Abstract：
PURPOSE:Dynamic myocardial perfusion computed tomography (DM-PCT) imaging offers benefits over quantitative assessment of myocardial blood flow (MBF) for diagnosis and risk stratification of coronary artery disease. However, one major drawback of DM-PCT imaging is that a high radiation level is imparted by repeated scanning. To address this issue, in this work, we developed a statistical iterative reconstruction algorithm based on the penalized weighted least-squares (PWLS) scheme by incorporating a motion adaptive sparsity prior (MASP) model to achieve high-quality DM-PCT imaging with low tube current dynamic data acquisition. For simplicity, we refer to the proposed algorithm as "PWLS-MASP''. METHODS:The MASP models both the spatial and temporal structured sparsity of DM-PCT sequence images with the assumption that the differences between adjacent frames after motion correction are sparse in the gradient image domain. To validate and evaluate the effectiveness of the present PWLS-MASP algorithm thoroughly, a modified XCAT phantom and preclinical porcine DM-PCT dataset were used in the study. RESULTS:The present PWLS-MASP algorithm can obtain high-quality DM-PCT images in both phantom and porcine cases, and outperforms the existing filtered back-projection algorithm and PWLS-based algorithms with total variation regularization (PWLS-TV) and robust principal component analysis regularization (PWLS-RPCA) in terms of noise reduction, streak artifacts mitigation, and time density curve estimation. Moreover, the PWLS-MASP algorithm can yield more accurate diagnostic hemodynamic parametric maps than the PWLS-TV and PWLS-RPCA algorithms. CONCLUSIONS:The study indicates that there is a substantial advantage in using the present PWLS-MASP algorithm for low-dose DM-PCT, and potentially in other dynamic tomography areas.
journal_name
Med Physjournal_title
Medical physicsauthors
Bian Z,Zeng D,Zhang Z,Gong C,Tian X,Yan G,Huang J,Guo H,Chen B,Zhang J,Feng Q,Chen W,Ma Jdoi
10.1002/mp.12285subject
Has Abstractpub_date
2017-09-01 00:00:00pages
e188-e201issue
9eissn
0094-2405issn
2473-4209journal_volume
44pub_type
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