Abstract：
:It is now accepted that two or more conformations may exist within the same DNA molecule, thereby generating conformational junctions. The presence of B-Z junctions between right- and left-handed DNA conformations has been detected in plasmids by a number of techniques. Preliminary characterization of the first example of a B-Z junction is a short DNA oligonucleotide has recently been reported [Sheardy, R. D. (1988) Nucleic Acids Res. 16, 1153-1167]. We report additional CD and NMR data that support the existence of the junction in this model oligomer. These studies indicate that only three base pairs are involved in the junction and only one of these is dramatically distorted. Furthermore, the NMR saturation-transfer experiments suggest the junction's internal motion is temperature dependent.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Sheardy RD,Winkle SAdoi
10.1021/bi00428a046subject
Has Abstractpub_date
1989-01-24 00:00:00pages
720-5issue
2eissn
0006-2960issn
1520-4995journal_volume
28pub_type
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