In vitro P-glycoprotein interactions and steady-state pharmacokinetic interactions between tolvaptan and digoxin in healthy subjects.

abstract：:Type 2 diabetes has now reached epidemic proportions across the world and is the cause of substantial morbidity and mortality. Patients with diabetes suffer from their mircovascular complications of retinopathy (blindness), nephropathy (renal failure, dialysis), and neuropathy (neropathic pain, trophic ulcers). Howeve...

journal_title：Journal of clinical pharmacology

authors： Mudaliar S

更新日期：2004-04-01 00:00:00

abstract：:The primary albumin binding site of indomethacin is remote from the bilirubin binding site. Indomethacin is, at most, a weak displacer of bilirubin at low serum drug concentrations. When administered at dosages less than 1 mg/kg, indomethacin would appear to be safe with respect to serum binding of bilirubin in premat...

journal_title：Journal of clinical pharmacology

authors： Rasmussen LF,Ahlfors CE,Wennberg RP

更新日期：1978-10-01 00:00:00

abstract：:Using the hot plate test, the potency and mechanism of the analgesic activity of levonantradol was studied in mice. Levonantradol is 10 to 30 times more potent than morphine; the antinociception can be only partially blocked by naloxone. Similar limited antagonism by cholinergics indicates possible opiodergic mechanis...

journal_title：Journal of clinical pharmacology

authors： Jacob JJ,Ramabadran K,Campos-Medeiros M

更新日期：1981-08-01 00:00:00

abstract：:Twelve healthy subjects participated in a study to determine the effect of multiple doses of troglitazone on the steady-state pharmacokinetics of digoxin. Subjects received digoxin 0.25 mg orally once daily on days 1 through 20 and 400 mg of troglitazone orally once daily on days 11 through 20. Serial plasma samples a...

journal_title：Journal of clinical pharmacology

authors： Loi CM,Knowlton PW,Stern R,Randinitis EJ,Vassos AB,Koup JR,Sedman AJ

更新日期：1998-02-01 00:00:00

abstract：:The authors evaluated the effect of high-dose aspirin at a therapeutic dose, using chlorzoxazone as a probe for CYP2E1 enzyme activity. In a randomized, open-label, 2-way crossover study, 10 healthy men were treated 3 times daily for 6 days with 1 g aspirin or placebo. On day 7, 1 dose of 400 mg chlorzoxazone was admi...

journal_title：Journal of clinical pharmacology

authors： Park JY,Kim KA,Park PW,Ha JM

更新日期：2006-01-01 00:00:00

abstract：:Angiotensin converting enzyme (ACE) inhibitors are increasingly important in antihypertensive therapy because of their efficacy, tolerability, and specific benefits in subsets of patients. They are pharmacologically diverse. Whereas most benefits have been proven with older agents (captopril, enalopril), newer agents,...

journal_title：Journal of clinical pharmacology

authors： Burris JF

更新日期：1995-04-01 00:00:00

abstract：:Beverage-drug interactions have remained an active area of research and have been the subject of extensive investigations in the past 2 decades. The known mechanisms of clinically relevant beverage-drug interactions include modulation of the activity of cytochrome P450 (CYP) 3A and organic anion-transporting polypepti...

journal_title：Journal of clinical pharmacology

authors： An G,Mukker JK,Derendorf H,Frye RF

更新日期：2015-12-01 00:00:00

abstract：:Six obese (mean weight 92 kg) and five normal (60 kg) subjects received 2 mg diazepam nightly for 30 nights. Determination of diazepam and desmethyldiazepam plasma concentrations during the dosing period and for a withdrawal period indicated that accumulation half-life for both diazepam (7.8 days in obese vs. 3.1 days...

journal_title：Journal of clinical pharmacology

authors： Abernethy DR,Greenblatt DJ,Divoll M,Shader RI

更新日期：1983-08-01 00:00:00

abstract：:A randomized, crossover study was conducted in healthy male volunteers to assess the diurnal variation in the steady-state pharmacokinetics of valproate after multiple 250-mg oral and intravenous infusion doses after an intravenous 750-mg loading dose. Multiple blood samples were collected throughout each 168-hour stu...

journal_title：Journal of clinical pharmacology

authors： Hussein Z,Mukherjee D,Lamm J,Cavanaugh JH,Granneman GR

更新日期：1994-07-01 00:00:00

abstract：:Approximately equianalgesic oral doses of codeine, an oxycodone compound resembling Percodan, and pentazocine were compared for adverse effects in a double-blind, randomized study of four doses of each drug given over two days to 247 postsurgical patients with pain. Placebo and parenteral morphine were also treated as...

journal_title：Journal of clinical pharmacology

authors： Kantor TG,Hopper M,Laska E

更新日期：1981-01-01 00:00:00

abstract：:Unresolved issues of ethical, methodological, and legal concerns in the use of normal healthy volunteers persist. Financial incentives in their recruitment offer a unique ethical dilemma because of questions surrounding payment. A review of literature was conducted to obtain research systematically examining volunteer...

journal_title：Journal of clinical pharmacology

authors： Tishler CL,Bartholomae S

更新日期：2002-04-01 00:00:00

abstract：:Antibody-drug conjugates (ADCs) represent an innovative therapeutic approach that provides novel treatment options and hope for patients with cancer. By coupling monoclonal antibodies (mAbs) to cytotoxic small-molecule payloads with a plasma-stable linker, ADCs offer the potential for increased drug specificity and fe...

journal_title：Journal of clinical pharmacology

authors： Vezina HE,Cotreau M,Han TH,Gupta M

更新日期：2017-10-01 00:00:00

abstract：:Atazanavir, a potent protease inhibitor of human immunodeficiency virus (HIV), exhibits pH-dependent solubility. Previous studies have indicated that coadministration with omeprazole 40 mg once daily significantly decreased atazanavir exposure by approximately 75%. Concomitant use of omeprazole and atazanavir is curre...

journal_title：Journal of clinical pharmacology

authors： Zhu L,Persson A,Mahnke L,Eley T,Li T,Xu X,Agarwala S,Dragone J,Bertz R

更新日期：2011-03-01 00:00:00

abstract：:Gender and body weight influence the pharmacokinetics and pharmacodynamics of many drugs. This pooled analysis of 17 clinical studies evaluated the effect of gender, body mass index (BMI), body weight, and lean body weight (LBW) on the pharmacokinetics of the direct renin inhibitor aliskiren in healthy volunteers (n =...

journal_title：Journal of clinical pharmacology

authors： Jarugula V,Yeh CM,Howard D,Bush C,Keefe DL,Dole WP

更新日期：2010-12-01 00:00:00

abstract：:HMR1031 is a potent and specific antagonist of the integrin VLA-4 (alpha4beta1) binding to vascular cell adhesion molecule-1 (VCAM-1) and fibronectin. HMR1031 is an inhaled drug being developed for the treatment of asthma using an Ultrahaler dry-powder inhalation device. A pharmacoscintigraphic study of HMR1031 sugges...

journal_title：Journal of clinical pharmacology

authors： Shah B,Jensen BK,Zhang J,Hunt T,Rohatagi S

更新日期：2003-12-01 00:00:00

abstract：:The effect of desipramine on chronic ventricular ectopic depolarizations (VEDs) was studied in 10 patients with at least 30 VEDs per hour. A single-blind, placebo-controlled, dose-ranging protocol was followed. Efficacy was defined as a decrease in VED frequency of at least 75%, base on three 24 hour ambulatory ECGs o...

journal_title：Journal of clinical pharmacology

authors： Fenster PE,Bressler R,Kipps J

更新日期：1989-02-01 00:00:00

abstract：:Many drugs have incomplete systemic availability after oral dosage. This can be attributed to incomplete absorption from the gastrointestinal tract, or to presystemic extraction, in which a fraction of an orally administered dose is biotransformed before reaching the systemic circulation. Presystemic extraction can oc...

journal_title：Journal of clinical pharmacology

authors： Greenblatt DJ

更新日期：1993-07-01 00:00:00

abstract：:Renal electrolyte excretion patterns were determined in nonedematous healthy volunteers following bumetanide and furosemide in two separate clinical studies. In study 1, intravenous bumetanide was administered to 24 subjects at four dose levels. In study 2, bumetanide (1 or 2 mg) or furosemide (40 or 80 mg) was admini...

journal_title：Journal of clinical pharmacology

authors： Hutcheon DE,Vincent ME,Sandhu RS

更新日期：1981-11-01 00:00:00

abstract：:Data from 60 patients treated with amikacin were analyzed for factors associated with nephrotoxicity. In 42 of these patients, data were examined for factors associated with clinical outcome. Variables evaluated included patient weight, age, sex, serum creatinine level, creatinine clearance, duration of therapy, total...

journal_title：Journal of clinical pharmacology

authors： Williams PJ,Hull JH,Sarubbi FA,Rogers JF,Wargin WA

更新日期：1986-02-01 00:00:00

abstract：:This analysis was conducted to characterize the pharmacokinetics and pharmacodynamics of pegfilgrastim and to develop a pharmacokinetic-pharmacodynamic model to describe the granulopoietic effects of pegfilgrastim and the homeostatic regulation of pegfilgrastim clearance in healthy subjects. Pegfilgrastim serum concen...

journal_title：Journal of clinical pharmacology

authors： Roskos LK,Lum P,Lockbaum P,Schwab G,Yang BB

更新日期：2006-07-01 00:00:00

abstract：:The disposition of nalmefene, an opioid antagonist intended for the reversal of opioid-induced respiratory depression, and its primary metabolite nalmefene glucuronide, were characterized in adult volunteers with normal renal function and in patients with end-stage renal disease (ESRD). The effect of hemodialysis on t...

journal_title：Journal of clinical pharmacology

authors： Matzke GR,Frye RF,Alexander AC,Reynolds R,Dixon R,Johnston J,Rault RM

更新日期：1996-02-01 00:00:00

abstract：:The role of dopaminergic receptors on renal function has been extensively studied. Recently dopaminergic receptor has been classified in two subtypes D1 and D2, which seem to have different modulatory function. However, the role of dopaminergic receptors on cardiovascular function and more specifically the potential r...

journal_title：Journal of clinical pharmacology

authors： Luchsinger A,Velasco M,Urbina A,Morillo J,Romero E,Alvarez R,Pieretti OH

更新日期：1992-01-01 00:00:00

abstract：:This article describes the population pharmacokinetics (PK) of dalteparin in pediatric patients with venous thromboembolism (VTE). A prospective multicenter open-label study was conducted in children who required anticoagulation for the treatment of VTE. The study population included children with and without cancer. ...

journal_title：Journal of clinical pharmacology

authors： Damle B,Jen F,Sherman N,Jani D,Sweeney K

更新日期：2021-02-01 00:00:00

abstract：:Although physiologic modeling has not gained the widespread acceptance that was originally projected, it may serve as the basis for future PK/PD modeling approaches. In addition, with more effort applied to developing in vitro and animal-to-human predictions, physiologic modeling may assume a higher position in the ph...

journal_title：Journal of clinical pharmacology

authors： Colburn WA

更新日期：1988-08-01 00:00:00

abstract：:Therapeutic drug monitoring (TDM) has become standard clinical practice for gentamicin, amikacin, and vancomycin to optimize efficacy and reduce toxicity. TDM after the first dose of antibiotic was adopted in our institution. This study aims to evaluate if target therapeutic drug concentrations could be achieved more ...

journal_title：Journal of clinical pharmacology

authors： Lim WXS,Chua WBB,Chua JM,Lee Q,Chan JW,Sultana R,Poh BH

更新日期：2020-01-01 00:00:00

abstract：:Weight loss has been associated with improvement in insulin sensitivity. It is consequently a cornerstone in the management of type 2 diabetes mellitus (T2DM). However, the strictly quantitative relationship between weight loss, insulin sensitivity, and clinically relevant glucose homeostasis biomarkers as well as cha...

journal_title：Journal of clinical pharmacology

authors： Farhan N,Gebert I,Xing Y,Wieser K,Lingineni K,Ma X,Chien JY,Garhyan P,Schmidt S

更新日期：2021-02-01 00:00:00

abstract：:The efficacy of a eutectic mixture of local anesthetics (EMLA) in alleviating the pain associated with subcutaneous needle insertion for infusion of the iron-chelating agent, deferoxamine, was examined in 12 patients with homozygous beta-thalassemia. As reported by the patient using a 100-mm visual analogue scale, the...

journal_title：Journal of clinical pharmacology

authors： Berkovitch M,Davis S,Matsui D,Donsky J,Koren G,Olivieri NF

更新日期：1995-03-01 00:00:00

abstract：:In this study of the relationship between dose and plasma concentration of verapamil, controlled-release verapamil in doses of 120 mg, 180 mg, 360 mg, and 540 mg were examined. The 48 study subjects received verapamil daily during each of the 4 sequential 5-day dosing segments. Blood samples were collected frequently ...

journal_title：Journal of clinical pharmacology

authors： Gupta SK,Hwang S,Atkinson L,Longstreth J

更新日期：1996-01-01 00:00:00

abstract：:This open-label study evaluated apixaban pharmacokinetics, pharmacodynamics, and safety in subjects with mild, moderate, or severe renal impairment and in healthy subjects following a single 10-mg oral dose. The primary analysis determined the relationship between apixaban AUC∞ and 24-hour creatinine clearance (CLcr )...

journal_title：Journal of clinical pharmacology

authors： Chang M,Yu Z,Shenker A,Wang J,Pursley J,Byon W,Boyd RA,LaCreta F,Frost CE

更新日期：2016-05-01 00:00:00

abstract：:The pharmacokinetics of enoximone and its sulfoxide metabolite were determined following administration of a single oral dose of 1 or 2 mg/kg in seven patients with congestive heart failure, and in two normal volunteers following a single 75-mg capsule, and were compared to those published previously. Plasma concentra...

journal_title：Journal of clinical pharmacology

authors： Lima JJ,Leier CV,Holtz L,Sterechele J,Shields BJ,MacKichan JJ

更新日期：1987-09-01 00:00:00