Abstract:
:Infections caused by Staphylococcus aureus are prevalent. The dramatically reduced discovery of new antibiotics, as well as the persistent emergence of resistant bacteria, represents a major health problem in both hospital and community settings. Using antibiotic enhancers to rescue existing classes of antibiotics is an attractive strategy. In this study, 16-aldehyde tanshinone I (ALT) was synthesized and bacteriostatic activity was explored. In addition, synergistic or additive activity between ALT and aminoglycoside antibiotics or β-lactam antibiotics in vitro was identified. Moreover, ALT was documented to augment clearance of streptomycin (STR) and ampicillin (AMP) against S. aureus in a murine infection model. Primary mechanistic insight indicated that ALT could damage the bacterial cell membrane, leading to accumulation of antibiotics inside bacterial cells. This finding might be useful for treating infections caused by S. aureus and expand the scope of application of tanshinones.
journal_name
Res Microbioljournal_title
Research in microbiologyauthors
Wang D,Lu C,Sun F,Cui M,Mu H,Duan J,Geng Hdoi
10.1016/j.resmic.2016.08.002subject
Has Abstractpub_date
2017-01-01 00:00:00pages
46-54issue
1eissn
0923-2508issn
1769-7123pii
S0923-2508(16)30084-5journal_volume
168pub_type
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journal_title:Research in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.resmic.2005.12.002
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journal_title:Research in microbiology
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pub_type: 杂志文章,评审
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abstract::A Gram-negative, short rod, aerobic bacterium, designated W11(T), was isolated from seawater. Heterotrophic growth was observed at 10-45 °C and pH 6-10. Optimal growth was observed at 30-37 °C and pH 7-9. It can grow in the presence of 0.5-12% NaCl (w/v), and the optimal NaCl required for growth was 5-6%. 16S rRNA gen...
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