Axon degeneration: make the Schwann cell great again.

abstract：:The present study investigated the influence of anti-estrogen treatment (fulvestrant) on pituitary adenoma cell line GH3 biological activity, the estrogen receptor α pathway, the WnT pathway, and mechanisms of decreased Wnt inhibitory factor-1 expression in GH3 cells. Results showed that fulvestrant suppressed GH3 cel...

journal_title：Neural regeneration research

authors： Bai J,Wang Y,Li C,Zhang Y

更新日期：2012-02-05 00:00:00

abstract：:Myelin regeneration is indispensably important for patients suffering from several central nervous system (CNS) disorders such as multiple sclerosis (MS) and spinal cord injury (SCI), because it is not only essential for restoring neurophysiology, but also protects denuded axons for secondary degeneration. Understandi...

journal_title：Neural regeneration research

authors： Bhatt A,Fan LW,Pang Y

更新日期：2014-07-15 00:00:00

abstract：:Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the act...

journal_title：Neural regeneration research

authors： Yong CQY,Tang BL

更新日期：2019-04-01 00:00:00

abstract：:Active Achilles tendon kinesitherapy facilitates the functional recovery of a ruptured Achilles tendon. However, protein expression during the healing process remains a controversial issue. New Zealand rabbits, aged 14 weeks, underwent tenotomy followed immediately by Achilles tendon microsurgery to repair the Achille...

journal_title：Neural regeneration research

authors： Jielile J,Aibai M,Sabirhazi G,Shawutali N,Tangkejie W,Badelhan A,Nuerduola Y,Satewalede T,Buranbai D,Hunapia B,Jialihasi A,Bai J,Kizaibek M

更新日期：2012-12-15 00:00:00

abstract：:Amniotic membranes have been widely used in ophthalmology and skin injury repair because of their anti-inflammatory properties. In this study, we measured therapeutic efficacy and determined if amniotic membranes could be used for facial nerve repair. The facial nerves of eight rats were dissected and end-to-end anast...

journal_title：Neural regeneration research

authors： Karaman M,Tuncel A,Sheidaei S,Senol MG,Karabulut MH,Deveci I,Karaman N

更新日期：2013-04-15 00:00:00

abstract：:Extracellular vesicles, including exosomes and microvesicles, play a fundamental role in the activity of the nervous system, participating in signal transmission between neurons and providing the interaction of central nervous system with all body systems. In many neurodegenerative diseases, neurons pack toxic substan...

journal_title：Neural regeneration research

authors： Shaimardanova AA,Solovyeva VV,Chulpanova DS,James V,Kitaeva KV,Rizvanov AA

更新日期：2020-04-01 00:00:00

abstract：:Recent studies have shown that tea polyphenols can cross the blood-brain barrier, inhibit apoptosis and play a neuroprotective role against cerebral ischemia. Furthermore, tea polyphenols can decrease DNA damage caused by free radicals. We hypothesized that tea polyphenols repair DNA damage and inhibit neuronal apopto...

journal_title：Neural regeneration research

authors： Wang Z,Xue R,Lei X,Lv J,Wu G,Li W,Xue L,Lei X,Zhao H,Gao H,Wei X

更新日期：2012-10-25 00:00:00

abstract：Objective:To critically assess the neurological recovery and antioxidant effects of resveratrol in rat models of spinal cord injury. Data sources:Using "spinal cord injury", "resveratrol" and "animal experiment" as the main search terms, all studies on the treatment of spinal cord injury in rats by resveratrol were se...

journal_title：Neural regeneration research

authors： Xu BP,Yao M,Li ZJ,Tian ZR,Ye J,Wang YJ,Cui XJ

更新日期：2020-03-01 00:00:00

abstract：:Tissue plasminogen activator is usually used for the treatment of acute ischemic stroke, but the role of endogenous tissue plasminogen activator in traumatic brain injury has been rarely reported. A rat model of traumatic brain injury was established by weight-drop method. The tissue plasminogen activator inhibitor ne...

journal_title：Neural regeneration research

authors： Zhao JJ,Liu ZW,Wang B,Huang TQ,Guo D,Zhao YL,Song JN

更新日期：2020-04-01 00:00:00

abstract：:The blood-spinal cord barrier plays a vital role in recovery after spinal cord injury. The neurovascular unit concept emphasizes the relationship between nerves and vessels in the brain, while the effect of the blood-spinal cord barrier on the neurovascular unit is rarely reported in spinal cord injury studies. Mouse ...

journal_title：Neural regeneration research

authors： Ye LX,An NC,Huang P,Li DH,Zheng ZL,Ji H,Li H,Chen DQ,Wu YQ,Xiao J,Xu K,Li XK,Zhang HY

更新日期：2021-04-01 00:00:00

abstract：:Spinal cord injury that results in severe neurological disability is often incurable. The poor clinical outcome of spinal cord injury is mainly caused by the failure to reconstruct the injured neural circuits. Several intrinsic and extrinsic determinants contribute to this inability to reconnect. Epigenetic regulation...

journal_title：Neural regeneration research

authors： Zhang BY,Chang PY,Zhu QS,Zhu YH,Saijilafu.

更新日期：2020-09-01 00:00:00

abstract：:Schwann cell transplantation is a promising method to promote neural repair, and can be used for peripheral nerve protection and myelination. Microcapsule technology largely mitigates immune rejection of transplanted cells. We previously showed that microencapsulated olfactory ensheathing cells can reduce neuropathic ...

journal_title：Neural regeneration research

authors： Zhang YL,Chen DJ,Yang BL,Liu TT,Li JJ,Wang XQ,Xue GY,Liu ZX

更新日期：2018-11-01 00:00:00

abstract：:In this study, rats were put into traumatic brain injury-induced coma and treated with median nerve electrical stimulation. We explored the wake-promoting effect, and possible mechanisms, of median nerve electrical stimulation. Electrical stimulation upregulated the expression levels of orexin-A and its receptor OX1R ...

journal_title：Neural regeneration research

authors： Feng Z,Zhong YJ,Wang L,Wei TQ

更新日期：2015-04-01 00:00:00

abstract：:Microtubule-associated protein 1B plays an important role in axon guidance and neuronal migration. In the present study, we sought to discover the mechanisms underlying microtubule-associated protein 1B mediation of axon guidance and neuronal migration. We exposed bone marrow mesenchymal stem cells to okadaic acid or ...

journal_title：Neural regeneration research

authors： Xia P,Pan S,Cheng J,Yang M,Qi Z,Hou T,Yang X

更新日期：2014-09-15 00:00:00

abstract：:Previous animal studies have shown that stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) signaling pathway plays an important role in the targeted migration of bone marrow-derived mesenchymal stem cells (BMSCs) to the injured area. In the present study, we aimed to investigate the potential role ...

journal_title：Neural regeneration research

authors： Peyvandi AA,Roozbahany NA,Peyvandi H,Abbaszadeh HA,Majdinasab N,Faridan M,Niknazar S

更新日期：2018-01-01 00:00:00

abstract：:The potential impact of human leukocyte antigen (HLA) genotype variations on development of diabetic peripheral neuropathy (DPN) is not well determined. This study aimed to identify the association of HLA class II alleles with DPN in type 2 diabetes (T2D) patients. Totally 106 T2D patients, 49 with DPN and 57 without ...

journal_title：Neural regeneration research

authors： Marzban A,Kiani J,Hajilooi M,Rezaei H,Kahramfar Z,Solgi G

更新日期：2016-11-01 00:00:00

abstract：:A significant amount of evidence indicates that microRNAs (miRNAs) play an important role in drug addiction. The nucleus accumbens (NAc) is a critical part of the brain's reward circuit and is involved in a variety of psychiatric disorders, including depression, anxiety, and drug addiction. However, few studies have e...

journal_title：Neural regeneration research

authors： Kim J,Im HI,Moon C

更新日期：2018-01-01 00:00:00

abstract：:For decades visual field defects were considered irreversible because it was thought that in the visual system the regeneration potential of the neuronal tissues is low. Nevertheless, there is always some potential for partial recovery of the visual field defect that can be achieved through induction of neuroplasticit...

journal_title：Neural regeneration research

authors： Sabel BA,Gao Y,Antal A

更新日期：2020-10-01 00:00:00

abstract：:The acute effect of acupuncture on Alzheimer's disease, i.e., on brain activation during treatment, has been reported. However, the effect of long-term acupuncture on brain activation in Alzheimer's disease is unclear. Therefore, in this study, we performed long-term needling at Zusanli (ST36) or a sham point (1.5 mm ...

journal_title：Neural regeneration research

authors： Lu YJ,Cai XW,Zhang GF,Huang Y,Tang CZ,Shan BC,Cui SY,Chen JQ,Qu SS,Zhong Z,Lai XS,Steiner GZ

更新日期：2017-07-01 00:00:00

abstract：:The present study aimed to explore the mechanism underlying the protective effects of hydrogen sulfide against neuronal damage caused by cerebral ischemia/reperfusion. We established the middle cerebral artery occlusion model in rats via the suture method. Ten minutes after middle cerebral artery occlusion, the animal...

journal_title：Neural regeneration research

authors： Li XJ,Li CK,Wei LY,Lu N,Wang GH,Zhao HG,Li DL

更新日期：2015-06-01 00:00:00

abstract：:Three-dimensional (3D) histology utilizes tissue clearing techniques to turn intact tissues transparent, allowing rapid interrogation of tissue architecture in three dimensions. In this article, we summarized the available tissue clearing methods and classified them according to their physicochemical principles of ope...

journal_title：Neural regeneration research

authors： Lai HM,Ng HM,Wu W

更新日期：2017-01-01 00:00:00

abstract：:Serum biomarkers may play a reliable role in predicting the outcomes of patients with aneurysmal subarachnoid hemorrhage. This study retrospectively analyzed the relationship between serum biomarkers on admission and outcomes in patients with aneurysmal subarachnoid hemorrhage. We recruited 146 patients with aneurysma...

journal_title：Neural regeneration research

authors： Liu JH,Li XK,Chen ZB,Cai Q,Wang L,Ye YH,Chen QX

更新日期：2017-12-01 00:00:00

abstract：:Stroke is one of the leading causes of death and disability in adults worldwide, resulting in huge social and financial burdens. Extracts from herbs, especially those used in Chinese medicine, have emerged as new pharmaceuticals for stroke treatment. Here we review the evidence from preclinical studies investigating n...

journal_title：Neural regeneration research

authors： Zhang B,Saatman KE,Chen L

更新日期：2020-03-01 00:00:00

abstract：:The sciatic functional index (SFI) is a popular parameter for peripheral nerve evaluation that relies on footprints obtained with ink and paper. Drawbacks include smearing artefacts and a lack of dynamic information during measurement. Modern applications use digitized systems that can deliver results with less analyt...

journal_title：Neural regeneration research

authors： Fricker L,Penna V,Lampert F,Stark GB,Witzel C,Koulaxouzidis G

更新日期：2016-05-01 00:00:00

abstract：:Emerging evidence supports that the stress response to peripheral nerve injury extends beyond the injured neuron, with alterations in associated transcription factors detected both locally and remote to the lesion. Stress-induced nuclear translocation of the transcription factor forkhead class box O3a (FOXO3a) was ini...

journal_title：Neural regeneration research

authors： Hasmatali JCD,De Guzman J,Johnston JM,Noyan H,Juurlink BH,Misra V,Verge VMK

更新日期：2020-12-01 00:00:00

abstract：:Microglia-associated neuroinflammation plays an important role in the pathophysiology of ischemic stroke. Microglial activation and polarization, and the inflammatory response mediated by these cells play important roles in the development, progression and outcome of brain injury after ischemic stroke. Currently, ther...

journal_title：Neural regeneration research

authors： Zhang W,Tian T,Gong SX,Huang WQ,Zhou QY,Wang AP,Tian Y

更新日期：2021-01-01 00:00:00

abstract：:White adipose tissue (WAT) stores energy and also plays an important endocrine role in producing adipokines for communication with the peripheral and central nervous system. WAT consists of the major lipogenic unilocular adipocytes and the minor populations of beige and brite multilocular adipocytes. These multilocula...

journal_title：Neural regeneration research

authors： Lee A,Ziouzenkova O

更新日期：2019-02-01 00:00:00

abstract：:Although numerous studies have examined the neurotoxicity of acrylamide in adult animals, the effects on neuronal development in the embryonic and lactational periods are largely unknown. Thus, we examined the toxicity of acrylamide on neuronal development in the hippocampus of fetal rats during pregnancy. Sprague-Daw...

journal_title：Neural regeneration research

authors： Lai SM,Gu ZT,Zhao MM,Li XX,Ma YX,Luo L,Liu J

更新日期：2017-10-01 00:00:00

abstract：:Throughout the globe, diabetes mellitus (DM) is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder. DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to di...

journal_title：Neural regeneration research

authors： Maiese K

更新日期：2016-03-01 00:00:00

abstract：:TMP269 is a selective class IIA histone deacetylase inhibitor that has a protective effect on the central nervous system, whose specific mechanism of action is unclear. We aimed to reveal the optimal concentration of TMP269 for protecting against cerebral ischemia/reperfusion injury and its neuroprotective mechanism. ...

journal_title：Neural regeneration research

authors： Su L,Liang D,Kuang SY,Dong Q,Han X,Wang Z

更新日期：2020-02-01 00:00:00