Reversal agents in development for the new oral anticoagulants.

Abstract:

:The new oral anticoagulants have many advantages over vitamin K antagonists, but they are still associated with a troublesome incidence of major bleeding. Additionally, the absence of a reversal agent for the new oral anticoagulants is a barrier to their more widespread use. Currently, there are 3 potential reversal agents in development: idarucizumab is a humanized murine monoclonal antibody fragment directed specifically at dabigatran; andexanet alfa is a recombinant modified decoy factor Xa that binds to factor Xa inhibitors; and PER977 is a small molecule that binds to factor Xa and IIa inhibitors and to heparin-based anticoagulants through charge interaction. These agents have undergone phase I clinical testing, appear to be well tolerated in healthy volunteers, and are effective in neutralizing their respective targets. All 3 are currently undergoing or entering into a phase II or III clinical study. This article reviews the available data for idarucizumab, andexanet alfa, and PER977.

journal_name

Postgrad Med

journal_title

Postgraduate medicine

authors

Costin J,Ansell J,Laulicht B,Bakhru S,Steiner S

doi

10.3810/pgm.2014.11.2829

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

19-24

issue

7

eissn

0032-5481

issn

1941-9260

journal_volume

126

pub_type

杂志文章,评审
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