Pharmacotherapy of congestive heart failure. An evaluation of recent advances.

Abstract:

:Vasodilator therapy represents an important step forward in the treatment of chronic left ventricular failure. Angiotensin converting enzyme (ACE) inhibitors appear to be the most versatile vasodilators, but selected direct-acting vasodilators, sympathetic inhibitors (prazosin), and possibly calcium channel antagonists (nifedipine and diltiazem) may be useful in certain situations. The bipyridine derivatives possess potent inotropic and vasodilating properties. The efficacy of intravenously administered amrinone and milrinone has been proven in the treatment of refractory left ventricular failure. Whether oral administration of milrinone or other bipyridine derivatives will prove to be safe and effective in the long-term treatment of chronic left ventricular failure remains uncertain.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Alpert MA

doi

10.1080/00325481.1987.11699832

subject

Has Abstract

pub_date

1987-05-01 00:00:00

pages

257-67

issue

6

eissn

0032-5481

issn

1941-9260

journal_volume

81

pub_type

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