabolic flux through glycosyltransferase networks regulates glycosylation events in the cell.
journal_name
Curr Opin Struct Bioljournal_title
Current opinion in structural biologyauthors
McDonald AG,Hayes JM,Davey GPdoi
10.1016/j.sbi.2016.08.007subject
Has Abstractpub_date
2016-10-01 00:00:00pages
97-103eissn
0959-440Xissn
1879-033Xpii
S0959-440X(16)30128-2journal_volume
40pub_type
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