Pharmacokinetics and rectal bioavailability of hydrocortisone acetate after single and multiple administration in healthy subjects and patients.

abstract：:Effective and practical preventive procedures for postflight orthostatic intolerance are highly desirable. The current practice of attempts to expand plasma volume by ingestion of salt and fluids before reentry has proven benefits. This study evaluated alternative options using fludrocortisone (F) to expand plasma vol...

journal_title：Journal of clinical pharmacology

authors： Vernikos J,Dallman MF,Van Loon G,Keil LC

更新日期：1991-10-01 00:00:00

abstract：:The type II histamine receptor antagonists, cimetidine and ranitidine, widely used in treatment of peptic ulcer disease have been reported to cause bradycardia. To evaluate the cardiovascular effects of H2 antagonists nineteen healthy volunteers were entered into a double-blind crossover comparison of cimetidine 300 m...

journal_title：Journal of clinical pharmacology

authors： Hughes DG,Dowling EA,DeMeersman RE,Garnett WR,Karnes HT

更新日期：1989-05-01 00:00:00

abstract：:We compared the gastrointestinal (GI) tolerability and assessed for bioequivalent absorption of R-lipoic acid (LA) in people with progressive multiple sclerosis (MS) in a single-center, double-blind, randomized crossover trial. Participants randomly assigned to formulation sequence took 600 mg of R-LA or 1200 mg of a ...

journal_title：Journal of clinical pharmacology

authors： Cameron M,Taylor C,Lapidus J,Ramsey K,Koop D,Spain R

更新日期：2020-08-01 00:00:00

abstract：:Etoricoxib is a potent selective COX-2 inhibitor in man. Ex vivo whole-blood assays assessed COX-2 inhibition after oral administration of etoricoxib in single (5-500 mg) and multiple (25-150 mg) once-daily doses to healthy human subjects. A separate study examined ex vivo gastric mucosal PGE2 synthesis after etoricox...

journal_title：Journal of clinical pharmacology

authors： Dallob A,Hawkey CJ,Greenberg H,Wight N,De Schepper P,Waldman S,Wong P,DeTora L,Gertz B,Agrawal N,Wagner J,Gottesdiener K

更新日期：2003-06-01 00:00:00

abstract：:This study aimed to investigate a food effect on the bio-availability of modified-release (MR) trimetazidine tablets in 36 healthy volunteers. Trimetazidine, an anti-ischemic drug, protects the myocardial cell from the harmful effects of ischemia. The authors investigated the effect of being under a fasting or fed sta...

journal_title：Journal of clinical pharmacology

authors： Ozbay L,Unal DO,Erol D

更新日期：2012-10-01 00:00:00

abstract：:Nine patients with resistant hypertension received captopril for 12 months. Five received captopril alone, four required additional therapy. In the former, mean blood pressure fell from 109 +/- 4.2 mm Hg to 84 +/- 7.5 mm Hg (P less than 0.025) after seven days. A rise to 101 +/- 19 mm Hg was noted at six and 12 months...

journal_title：Journal of clinical pharmacology

authors： Sullivan JM,Taylor JC,Patrick DR,Johnson JG,Ratts TE,Muirhead EE

更新日期：1982-10-01 00:00:00

abstract：:Data from 60 patients treated with amikacin were analyzed for factors associated with nephrotoxicity. In 42 of these patients, data were examined for factors associated with clinical outcome. Variables evaluated included patient weight, age, sex, serum creatinine level, creatinine clearance, duration of therapy, total...

journal_title：Journal of clinical pharmacology

authors： Williams PJ,Hull JH,Sarubbi FA,Rogers JF,Wargin WA

更新日期：1986-02-01 00:00:00

abstract：:To determine the impact of gastric hypoacidity and acidic beverages on delavirdine mesylate pharmacokinetics in HIV-infected subjects, matched subjects with (n = 11) and without (n = 10) gastric hypoacidity received delavirdine 400 mg tid with either water or an acidic beverage (usually orange juice). The pharmacokine...

journal_title：Journal of clinical pharmacology

authors： Shelton MJ,Hewitt RG,Adams JM,Cox SR,Chambers JH,Morse GD

更新日期：2003-02-01 00:00:00

abstract：:Direct comparisons of the pharmacokinetic (PK) and systemic pharmacodynamic (PD) properties of inhaled corticosteroids after single and multiple dosing in the same subjects are scarce. The objective of this study was to compare thePK/PDproperties of clinically equivalent, single, and multiple doses of dry-powder formu...

journal_title：Journal of clinical pharmacology

authors： Möllmann H,Wagner M,Krishnaswami S,Dimova H,Tang Y,Falcoz C,Daley-Yates PT,Krieg M,Stöckmann R,Barth J,Lawlor C,Möllmann AC,Derendorf H,Hochhaus G

更新日期：2001-12-01 00:00:00

abstract：:There has been a considerable revolution in the field of hypertension therapy. We have gone through an era in which patients with severe hypertension and those with accelerated hypertension had a very short life expectancy. Currently blood pressure can be readily controlled with a marked improvement in longevity. We h...

journal_title：Journal of clinical pharmacology

authors： Somberg J,Ehrenpreis S,Shroff G,Khosla S

更新日期：1993-03-01 00:00:00

abstract：:Health-related quality of life in people with intellectual disabilities can be affected by challenging behaviors and side effects of antipsychotics. The aim of this study was to evaluate the effect of discontinuation antipsychotic drugs on health-related quality of life, including data from 2 discontinuation trials: a...

journal_title：Journal of clinical pharmacology

authors： Ramerman L,Hoekstra PJ,de Kuijper G

更新日期：2019-02-01 00:00:00

abstract：:The objectives of the 3 phase I studies described herein were (1) to compare the pharmacokinetics of gabapentin delivered from a novel gastric-retentive dosage form vs an immediate-release formulation, (2) to assess the dose proportionality of the gastric-retentive extended-release formulation, and (3) to determine th...

journal_title：Journal of clinical pharmacology

authors： Chen C,Cowles VE,Hou E

更新日期：2011-03-01 00:00:00

abstract：:Many biologically active synthetic drugs contain chiral centers, although they are used as racemic mixtures. Enantiomers are hard to distinguish in the chemical laboratory but are readily discriminated in the body and differ in their biological activities and disposition. The pharmacokinetic profiles of enantiomers ca...

journal_title：Journal of clinical pharmacology

authors： Caldwell J

更新日期：1992-10-01 00:00:00

abstract：:The decrease in renal blood flow (RBF) observed in patients with hypertension can be increased with converting enzyme inhibition (CEI). It is unknown whether the decrease in RBF observed with age can also be increased with CEI. This study compared the short- and long-term effects of captopril monotherapy in young (les...

journal_title：Journal of clinical pharmacology

authors： Penner SB,Mitenko PA,Aoki FY,Sitar DS,Smyth DD,McKenzie JK

更新日期：1991-01-01 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics of verapamil were investigated in six chronic hemodialysis patients. A single oral 120-mg dose was administered both on a non-hemodialysis day and a hemodialysis day separated by greater than or equal to 7 days. Blood pressure and PR interval were measured simultaneously with ...

journal_title：Journal of clinical pharmacology

authors： Hanyok JJ,Chow MS,Kluger J,Izard MW

更新日期：1988-09-01 00:00:00

abstract：:The study evaluated whether a liquid suspension of adefovir dipivoxil (ADV) is effective and safe when dose adjusted based on varying degrees of renal impairment in patients with chronic hepatitis B. Patients had stable mild, moderate, or severe renal impairment or end-stage renal disease. Twenty-eight patients were e...

journal_title：Journal of clinical pharmacology

authors： Shiffman ML,Pol S,Rostaing L,Schiff E,Thabut D,Zeuzem S,Zong J,Frederick D,Rousseau F

更新日期：2011-09-01 00:00:00

abstract：:This study aimed to evaluate the safety and tolerability of intravenous (IV) levetiracetam (LEV) as a monotherapy in children aged 1 month-16 years and to explore the pharmacokinetics (PK) of IV LEV and the time to seizure after IV then oral administration of LEV in pediatric children with epilepsy. Children diagnosed...

journal_title：Journal of clinical pharmacology

authors： Kim MJ,Yum MS,Yeh HR,Ko TS,Lim HS

更新日期：2018-12-01 00:00:00

abstract：:The efficacy and tolerability of aminoglutethimide for the treatment of Cushing's syndrome was assessed in 66 cases three of which are described in the present paper. Aminoglutethimide provided palliation from the signs and symptoms of hypercorticism in 13 of 21 patients with metastatic adrenocortical carcinoma and fo...

journal_title：Journal of clinical pharmacology

authors： Misbin RI,Canary J,Willard D

更新日期：1976-11-01 00:00:00

abstract：:The Cardiac Antiarrhythmic Suppression Trial (CAST) showed flecainide and encainide induced excess mortality compared with placebo. Labeling drugs as Class 1C is based on clinical observations, comprising measurements of the electrocardiographic parameters QRS. H-V and J-T intervals and of effective refractory period ...

journal_title：Journal of clinical pharmacology

authors： Vaughan Williams EM

更新日期：1991-02-01 00:00:00

abstract：:A two-period, crossover trial was conducted in the hypobaric chamber on human subjects to compare the influence of inflight exercise (experimental) and restricted activity (control) on altitude decompression sickness (DCS) during simulated extravehicular activities. Out of 39 pairs (total of 78 exposures), 4 cases of ...

journal_title：Journal of clinical pharmacology

authors： Kumar KV,Powell MR,Waligora JM

更新日期：1994-06-01 00:00:00

abstract：:Steady state pharmacokinetics, absolute bioavailability, and dose proportionality of cefepime were evaluated in healthy male subjects after single (250, 500, 1000, or 2000 mg) and multiple (1000 mg every 12 hours for 10 days) intramuscular injections. Safety and tolerance were also monitored. High performance liquid c...

journal_title：Journal of clinical pharmacology

authors： Barbhaiya RH,Knupp CA,Tenney J,Martin RR,Weidler DJ,Pittman KA

更新日期：1990-10-01 00:00:00

abstract：:Optimal design has been used in the past mainly to optimize sampling schedules for clinical trials. Optimization on design variables other than sampling times has been published in the literature only once before. This study shows, as an example, optimization on the length of treatment periods to obtain reliable estim...

journal_title：Journal of clinical pharmacology

authors： Hennig S,Nyberg J,Hooker AC,Karlsson MO

更新日期：2009-03-01 00:00:00

abstract：:A single-center, double-blind, placebo-controlled, randomized study was conducted to determine the pharmacokinetics, safety, and tolerability of single, rising intramuscular (i.m.) doses and the single maximum tolerated dose of parecoxib sodium, a prodrug of the novel COX-2 selective anti-inflammatory analgesic drug v...

journal_title：Journal of clinical pharmacology

authors： Karim A,Laurent A,Slater ME,Kuss ME,Qian J,Crosby-Sessoms SL,Hubbard RC

更新日期：2001-10-01 00:00:00

abstract：:This study was undertaken to determine whether rofecoxib can interfere with CYP1A2 activity in humans using theophylline as a probe substrate. Single oral doses of theophylline were administered to each of three panels of 12 healthy subjects receiving daily doses of rofecoxib for 7 days to examine the effect of rofeco...

journal_title：Journal of clinical pharmacology

authors： Bachmann K,White D,Jauregui L,Schwartz JI,Agrawal NG,Mazenko R,Larson PJ,Porras AG

更新日期：2003-10-01 00:00:00

abstract：:Precision medicine in oncology is the result of an increasing awareness of patient-specific clinical features coupled with the development of genomic-based diagnostics and targeted therapeutics. Companion diagnostics designed for specific drug-target pairs were the first to widely utilize clinically applicable tumor b...

journal_title：Journal of clinical pharmacology

authors： Schmidt KT,Chau CH,Price DK,Figg WD

更新日期：2016-12-01 00:00:00

abstract：:The pharmacokinetics and safety of a single oral dose of 200-mg plant-derived pharmaceutical formulation of highly purified cannabidiol (CBD) in oral solution (Epidiolex in the United States; 100 mg/mL) were assessed in subjects with mild to severe hepatic impairment (n =  8 each for mild and moderate, n = 6 for sever...

journal_title：Journal of clinical pharmacology

authors： Taylor L,Crockett J,Tayo B,Morrison G

更新日期：2019-08-01 00:00:00

abstract：:Ixekizumab (LY2439821), a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody that selectively binds and neutralizes interleukin (IL) 17A has demonstrated efficacy in the treatment of psoriasis. A population pharmacokinetics-pharmacodynamics model was developed using NONMEM 7.2 to describe the temporal re...

journal_title：Journal of clinical pharmacology

authors： Tham LS,Tang CC,Choi SL,Satterwhite JH,Cameron GS,Banerjee S

更新日期：2014-10-01 00:00:00

abstract：:This report briefly discusses some aspects of autonomic cardiovascular dysfunction as related to changes in orthostatic function in patients, bed rest subjects, and astronauts. This relationship is described in normal individuals to provide the basis for discussion of parameters that may be altered in patients, bed re...

journal_title：Journal of clinical pharmacology

authors： Lathers CM,Charles JB

更新日期：1993-11-01 00:00:00

abstract：:Microgravity is produced for 20 to 30 seconds in NASA's KC-135 aircraft at the end of a 2 G pullup for each of 40 parabolas per flight. Continuous transcranial Doppler ultrasound, arterial blood pressure, and acceleration levels were recorded for 12 male and 8 female healthy subjects without known cardiovascular or ce...

journal_title：Journal of clinical pharmacology

authors： Bondar RL,Stein F,Kassam MS,Dunphy PT,Bennett BS,Johnston KW

更新日期：1991-10-01 00:00:00

abstract：:The primary objective of this study was to identify intravenous regimens of tipifarnib that would mimic the systemic exposure obtained after the current twice-daily oral administration of tipifarnib. After determination of an intravenous dose that 6 subjects with advanced cancer could tolerate, another 26 subjects wer...

journal_title：Journal of clinical pharmacology

authors： Zhang S,Zannikos P,Awada A,Piccart-Gebhart M,Dirix LY,Fumoleau P,Verhaeghe T,Francois M,De Porre P

更新日期：2006-10-01 00:00:00