The influence of antisense oligonucleotides against STAT5 on the regulation of normal haematopoiesis in a bone marrow model.

abstract：OBJECTIVES:During human pregnancy, the endothelial cells of the uterine spiral arteries (SPA) are extensively replaced by a subtype of placental trophoblasts, endovascular extravillous trophoblasts (enEVTs), thus establishing a placental-maternal circulation. On this pathway, foetus-derived placental villi and enEVTs b...

journal_title：Cell proliferation

authors： Ma Y,Yang Q,Fan M,Zhang L,Gu Y,Jia W,Li Z,Wang F,Li YX,Wang J,Li R,Shao X,Wang YL

更新日期：2020-05-01 00:00:00

abstract：:Autophagy follows a lysosomal degradation pathway in which a cell digests its own components. It is highly regulated by a limited number of autophagy-related genes (Atg) and the proteins they encode, that are crucial for cells to undergo the process via modulating autophagsome formation. Recently, accumulating evidenc...

journal_title：Cell proliferation

authors： Chen Y,Liu XR,Yin YQ,Lee CJ,Wang FT,Liu HQ,Wu XT,Liu J

更新日期：2014-04-01 00:00:00

abstract：:Rabbit embryo-fetal fluid (EFF) contains regulatory factors of cell proliferation which increase the duration of the cell cycle, induce a quiescent status in some cells and lead up to cell death in others. The objective of this study was to demonstrate which of the two processes, namely necrosis or apoptosis, was resp...

journal_title：Cell proliferation

authors： Lapointe J,Bergeron D,Dufour M,Dubé D,Govindan MV,Lambert RD

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVES:Translational research using adult stem cells derived from various tissues has been highlighted in cell-based therapy. However, there are many limitations to using conventional culture systems of adult stem cells for clinically applicability, including limited combinations of cytokines and use of nutrients d...

journal_title：Cell proliferation

authors： Shin KS,Lee HJ,Jung J,Cha DH,Kim GJ

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Erythropoietin has been shown to have a protective effect in certain models of ischaemia-reperfusion, and in some cases the protection has been correlated with activation of signalling pathways known to play a role in cell survival and proliferation. We have studied whether erythropoietin would overcome direc...

journal_title：Cell proliferation

authors： Andreucci M,Fuiano G,Presta P,Lucisano G,Leone F,Fuiano L,Bisesti V,Esposito P,Russo D,Memoli B,Faga T,Michael A

更新日期：2009-08-01 00:00:00

abstract：:The relationship of cyclin-dependent kinase inhibitor 3 (CDKN3) with tumours has previously been presented in a number of publications. However, the molecular network and interpretation of CDKN3 through the cell cycle between non-malignancy associated hepatitis/cirrhosis and hepatocellular carcinoma (HCC) have remaine...

journal_title：Cell proliferation

authors： Wang L,Sun L,Huang J,Jiang M

更新日期：2011-06-01 00:00:00

abstract：:Breast cancer has seriously been threatening physical and mental health of women in the world, and its morbidity and mortality also show clearly upward trend in China over time. Through inquiry, we find that survival rate of patients with early-stage breast cancer is significantly higher than those with middle- and la...

journal_title：Cell proliferation

authors： He Z,Chen Z,Tan M,Elingarami S,Liu Y,Li T,Deng Y,He N,Li S,Fu J,Li W

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:The bone tissue engineering primarily focuses on three-dimensional co-culture systems, which physical and biological properties resemble the cell matrix of actual tissues. The complex dialogue between bone-forming and endothelial cells (ECs) in a tissue-engineered construct will directly regulate angiogenesi...

journal_title：Cell proliferation

authors： Li L,Li J,Zou Q,Zuo Y,Cai B,Li Y

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:Cardiac atrial appendage stem cells (CASCs) have recently emerged as an attractive candidate for cardiac regeneration after myocardial infarction. As with other cardiac stem cells, CASCs have to be expanded ex vivo to obtain clinically relevant cell numbers. However, foetal calf serum (FCS), which is routine...

journal_title：Cell proliferation

authors： Windmolders S,Willems L,Daniëls A,Linsen L,Fanton Y,Hendrikx M,Koninckx R,Rummens JL,Hensen K

更新日期：2015-04-01 00:00:00

abstract：:The effect of various GnRH analogues, and their conjugates on proliferation, clonogenicity and cell cycle phase distribution of MCF-7 and Ishikawa human cancer cell lines was studied. GnRH-III, a sea lamprey GnRH analogue reduced cell proliferation by 35% and clonogenicity by 55%. Structural modifications either decre...

journal_title：Cell proliferation

authors： Kálnay A,Pályi I,Vincze B,Mihalik R,Mezõ I,Pató J,Seprõdi J,Lovas S,Murphy RF

更新日期：2000-10-01 00:00:00

abstract：:WR-1065 (2-[(aminopropyl)amino]ethanethiol) reduces cytotoxic and mutagenic effects caused by exposure of cells to radiation and chemotherapeutic drugs, but the mechanisms involved are not fully known. We have observed an accumulation of cells in G2 in WR-1065 treated Chinese hamster ovary cells grown in alpha-minimal...

journal_title：Cell proliferation

authors： Murley JS,Grdina DJ,Meechan PJ

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVES:Silicate bioactive glass (BG) has been widely demonstrated to stimulate both of the hard and soft tissue regeneration, in which ion products released from BG play important roles. However, the mechanism by which ion products act on cells on cells is unclear. MATERIALS AND METHODS:Human umbilical vein endoth...

journal_title：Cell proliferation

authors： Yan L,Li H,Xia W

更新日期：2020-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a primary liver malignancy with a high global prevalence and a dismal prognosis. Studies are urgently needed to examine the molecular pathogenesis and biological characteristics of HCC. Chromatin remodelling, an integral component of the DNA damage response, protects against DNA damag...

journal_title：Cell proliferation

authors： Hu B,Lin JZ,Yang XB,Sang XT

更新日期：2020-04-01 00:00:00

abstract：:Proliferation and multidrug resistance status are key predictors of therapeutic outcome in acute myeloid leukaemia (AML). Anthracyclines such as daunorubicin (DNR) are typically used to treat AML and can induce drug resistance. The goal of the studies described here was to select a combination of fluorescent probes th...

journal_title：Cell proliferation

authors： Boutonnat J,Barbier M,Muirhead K,Mousseau M,Ronot X,Seigneurin D

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVES:Mitophagy is considered to be a key mechanism in the pathogenesis of intestinal ischaemic reperfusion (IR) injury. NOD-like receptor X1 (NLRX1) is located in the mitochondria and is highly expressed in the intestine, and is known to modulate ROS production, mitochondrial damage, autophagy and apoptosis. Howe...

journal_title：Cell proliferation

authors： Li S,Zhou Y,Gu X,Zhang X,Jia Z

更新日期：2021-01-11 00:00:00

abstract：OBJECTIVES:Stiffness of bone tissue differs response to its physiological or pathological status, such as osteoporosis or osteosclerosis. Consequently, the function of cells residing in bone tissue including osteoblasts (OBs), osteoclasts and osteocytes will be affected. However, to the best of our knowledge, the detai...

journal_title：Cell proliferation

authors： Zhang T,Lin S,Shao X,Zhang Q,Xue C,Zhang S,Lin Y,Zhu B,Cai X

更新日期：2017-06-01 00:00:00

abstract：:The R- cell line is a 3T3-like cell line originating from mouse embryos with a homozygous disruption of the type 1 insulin-like growth factor receptor (IGF-IR) genes. Although R- cells cannot grow at all in serum-free medium (SFM) supplemented by several known growth factors, either singly or in combination, they are ...

journal_title：Cell proliferation

authors： Xu SQ,Sell C,DuBois GC,Baserga R

更新日期：1997-06-01 00:00:00

abstract：:A model of intestinal crypt organization is suggested based on the assumption that stem cells have a finite replicative life span. The model assumes the existence in a crypt of a quiescent ('deep') stem cell and a few more actively cycling ('proximate') stem cells. Monte Carlo computer simulation of published intestin...

journal_title：Cell proliferation

authors： Lobachevsky PN,Radford IR

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVES:To evaluate the effects of rRNA synthesis inhibition on cell cycle progression and cell population growth according to the RB and p53 status. MATERIAL AND METHODS:RB- and p53-proficient U2OS cells and the RB- and p53-deficient SAOS-2 cells were used, rRNA transcription hindered by actinomycin D, and cell cy...

journal_title：Cell proliferation

authors： Montanaro L,Mazzini G,Barbieri S,Vici M,Nardi-Pantoli A,Govoni M,Donati G,Treré D,Derenzini M

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:Cancer stem cells (CSCs) compose a subpopulation of cells within a tumour that can self-renew and proliferate. Growth factors such as epidermal growth factor (EGF) and basic fibroblast growth factor (b-FGF) promote cancer stem cell proliferation in many solid tumours. This study assesses whether EGF, bFGF an...

journal_title：Cell proliferation

authors： Feng Y,Dai X,Li X,Wang H,Liu J,Zhang J,Du Y,Xia L

更新日期：2012-10-01 00:00:00

abstract：:Stem cells are regenerating medicine. Advances in stem cell biology, and bone marrow-derived mesenchymal stem cells in particular, are demonstrating that many clinical options once thought to be science fiction may be attainable as fact. The extra- and intra-cellular signalling used by stem cells as they differentiate...

journal_title：Cell proliferation

authors： Otto WR,Rao J

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVES:Worldwide, lung cancer accounts for the majority of cancer-related deaths. Aberrant expression of miRNAs has increasingly been reported to be associated with tumour progression. This study aimed to explore the role of miR-301b in regulating apoptosis in lung cancer. MATERIALS AND METHODS:Expression of miR-3...

journal_title：Cell proliferation

authors： Wu D,Chen B,Cui F,He X,Wang W,Wang M

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:To determine the inhibitory effect and mechanism of Notch signalling on adipogenesis of mouse adipose-derived stem cells (mASCs). MATERIALS AND METHODS:Varied concentrations of N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butylester (DAPT) were added to mASCs 3 days before adipogenic induction w...

journal_title：Cell proliferation

authors： Huang Y,Yang X,Wu Y,Jing W,Cai X,Tang W,Liu L,Liu Y,Grottkau BE,Lin Y

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:Limbal stem cells (LSC) are self-renewing, highly proliferative cells in vitro, which express a set of specific markers and in vivo have the capacity to reconstruct the entire corneal epithelium in cases of ocular surface injury. Currently, LSC transplantation is a commonly used procedure in patients with ei...

journal_title：Cell proliferation

authors： Monteiro BG,Serafim RC,Melo GB,Silva MC,Lizier NF,Maranduba CM,Smith RL,Kerkis A,Cerruti H,Gomes JA,Kerkis I

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVES:Intracellular reactive oxygen species (ROS) induced by receptor activator of NF-kB ligand (RANKL) has been proven to be a critical factor in the development of osteoclasts. This study aimed to prove that schisandrin A (Sch), a novel anti-oxidant compound, is able to suppress osteoclastogenesis and prevent bo...

journal_title：Cell proliferation

authors： Ni S,Qian Z,Yuan Y,Li D,Zhong Z,Ghorbani F,Zhang X,Zhang F,Zhang Z,Liu Z,Yu B

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVES:In order to provide a more comprehensive understanding of the effects of SARS-CoV-2 on oral health and possible saliva transmission, we performed RNA-seq profiles analysis from public databases and also a questionnaire survey on oral-related symptoms of COVID-19 patients. MATERIALS AND METHODS:To analyse AC...

journal_title：Cell proliferation

authors： Chen L,Zhao J,Peng J,Li X,Deng X,Geng Z,Shen Z,Guo F,Zhang Q,Jin Y,Wang L,Wang S

更新日期：2020-12-01 00:00:00

abstract：:Laminin-2 (LN-2, alpha2beta1gamma1) is a basement membrane-associated laminin isoform usually considered in the context of muscle and nerve tissues. To test the hypothesis that LN-2 can additionally modulate epithelial cell biology, an analysis of the role of LN-2 in cell adhesion, activation of signalling intermediat...

journal_title：Cell proliferation

authors： Dowgiert J,Sosne G,Kurpakus-Wheater M

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVES:Osteopetrosis is a rare inherited skeletal disease characterized by increased bone mineral density due to the loss of osteoclast function or differentiation potential. MATERIALS AND METHODS:The study involved a Chinese patient with osteopetrosis (the proband) and her immediate family members and 180 control...

journal_title：Cell proliferation

authors： Yuan Y,Yang L,Liu T,Zhang H,Lu Q

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:Increasing evidences suggest that inducing mesenchymal stem cells to differentiate into osteoblasts has been as an especially important component in the prevention and therapy for degenerative bone disease. Here, we identify a novel lncRNA, linc02349, which increases significantly during osteogenic different...

journal_title：Cell proliferation

authors： Cao L,Liu W,Zhong Y,Zhang Y,Gao D,He T,Liu Y,Zou Z,Mo Y,Peng S,Shuai C

更新日期：2020-05-01 00:00:00

abstract：:L-type voltage-gated calcium ion channels (L-VGCCs) have been demonstrated to be the mediator of several significant intracellular activities in excitable cells, such as neurons, chromaffin cells and myocytes. Recently, an increasing number of studies have investigated the function of L-VGCCs in non-excitable cells, p...

journal_title：Cell proliferation

authors： Tan YZ,Fei DD,He XN,Dai JM,Xu RC,Xu XY,Wu JJ,Li B

更新日期：2019-07-01 00:00:00