Abstract:
:Moricizine, a unique Class I antiarrhythmic agent, was orally administered with and without a meal to 24 healthy male subjects to determine the effect of food on moricizine absorption and bioavailability. Relative to the fasting state, a standardized breakfast delayed the time to peak plasma moricizine concentration (1.2 vs. 0.9 hr; P less than .03) and lowered peak plasma moricizine concentration by 24% (0.55 vs. 0.72 microgram/mL; P less than .03). Bioavailability, as measured by area under the plasma moricizine concentration versus time curve, was not significantly altered by the meal.
journal_name
J Clin Pharmacoljournal_title
Journal of clinical pharmacologyauthors
Pieniaszek HJ Jr,Rakestraw DC,Schary WL,Williams RLdoi
10.1002/j.1552-4604.1991.tb01912.xsubject
Has Abstractpub_date
1991-09-01 00:00:00pages
792-5issue
9eissn
0091-2700issn
1552-4604journal_volume
31pub_type
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