Lymphocyte suppression by rolipram with other immunosuppressive drugs.

abstract：:In this study of the relationship between dose and plasma concentration of verapamil, controlled-release verapamil in doses of 120 mg, 180 mg, 360 mg, and 540 mg were examined. The 48 study subjects received verapamil daily during each of the 4 sequential 5-day dosing segments. Blood samples were collected frequently ...

journal_title：Journal of clinical pharmacology

authors： Gupta SK,Hwang S,Atkinson L,Longstreth J

更新日期：1996-01-01 00:00:00

abstract：:For more than a decade, first responders and the general public have been able to treat suspected opioid overdoses using an improvised nasal naloxone device (INND) constructed from a prefilled syringe containing 2 mg of naloxone (1 mg/mL) attached to a mucosal atomization device. In recent years, the U.S. Food and Dru...

journal_title：Journal of clinical pharmacology

authors： Krieter PA,Chiang CN,Gyaw S,McCann DJ

更新日期：2019-08-01 00:00:00

abstract：:The effect of food on the pharmacokinetics of 15 mg oxybutynin XL was evaluated in a single-dose, randomized, crossover, open-label study in healthy volunteers. A validated, stereospecific, high-performance liquid chromatography assay was used to simultaneously determine the plasma concentrations of R- and S-oxybutyni...

journal_title：Journal of clinical pharmacology

authors： Sathyan G,Hu W,Gupta SK

更新日期：2001-02-01 00:00:00

abstract：:The search for effective treatments of Alzheimer's disease (AD) is one of the major challenges facing modern medicine. Acetylcholinesterase (AChE) inhibitors (AChEIs) are effective for the treatment of mild to moderate AD, and memantine, an N-methyl-D-aspartate (NMDA) inhibitor, has been approved for moderate to sever...

journal_title：Journal of clinical pharmacology

authors： Geerts H,Grossberg GT

更新日期：2006-07-01 00:00:00

abstract：:Ten years' experience with a system of modifying the scoring of examinations in pharmacology based on feedback comments from students on individual questions are analyzed. Each examination (3 per year for 10 years), approximately 100 items in length, was subjected to rigorous editing by a faculty committee and an inde...

journal_title：Journal of clinical pharmacology

authors： Smith CM

更新日期：1997-05-01 00:00:00

abstract：:Magnesium sulfate is the anticonvulsant of choice for eclampsia prophylaxis and treatment; however, the recommended dosing regimens are costly and cumbersome and can be administered only by skilled health professionals. The objectives of this study were to develop a robust exposure-response model for the relationship ...

journal_title：Journal of clinical pharmacology

authors： Du L,Wenning LA,Carvalho B,Duley L,Brookfield KF,Witjes H,de Greef R,Lumbiganon P,Titapant V,Kongwattanakul K,Long Q,Sangkomkamhang US,Gülmezoglu AM,Oladapo OT

更新日期：2019-11-01 00:00:00

abstract：:Compared with aminoglycosides, chloramphenicol, sulfonamides, tetracyclines, and even penicillins, the cephalosporins represent a remarkably safe class of antibiotics. Among the cephalosporins, the extended spectrum, third generation agents developed generally produce few side effects and appear to be less allergenic ...

journal_title：Journal of clinical pharmacology

authors： Neu HC

更新日期：1990-05-01 00:00:00

abstract：:Validation of study methods is a prerequisite for their usability. Empirical quality criteria based on test-theoretical principles are useful for this purpose. These criteria are discussed for several noninvasive methods used in cardiovascular clinical pharmacology: electrocardiography, systolic time intervals, blood ...

journal_title：Journal of clinical pharmacology

authors： de Mey C,Erb KA

更新日期：1997-01-01 00:00:00

abstract：:Quinapril, a nonsulfhydryl ACE inhibitor, was evaluated in ten New York Heart Association (NYHA) functional class (FC) II-III CHF patients to determine its effects on regional blood flow [effective renal plasma flow (ERPF), renal blood flow (RBF), renal vascular resistance (RVR), hepatic blood flow (HBF), hepatic vasc...

journal_title：Journal of clinical pharmacology

authors： Munger MA,Chance M,Nair R,Prescott AW,Nara AR,Simonson MS,Green JA,Posvar EL

更新日期：1992-01-01 00:00:00

abstract：:Many drugs have incomplete systemic availability after oral dosage. This can be attributed to incomplete absorption from the gastrointestinal tract, or to presystemic extraction, in which a fraction of an orally administered dose is biotransformed before reaching the systemic circulation. Presystemic extraction can oc...

journal_title：Journal of clinical pharmacology

authors： Greenblatt DJ

更新日期：1993-07-01 00:00:00

abstract：:The pharmacokinetics of dexketoprofen trometamol were evaluated in two studies using healthy volunteers. In the first study, the relative bioavailability of a single oral capsule of dexketoprofen free acid 25 mg or dexketoprofen trometamol 25 mg (given as 37 mg of the trometamol salt) was compared to ketoprofen 50 mg ...

journal_title：Journal of clinical pharmacology

authors： Barbanoj MJ,Gich I,Artigas R,Tost D,Moros C,Antonijoan RM,García ML,Mauleón D

更新日期：1998-12-01 00:00:00

abstract：:The objective of this study is to identify gender-related differences in the types of symptoms and drugs reported to cause an adverse drug reaction. Patient data from the Sunnybrook Health Science Centre ADR Clinic for the period from April 1986 to May 1996 were reviewed. Of the 2,367 patients assessed, 74.1% were fem...

journal_title：Journal of clinical pharmacology

authors： Tran C,Knowles SR,Liu BA,Shear NH

更新日期：1998-11-01 00:00:00

abstract：:Oral contraceptives (OCs) are the most widely used form of birth control among women of childbearing potential. Knowledge of potential drug-drug interactions (DDIs) with OCs becomes imperative to provide information on the medication to women of childbearing potential and enable their inclusion in clinical trials, esp...

journal_title：Journal of clinical pharmacology

authors： Sun H,Sivasubramanian R,Vaidya S,Barve A,Jarugula V

更新日期：2020-12-01 00:00:00

abstract：:Chemotherapy-induced nausea and vomiting (CINV) is a common treatment-related adverse event that negatively impacts the quality of life of cancer patients. During pediatric drug development, extrapolation of efficacy from adult to pediatric populations is a pathway that can minimize the exposure of children to unneces...

journal_title：Journal of clinical pharmacology

authors： Momper JD,Heinrichs MT,Krudys K,Griebel D,Kumar S,Kim I,Mehrotra N,Mulberg AE,Garimella N,Nelson R,Reaman G,Sinha V,Yao L,Zineh I,Burckart G,Sachs H,Mulugeta Y

更新日期：2020-06-01 00:00:00

abstract：:Recent advances in in vitro metabolism methods have led to an improved ability to predict clinically relevant metabolic drug-drug interactions. To address the relationships of in vitro metabolism data and in vivo metabolism outcomes, the Office of Clinical Pharmacology and Biopharmaceutics in the Center for Drug Evalu...

journal_title：Journal of clinical pharmacology

authors： Davit B,Reynolds K,Yuan R,Ajayi F,Conner D,Fadiran E,Gillespie B,Sahajwalla C,Huang SM,Lesko LJ

更新日期：1999-09-01 00:00:00

abstract：:Sixteen healthy volunteers were given either oral or intravenous doses of aminophylline (125 mg) at 9:00 A.M. and 9:00 P.M. under controlled food conditions. Measured at regular time intervals by homogeneous enzyme immunoassay, the plasma theophylline concentrations 1.5 and 2 hours after oral aminophylline were signif...

journal_title：Journal of clinical pharmacology

authors： Watanabe H,Nakano S,Nagai K,Ogawa N

更新日期：1984-11-01 00:00:00

abstract：:To test the effects of fluvastatin on low-density lipoprotein (LDL) receptor activity in patients with heterozygous familial hypercholesterolemia, the authors measured LDL receptor activity in stimulated T-lymphocytes prepared from 34 patients before and after treatment with 40 mg fluvastatin daily for 12 weeks. Maxim...

journal_title：Journal of clinical pharmacology

authors： Raungaard B,Brorholt-Petersen JU,Jensen HK,Faergeman O

更新日期：2000-04-01 00:00:00

abstract：:The overall response rate (ORR) is a largely adopted outcome measure in early-phase oncology trials. ORR is highly relevant in cancer drug development at the time of deciding whether to move to confirmatory phase 3 trials; moreover, ORR is gaining increasing relevance in fast-track registration procedures. No systemat...

journal_title：Journal of clinical pharmacology

authors： Dello Russo C,Cappoli N,Pilunni D,Navarra P

更新日期：2020-11-26 00:00:00

abstract：:The medication history among hospitalized patients often relies on patients' self-reports due to insufficient communication between health care professionals. The aim of the present study was to estimate the reliability of patients' self-reported medication use. Five hundred patients admitted to an acute medical depar...

journal_title：Journal of clinical pharmacology

authors： Glintborg B,Hillestrøm PR,Olsen LH,Dalhoff KP,Poulsen HE

更新日期：2007-11-01 00:00:00

abstract：:This multicenter, randomized, open-label, parallel-group, phase-1 study assessed the pharmacokinetics (PK), safety, and tolerability of the investigational intramuscular paliperidone palmitate 3-month (PP3M) formulation in patients with schizophrenia or schizoaffective disorder. A total of 328 patients (men or women, ...

journal_title：Journal of clinical pharmacology

authors： Ravenstijn P,Remmerie B,Savitz A,Samtani MN,Nuamah I,Chang CT,De Meulder M,Hough D,Gopal S

更新日期：2016-03-01 00:00:00

abstract：:This study aimed to evaluate the safety and tolerability of intravenous (IV) levetiracetam (LEV) as a monotherapy in children aged 1 month-16 years and to explore the pharmacokinetics (PK) of IV LEV and the time to seizure after IV then oral administration of LEV in pediatric children with epilepsy. Children diagnosed...

journal_title：Journal of clinical pharmacology

authors： Kim MJ,Yum MS,Yeh HR,Ko TS,Lim HS

更新日期：2018-12-01 00:00:00

abstract：:The objective of this study was to measure the steady-state cerebrospinal fluid (CSF) concentration of LY450108 and LY451395 (positive modulators of AMPA receptors) in healthy subjects after the administration of 1 mg and 5 mg. Secondary objectives included the evaluation of safety, pharmacokinetics, and steady-state ...

journal_title：Journal of clinical pharmacology

authors： Jhee SS,Chappell AS,Zarotsky V,Moran SV,Rosenthal M,Kim E,Chalon S,Toublanc N,Brandt J,Coutant DE,Ereshefsky L

更新日期：2006-04-01 00:00:00

abstract：:Numerous physiologic variations, including urinary protein excretion, low serum albumin concentrations, and reductions in kidney function (clearance), exist in patients with glomerulonephritis. These factors could alter the disposition of numerous drugs. The purpose of the current article was to review the influence o...

journal_title：Journal of clinical pharmacology

authors： Joy MS

更新日期：2012-01-01 00:00:00

abstract：:The clinical effects of a cardioselective beta-adrenergic blocking drug, acebutolol, were studied in 25 patients with chronic stable angina, using a seven-week single-blind placebo leads to acebutolol (mean dose 913 mg/day) phase followed by 12-week randomized double-blind placebo leads to acebutolol (mean dose 968 mg...

journal_title：Journal of clinical pharmacology

authors： Lee G,DeMaria AN,Favrot L,Hermanovich J,Kozina J,Krieg P,Kimchi A,Laddu A,Mason DT

更新日期：1982-08-01 00:00:00

abstract：:Inflammatory conditions, such as rheumatoid arthritis, reduce response to calcium channel and beta-adrenergic antagonists but not the angiotensin II type 1 receptor (AT(1)R) antagonist valsartan. Inflammation also reduces clearance of some drugs or active metabolite, thereby reducing response. Active (n = 14) and cont...

journal_title：Journal of clinical pharmacology

authors： Daneshtalab N,Lewanczuk RZ,Russell AS,Jamali F

更新日期：2006-11-01 00:00:00

abstract：:Direct comparisons of the pharmacokinetic (PK) and systemic pharmacodynamic (PD) properties of inhaled corticosteroids after single and multiple dosing in the same subjects are scarce. The objective of this study was to compare thePK/PDproperties of clinically equivalent, single, and multiple doses of dry-powder formu...

journal_title：Journal of clinical pharmacology

authors： Möllmann H,Wagner M,Krishnaswami S,Dimova H,Tang Y,Falcoz C,Daley-Yates PT,Krieg M,Stöckmann R,Barth J,Lawlor C,Möllmann AC,Derendorf H,Hochhaus G

更新日期：2001-12-01 00:00:00

abstract：:The objective of this study was to evaluate the effect of the acute administration of marijuana (MJ) on cardiovascular (CV) function and CNS pharmacokinetics (PK) of [(15)O]water in occasional (O) versus chronic (C) MJ users. Each subject received four injections of [(15)O]water (one prior and three postsmoking) on tw...

journal_title：Journal of clinical pharmacology

authors： Ponto LL,O'Leary DS,Koeppel J,Block RI,Watkins GL,Richmond JC,Ward CA,Clermont DA,Schmitt BA,Hichwa RD

更新日期：2004-07-01 00:00:00

abstract：:In 1989, the second-year medical school pharmacology course at New York Medical College was revised to help improve student and faculty morale, improve scores on class exams and the U.S. Medical Licensing Examination (USMLE), and encourage more active student participation in the course. Rather than incorporating new ...

journal_title：Journal of clinical pharmacology

authors： DelliPizzi A

更新日期：2000-01-01 00:00:00

abstract：:Renal electrolyte excretion patterns were determined in nonedematous healthy volunteers following bumetanide and furosemide in two separate clinical studies. In study 1, intravenous bumetanide was administered to 24 subjects at four dose levels. In study 2, bumetanide (1 or 2 mg) or furosemide (40 or 80 mg) was admini...

journal_title：Journal of clinical pharmacology

authors： Hutcheon DE,Vincent ME,Sandhu RS

更新日期：1981-11-01 00:00:00

abstract：:The pharmacokinetics and bioavailability of hydrocortisone after rectal administration of a hydrocortisone acetate foam were determined after single and multiple dosing in healthy subjects as well as in patients with inflammatory bowel disease. Endogenous hydrocortisone was suppressed by dexamethasone administration. ...

journal_title：Journal of clinical pharmacology

authors： Tromm A,Möllmann H,Barth J,Hochhaus G,Krieg M,Bigalke C,Möllmann A,Derendorf H

更新日期：2001-05-01 00:00:00