Pediatric-onset Chronic Nonspecific Multiple Ulcers of Small Intestine: A Nationwide Survey and Genetic Study in Japan.

Abstract:

:We performed a Japanese nationwide survey of pediatric-onset chronic nonspecific multiple ulcers of the small intestine between January 2000 and July 2013 in 176 institutions of pediatric surgery or pediatric gastroenterology and clarified the clinical features associated with genetic abnormalities in the Solute Carrier Organic Anion Transporter Family, Member 2A1 (SLCO2A1) gene. A total of 4 cases (3 girls and 1 boy) were diagnosed in this series, which had to be differentiated from Crohn disease, Behçet disease, tuberculosis, or drug-induced enteropathy. Clinical symptoms appeared in infants and accurate diagnosis required several years. Medical therapies for inflammatory bowel disease were administered in all patients; however, 2 of the 4 patients had mutation in the SLCO2A1 gene which are responsible for primary hypertrophic osteoarthopathy, and underwent strictureplasty or ileal resection after long-term follow-up. Pediatric gastroenterologists should include this new entity in the differential diagnosis of small intestinal ulcers and inflammatory bowel disease.

authors

Uchida K,Nakajima A,Ushijima K,Ida S,Seki Y,Kakuta F,Abukawa D,Tsukahara H,Maisawa SI,Inoue M,Araki T,Umeno J,Matsumoto T,Taguchi T

doi

10.1097/MPG.0000000000001321

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

565-568

issue

4

eissn

0277-2116

issn

1536-4801

journal_volume

64

pub_type

杂志文章
  • Repeatability of gastric volume measurements and intragastric content using ultrasound in preterm infants.

    abstract:OBJECTIVES:The aim of the present study was to determine whether serial gastric volumes and intragastric curding are repeatable within individual preterm infants when given sequential feeds of the same volume and composition. Infant and feeding characteristics that may influence differences in measured gastric volumes,...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000397

    authors: Perrella SL,Hepworth AR,Simmer KN,Hartmann PE,Geddes DT

    更新日期:2014-08-01 00:00:00

  • Dependability of esophageal pH-monitoring data in infants on cutoff limits: the oscillatory index.

    abstract::The cutoff limit for pathologic gastroesophageal reflux (GER) has been arbitrary, although generally accepted determined at pH 4.00. The influence of a small pH error (0.25 pH units above or below pH 4.00) was analyzed in 173 consecutive pH monitorings. This appeared to cause a misinterpretation of the data in 51 of 1...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199010000-00004

    authors: Vandenplas Y,Lepoudre R,Helven R

    更新日期:1990-10-01 00:00:00

  • Lutein and preterm infants with decreased concentrations of brain carotenoids.

    abstract:OBJECTIVES:Lutein and zeaxanthin are dietary carotenoids that may influence visual and cognitive development. The objective of this study was to provide the first data on distribution of carotenoids in the infant brain and compare concentrations in preterm and term infants. METHODS:Voluntarily donated brain tissues fr...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000389

    authors: Vishwanathan R,Kuchan MJ,Sen S,Johnson EJ

    更新日期:2014-11-01 00:00:00

  • Treatment of recurrent abdominal pain: components analysis of four treatment protocols.

    abstract:BACKGROUND:Recurrent abdominal pain (RAP) affects up to 34% of the world's population of children. Medical management has been limited, but behavioral strategies have been shown to be effective. In this study several components of published treatment protocols were adapted and/or improved and then compared using a pret...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-200007000-00011

    authors: Humphreys PA,Gevirtz RN

    更新日期:2000-07-01 00:00:00

  • Immunogenecity of hepatitis A and B vaccination in pediatric patients with inflammatory bowel disease.

    abstract:OBJECTIVES:Aim of the study was to evaluate the response to hepatitis A and B vaccination in pediatric patients with inflammatory bowel disease (IBD). METHODS:A total of 47 patients with IBD (25 ulcerative colitis, 14 Crohn's disease, and 8 indeterminate colitis) ages 3 to 17 years were compared with 50 healthy age- a...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31827dd87d

    authors: Urganci N,Kalyoncu D

    更新日期:2013-04-01 00:00:00

  • Development of the gastrointestinal endoscopy competency assessment tool for pediatric colonoscopy (GiECAT KIDS).

    abstract:OBJECTIVES:Many aspects of pediatric colonoscopy differ from adult practice. To date, there is no validated measure of endoscopic competence for use in pediatrics. Using Delphi methodology, we aimed to determine expert consensus regarding items required on a checklist and global rating scale designed to assess the comp...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000358

    authors: Walsh CM,Ling SC,Walters TD,Mamula P,Lightdale JR,Carnahan H

    更新日期:2014-10-01 00:00:00

  • Allergenicity of whey protein: its modification by tryptic in vitro hydrolysis of the protein.

    abstract::Enzymatic in vitro hydrolysis was evaluated as a possible treatment to abolish the allergenicity of whey proteins in view of their use in infant formulas. Guinea pigs without prior immunological contact (including fetal life) with cow's milk were fed various preparations of cow's milk proteins. Oral exposure to milk o...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:

    authors: Pahud JJ,Monti JC,Jost R

    更新日期:1985-06-01 00:00:00

  • Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition.

    abstract::The number of surviving children born prematurely has increased substantially during the last 2 decades. The major goal of enteral nutrient supply to these infants is to achieve growth similar to foetal growth coupled with satisfactory functional development. The accumulation of knowledge since the previous guideline ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,实务指引

    doi:10.1097/MPG.0b013e3181adaee0

    authors: Agostoni C,Buonocore G,Carnielli VP,De Curtis M,Darmaun D,Decsi T,Domellöf M,Embleton ND,Fusch C,Genzel-Boroviczeny O,Goulet O,Kalhan SC,Kolacek S,Koletzko B,Lapillonne A,Mihatsch W,Moreno L,Neu J,Poindexter B,Punti

    更新日期:2010-01-01 00:00:00

  • Recommendations for Diagnosis and Management of Autoimmune Pancreatitis in Childhood: Consensus From INSPPIRE.

    abstract:OBJECTIVES:Autoimmune pancreatitis (AIP) represents a complex immune-mediated pancreas disorder. Pediatric AIP (P-AIP) is rare. We have recently summarized the characteristic features of P-AIP. We now aim to develop recommendation statements to standardize the diagnostic and therapeutic approach to P-AIP and facilitate...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1097/MPG.0000000000002028

    authors: Scheers I,Palermo JJ,Freedman S,Wilschanski M,Shah U,Abu-El-Haija M,Barth B,Fishman DS,Gariepy C,Giefer MJ,Heyman MB,Himes RW,Husain SZ,Lin TK,Liu Q,Lowe M,Mascarenhas M,Morinville V,Ooi CY,Perito ER,Piccoli DA,

    更新日期:2018-08-01 00:00:00

  • Allopurinol: a useful adjunct to thiopurine therapy for pediatric ulcerative colitis in the biologic era.

    abstract::Thiopurines are used as a maintenance therapy in patients with ulcerative colitis (UC). For some patients the metabolism of thiopurines is unfavorable, leading to increased adverse effects, including hepatotoxicity. There are many reports in the adult literature concerning the manipulation of thiopurine metabolism wit...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000344

    authors: Ihekweazu FD,Kellermayer R

    更新日期:2014-07-01 00:00:00

  • Etiology of Diarrhea, Nutritional Outcomes, and Novel Intestinal Biomarkers in Tanzanian Infants.

    abstract:OBJECTIVE:Diarrheal diseases are a leading cause of morbidity and mortality worldwide, but the etiology of diarrhea and its relation to nutritional outcomes in resource-limited settings is poorly defined. We sought to determine the etiology of community-acquired diarrhea in Tanzanian infants and to assess the associati...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001323

    authors: Gosselin KB,Aboud S,McDonald CM,Moyo S,Khavari N,Manji K,Kisenge R,Fawzi W,Kellogg M,Tran HQ,Kibiki G,Gratz J,Liu J,Gewirtz A,Houpt E,Duggan C

    更新日期:2017-01-01 00:00:00

  • Baseline Characteristics and Disease Phenotype in Inflammatory Bowel Disease.

    abstract:OBJECTIVES:Predicting short-term relapses and long-term prognosis is of utmost importance in paediatric inflammatory bowel disease (IBD). Our aim was to investigate the short-term disease outcome and medication during the first year in a paediatric incident cohort from Hungary. In addition, association laboratory marke...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000885

    authors: Müller KE,Lakatos PL,Kovacs JB,Arato A,Varkonyi A,Nemes E,Tarnok A,Toth G,Papp M,Solyom E,Horvath A,Guthy I,Kovacs M,Veres G,Hungarian Pediatric IBD Registry Group.

    更新日期:2016-01-01 00:00:00

  • Diet and Exercise in Pediatric Liver Transplant Recipients: Behaviors and Association With Metabolic Syndrome.

    abstract:OBJECTIVE:The aim of the study is to analyze the impact of physical activity and eating behaviors on precursors of cardiovascular disease-including overweight/obesity, hypertension, low high-density lipoprotein, and impaired glucose tolerance-in pediatric liver transplant (LT) recipients and matched controls. METHOD:C...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002150

    authors: Chambers JH,Zerofsky M,Lustig RH,Rosenthal P,Perito ER

    更新日期:2019-01-01 00:00:00

  • Use of Breast Milk and Other Feeding Practices Following Gastrointestinal Surgery in Infants.

    abstract:OBJECTIVES:The aim of the study was to characterize the enteral feeding practices in infants after gastrointestinal surgery. METHODS:We performed a retrospective analysis of infants who underwent intestinal surgery at age <6 months who survived to be fed enterally between January 2012 and June 2017. Demographics, surg...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002128

    authors: Varma S,Bartlett EL,Nam L,Shores DR

    更新日期:2019-02-01 00:00:00

  • Effect of protein source and iron content of infant formula on stool characteristics.

    abstract::Formula-fed, term infants were evaluated in two studies that assessed the influence on stool characteristics of protein source and iron content of the formula. Parental observations of infants' stool characteristics were recorded on standard forms. Green was the primary stool color for infants receiving whey-predomina...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198510000-00015

    authors: Malacaman EE,Abbousy FK,Crooke D,Nauyok G Jr

    更新日期:1985-10-01 00:00:00

  • Eosinophilic gastroenteropathy in childhood.

    abstract::Eosinophilic gastroenteropathy (EG) is an uncommon, idiopathic disease in children that is characterized by eosinophilic inflammation of the intestine. Over a 7-year period 17 infants and children with EG were evaluated; the retrospective review of their clinical data constitutes the basis of this report. A scale deve...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198805000-00011

    authors: Whitington PF,Whitington GL

    更新日期:1988-05-01 00:00:00

  • Plasma and urine riboflavin and pyridoxine concentrations in enterally fed very-low-birth-weight neonates.

    abstract::Preterm infant formulas (PIFs) for very-low-birth-weight (VLBW) infants (birth weight, < 1,500 g) are augmented to provide daily riboflavin and pyridoxine at levels up to five-fold greater than in term infant formula and 18-fold greater than in human milk. We evaluated plasma riboflavin and pyridoxine concentrations i...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1097/00005176-199608000-00008

    authors: Porcelli PJ,Adcock EW,DelPaggio D,Swift LL,Greene HL

    更新日期:1996-08-01 00:00:00

  • Discriminant score for celiac disease based on immunohistochemical analysis of duodenal biopsies.

    abstract:OBJECTIVES:Celiac disease (CD) represents a spectrum, which includes cases with minor histological abnormalities (potential CD). The aim of this work is to evaluate the contribution of immunohistochemical analysis of duodenal biopsies to the diagnosis of gluten-related minor enteropathy. METHODS:Duodenal biopsies from...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000675

    authors: Tosco A,Maglio M,Paparo F,Greco L,Troncone R,Auricchio R

    更新日期:2015-05-01 00:00:00

  • Long-chain PUFA in granulocytes, mononuclear cells, and RBC in patients with cystic fibrosis: relation to liver disease.

    abstract:BACKGROUND AND AIM:Patients with cystic fibrosis (CF) have low levels of n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) in plasma or red blood cells (RBC), as also seen in other chronic and acute liver diseases. The differences may be more pronounced in CF transmembrane conductance regulator protein (CFTR)-reg...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e318249438c

    authors: Jørgensen MH,Ott P,Michaelsen KF,Porsgaard T,Jensen F,Lanng S

    更新日期:2012-07-01 00:00:00

  • Diagnostic value of serum gamma-glutamyl transpeptidase activity in liver diseases in children.

    abstract::The clinical usefulness of serum gamma-glutamyl transpeptidase (gamma GT) assay for the diagnosis of liver disease in children was assessed retrospectively in 398 children investigated from 1981 to 1986, in whom diagnosis was ascertained according to currently accepted criteria including liver histology in each case. ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199101000-00005

    authors: Maggiore G,Bernard O,Hadchouel M,Lemonnier A,Alagille D

    更新日期:1991-01-01 00:00:00

  • Celiac disease with mild to moderate histologic changes is a common cause of chronic diarrhea in Indian children.

    abstract:OBJECTIVES:In developed countries, small bowel histology in coeliac disease is a spectrum, ranging from normal with increased intraepithelial lymphocytes to the classic flat mucosa. In developing countries, mild to moderate enteropathies in children with chronic diarrhea and growth failure are assumed to be caused by t...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000172261.24115.29

    authors: Bhatnagar S,Gupta SD,Mathur M,Phillips AD,Kumar R,Knutton S,Unsworth DJ,Lock RJ,Natchu UC,Mukhopadhyaya S,Saini S,Bhan MK

    更新日期:2005-08-01 00:00:00

  • Cholestasis associated with total parenteral nutrition.

    abstract::It appears that neonates, especially those with very low birthweights, may be at especially high risk of developing cholestasis associated with total parenteral nutrition (TPN). Within 2 weeks of starting intravenous alimentation, it would appear highly desirable to be able to start at least small enteral feedings to ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/00005176-198601000-00004

    authors: Merritt RJ

    更新日期:1986-01-01 00:00:00

  • Randomized, double-blind, placebo-controlled pilot trial of megestrol acetate in malnourished children with cystic fibrosis.

    abstract:BACKGROUND:Undernutrition is common in patients with cystic fibrosis (CF). Nutritional rehabilitation has been shown to improve linear growth, pulmonary function, well-being, and resistance to infection in this population. The purpose of this study was to determine whether the administration of megestrol acetate (MA) i...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-200009000-00012

    authors: Marchand V,Baker SS,Stark TJ,Baker RD

    更新日期:2000-09-01 00:00:00

  • Long-term outcome of intractable ulcerating enterocolitis of infancy.

    abstract:BACKGROUND:Chronic enterocolitis is rare in infancy and accounts for less than 0.5% of all newly diagnosed inflammatory bowel disease (IBD) in the UK. Presentation at this young age is usually indicative of underlying immunodeficiency/immunodysregulation. A group of such infants suffer intractable ulcerating enterocoli...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000159622.88342.bc

    authors: Thapar N,Shah N,Ramsay AD,Lindley KJ,Milla PJ

    更新日期:2005-05-01 00:00:00

  • Association of Maternal Secretor Status and Human Milk Oligosaccharides With Milk Microbiota: An Observational Pilot Study.

    abstract:BACKGROUND AND OBJECTIVES:Breast milk contains several bioactive factors including human milk oligosaccharides (HMOs) and microbes that shape the infant gut microbiota. HMO profile is determined by secretor status; however, their influence on milk microbiota is still uncovered. This study is aimed to determine the impa...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002216

    authors: Cabrera-Rubio R,Kunz C,Rudloff S,García-Mantrana I,Crehuá-Gaudiza E,Martínez-Costa C,Collado MC

    更新日期:2019-02-01 00:00:00

  • A study of liver HBV DNA during follow-up of acute viral hepatitis in children.

    abstract::Twenty-nine children with acute icteric hepatitis were classified as follows after serological tests for the agents of viral hepatitis: hepatitis B 17 patients, hepatitis A 3 patients, hepatitis A + B 1 patient, possible non-A, non-B hepatitis 8 patients. In four of these cases, hepatitis A or non-A, non-B occurred in...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198807000-00005

    authors: Marconi M,Scotto J,Laliam M,Hadchouel M,Dazza MC,Larouzé B

    更新日期:1988-07-01 00:00:00

  • Dietary fiber in weaning cereals: a study of the effect on stool characteristics and absorption of energy, nitrogen, and minerals in healthy infants.

    abstract::We evaluated the effect of increased dietary fiber (DF) content in weaning cereals based on wheat/soy (8.0 and 1.8% DF) and wheat/milk (5.3 and 2.0% DF) in healthy, formula-fed infants 7-17 weeks old. The study had a cross-over design, each infant acting as his or her own control. Stool characteristics and anthropomet...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-199602000-00008

    authors: Davidsson L,Mackenzie J,Kastenmayer P,Rose A,Golden BE,Aggett PJ,Hurrell RF

    更新日期:1996-02-01 00:00:00

  • Effect of orally administered epidermal growth factor on intestinal recovery of neonatal pigs infected with rotavirus.

    abstract::The effect of oral epidermal growth factor (EGF) on histological and biochemical changes in epithelium in the small intestine was studied in colostrum-deprived neonatal pigs. Forty-eight pigs were infected at 4 days of age with 2 x 10(7) plaque-forming units of porcine group A rotavirus and orally fed a simulated sow-...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199411000-00003

    authors: Zijlstra RT,Odle J,Hall WF,Petschow BW,Gelberg HB,Litov RE

    更新日期:1994-11-01 00:00:00

  • Assessment of preclinical vitamin A deficiency in children with persistent diarrhea.

    abstract::To explore the relationship between vitamin A deficiency and persistent diarrhea among young children, we studied the vitamin A status of 23 children greater than 5 years of age with persistent diarrhea by performing conjunctival impression cytology (CIC) and the relative dose-response test (RDR) as a measure of liver...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199108000-00009

    authors: Usha N,Sankaranarayanan A,Walia BN,Ganguly NK

    更新日期:1991-08-01 00:00:00

  • Management of Juvenile Polyposis Syndrome in Children and Adolescents: A Position Paper From the ESPGHAN Polyposis Working Group.

    abstract::The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Polyposis Working Group developed recommendations to assist clinicians and health care providers with appropriate management of patients with juvenile polyposis. This is the first juvenile polyposis Position Paper published by ESP...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/MPG.0000000000002246

    authors: Cohen S,Hyer W,Mas E,Auth M,Attard TM,Spalinger J,Latchford A,Durno C

    更新日期:2019-03-01 00:00:00