Abstract：
:The primary objective was to create a clinically relevant model of right ventricular hypertension and to study right ventricular myocardial pathophysiology in growing organism. The secondary objective was to analyse the effect of oral enoximone (phosphodiesterase inhibitor) therapy on right ventricular haemodynamic parameters and myocardial changes in biomodel of right ventricular hypertension. The study included a total of 12 piglets of 42 days of age. Under general anaesthesia, pulmonary artery banding (PAB) was performed surgically to constrict the main pulmonary artery to about 70-80 % of its original dimension. The study presented two groups of animals labelled C (control animals with PAB; n = 8) and E (animals with PAB and oral administration of enoximone; n = 4). Direct pressure and echocardiographic measurements were taken during operation (time-1), and again at 40 days after surgery (time-2). The animals were killed, and tissue samples from the heart chambers were collected for quantitative morphological assessment. Statistical analysis was performed on all acquired data. At time-2, the median weight of animals doubled and the median systolic pressure gradient across the PAB increased (46.59 ± 15.87 mmHg vs. 20.29 ± 5.76 mmHg; p < 0.001). Changes in haemodynamic parameters were compatible with right ventricular diastolic dysfunction in all the animals. Apoptosis, tissue proliferation and fibrosis were identified in all the myocardial tissue samples. Right ventricular pressure overload leads to increased apoptosis of cardiac myocytes, proliferation and myocardial fibrosis. Our study did not show evidence of haemodynamic benefit or myocardial protective effect of oral enoximone treatment.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Kobr J,Slavik Z,Uemura H,Saeed I,Furck A,Pizingerová K,Fremuth J,Tonar Zdoi
10.1007/s00246-016-1463-ysubject
Has Abstractpub_date
2016-12-01 00:00:00pages
1498-1506issue
8eissn
0172-0643issn
1432-1971pii
10.1007/s00246-016-1463-yjournal_volume
37pub_type
杂志文章abstract：:Natriuretic peptides (NP) are released from the heart in response to pressure and volume overload. The biologic properties of NPs include counterregulation of the rennin-angiotensin-aldosterone pathway and a decrease in sympathetic tone resulting in diuresis, natriuresis, and vasodilation. Natriuretic peptides help to...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00246-010-9758-x
更新日期：2010-11-01 00:00:00
abstract：:We report a 4-month-old infant with torsade de pointes secondary to procainamide treatment. The infant presented with atrial flutter and converted to normal sinus rhythm with intravenous procainamide. Oral procainamide therapy was initiated as the infusion was tapered, and the patient subsequently developed incessant ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF00796823
更新日期：1995-03-01 00:00:00
abstract：:Acute respiratory distress syndrome (ARDS) in children after open heart surgery, although uncommon, can be a significant source of morbidity. Because high-frequency oscillatory ventilation (HFOV) had been used successfully with pediatric patients who had no congenital heart defects, this therapy was used in our unit. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-013-0655-y
更新日期：2013-08-01 00:00:00
abstract：:Plastic bronchitis (PB) is a poorly understood disease that can complicate any underlying pulmonary disease. However, it appears to most often occur in patients with surgically palliated congenital heart disease, particularly after the Fontan procedure. Few data exist about the prevalence and etiology of PB in this po...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0430-5
更新日期：2013-02-01 00:00:00
abstract：:In August 2010, the Nit-Occlud® Lê (EUREVECO) became available for transcatheter coil occlusion of ventricular septal defects (VSDs). Retrospective European Registry for VSD Closure using the Nit-Occlud® Lê-VSD-Coil; analysis of the feasibility, results, safety and follow-up of VSD-closure over a 3-year period in 18 E...
journal_title：Pediatric cardiology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00246-016-1502-8
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Cardiac magnetic resonance imaging (MRI) is an important diagnostic tool for congenital heart disease (CHD), as reflected by class 1 recommendations for the use of cardiac MRI by various consensus panels. However, little is known about the safety and clinical utility of cardiac MRI for these critically ill i...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-008-9295-z
更新日期：2009-02-01 00:00:00
abstract：:A 5-year-old boy born with a congenital heart defect had insertion of an epicardial pacemaker that was found on routine evaluation to have been displaced into the rectovesical pouch. He underwent transvenous insertion of another pacemaker, and the displaced pacemaker was successfully retrieved by laparoscopy without i...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-011-9972-1
更新日期：2011-12-01 00:00:00
abstract：:Successful balloon valvuloplasty for critical pulmonary valve stenosis is described in an 800-g infant. A modified catheter was required to cross the valve in the smallest child known to undergo this procedure. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002460010288
更新日期：2001-11-01 00:00:00
abstract：:The original version of the article unfortunately contained an alignment error in Table 1. The correct version of Table 1 is given below. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00246-018-1978-5
更新日期：2019-01-01 00:00:00
abstract：:Studies of larger patient groups for systematic assessment of the anatomical accuracy of magnetic resonance imaging (MRI) for partial anomalous pulmonary venous drainage (PAPVD) have been performed so far only in adults. This study was undertaken to evaluate whether MRI can precisely depict pulmonary venous anatomy in...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-008-9367-0
更新日期：2009-05-01 00:00:00
abstract：:Kawasaki disease (KD) is a self-limiting systemic vasculitis of unknown etiology. KD is often complicated by coronary artery aneurysms (CAAs), which develop in about 20-25% of untreated children and 3-5% of children treated with intravenous immunoglobulin therapy. To identify the risk loci for CAA susceptibility in pa...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-018-1992-7
更新日期：2019-03-01 00:00:00
abstract：:Patency of the ductus arteriosus (PDA) is a common finding in small premature infants. Recently pulsed-Doppler-cross sectional echocardiography (PD-CSE) has been successfully used in these patients. We report a case of a premature infant with an unusual PD-CSE pattern. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02279882
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:This study aimed to measure and compare right ventricular (RV) function in normal infants and those with pulmonary hypertension (PHT) using the myocardial performance index (RVMPI) and to investigate the relationship between RV function and pulmonary artery pressure. METHODS:A case-control study measured RV...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-008-9285-1
更新日期：2009-02-01 00:00:00
abstract：:In case of progressive cyanosis after modified Fontan procedure, intrahepatic shunting should be considered. Ligation of the hepatic vein is safe and effective in managing this condition, and it is important to ensure that the pressure difference between superior vena cava and the portal vein system remains minimal af...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900505
更新日期：1999-11-01 00:00:00
abstract：:Color-coded two-dimensional (2D) echocardiography confirmed the presence of severe congenital mitral regurgitation in an 8-month-old infant. Intraoperative inspection revealed an isolated perforation in the anterior leaflet. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02239570
更新日期：1990-04-01 00:00:00
abstract：:This study was conducted to determine the efficacy of procainamide therapy for rapid rate control of postoperative junctional tachycardia (JT). Postoperative JT is one of the most difficult forms of tachycardia to manage. Reported success with a variety of treatments of JT in infants and children has been inconsistent...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469910018
更新日期：2000-03-01 00:00:00
abstract：:After surgical repair of an aortic coarctation a term infant presented with severe pulmonary hypertension and cyanosis unresponsive to treatment including extracorporeal membrane oxygenation. The atypical clinical course became apparent once the accompanying diagnosis of congenital alveolar capillary dysplasia with mi...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-007-9063-5
更新日期：2008-01-01 00:00:00
abstract：:Identification of heart transplant recipients at highest risk for a poor outcome could lead to improved posttransplantation survival. A chart review of primary heart transplantations from 1993 to 2006 was performed. Analysis was performed to evaluate the risk of graft loss for those with a transplantation age less tha...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-011-0077-7
更新日期：2012-01-01 00:00:00
abstract：:This retrospective study aimed to determine the superior vena cava (SVC) and left innominate vein (INV) normative cross-sectional area in children noninvasively using age as a predictor and also to compare the correlation of the area measured with the diameter on multidetector computed tomography (MDCT). Analysis of t...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-014-0893-7
更新日期：2014-08-01 00:00:00
abstract：:Renovascular hypertension is an uncommon disease, but it causes 5-10% of all childhood hypertension. The most common cause of renal artery stenosis is fibromuscular dysplasia, resulting in at least 60% of renovascular hypertension cases. This report describes a case of a renal artery stenosis confirmed by multidetecto...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-011-9944-5
更新日期：2011-06-01 00:00:00
abstract：:A 2-year-old girl with cor triatriatum with unroofed coronary sinus and persistent left superior vena cava underwent preoperative radiofrequency catheter ablation for atrial tachycardia attack that developed after admission to our hospital. The procedure was not successful. Cryoablation was successfully performed duri...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-002-0376-0
更新日期：2003-09-01 00:00:00
abstract：:Global ventricular response to exercise may be useful in follow-up of patients with residual right outflow tract lesions after congenital heart disease repair. In this context, impedance cardiography is considered accurate for stroke volume (SV) measurement during exercise testing, however, to date, only partial asses...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-017-1725-3
更新日期：2018-01-01 00:00:00
abstract：:Regional wall motion patterns in tetralogy of Fallot and its postoperative modifications by electrical and hemodynamic factors were assessed by Fourier analysis of gated radionuclide angiograms in 24 studies performed in children after surgical correction of tetralogy of Fallot. The range of right ventricular (RV) pha...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02328631
更新日期：1989-01-01 00:00:00
abstract：:Contrary to acquired arteriovenous fistulas, the congenital malformations are very rare. Here we report a case of congenital arteriovenous fistula forming a communication between the right subclavian artery to subclavian vein. To our knowledge, there is no similar case in which an infant has been successfully operated...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002460010056
更新日期：2000-05-01 00:00:00
abstract：:Device closure of atrial septal defects (ASDs) is rapidly becoming routine in children. Comparisons are often made to older surgical series with higher morbidities. However outcomes including reintervention, late failure, and the need for long-term follow-up must be considered and compared to those of a current surgic...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-002-0131-6
更新日期：2003-09-01 00:00:00
abstract：:The objective of this study was to compare histopathological changes in hypoplastic left heart syndrome right ventricles (RV) of patients undergoing Sano and modified Blalock-Taussig (MBT) shunt and correlate them with echocardiographic findings. Myocardial tissue samples were obtained from hearts with Sano or MBT shu...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0462-x
更新日期：2013-02-01 00:00:00
abstract：:Intramural coronary artery is known to be a risk factor for early death after an arterial switch operation (ASO). We evaluated the early and mid-term results of ASO for patients with intramural coronary artery. From September 2008 to March 2012, seven patients with an intramural coronary artery underwent ASO at our ho...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-014-0968-5
更新日期：2015-01-01 00:00:00
abstract：:Congenital heart defects (CHDs) are the leading cause of death in infants under 1 year of age. Aberrations in the expression and function of cardiac transcription factors (TFs) are a major contributor to CHDs. Despite the numerous studies undertaken to functionally characterize these TFs, their exact role in different...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02099-y
更新日期：2019-06-01 00:00:00
abstract：:Postoperative coarctation (CoA) patients are often found to have signs of persistent myocardial dysfunction. M-mode echocardiography was performed to study left ventricular (LV) size, mass, and systolic function and Doppler ultrasonography to study LV filling and flow velocity in the LV outflow tract and aorta in 28 "...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900124
更新日期：1997-03-01 00:00:00
abstract：:This report describes a case involving the rare combination of persistent truncus arteriosus type A2, double aortic arch, and mitral stenosis. At the age of 26 days, the patient underwent division of the right-sided aortic arch with tracheal compression and bilateral pulmonary banding. Fontan completion was successful...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0572-5
更新日期：2013-01-01 00:00:00
