Abstract:
OBJECTIVES:Recurrence of cranial bone fusion following surgical resection in craniosynostosis patients commonly requires additional surgical procedures. Surgical implantation of engineered 3D scaffolds that control tissue mineralization could be utilized to diminish recurrence of fusion. This study investigated the ability of composite scaffolds to control tissue mineralization when cultured in vitro. SETTING AND SAMPLE POPULATION:Precision-engineered scaffolds with calvarial cells were cultured in vitro at the Department of Orthodontics and Pediatric Dentistry, University of Michigan. MATERIAL & METHODS:Polycaprolactone (PCL) scaffolds were fabricated using a novel precision extrusion deposition technique. Polyethylene glycol (PEG) hydrogel was coated onto select scaffolds to inhibit mineralization. MC3T3E1(C4) calvarial cells were cultured with scaffolds in media containing ascorbate and phosphate to promote osteoblast differentiation and mineralization. Scaffolds were assayed for osteoblast differentiation by alkaline phosphatase assay. Scaffolds were assayed for mineralization by nano-computed tomography (nano-CT) and by von Kossa staining of histologic sections. RESULTS:MC3T3E1(C4) cells differentiated into osteoblasts and formed mineral when cultured on uncoated PCL scaffolds. MC3T3E1(C4) cells were significantly diminished in their ability to differentiate into osteoblasts when cultured on hydrogel-coated scaffold. CONCLUSION:Results of this study indicate that this novel printing technology can be used to fabricate 3D scaffolds to promote and inhibit tissue mineralization in a region-specific manner. Future studies are needed to establish utility of such scaffolds in vivo.
journal_name
Orthod Craniofac Resjournal_title
Orthodontics & craniofacial researchauthors
Fedore CW,Tse LYL,Nam HK,Barton KL,Hatch NEdoi
10.1111/ocr.12159subject
Has Abstractpub_date
2017-06-01 00:00:00pages
12-17eissn
1601-6335issn
1601-6343journal_volume
20 Suppl 1pub_type
杂志文章abstract:OBJECTIVES:The aim of this study was to compare three-dimensional airway changes resulting from mandibular advancement surgery and mandibular advancement surgery with constriction. SETTING AND SAMPLE POPULATION:The University of Michigan School of Dentistry and Medical Center. A total of 42 patients undergoing mandibu...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12292
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:The aim of this qualitative study was to explore and describe adolescents' experiences of treatment with removable functional appliances. SETTING AND SAMPLE POPULATION:Public Dental Service, Gothenburg, Sweden. MATERIAL AND METHODS:Individual interviews focusing on adolescents' experiences of using a remov...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/ocr.12093
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to investigate the effects of reduced masticatory function on midline suture growth and morphology in growing pigs. SETTING AND SAMPLE POPULATION:The sample was 20 pigs separated into two dietary groups and raised at the Department of Anthropology, Harvard University. Midline s...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2010.01483.x
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:To evaluate cephalometrically craniofacial morphology in children with operated sagittal synostosis and to compare the findings with age- and sex-matched controls. SETTING AND SAMPLE POPULATION:Forty-two children (37 boys) with operated primary sagittal synostosis were compared retrospectively with age- and...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12056
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:In patients with facial paralysis, facial reanimation surgery may be needed to normalize facial soft tissue function/movements. Critical for this normalization is the dynamics of the nasolabial folds (NLFs). The objective of this prospective, observational study was to determine the 3D morphologic dynamics o...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12400
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVES:Bone repair strategies continue to be developed for alternatives to autografting, allogeneic implants of banked bone, and other bone substitutes. Efforts have included the delivery of potent growth and/or differentiation factors and the use of gene therapy. For bone regeneration, gene therapy is the delivery...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2005.00332.x
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVES:to evaluate the accuracy of cone beam computed tomography (CBCT) for volumetric measurement of teeth, using micro-computed tomography (Micro-CT) as the reference standard. SETTING AND SAMPLE POPULATION:The Department of Orthodontics at Sichuan University. The sample consisted of 27 maxillary and mandibular ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2011.01525.x
更新日期:2011-11-01 00:00:00
abstract::The skin and the oral mucosa act as a barrier against the external environment. Loss of this barrier function causes dehydration and a high risk of infection. For the treatment of extensive skin wounds such as in severe burns, autologous skin for transplantation is often not available in sufficient amounts. Reconstruc...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,评审
doi:10.1111/j.1601-6343.2009.01475.x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVES:To determine whether the use of chewing gum reduced the impact and pain of fixed orthodontic appliances. SETTING AND SAMPLE POPULATION:The Orthodontic Department of the Charles Clifford Dental Hospital, Sheffield, UK. Fifty-seven patients aged 18 years or younger and who were about to start fixed orthodonti...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1601-6343.2012.01546.x
更新日期:2012-08-01 00:00:00
abstract::The mental health of children, adolescents, and adults with orofacial clefts has been studied extensively. Outcomes of interest have included parental adaptation, parent-child attachment, child development, intellectual and academic outcomes, behavioral adaptation, and quality of life. The literature sheds light on me...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,评审
doi:10.1111/j.1601-6343.2007.00394.x
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVES:To explore centre-level variation in otitis media with effusion (OME), hearing loss and treatments in children in Cleft Care UK (CCUK) and to examine the association between OME, hearing loss and developmental outcomes at 5 and 7 years. SETTING AND SAMPLE POPULATION:Two hundred and sixty-eight 5-year-old Br...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12184
更新日期:2017-06-01 00:00:00
abstract:INTRODUCTION:Functional appliances lead, in different degrees, to loss of anchorage in the lower arch. By anchoring them to the mandibular bone, any dental side effects may be avoided and the skeletal effect enhanced. Stability of bone-borne fixation would be affected by forces created by the pull of the masticatory mu...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12004
更新日期:2013-02-01 00:00:00
abstract:INTRODUCTION:Hypohidrotic ectodermal dysplasia (HED) is a human heritable disorder characterized by sparse hair, reduced ability to sweat and hypodontia. The HED exhibits X-linked, autosomal recessive and autosomal dominant mode of inheritance. Mutations in four genes including EDA, EDAR, EDARADD, and WNT10A are known ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2011.01521.x
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:Three-dimensional evaluation of skeletal mandibular changes following Herbst appliance treatment. SETTING AND SAMPLE POPULATION:Retrospective case-control study, based on a sample size calculation. Twenty-five pubertal patients treated with Herbst appliance (HAG), and 25 matched Class II patients who receiv...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12154
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:To explore asymmetry values of antimeric deciduous tooth crown dimensions in three types of twins: monozygotic (MZ), dizygotic same-sex (DZ) and opposite-sex (OS) vs. single-born controls. SETTING AND SAMPLE POPULATION:Mesiodistal and labio-lingual crown dimensions of second deciduous molars and mesiodistal...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12122
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:An investigation to determine the changing facial appearance of identical twins. DESIGN:Clinical study. MATERIALS AND METHODS:Two Minolta Vivid 900 3D optical laser scanners were placed as a stereo pair to capture the soft tissues of a pair of identical twins. Each scan took approximately 2.5 s. The scanned...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2005.00320.x
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:This paper describes the use of adult facial template in gender-specific facial analysis. SUBJECTS AND METHODS:Eighty adults, mean age 24.5, were selected for the study. Laser-scanned images of the subjects were obtained under a reproducible and controlled environment with two Minolta Vivid 900 (Osaka, Japan) ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2006.00359.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:This investigation evaluates the evidence of case-based reasoning (CBR) in providing additional information on the prediction of future Class III craniofacial growth. SETTINGS AND SAMPLE POPULATION:The craniofacial characteristics of 104 untreated Class III subjects (7-17 years of age), monitored with two la...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12466
更新日期:2021-01-08 00:00:00
abstract:OBJECTIVES:To evaluate root surface changes and resorption following toothborne rapid maxillary expansion (RME) using cone beam computed tomography (CBCT). SETTING AND SAMPLE POPULATION:The Department of Orthodontics at The University of Texas Health Science Center. Twenty-four consecutively treated patients (mean age...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12069
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVES:To evaluate whether changes in the concentration of different biomarkers in the gingival crevicular fluid (GCF) can be used to detect the root resorption process in adult or adolescent patients undergoing treatment with a fixed appliance, in comparison with untreated subjects or treated patients not showing ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12329
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:To measure skull thickness in a group of subjects with skeletal Class II and a group with skeletal Class III malocclusion and compare these results with a group with Class I occlusion. SETTING AND SAMPLE POPULATION:Department of Orthodontics, School of Dentistry, University of Copenhagen. The Class II group...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2008.00434.x
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To evaluate orthodontic tooth movement (OTM) in rats treated with two types of bisphosphonates (BPs), alendronate sodium (A) and zoledronic acid (Z). DESIGN:In all, 15 male Wistar rats were randomly divided into three groups. Group OTM+A: orthodontic tooth movement and subcutaneous administration of alendron...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12192
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the stability of Natural Head Position (NHP) over time using the 3dMDface System. SETTING AND SAMPLE POPULATION:This was an experimental study. Three-dimensional facial images of 40 students were captured on two different occasions, with an interval of at least two weeks. ...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12344
更新日期:2020-02-01 00:00:00
abstract::Advances in precision medicine portend similar progress in orthodontics and will be increasingly harnessed to achieve customized treatment approaches and enhance treatment efficiencies. Our goal is to provide a background on emerging advances in computer technologies and biomedicine and highlight their current and lik...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章,评审
doi:10.1111/ocr.12171
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:To test the hypothesis that there are no gender differences in the outcomes of patients with class II malocclusion treated with the headgear-activator Teuscher appliance (HATA). DESIGN:Retrospective, longitudinal SETTING AND SAMPLE POPULATION:Puerto Rico and Scotland, UK. Thirty-one patients requiring corr...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1034/j.1600-0854.2003.c245.x
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVES:Relapse of teeth that have moved during orthodontic treatment is a major clinical issue with respect to the goals of successful treatment. Such relapse is a physiologic response of the supporting tissues to application of force, and is mainly attributed to occlusal instability and increased mechanical tensio...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/j.1601-6343.2009.01463.x
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:To introduce a new, fast, reliable, and free from software-related bias method to predict three-dimensionally the root position and angulation during and after orthodontic treatment. The final goal is to keep to a minimum the use of ionizing radiation by eliminating the necessity of multiple radiation exposu...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12252
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVES:This study sought to investigate the three-dimensional (3D) changes in anteroposterior, vertical and mediolateral positions and orientations of the mandibular condyle as well as joint space parameters following maxillary first premolar extraction and incisor retraction in skeletal Class II patients. SETTING...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12141
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:To investigate the 3D morphological variations in 169 temporomandibular ioint (TMJ) condyles, using novel imaging statistical modeling approaches. SETTING AND SAMPLE POPULATION:The Department of Orthodontics and Pediatric Dentistry at the University of Michigan. Cone beam CT scans were acquired from 69 subj...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12070
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of lithium on alveolar bone formation during orthodontic retention in rats. MATERIALS AND METHODS:After 2 weeks of orthodontic tooth movement (OTM), 42 8-week-old male Wistar rats were randomly divided into two orthodontic retention groups: one without (control) and the other with L...
journal_title:Orthodontics & craniofacial research
pub_type: 杂志文章
doi:10.1111/ocr.12190
更新日期:2017-08-01 00:00:00