The genetic architecture of local adaptation and reproductive isolation in sympatry within the Mimulus guttatus species complex.

Abstract:

:The genetic architecture of local adaptation has been of central interest to evolutionary biologists since the modern synthesis. In addition to classic theory on the effect size of adaptive mutations by Fisher, Kimura and Orr, recent theory addresses the genetic architecture of local adaptation in the face of ongoing gene flow. This theory predicts that with substantial gene flow between populations local adaptation should proceed primarily through mutations of large effect or tightly linked clusters of smaller effect loci. In this study, we investigate the genetic architecture of divergence in flowering time, mating system-related traits, and leaf shape between Mimulus laciniatus and a sympatric population of its close relative M. guttatus. These three traits are probably involved in M. laciniatus' adaptation to a dry, exposed granite outcrop environment. Flowering time and mating system differences are also reproductive isolating barriers making them 'magic traits'. Phenotypic hybrids in this population provide evidence of recent gene flow. Using next-generation sequencing, we generate dense SNP markers across the genome and map quantitative trait loci (QTLs) involved in flowering time, flower size and leaf shape. We find that interspecific divergence in all three traits is due to few QTL of large effect including a highly pleiotropic QTL on chromosome 8. This QTL region contains the pleiotropic candidate gene TCP4 and is involved in ecologically important phenotypes in other Mimulus species. Our results are consistent with theory, indicating that local adaptation and reproductive isolation with gene flow should be due to few loci with large and pleiotropic effects.

journal_name

Mol Ecol

journal_title

Molecular ecology

authors

Ferris KG,Barnett LL,Blackman BK,Willis JH

doi

10.1111/mec.13763

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

208-224

issue

1

eissn

0962-1083

issn

1365-294X

journal_volume

26

pub_type

杂志文章
  • Structure and evolution of the sea star egg receptor for sperm bindin.

    abstract::Selection on coevolving sperm- and egg-recognition molecules is a potent engine of population divergence leading to reproductive isolation and speciation. The study of receptor-ligand pairs can reveal co-evolution of male- and female-expressed genes or differences between their evolution in response to selective facto...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.12251

    authors: Hart MW

    更新日期:2013-04-01 00:00:00

  • Estimation of gene flow in the tropical-rainforest tree Neobalanocarpus heimii (Dipterocarpaceae), inferred from paternity analysis.

    abstract::Pollen flow and population genetic structure among 30 potentially flowering individuals of Neobalanocarpus heimii, a tropical emergent tree, were investigated in a lowland tropical rainforest of Malaysia using microsatellite polymorphism. The 248 offspring in the vicinity of five reproductive trees of the 30 potential...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.2000.01081.x

    authors: Konuma A,Tsumura Y,Lee CT,Lee SL,Okuda T

    更新日期:2000-11-01 00:00:00

  • Multiple scales of genetic connectivity in a brooding coral on isolated reefs following catastrophic bleaching.

    abstract::Understanding the pattern of connectivity among populations is crucial for the development of realistic and spatially explicit population models in marine systems. Here we analysed variation at eight microsatellite loci to assess the genetic structure and to infer patterns of larval dispersal for a brooding coral, Ser...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294X.2006.03187.x

    authors: Underwood JN,Smith LD,Van Oppen MJ,Gilmour JP

    更新日期:2007-02-01 00:00:00

  • Positive relationships between genetic diversity and abundance in fishes.

    abstract::Molecular markers, such as mitochondrial DNA and microsatellite loci, are widely studied to assess population genetics and phylogeography; however, the selective neutrality of these markers is increasingly being questioned. Given the importance of molecular markers in fisheries science and conservation, we evaluated t...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294X.2010.04822.x

    authors: McCusker MR,Bentzen P

    更新日期:2010-11-01 00:00:00

  • Phylogenetic community ecology of soil biodiversity using mitochondrial metagenomics.

    abstract::High-throughput DNA methods hold great promise for the study of taxonomically intractable mesofauna of the soil. Here, we assess species diversity and community structure in a phylogenetic framework, by sequencing total DNA from bulk specimen samples and assembly of mitochondrial genomes. The combination of mitochondr...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.13195

    authors: Andújar C,Arribas P,Ruzicka F,Crampton-Platt A,Timmermans MJ,Vogler AP

    更新日期:2015-07-01 00:00:00

  • Ever deeper phylogeographies: trees retain the genetic imprint of Tertiary plate tectonics.

    abstract::Changes in species distributions after the last glacial maximum (c. 18 000 years bp) are beginning to be understood, but information diminishes quickly as one moves further back in time. In this issue of Molecular Ecology, Magri et al. (2007) present the fascinating case of a Mediterranean tree species whose populatio...

    journal_title:Molecular ecology

    pub_type: 评论,历史文章,杂志文章

    doi:10.1111/j.1365-294X.2007.03604.x

    authors: Hampe A,Petit RJ

    更新日期:2007-12-01 00:00:00

  • Did the pleistocene glaciations promote divergence? Tests of explicit refugial models in montane grasshopprers.

    abstract::There is a long-standing debate over whether or not the Pleistocene glaciations promoted speciation. While some models predict that extensive mixing of populations during interglacial expansion would have inhibited divergence, others postulate that divergence among allopatric glacial refuges or founder events during r...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.2001.01206.x

    authors: Knowles LL

    更新日期:2001-03-01 00:00:00

  • Evolution and molecular mechanisms of adaptive developmental plasticity.

    abstract::Aside from its selective role in filtering inter-individual variation during evolution by natural selection, the environment also plays an instructive role in producing variation during development. External environmental cues can influence developmental rates and/or trajectories and lead to the production of distinct...

    journal_title:Molecular ecology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-294X.2011.05016.x

    authors: Beldade P,Mateus AR,Keller RA

    更新日期:2011-04-01 00:00:00

  • Demographic modelling with whole-genome data reveals parallel origin of similar Pundamilia cichlid species after hybridization.

    abstract::Modes and mechanisms of speciation are best studied in young species pairs. In older taxa, it is increasingly difficult to distinguish what happened during speciation from what happened after speciation. Lake Victoria cichlids in the genus Pundamilia encompass a complex of young species and polymorphic populations. On...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.13838

    authors: Meier JI,Sousa VC,Marques DA,Selz OM,Wagner CE,Excoffier L,Seehausen O

    更新日期:2017-01-01 00:00:00

  • Molecular analysis of predation: a review of best practice for DNA-based approaches.

    abstract::Molecular analysis of predation, through polymerase chain reaction amplification of prey remains within the faeces or digestive systems of predators, is a rapidly growing field, impeded by a lack of readily accessible advice on best practice. Here, we review the techniques used to date and provide guidelines accessibl...

    journal_title:Molecular ecology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-294X.2007.03613.x

    authors: King RA,Read DS,Traugott M,Symondson WO

    更新日期:2008-02-01 00:00:00

  • Population subdivision among desert bighorn sheep (Ovis canadensis) ewes revealed by mitochondrial DNA analysis.

    abstract::We used behavioural observations and mitochondrial DNA (mtDNA) sequence analysis to examine demographic and genetic structure within and among home-range groups of desert bighorn sheep (Ovis canadensis) ewes in the Peninsular Ranges of southern California, USA. We identified substantial genetic variation in the first ...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.1999.00536.x

    authors: Boyce WM,Ramey RR 2nd,Rodwell TC,Rubin ES,Singer RS

    更新日期:1999-01-01 00:00:00

  • Genetic structure and distinctness of Apis mellifera L. populations from the Canary Islands.

    abstract::The genetic structure of Apis mellifera populations from the Canary Islands has been assessed by mitochondrial (restriction fragment length polymorphisms of the intergenic transfer RNAleu-COII region) and nuclear (microsatellites) studies. These populations show a low level of genetic variation in terms of average num...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.2001.01303.x

    authors: De la Rúa P,Galián J,Serrano J,Moritz RF

    更新日期:2001-07-01 00:00:00

  • Features of DNA fragments obtained by random amplified polymorphic DNA (RAPD) assays

    abstract::Random amplified polymorphic DNA (RAPD) fragments were prepared from samples of Calonectris diomedea (Cory's shearwater, Aves) and Haemonchus contortus (Nematoda) DNA by polymerase chain reaction (PCR) using decamers containing two restriction enzyme sites as primers. Six of 19 studied RAPD fragments probably originat...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.1999.00605.x

    authors: Rabouam C,Comes AM,Bretagnolle V V,Humbert JF,Periquet G,Bigot Y

    更新日期:1999-03-01 00:00:00

  • Disruptive selection without genome-wide evolution across a migratory divide.

    abstract::Transcontinental migration is a fascinating example of how animals can respond to climatic oscillation. Yet, quantitative data on fitness components are scarce, and the resulting population genetic consequences are poorly understood. Migratory divides, hybrid zones with a transition in migratory behaviour, provide a n...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.13521

    authors: von Rönn JA,Shafer AB,Wolf JB

    更新日期:2016-06-01 00:00:00

  • Long-term population isolation in the endangered tropical tree species Caesalpinia echinata Lam. revealed by chloroplast microsatellites.

    abstract::Habitat fragmentation represents the single most serious threat to the survival of tropical ecosystems. In formulating strategies to counteract the detrimental effects of fragmentation, knowledge of the levels and patterns of genetic diversity within and between natural populations is vital to the establishment of any...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.2003.01991.x

    authors: Lira CF,Cardoso SR,Ferreira PC,Cardoso MA,Provan J

    更新日期:2003-12-01 00:00:00

  • The evolutionary history of Afrocanarian blue tits inferred from genomewide SNPs.

    abstract::A common challenge in phylogenetic reconstruction is to find enough suitable genomic markers to reliably trace splitting events with short internodes. Here, we present phylogenetic analyses based on genomewide single-nucleotide polymorphisms (SNPs) of an enigmatic avian radiation, the subspecies complex of Afrocanaria...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.13008

    authors: Gohli J,Leder EH,Garcia-Del-Rey E,Johannessen LE,Johnsen A,Laskemoen T,Popp M,Lifjeld JT

    更新日期:2015-01-01 00:00:00

  • Extra-pair paternity in waved albatrosses.

    abstract::We estimated the rate of extra-pair fertilizations (EPFs) in waved albatrosses (Phoebastria irrorata) on Isla Española, Galápagos, Ecuador, using multilocus minisatellite DNA fingerprinting. Waved albatrosses are socially monogamous, long-lived seabirds whose main population is on Española. Aggressive extra-pair copul...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.2000.00996.x

    authors: Huyvaert KP,Anderson DJ,Jones TC,Duan W,Parker PG

    更新日期:2000-09-01 00:00:00

  • Standardizing for microsatellite length in comparisons of genetic diversity.

    abstract::Mutation rates at microsatellites tend to increase with the number of repeats of the motif, leading to higher levels of polymorphism at long microsatellites. To standardize levels of diversity when microsatellites differ in size, we investigate the relationship between tract length and variation and provide a formula ...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294X.2005.02446.x

    authors: Petit RJ,Deguilloux MF,Chat J,Grivet D,Garnier-Géré P,Vendramin GG

    更新日期:2005-03-01 00:00:00

  • The comparative genomic landscape of adaptive radiation in crater lake cichlid fishes.

    abstract::Factors ranging from ecological opportunity to genome composition might explain why only some lineages form adaptive radiations. While being rare, particular systems can provide natural experiments within an identical ecological setting where species numbers and phenotypic divergence in two closely related lineages ar...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.15774

    authors: Xiong P,Hulsey CD,Fruciano C,Wong WY,Nater A,Kautt AF,Simakov O,Pippel M,Kuraku S,Meyer A,Franchini P

    更新日期:2020-12-11 00:00:00

  • Migration, pathogens and the avian microbiome: A comparative study in sympatric migrants and residents.

    abstract::Animals generally benefit from their gastrointestinal microbiome, but the factors that influence the composition and dynamics of their microbiota remain poorly understood. Studies of nonmodel host species can illuminate how microbiota and their hosts interact in natural environments. We investigated the role of migrat...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.15660

    authors: Turjeman S,Corl A,Wolfenden A,Tsalyuk M,Lublin A,Choi O,Kamath PL,Getz WM,Bowie RCK,Nathan R

    更新日期:2020-12-01 00:00:00

  • Diversity and distribution of subterranean bacteria in groundwater at Oklo in Gabon, Africa, as determined by 16S rRNA gene sequencing.

    abstract::This paper describes how ground water was sampled, DNA extracted, amplified and cloned and how information available in the ribosomal 16S rRNA gene was used for mapping diversity and distribution of subterranean bacteria in groundwater at the Bangombé site in the Oklo region. The results showed that this site was inha...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294x.1996.tb00332.x

    authors: Pedersen K,Arlinger J,Hallbeck L,Pettersson C

    更新日期:1996-06-01 00:00:00

  • Contrasting patterns of mitochondrial and microsatellite population structure in fragmented populations of greater prairie-chickens.

    abstract::Greater prairie-chickens (Tympanuchus cupido pinnatus) were once found throughout the tallgrass prairie of midwestern North America but over the last century these prairies have been lost or fragmented by human land use. As a consequence, many current populations of prairie-chickens have become isolated and small. Thi...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.2003.02013.x

    authors: Johnson JA,Toepfer JE,Dunn PO

    更新日期:2003-12-01 00:00:00

  • Genetic structure of populations of whale sharks among ocean basins and evidence for their historic rise and recent decline.

    abstract::This study presents genetic evidence that whale sharks, Rhincodon typus, are comprised of at least two populations that rarely mix and is the first to document a population expansion. Relatively high genetic structure is found when comparing sharks from the Gulf of Mexico with sharks from the Indo-Pacific. If mixing o...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.12754

    authors: Vignaud TM,Maynard JA,Leblois R,Meekan MG,Vázquez-Juárez R,Ramírez-Macías D,Pierce SJ,Rowat D,Berumen ML,Beeravolu C,Baksay S,Planes S

    更新日期:2014-05-01 00:00:00

  • Breeding origin and migration pattern of dunlin (Calidris alpina) revealed by mitochondrial DNA analysis.

    abstract::The large-scale migration of birds has been studied extensively by recoveries of ringed birds. However, there is very little ringing data from the arctic breeding grounds of waders. Here, the migration pattern of the dunlin, Calidris alpina, is studied with population genetic markers, using haplotype frequencies to es...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.2001.01256.x

    authors: Wennerberg L

    更新日期:2001-05-01 00:00:00

  • Perspective.

    abstract::Reef corals are especially sensitive to environmental change since their survival is dependent on a delicate balance between the coral host and its algal endosymbiont. Predicting the responses of reef ecosystems to global climate change requires a detailed understanding of the diversity of both partners in this symbio...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/j.1365-294X.2007.03254.x

    authors: van Oppen MJ

    更新日期:2007-03-01 00:00:00

  • Caste- and pesticide-specific effects of neonicotinoid pesticide exposure on gene expression in bumblebees.

    abstract::Social bees are important insect pollinators of wildflowers and agricultural crops, making their reported declines a global concern. A major factor implicated in these declines is the widespread use of neonicotinoid pesticides. Indeed, recent research has demonstrated that exposure to low doses of these neurotoxic pes...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.15047

    authors: Colgan TJ,Fletcher IK,Arce AN,Gill RJ,Ramos Rodrigues A,Stolle E,Chittka L,Wurm Y

    更新日期:2019-04-01 00:00:00

  • Genetic patterns across an invasion's history: a test of change versus stasis for the Eurasian round goby in North America.

    abstract::Biological invasions comprise accidental evolutionary experiments, whose genetic compositions underlie relative success, spread and persistence in new habitats. However, little is known about whether, or how, their population genetic patterns change temporally and/or spatially across the invasion's history. Theory pre...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.13997

    authors: Snyder MR,Stepien CA

    更新日期:2017-02-01 00:00:00

  • A genomic map of climate adaptation in Mediterranean cattle breeds.

    abstract::Domestic species such as cattle (Bos taurus taurus and B. t. indicus) represent attractive biological models to characterize the genetic basis of short-term evolutionary response to climate pressure induced by their post-domestication history. Here, using newly generated dense SNP genotyping data, we assessed the stru...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.15004

    authors: Flori L,Moazami-Goudarzi K,Alary V,Araba A,Boujenane I,Boushaba N,Casabianca F,Casu S,Ciampolini R,Coeur D'Acier A,Coquelle C,Delgado JV,El-Beltagi A,Hadjipavlou G,Jousselin E,Landi V,Lauvie A,Lecomte P,Ligda C,Mari

    更新日期:2019-03-01 00:00:00

  • Relationship between aquifer biofilms and unattached microbial indicators of urban groundwater contamination.

    abstract::Aquifers, springs and other groundwater-dependent ecosystems are threatened by urban land use, which causes water quality deterioration through nutrient loading, sewage infiltration, groundwater extraction and, along coasts, seawater intrusion. The presence of certain microbes in groundwater can indicate that an aquif...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1111/mec.15713

    authors: Scharping RJ,Garey JR

    更新日期:2020-10-28 00:00:00

  • Microsatellite analysis of kinkajou social organization.

    abstract::Kinkajou social groups generally consist of one adult female, two males, one subadult and one juvenile. Based on analysis of variation in 11 microsatellite loci, we assess the degree of kinship within and between four social groups totaling 25 kinkajous. We use exclusion and likelihood analyses to assign parents for s...

    journal_title:Molecular ecology

    pub_type: 杂志文章

    doi:10.1046/j.1365-294x.2000.00921.x

    authors: Kays RW,Gittleman JL,Wayne RK

    更新日期:2000-06-01 00:00:00