Antibody-Drug Conjugates as Cancer Therapeutics: Past, Present, and Future.

abstract：:Moricizine, a unique Class I antiarrhythmic agent, was orally administered with and without a meal to 24 healthy male subjects to determine the effect of food on moricizine absorption and bioavailability. Relative to the fasting state, a standardized breakfast delayed the time to peak plasma moricizine concentration (...

journal_title：Journal of clinical pharmacology

authors： Pieniaszek HJ Jr,Rakestraw DC,Schary WL,Williams RL

更新日期：1991-09-01 00:00:00

abstract：:We compared the pharmacokinetic (PK) exposure parameters of efavirenz (EFV) and its major inactive metabolite, 8-hydroxy-efavirenz (8-OH-EFV), in an open-label, single-sequence, and parallel design of HIV-infected and tuberculosis (TB)-HIV-coinfected Ethiopian patients in the HIV-TB Pharmagene study with 20 and 33 pat...

journal_title：Journal of clinical pharmacology

authors： Habtewold A,Aklillu E,Makonnen E,Amogne W,Yimer G,Aderaye G,Bertilsson L,Owen JS,Burhenne J

更新日期：2016-12-01 00:00:00

abstract：:Nicotinic acid is a water-soluble B-complex vitamin that has been shown, in high doses, to lower total plasma cholesterol (C), LDL-C, and VLDL-triglycerides (Tg), while raising HDL-C in patients with type II, III, IV, and V hyperlipoproteinemia. Its exact mechanism of action is not known, but it appears to lower the p...

journal_title：Journal of clinical pharmacology

authors： Drood JM,Zimetbaum PJ,Frishman WH

更新日期：1991-07-01 00:00:00

abstract：:Interactions between tolvaptan and digoxin were determined in an open-label, sequential study where 14 healthy subjects received tolvaptan 60 mg once daily (QD) on days 1 and 12 to 16 and digoxin 0.25 mg QD on days 5 to 16. Mean maximal concentrations (C(max)) and area under the curve during the dosing interval (AUC(τ...

journal_title：Journal of clinical pharmacology

authors： Shoaf SE,Ohzone Y,Ninomiya S,Furukawa M,Bricmont P,Kashiyama E,Mallikaarjun S

更新日期：2011-05-01 00:00:00

abstract：:To study the pharmacokinetics and pharmacodynamics of two intravenous nizatidine dosing regimens, serial plasma concentrations and continuous intragastric pH were monitored simultaneously in 10 subjects with a documented history of duodenal or gastric ulcers. A 24-hour gastric pH profile was characterized for a 300 mg...

journal_title：Journal of clinical pharmacology

authors： Danziger L,Furmaga KM,Rodvold KA,Bombeck CT,Fischer JH

更新日期：1989-10-01 00:00:00

abstract：:The objective of this study was to establish effects of inhaled loxapine on the QTc interval in this randomized, placebo-controlled, double-blind crossover study. Forty-eight healthy volunteers received a single inhaled placebo or 10 mg loxapine. Plasma concentrations of loxapine increased with a median Tmax of 1 minu...

journal_title：Journal of clinical pharmacology

authors： Spyker DA,Voloshko P,Heyman ER,Cassella JV

更新日期：2014-06-01 00:00:00

abstract：:The efficacy of a eutectic mixture of local anesthetics (EMLA) in alleviating the pain associated with subcutaneous needle insertion for infusion of the iron-chelating agent, deferoxamine, was examined in 12 patients with homozygous beta-thalassemia. As reported by the patient using a 100-mm visual analogue scale, the...

journal_title：Journal of clinical pharmacology

authors： Berkovitch M,Davis S,Matsui D,Donsky J,Koren G,Olivieri NF

更新日期：1995-03-01 00:00:00

abstract：:Procainamide administration often results in excessively high serum N-acetylprocainamide (NAPA) concentrations and subtherapeutic serum procainamide concentrations. Inhibition of N-acetylation of procainamide may prevent accumulation of excessive NAPA while maintaining therapeutic serum procainamide concentrations. Th...

journal_title：Journal of clinical pharmacology

authors： Tisdale JE,Rudis MI,Padhi ID,Svensson CK,Webb CR,Borzak S,Ware JA,Krepostman A,Zarowitz BJ

更新日期：1995-09-01 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics of flunisolide were studied in healthy volunteers after inhalation. In the morning on the day the study began, volunteers inhaled 0.5 mg of flunisolide with and without oral administration of charcoal, or 1 mg, 2 mg, and 3 mg of flunisolide with concomitant administration of c...

journal_title：Journal of clinical pharmacology

authors： Möllmann H,Derendorf H,Barth J,Meibohm B,Wagner M,Krieg M,Weisser H,Knöller J,Möllmann A,Hochhaus G

更新日期：1997-10-01 00:00:00

abstract：:Sinbaglustat (ACT-519276), a brain-penetrating inhibitor of glucosylceramide synthase and nonlysosomal glucosylceramidase, is developed as a new therapy for lysosomal storage disorders. In the first-in-human study, sinbaglustat was primarily excreted unchanged in urine. This study was conducted to evaluate the effect ...

journal_title：Journal of clinical pharmacology

authors： Melchior M,Dingemanse J,Alatrach A,Feldkamp T,Sidharta PN,Géhin M

更新日期：2020-12-23 00:00:00

abstract：:Health-related quality of life in people with intellectual disabilities can be affected by challenging behaviors and side effects of antipsychotics. The aim of this study was to evaluate the effect of discontinuation antipsychotic drugs on health-related quality of life, including data from 2 discontinuation trials: a...

journal_title：Journal of clinical pharmacology

authors： Ramerman L,Hoekstra PJ,de Kuijper G

更新日期：2019-02-01 00:00:00

abstract：:The safety and efficacy of intravenous (i.v.) torsemide as adjunctive therapy for acute cardiogenic pulmonary edema was evaluated. Thirteen patients were treated with i.v. torsemide and six patients, with i.v. furosemide, as a positive control. Doses of torsemide, 20 mg or 40 mg, and furosemide, 40 mg or 80 mg, were a...

journal_title：Journal of clinical pharmacology

authors： Stringer KA,Watson W,Gratton M,Wolfe R

更新日期：1994-11-01 00:00:00

abstract：:To determine if ordinary doses of nitrates produce a significant increase in methemoglobin, methemoglobin levels were measured in 59 randomly selected patients with coronary artery disease and unstable angina pectoris who were receiving organic nitrate therapy. Patients were taking isosorbide dinitrate, 2% nitroglycer...

journal_title：Journal of clinical pharmacology

authors： Arsura E,Lichstein E,Guadagnino V,Nicchi V,Sanders M,Hollander G,Greengart A

更新日期：1984-04-01 00:00:00

abstract：:To enhance protection of humans exposed to long-duration low-gravity environments such as the Space Shuttle and National Aerospace Plane during re-entry or in the short-duration high(-)+Gz environment of fighter aircraft, the effects of +Gz acceleration on cardiovascular hemodynamics must be understood. This study rep...

journal_title：Journal of clinical pharmacology

authors： Tripp LD,Jennings TJ,Seaworth JF,Howell LL,Goodyear C

更新日期：1994-05-01 00:00:00

abstract：:To evaluate the effect of febuxostat on the pharmacokinetics of indomethacin and naproxen and vice versa, 2 multiple-dose, 3-period crossover studies were performed in healthy subjects. In study 1, subjects received febuxostat 80 mg once daily, indomethacin 50 mg twice daily, or both. In study 2, subjects received feb...

journal_title：Journal of clinical pharmacology

authors： Khosravan R,Wu JT,Joseph-Ridge N,Vernillet L

更新日期：2006-08-01 00:00:00

abstract：:A new polymeric matrix technology provides a sustained-release formulation of diltiazem hydrochloride (diltiazem SR) suitable for once-daily therapy. The efficacy and safety of diltiazem SR were evaluated in a multicenter, randomized, double-blind, placebo-controlled, parallel-group study. After a single-blind, placeb...

journal_title：Journal of clinical pharmacology

authors： Whelton A,Eff J,Magner DJ

更新日期：1992-09-01 00:00:00

abstract：:Ball-and-stick mechanical models, typically associated with chemists, have been helpful in understanding structural problems and the relationship between structure and biologic activity. With progress in computer speed, graphics performance, and software innovation, molecules of biological interest can be subjected to...

journal_title：Journal of clinical pharmacology

authors： Bowen JP,Charifson PS,Fox PC,Kontoyianni M,Miller AB,Schnur D,Stewart EL,Van Dyke C

更新日期：1993-12-01 00:00:00

abstract：:A randomized, single-blind, placebo-controlled, parallel-group study was conducted to assess the effect of age and gender on the pharmacokinetics and pharmacodynamics of rivaroxaban - an oral, direct Factor Xa inhibitor. Subjects (n = 34) were enrolled into four groups: young males or females (aged 18-45 years) and el...

journal_title：Journal of clinical pharmacology

authors： Kubitza D,Becka M,Roth A,Mueck W

更新日期：2013-03-01 00:00:00

abstract：:Although physiologic modeling has not gained the widespread acceptance that was originally projected, it may serve as the basis for future PK/PD modeling approaches. In addition, with more effort applied to developing in vitro and animal-to-human predictions, physiologic modeling may assume a higher position in the ph...

journal_title：Journal of clinical pharmacology

authors： Colburn WA

更新日期：1988-08-01 00:00:00

abstract：:The authors examined the pharmacokinetics of the CD19 receptor-directed tyrosine kinase inhibitor B43-Genistein in 17 patients (4 children, 13 adults) with B-lineage lymphoid malignancies, including 12 patients with acute lymphoblastic leukemia (ALL) and 5 patients with non-Hodgkin's lymphoma (NHL). The immunoconjugat...

journal_title：Journal of clinical pharmacology

authors： Chen CL,Levine A,Rao A,O'Neill K,Messinger Y,Myers DE,Goldman F,Hurvitz C,Casper JT,Uckun FM

更新日期：1999-12-01 00:00:00

abstract：:The enhanced nonenzymatic isomerization of pravastatin to SQ 31,906, a relatively inactive metabolite, has been demonstrated to occur on exposure to gastric acidity in humans. However, the effect of gastric metabolism on the pharmacodynamics of pravastatin has not been studied. In addition, it was hypothesized that so...

journal_title：Journal of clinical pharmacology

authors： Ito MK

更新日期：1998-04-01 00:00:00

abstract：:Microdialysis is a technique that allows the measurement of free antibiotic concentrations in different tissues, which are responsible for the antibacterial activity at the infection site. In an open, randomized, 2-way crossover study in healthy volunteers, the muscle penetration of orally administered cefpodoxime (40...

journal_title：Journal of clinical pharmacology

authors： Liu P,Müller M,Grant M,Obermann B,Derendorf H

更新日期：2005-05-01 00:00:00

abstract：:The authors evaluated the effect of high-dose aspirin at a therapeutic dose, using chlorzoxazone as a probe for CYP2E1 enzyme activity. In a randomized, open-label, 2-way crossover study, 10 healthy men were treated 3 times daily for 6 days with 1 g aspirin or placebo. On day 7, 1 dose of 400 mg chlorzoxazone was admi...

journal_title：Journal of clinical pharmacology

authors： Park JY,Kim KA,Park PW,Ha JM

更新日期：2006-01-01 00:00:00

abstract：:In June 1999, the Food and Drug Administration issued draft guidance for bioequivalence studies for nasal aerosols and nasal sprays for local action. The purpose of this opinion paper is to highlight the need for a balanced scientific debate before this guidance is used by underscoring the areas in the document that a...

journal_title：Journal of clinical pharmacology

authors： Harrison LI

更新日期：2000-07-01 00:00:00

abstract：:A single-dose, randomized, double-blind study of parallel design was conducted to determine the analgesic efficacy and safety of ketorolac tromethamine in patients who experience moderate or severe pain after the surgical removal of three or more third molars, one of which was a bony-impacted mandibular molar. Meperid...

journal_title：Journal of clinical pharmacology

authors： Fricke JR Jr,Angelocci D,Fox K,McHugh D,Bynum L,Yee JP

更新日期：1992-04-01 00:00:00

abstract：:Pentoxifylline, a nonselective phosphodiesterase inhibitor, has immunomodulatory activity in vitro and in vivo and potentiates the suppressive effects of glucocorticoids and cyclosporine on lymphocyte proliferation in vitro. Since phosphodiesterase isotypes 3 and 4 predominate in lymphocytes, the authors measured the ...

journal_title：Journal of clinical pharmacology

authors： Briggs WA,Wu Q,Orgul O,Choi M,Scheel PJ Jr,Burdick J

更新日期：1999-08-01 00:00:00

abstract：:Clinical pharmacology of L-asparaginase was compared by intramuscular and intravenous injections in 12 patients with metastatic cancer or leukemia. Following a single intramuscular injection at the gluteal site of L-asparaginase (10,000 IU/m2), the enzyme appeared in plasma as measured initially at 1 hour, but plateau...

journal_title：Journal of clinical pharmacology

authors： Ho DH,Yap HY,Brown N,Benjamin RS,Friereich EJ,Blumenschein GR,Bodey GP

更新日期：1981-02-01 00:00:00

abstract：:Caffeine has been used frequently in the treatment and prevention of apnea of prematurity. The metabolism of caffeine depends on the activities of the hepatic enzymes that vary from one infant to another. The objective of this study was to determine the influence of postnatal age (PNA), birth weight (BW), study weight...

journal_title：Journal of clinical pharmacology

authors： al-Alaiyan S,al-Rawithi S,Raines D,Yusuf A,Legayada E,Shoukri MM,el-Yazigi A

更新日期：2001-06-01 00:00:00

abstract：:Ciramadol, a new analgesic with mixed narcotic agonist-antagonist actions, was compared with codeine and placebo in a double-blind study in 343 patients with postoperative pain. The patients received a single oral dose of either 30 or 60 mg of ciramadol, 60 mg of codeine, or placebo. As indicated by three efficacy mea...

journal_title：Journal of clinical pharmacology

authors： Graf DF,Pandit SK,Kothary SP,Freeland GR

更新日期：1985-11-01 00:00:00

abstract：:Pain is a troublesome nonmotor symptom of Parkinson's disease (PD). This double-blind exploratory pilot study (NCT01744496) was the first to specifically investigate the effect of a dopamine agonist on PD-associated pain as primary outcome. Patients with advanced PD (ie, receiving levodopa) and at least moderate PD-as...

journal_title：Journal of clinical pharmacology

authors： Rascol O,Zesiewicz T,Chaudhuri KR,Asgharnejad M,Surmann E,Dohin E,Nilius S,Bauer L

更新日期：2016-07-01 00:00:00