当前位置： SCI文献检索 > DIABETES RESEARCH AND CLINICAL PRACTICE期刊下所有文献 > Triple therapy combinations for the treatment of type 2 diabetes - A network meta-analysis.

Triple therapy combinations for the treatment of type 2 diabetes - A network meta-analysis.

Abstract：

AIM:To estimate and compare the results from all randomised trials of triple combinations of anti-diabetes therapies that reported the reduction of glycated haemoglobin (HbA1c) and associated effects on body weight and hypoglycaemia. METHODS:PubMed and the Cochrane Library were searched for trials with at least one study arm on triple therapy and which reported the differences in mean change in HbA1c between two study arms. These were included in a network meta-analysis. RESULTS:Altogether, 15,182 participants from 40 trials with treatment duration of 6-12months were included. Compared with none/placebo added to dual therapy, the addition of a drug therapy from six of eight drug classes to existing dual therapy resulted in significant additional mean reductions in HbA1c from -0.56% (-6.2mmol/mol; dipeptidyl peptidase 4 inhibitors) to -0.94% (-10.3mmol/mol; thiazolidinediones). Of the six drug classes, three were associated with less favourable weight change and two were associated with more favourable weight change when compared with none/placebo added to dual therapy. Furthermore, five drug classes were associated with greater odds of hypoglycaemia. Similar results were observed in analyses of studies with a 6month treatment duration and after excluding study arms that contained insulin. CONCLUSIONS:Overall triple therapy combinations were similar in improving diabetes control although there were some differences in adverse effects. By balancing the risks and benefits of each therapy, the estimates of pairwise comparisons of triple therapies for HbA1c, body weight and hypoglycaemia provided in this study may further inform evidence based practice.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Lee CM,Woodward M,Colagiuri S

doi

10.1016/j.diabres.2016.04.037

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

149-58

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(16)30101-2

journal_volume

116

pub_type

杂志文章,meta分析

相关文献

DIABETES RESEARCH AND CLINICAL PRACTICE文献大全
  • Waist circumference cut-off points for the diagnosis of metabolic syndrome in Iranian adults.

    abstract：AIMS:Central obesity, a prominent feature of metabolic syndrome (MetS), is commonly assessed by gender- and ethnicity-specific waist circumference (WC) cut-off values. Since 2006, the recommended WC cut-offs by the International Diabetes Federation (IDF) for Europeans are used in Iran because of limited data availabili...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2008.07.009

    authors： Esteghamati A,Ashraf H,Rashidi A,Meysamie A

    更新日期：2008-10-01 00:00:00

  • Patient decisional needs when considering treatment intensification for type 2 diabetes: A qualitative study in China.

    abstract：AIMS:This study explored decisional needs of patients with type 2 diabetes in China when considering treatment intensification to achieve good glycemic control, from both the patient's and practitioners' perspectives. METHODS:Interviews were conducted with 35 patients, and individual interviews and focus groups with 2...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108471

    authors： Zheng H,Toupin-April K,An Y,He S,Sigal RJ,Coyle D,Wells GA,Li G

    更新日期：2020-12-01 00:00:00

  • Post-prandial glucose and insulin responses to different types of spaghetti and bread.

    abstract：:The glycemic response following ingestion of carbohydrate in various forms is different. The factors involved are not fully elucidated. In this study the glycemic and insulin responses to 50 g of carbohydrate in the form of white bread (WB), semolina bread (SB), white spaghetti (WS) and wholemeal spaghetti (BS) were c...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(87)80043-8

    authors： d'Emden MC,Marwick TH,Dreghorn J,Howlett VL,Cameron DP

    更新日期：1987-07-01 00:00:00

  • Clinical determinants of aspirin resistance in diabetes.

    abstract：:Recent studies indicate that not all diabetic subjects benefit from aspirin therapy. Our objective is to characterize diabetic subjects with aspirin resistance using urine thromboxane, and VerifyNow measures. Our results suggest that cardiovascular disease, microalbuminuria, poor diabetes control, and increased waist ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2010.07.008

    authors： Yassine HN,Davis-Gorman G,Stump CS,Thomson SS,Peterson J,McDonagh PF

    更新日期：2010-10-01 00:00:00

  • Predictors of mortality from type 2 diabetes mellitus in Canterbury, New Zealand; a ten-year cohort study.

    abstract：:The aim was to establish mortality rates in a cohort of subjects with type 2 diabetes mellitus over 10 years in Canterbury, New Zealand (NZ) and to determine baseline prognostic factors. Subjects (447) with type 2 diabetes (208 male, 239 female; age range 30-82 years, median 62 years; of predominantly European origin)...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(01)00246-7

    authors： Florkowski CM,Scott RS,Coope PA,Moir CL

    更新日期：2001-08-01 00:00:00

  • Association of serum apolipoprotein C III levels and apolipoprotein C III gene Sst I polymorphism with carotid intima-media thickness in Chinese type 2 diabetic patients.

    abstract：:Apolipoprotein C III (apo C III) plays a central role in regulating plasma metabolism of triglyceride-rich lipoprotein (TRL). The G3238C allele (Sst I) in the 3'-untranslated region has been found to be associated with raised apo C III levels and hypertriglyceridemia (HTG). Some studies suggest that apo C III and the ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2004.02.020

    authors： Chen X,Tian H,Liu R

    更新日期：2004-10-01 00:00:00

  • The reduction and redistribution of plantar pressures using foot orthoses in diabetic patients.

    abstract：:High pressures on the soles of the feet of diabetic patients cause plantar ulcerations, and reduction of this pressure is important in the treatment and prevention of such ulcers. The effects of foot orthoses on the distribution of plantar pressures were investigated using a pressure-sensitive insole containing 960 se...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(96)01214-4

    authors： Kato H,Takada T,Kawamura T,Hotta N,Torii S

    更新日期：1996-03-01 00:00:00

  • In utero exposure to gestational diabetes mellitus and long term endocrine morbidity of the offspring.

    abstract：BACKGROUND:Gestational diabetes mellitus (GDM) is a worldwide public health problem. Few studies investigated the association of intra uterine exposure to GDM and long-term endocrine morbidity of offspring. OBJECTIVE:To assess whether in utero exposure to GDM increases the risk for long-term endocrine morbidity of the...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2018.09.003

    authors： Abokaf H,Shoham-Vardi I,Sergienko R,Landau D,Sheiner E

    更新日期：2018-10-01 00:00:00

  • Impact of COVID-19 lockdown on glycemic control in patients with type 1 diabetes.

    abstract：INTRODUCTION:The COVID-19 pandemic has forced governments to take exceptional measures to minimize its spread, imposing lockdown policies. The aim of this study was to evaluate the impact of lockdown on type 1 diabetes (T1D) glycemic control. MATERIAL AND METHODS:People with T1D using flash glucose monitoring were inc...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108348

    authors： Fernández E,Cortazar A,Bellido V

    更新日期：2020-08-01 00:00:00

  • Similar cardiovascular and autonomic responses in trained type 1 diabetes mellitus and healthy participants in response to half marathon.

    abstract：AIMS:This field experiment examined whether trained people with type 1 diabetes mellitus (T1D) have similar cardiovascular and baroreflex alterations after a 21-km running race when compared to healthy people. METHODS:Nine T1D (39.0 ± 11.1 yr; 175.0 ± 10.2 cm; 70.8 ± 8.7 kg) were matched with 9 healthy participants (4...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2019.107995

    authors： Mourot L,Fornasiero A,Rakobowchuk M,Skafidas S,Brighenti A,Stella F,Zignoli A,Savoldelli A,Pellegrini B,Danese E,Lippi G,Tarperi C,Schena F

    更新日期：2020-02-01 00:00:00

  • Is the metabolic syndrome inversely associates with butter, non-hydrogenated- and hydrogenated-vegetable oils consumption: Tehran lipid and glucose study.

    abstract：AIM:The aim of this study was to investigate the association between hydrogenated- (HVOs) and non-hydrogenated vegetable oils (non-HVOs) and butter and the metabolic syndrome (MetS) after 3-years of follow-up in adults. METHODS:This study was conducted between 2006-2008 and 2009-2011 within the framework of the Tehran...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.diabres.2015.11.008

    authors： Hosseinpour-Niazi S,Mirmiran P,Hosseini-Esfahani F,Azizi F

    更新日期：2016-02-01 00:00:00

  • Admission hyperglycemia and radiological findings of SARS-CoV2 in patients with and without diabetes.

    abstract：:Diabetes emerged as major risk factor for severe acute respiratory syndrome (SARS) and adverse outcome in patients with the coronavirus disease 2019 (COVID-19). Nevertheless, the role of admission hyperglycemia in patients with COVID-19 has not been well-explored, yet. With this retrospective analysis, we report for t...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108185

    authors： Iacobellis G,Penaherrera CA,Bermudez LE,Bernal Mizrachi E

    更新日期：2020-06-01 00:00:00

  • Risk of type 2 diabetes mellitus associated with plasma lipid levels: The rural Chinese cohort study.

    abstract：AIM:To investigate the association of type 2 diabetes mellitus (T2DM) risk and plasma lipid levels in rural Chinese. METHODS:Each lipid variable was divided into quartiles and dichotomized by clinical cutoff points. Cox proportional-hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (C...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2017.11.011

    authors： Zhang M,Zhou J,Liu Y,Sun X,Luo X,Han C,Zhang L,Wang B,Ren Y,Zhao Y,Zhang D,Liu X,Hu D

    更新日期：2018-01-01 00:00:00

  • Reduced lung diffusion capacity in type 2 diabetes is independent of heart failure.

    abstract：:In a case-control analysis comparing 303 patients with diabetes and 303 without (matched on age, race, sex and height), diabetics had reduced lung diffusion (DLCO) independent of smoking, obesity, clinical heart failure, asymptomatic left ventricular systolic and diastolic dysfunction: DLCO (mean±SE: 15.5±0.9 vs. 16.4...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2012.02.014

    authors： Klein OL,Jones M,Lee J,Collard HR,Smith LJ

    更新日期：2012-06-01 00:00:00

  • Factors influencing the clinical outcome of continuous subcutaneous insulin infusion in routine practice.

    abstract：:Possible factors that might influence the outcome of continuous subcutaneous insulin infusion (CSII) treatment were investigated in forty-nine, type 1, diabetic patients with median treatment of 3.25 years in routine diabetes care. In nine patients pump treatment was discontinued largely within the first 6 months. Pat...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(93)90145-u

    authors： Wredling R,Lins PE,Adamson U

    更新日期：1993-01-01 00:00:00

  • The evaluation of thiol/disulphide homeostasis in diabetic nephropathy.

    abstract：AIMS:Thiol/disulphide homeostasis plays a critical role in antioxidant defense, and detoxification in body. Although alteration of thiol/disulfide homeostasis had been shown in patients with diabetes, the thiol/disulfide balance in patients with type 2 diabetes and nephropathy is not yet known. METHODS:Twenty-six heal...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2019.01.022

    authors： Eren MA,Koyuncu İ,İncebıyık H,Karakaş H,Erel Ö,Sabuncu T

    更新日期：2019-02-01 00:00:00

  • Exendin-4 directly improves endothelial dysfunction in isolated aortas from obese rats through the cAMP or AMPK-eNOS pathways.

    abstract：AIMS:To determine whether exendin-4 might directly improve endothelial dysfunction in aorta isolated from high-fat diet-induced obese rats. METHODS:Wistar rats were randomly divided into control and obesity (OB) groups and fed. Vascular segments of obese rats were incubated in organ bath in the presence or absence of ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2012.04.001

    authors： Han L,Yu Y,Sun X,Wang B

    更新日期：2012-09-01 00:00:00

  • Qualitative evaluation of A Safer Ramadan, a structured education programme that addresses the safer observance of Ramadan for Muslims with Type 2 diabetes.

    abstract：AIMS:Muslims can choose to fast during Ramadan. Guidelines exist for providing clinical support for this group, but there is a lack of culturally tailored diabetes management interventions to provide guidance. The study evaluates the implementation of a programme developed to meet this need. METHODS:A Safer Ramadan is...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2019.107979

    authors： Darko N,Dallosso H,Hadjiconstantinou M,Hulley K,Khunti K,Davies M

    更新日期：2020-02-01 00:00:00

  • Cardiovascular autonomic neuropathy, autonomic symptoms and diabetic complications in 674 type 2 diabetes.

    abstract：AIMS:To determine the relationships between cardiovascular autonomic neuropathy (CAN) and autonomic symptoms, clinical parameters and diabetic complications in type 2 diabetes (T2DM). METHODS:The results of autonomic symptoms, clinical parameters, diabetes complications and cardiovascular reflex (CVR) tests of 674 T2D...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2008.08.012

    authors： Chen HT,Lin HD,Won JG,Lee CH,Wu SC,Lin JD,Juan LY,Ho LT,Tang KT

    更新日期：2008-11-01 00:00:00

  • All-trans retinoic acid improves the viability of ischemic skin flaps in diabetic rat models.

    abstract：AIMS:Endothelial progenitor cells (EPCs) play a critical role in neovascularization, which enhances proliferation under all-trans retinoic acid (ATRA) treatment. However, the effects of ATRA on the skin flap survival in diabetic flap ischemia remains unknown. METHODS:Ischemic random skin flaps were made in 40 diabetic...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2018.06.019

    authors： Weng Z,Wang C,Zhang C,Xu J,Chai Y,Jia Y,Han P,Wen G

    更新日期：2018-08-01 00:00:00

  • Intermediate-density lipoproteins, diabetes and coronary artery disease.

    abstract：:The results of various studies suggest that hypertriglyceridaemia is associated with an increased risk of coronary artery disease. It is unclear, however, which particular triglyceride (TG)-rich lipoproteins contribute to the risk. Different types of TG-rich lipoprotein differ in function, composition, size and densit...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,评审

    doi：10.1016/s0168-8227(98)00040-0

    authors： Steiner G

    更新日期：1998-07-01 00:00:00

  • Mitochondrial DNA mutations in diabetic heart.

    abstract：:Mutations of mitochondrial DNA have been found in cardiomyopathic and diabetic patients as well as mitochondrial myopathic patients. Mitochondrial DNA mutations are maternally transmitted. It has also been reported that these mutations can be acquired under the influence of free radicals. This article is a mini-review...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章,评审

    doi：10.1016/0168-8227(96)01239-9

    authors： Takeda N

    更新日期：1996-07-01 00:00:00

  • Relationship between age and autonomic neuropathy in diabetes mellitus.

    abstract：:The influence of age on diabetic autonomic neuropathy was studied. In the present study autonomic neuropathy was assessed by cardiac beat-to-beat variation during deep breathing (BBV) and pupil area prior to photic stimulus (A1). In the studies on BBV a total of 440 subjects (11-82 years in age) were divided into thre...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/0168-8227(90)90008-h

    authors： Kuroda N,Taniguchi H,Baba S,Yamamoto M

    更新日期：1990-04-01 00:00:00

  • Morphological changes in autonomic ganglionic cells of the heart in diabetic patients.

    abstract：:To clarify the histological changes of the cardiac autonomic nervous system in diabetes mellitus, ganglionic cells of the hearts of autopsy cases were examined light microscopically. In 7 severely diabetic patients, the ganglionic neurons showed cellular contraction, cytoplasmic condensation and poor staining of Nissl...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(86)80014-6

    authors： Tsujimura T,Nunotani H,Fushimi H,Inoue T

    更新日期：1986-06-01 00:00:00

  • Type 1 diabetes and COVID-19: The "lockdown effect".

    abstract：AIMS:The aim of this study was to evaluate the effect the lockdown imposed during COVID-19 outbreak on the glycemic control of people with Type 1 diabetes (T1D) using Continuous (CGM) or Flash Glucose Monitoring (FGM). MATERIALS AND METHODS:We retrospectively analyzed glucose reading obtained by FGM or CGM in T1D subj...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2020.108468

    authors： Aragona M,Rodia C,Bertolotto A,Campi F,Coppelli A,Giannarelli R,Bianchi C,Dardano A,Del Prato S

    更新日期：2020-12-01 00:00:00

  • Glucagon-like peptide-1 (7-36 amide): a potent glucagonostatic and insulinotropic hormone.

    abstract：:Glucagon-like peptide-1 (GLP-1) (1-37) and the fraction derived from it, GLP-1 (7-36 amide), are peptides encoded by the preproglucagon gene and possibly co-secreted with enteroglucagon. When added at a 25-nM concentration, GLP-1 (7-36 amide) decreased the release of glucagon from the perfused rat pancreas from 68.5 +...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(88)80063-9

    authors： Matsuyama T,Komatsu R,Namba M,Watanabe N,Itoh H,Tarui S

    更新日期：1988-10-14 00:00:00

  • Pakistan National Diabetes Survey: prevalence of glucose intolerance and associated factors in Baluchistan province.

    abstract：:The prevalence of diabetes mellitus (DM) and impaired glucose tolerance (IGT) and their relationship to age and obesity was estimated in a population-based survey in urban and rural areas in Baluchistan province, Pakistan. Cluster sampling of 834 adults (260 men, 574 women) in the urban and 570 adults (175 men, 395 wo...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(99)00017-0

    authors： Shera AS,Rafique G,Khawaja IA,Baqai S,King H

    更新日期：1999-04-01 00:00:00

  • Decreased carbohydrate intake is more important than increased fat intake in the glucose intolerance by a low-carbohydrate/high-fat diet.

    abstract：:A low-carbohydrate/high-fat evening meal impaired the glucose tolerance of healthy subjects to almost the same extent as the impairment caused by overnight fasting. This suggests that the decreased component (carbohydrate) is more relevant than the increased component (fat) to the impairment of glucose tolerance by a ...

    journal_title：Diabetes research and clinical practice

    pub_type： 信件

    doi：10.1016/s0168-8227(01)00291-1

    authors： Wang Y,Kaneko T,Wang PY,Sato A

    更新日期：2002-01-01 00:00:00

  • Clustering of components of the metabolic syndrome and risk for development of type 2 diabetes in Japanese male office workers.

    abstract：:To investigate the effects of the clustering of components of the metabolic syndrome (MS) on development of diabetes, we examined 3298 Japanese male office workers aged 35-59 years who did not have type 2 diabetes (a fasting plasma glucose level of > or =7.0 mmol/l or receipt of hypoglycemic medication) or a history o...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/j.diabres.2003.08.007

    authors： Nakanishi N,Nishina K,Okamoto M,Yoshida H,Matsuo Y,Suzuki K,Tatara K

    更新日期：2004-03-01 00:00:00

  • Vascular complications in young Asian Indian patients with type 1 diabetes mellitus.

    abstract：:To determine the prevalence of micro vascular and macro vascular complications in Asian Indian Type 1 diabetic subjects. There has been no major report on the prevalence of vascular complications in Type 1 diabetic patients in India. This study was done in Type 1 diabetic patients, aged < or =20 years at diagnosis of ...

    journal_title：Diabetes research and clinical practice

    pub_type： 杂志文章

    doi：10.1016/s0168-8227(99)00134-5

    authors： Ramachandran A,Snehalatha C,Sasikala R,Satyavani K,Vijay V

    更新日期：2000-04-01 00:00:00