Abstract:
:We previously reported that adenosine 5'-triphosphate (ATP) inhibited the growth of various bacteria, including mycobacteria, Staphylococcus, and Pseudomonas, without damaging bacterial surface structures. Notably, ATP's antibacterial activity was found to be attributable to its iron-chelating ability. ATP exhibited combined effects with some antimicrobials against Mycobacterium intracellulare and methicillin-resistant S. aureus, suggesting its usefulness as an adjunctive drug in the chemotherapy against certain intractable infections. In this study, we examined detailed profiles of the anti-Mycobacterium avium complex (MAC) activity of some antimicrobial agents, including clarithromycin (CLA), rifampin (RIF), rifabutin (RBT), and ethambutol (EMB), in combination with ATP. It was found that the anti-MAC activity of CLA+RIF, CLA+RBT, and CLA+EMB was markedly potentiated in a strain-dependent manner. In this case, the onset of the regrowth of antimicrobial agent-treated mycobacteria during cultivation was significantly delayed in the presence of ATP, indicating the usefulness of ATP as an adjunctive drug in chemotherapy against MAC infections.
journal_name
Diagn Microbiol Infect Disjournal_title
Diagnostic microbiology and infectious diseaseauthors
Tatano Y,Yamabe S,Sano C,Tomioka Hdoi
10.1016/j.diagmicrobio.2017.04.012subject
Has Abstractpub_date
2017-07-01 00:00:00pages
241-246issue
3eissn
0732-8893issn
1879-0070pii
S0732-8893(17)30141-4journal_volume
88pub_type
杂志文章abstract::The presence of Candida in the urine of a seriously ill, pediatric patient presents a management problem because of a lack of information concerning the natural history of candiduria and its relationship to disseminated candidiasis. In this retrospective study, the outcome of candiduria was examined in a group of 54 p...
journal_title:Diagnostic microbiology and infectious disease
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doi:10.1016/0732-8893(91)90045-h
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
pub_type: 临床试验,杂志文章
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
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journal_title:Diagnostic microbiology and infectious disease
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