p53-dependent up-regulation of CDKN1A and down-regulation of CCNE2 in response to beryllium.

abstract：OBJECTIVES:Articular cartilage plays a vital role in bearing and buffering. Injured cartilage and subchondral bone repair is a crucial challenge in cartilage tissue engineering due to the peculiar structure of osteochondral unit and the requirement of osteogenic/chondrogenic bi-directional differentiation. Based on the...

journal_title：Cell proliferation

authors： Shang L,Ma B,Wang F,Li J,Shen S,Li X,Liu H,Ge S

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:Liver regeneration is attenuated in old age and is substantially slower after 90% than after 70% partial hepatectomy (PH). We have previously demonstrated that the proliferative response to a primary mitogen is intact in aged mice, indicating that impaired liver regeneration is not due to loss of proliferati...

journal_title：Cell proliferation

authors： Columbano A,Simbula M,Pibiri M,Perra A,Deidda M,Locker J,Pisanu A,Uccheddu A,Ledda-Columbano GM

更新日期：2008-06-01 00:00:00

abstract：:Recent epidemiological studies have demonstrated a correlation between regular aspirin (acetylsalicylic acid) use and decrease risk for the development of fatal colorectal cancer. An increase in the size of the cell proliferation compartment in colorectal crypts has been correlated with an increased risk for the devel...

journal_title：Cell proliferation

authors： Barnes CJ,Lee M,Hardman WE,Cameron IL

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:Erythropoietin has been shown to have a protective effect in certain models of ischaemia-reperfusion, and in some cases the protection has been correlated with activation of signalling pathways known to play a role in cell survival and proliferation. We have studied whether erythropoietin would overcome direc...

journal_title：Cell proliferation

authors： Andreucci M,Fuiano G,Presta P,Lucisano G,Leone F,Fuiano L,Bisesti V,Esposito P,Russo D,Memoli B,Faga T,Michael A

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVES:It has been widely reported that maternal diabetes impairs oocyte quality. However, the responsible mechanisms remain to be explored. In the present study, we focused on whether SIRT3-GSK3β pathway mediates the meiotic defects in oocytes from diabetic mice. MATERIALS AND METHODS:GSK3β functions in mouse ooc...

journal_title：Cell proliferation

authors： Xin Y,Jin Y,Ge J,Huang Z,Han L,Li C,Wang D,Zhu S,Wang Q

更新日期：2021-01-01 00:00:00

abstract：:Cytokines and growth factors that take part in the regulation of haematopoietic cell development activate many signalling pathways in target cells. The STAT5 (signal transducers and activators of transcription) proteins are members of a family of signal transducers and activators of transcription that can be activated...

journal_title：Cell proliferation

authors： Baśkiewicz-Masiuk M,Paczkowski M,Machaliński B

更新日期：2004-06-01 00:00:00

abstract：INTRODUCTION/OBJECTIVES:The serine/threonine kinase homeodomain-interacting protein kinase 2 (HIPK2) is a co-regulator of an increasing number of transcription factors and cofactors involved in DNA damage response and development. We and others have cloned HIPK2 as an interactor of the p53 oncosuppressor, and have stud...

journal_title：Cell proliferation

authors： Iacovelli S,Ciuffini L,Lazzari C,Bracaglia G,Rinaldo C,Prodosmo A,Bartolazzi A,Sacchi A,Soddu S

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:Creation of functional, durable vasculature remains an important goal within the field of regenerative medicine. Engineered biological vasculature has the potential to restore or improve human tissue function. We hypothesized that the pleotropic effects of insulin-like growth factor 1 (IGF1) would enhance th...

journal_title：Cell proliferation

authors： Friedrich CC,Lin Y,Krannich A,Wu Y,Vacanti JP,Neville CM

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:Nonylphenol (NP) is present ubiquitously in both aquatic and terrestrial environments. This compound is considered an important endocrine disruptor and its toxic/oestrogenic activity has been investigated in a number of in vitro and in vivo studies. Human exposure to NP may occur by cutaneous absorption, ing...

journal_title：Cell proliferation

authors： Manente L,Sellitti A,Lucariello A,Laforgia V,De Falco M,De Luca A

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVES:In peripheral neuropathy, the underlying mechanisms of nerve and muscle degeneration include chronic inflammation and oxidative stress in fibrotic tissues. (-)-Epigallocatechin gallate (EGCG) is a major, active component in green tea and may scavenge free radical oxygen and attenuate inflammation. Conservati...

journal_title：Cell proliferation

authors： Qian Y,Yao Z,Wang X,Cheng Y,Fang Z,Yuan WE,Fan C,Ouyang Y

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the effects of rRNA synthesis inhibition on cell cycle progression and cell population growth according to the RB and p53 status. MATERIAL AND METHODS:RB- and p53-proficient U2OS cells and the RB- and p53-deficient SAOS-2 cells were used, rRNA transcription hindered by actinomycin D, and cell cy...

journal_title：Cell proliferation

authors： Montanaro L,Mazzini G,Barbieri S,Vici M,Nardi-Pantoli A,Govoni M,Donati G,Treré D,Derenzini M

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:Fibrotic cataract, including posterior capsule opacification (PCO) and anterior subcapsular cataract (ASC), renders millions of people visually impaired worldwide. However, the underlying mechanism remains poorly understood. Here, we report a miRNA-based regulatory pathway that controls pathological fibrosis...

journal_title：Cell proliferation

authors： Wang X,Wang L,Sun Y,Chen B,Xiong L,Chen J,Huang M,Wu J,Tan X,Zheng Y,Huang S,Liu Y

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:This study has aimed to study different culture systems that might stimulate an increase in cell proliferation of normal and osteoarthritis chondrocytes from articular cartilage in rat model. MATERIAL AND METHODS:Three culture systems using chondrocytes embedded in alginate beads were tested: chondrocytes cu...

journal_title：Cell proliferation

authors： Gomez-Camarillo MA,Almonte-Becerril M,Vasquez Tort M,Tapia-Ramirez J,Kouri Flores JB

更新日期：2009-04-01 00:00:00

abstract：:The essential oil extracted from clove (Syzygium aromaticum) is used as a topical application to relieve pain and promote healing in herbal medicine and also finds use in the fragrance and flavouring industries. Clove oil has two major components, eugenol and beta-caryophyllene, which constitute 78% and 13% of the oil...

journal_title：Cell proliferation

authors： Prashar A,Locke IC,Evans CS

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVES:Induced pluripotent stem cell (iPSC)-derived cardiomyocytes are a promising source of cells for regenerative heart disease therapies, but progress towards their use has been limited by their low differentiation efficiency and high cellular heterogeneity. Previous studies have demonstrated expression of adren...

journal_title：Cell proliferation

authors： Li XL,Zeng D,Chen Y,Ding L,Li WJ,Wei T,Ou DB,Yan S,Wang B,Zheng QS

更新日期：2017-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a primary liver malignancy with a high global prevalence and a dismal prognosis. Studies are urgently needed to examine the molecular pathogenesis and biological characteristics of HCC. Chromatin remodelling, an integral component of the DNA damage response, protects against DNA damag...

journal_title：Cell proliferation

authors： Hu B,Lin JZ,Yang XB,Sang XT

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:Vascular disorders are associated with phenotypical switching of vascular smooth muscle cells (VSMCs). We investigated the effect of bone morphogenetic protein (BMP)-2 in controlling VSMC phenotype and vascular disorder progression. Lysine (K)-specific demethylase 1A (KDM1A) has been identified to target BMP...

journal_title：Cell proliferation

authors： Zhang X,Huang T,Zhai H,Peng W,Zhou Y,Li Q,Yang H

更新日期：2020-01-01 00:00:00

abstract：:An ELISA was developed and optimized to measure cell proliferation using a monoclonal antibody to bromodeoxyuridine (BrdUrd). Incorporation of BrdUrd into myoblast monolayers, measured as the optical density at 492 nm, increased in response to fetal calf serum, IGF-I and EGF, the ELISA data correlated closely with dat...

journal_title：Cell proliferation

authors： Perros P,Weightman DR

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVE:Spinal cord tumours are highly malignant and often lead to paralysis and death due to their infiltrative nature, high recurrence rate and limited treatment options. In this study, we measured antitumour efficacy of the Salmonella typhimurium A1-R tumour-targeting bacterium strain, administered systemically or...

journal_title：Cell proliferation

authors： Kimura H,Zhang L,Zhao M,Hayashi K,Tsuchiya H,Tomita K,Bouvet M,Wessels J,Hoffman RM

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVES:  The focus of this study was to determine the dedicator of cytokinesis 2 (DOCK2), extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase-1 (JNK) and Akt signals involved in CXCL13-mediated prostate cancer (PCa) cell invasion and proliferation. MATERIALS AND METHODS:  Androgen-sensitive...

journal_title：Cell proliferation

authors： El-Haibi CP,Singh R,Sharma PK,Singh S,Lillard JW Jr

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVES:Thyroid carcinoma (TC) represents a malignant neoplasm affecting the thyroid. Current treatment strategies include the removal of part of the thyroid; however, this approach is associated with a significant risk of developing hypothyroidism. In order to adequately understand the expression profiles of TNRC6C...

journal_title：Cell proliferation

authors： Yang LX,Wu J,Guo ML,Zhang Y,Ma SG

更新日期：2019-05-01 00:00:00

abstract：:Epstein-Barr virus (EBV) infection in vitro causes transformation of B cells and generates B lymphoblastoid cell lines (LCLs). These LCLs have been widely used for the diagnostic of several genetic metabolic disorders. However, up to now, efficiency of LCL generation has been based on misleading subjective analysis. I...

journal_title：Cell proliferation

authors： Mello AS,Burin MG,Michellin K,Viapiana M,Giugliani R,Coelho JC,Bauer ME

更新日期：2006-02-01 00:00:00

abstract：:Rabbit embryo-fetal fluid (EFF) contains regulatory factors of cell proliferation which increase the duration of the cell cycle, induce a quiescent status in some cells and lead up to cell death in others. The objective of this study was to demonstrate which of the two processes, namely necrosis or apoptosis, was resp...

journal_title：Cell proliferation

authors： Lapointe J,Bergeron D,Dufour M,Dubé D,Govindan MV,Lambert RD

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVES:BCL2 family proteins have been widely studied over the past decade due to their essential roles in apoptosis, oncogenesis and anti-cancer therapy. However, the similarities and differences in the spatial pattern of the BCL2 gene family within the context of chromatin have not been well characterized. We soug...

journal_title：Cell proliferation

authors： Wang J,Li S,Lin S,Fu S,Qiu L,Ding K,Liang K,Du H

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:To evaluate the rapid repair potential of adipose-derived stem cells (ADSCs) co-overexpressing VEGF and GDNF on bilateral cavernous nerve injury (BCNI) in rat models. Progressive fibrosis of the penis that occurs shortly after BCNI is a key cause of clinical treatment difficulty of erectile dysfunction (ED)....

journal_title：Cell proliferation

authors： Yang W,Chen Z,Ma X,Ouyang X,Fang J,Wei H

更新日期：2020-02-01 00:00:00

abstract：:Atherosclerosis is an inflammatory-fibroproliferative response of the arterial wall involving a complex set of interconnected events where cell proliferation (lymphomonocytes, and endothelial and smooth-muscle cells) and substantial perturbations of intracellular cholesterol metabolism are considered to be among the m...

journal_title：Cell proliferation

authors： Batetta B,Bonatesta RR,Sanna F,Putzolu M,Mulas MF,Collu M,Dessì S

更新日期：2002-06-01 00:00:00

abstract：:The effect of various GnRH analogues, and their conjugates on proliferation, clonogenicity and cell cycle phase distribution of MCF-7 and Ishikawa human cancer cell lines was studied. GnRH-III, a sea lamprey GnRH analogue reduced cell proliferation by 35% and clonogenicity by 55%. Structural modifications either decre...

journal_title：Cell proliferation

authors： Kálnay A,Pályi I,Vincze B,Mihalik R,Mezõ I,Pató J,Seprõdi J,Lovas S,Murphy RF

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVES:High mobility group protein2 (HMGA2) and epithelial-to-mesenchymal transition are both related to progress of bladder cancer, however, the relationship between HMGA2, E-cadherin and vimentin in bladder cancer is not yet known. Thus, this study has examined expression of HMGA2, E-cadherin and vimentin in blad...

journal_title：Cell proliferation

authors： Ding X,Wang Y,Ma X,Guo H,Yan X,Chi Q,Li J,Hou Y,Wang C

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVES:Worldwide, lung cancer accounts for the majority of cancer-related deaths. Aberrant expression of miRNAs has increasingly been reported to be associated with tumour progression. This study aimed to explore the role of miR-301b in regulating apoptosis in lung cancer. MATERIALS AND METHODS:Expression of miR-3...

journal_title：Cell proliferation

authors： Wu D,Chen B,Cui F,He X,Wang W,Wang M

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:Silicate bioactive glass (BG) has been widely demonstrated to stimulate both of the hard and soft tissue regeneration, in which ion products released from BG play important roles. However, the mechanism by which ion products act on cells on cells is unclear. MATERIALS AND METHODS:Human umbilical vein endoth...

journal_title：Cell proliferation

authors： Yan L,Li H,Xia W

更新日期：2020-11-01 00:00:00