Abstract:
:Emerging data suggest that the mechanisms by which RNA-binding proteins (RBPs) interact with RNA and the rules governing specificity might be substantially more complex than those underlying their DNA-binding counterparts. Even our knowledge of what constitutes the RNA-bound proteome is contentious; recent studies suggest that 10-30% of RBPs contain no known RNA-binding domain. Adding to this situation is a growing disconnect between the avalanche of identified interactions between proteins and long noncoding RNAs and the absence of biophysical data on these interactions. RNA-protein interactions are also at the centre of what might emerge as one of the biggest shifts in thinking about cell and molecular biology this century, following from recent reports of ribonucleoprotein complexes that drive reversible membrane-free phase separation events within the cell. Unexpectedly, low-complexity motifs are important in the formation of these structures. Here we briefly survey recent advances in our understanding of the specificity of RBPs.
journal_name
Curr Opin Struct Bioljournal_title
Current opinion in structural biologyauthors
Helder S,Blythe AJ,Bond CS,Mackay JPdoi
10.1016/j.sbi.2016.05.005subject
Has Abstractpub_date
2016-06-01 00:00:00pages
83-91eissn
0959-440Xissn
1879-033Xpii
S0959-440X(16)30040-9journal_volume
38pub_type
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