Aminoglutethimide in the treatment of Cushing's syndrome.

abstract：:The purpose of this analysis was to develop a population pharmacokinetic model for CS-917, an oral hypoglycemic prodrug, and its 3 metabolites. The population pharmacokinetic model was used to predict exposure of the active moiety R-125338 and thus to identify potential CS-917 dosage reduction criteria. The dataset in...

journal_title：Journal of clinical pharmacology

authors： Kastrissios H,Walker JR,Carrothers TJ,Kshirsagar S,Khariton T,Habtemariam B,Mager DE,Rohatagi S

更新日期：2012-03-01 00:00:00

abstract：:The approved antiretroviral drugs, emtricitabine and tenofovir disoproxil fumarate, were considered good candidates for a fixed-dose combination product that could be administered as a single pill once daily (qd), thereby simplifying existing treatment regimens and promoting patient adherence. As both drugs are extens...

journal_title：Journal of clinical pharmacology

authors： Blum MR,Chittick GE,Begley JA,Zong J

更新日期：2007-06-01 00:00:00

abstract：:Ciramadol, a new analgesic with mixed narcotic agonist-antagonist actions, was compared with codeine and placebo in a double-blind study in 343 patients with postoperative pain. The patients received a single oral dose of either 30 or 60 mg of ciramadol, 60 mg of codeine, or placebo. As indicated by three efficacy mea...

journal_title：Journal of clinical pharmacology

authors： Graf DF,Pandit SK,Kothary SP,Freeland GR

更新日期：1985-11-01 00:00:00

abstract：:Monitoring drug levels in patients is standard practice in presentday critical care medicine. Clinical laboratories, however, are often unable to assay drug levels immediately following phlebotomy. This may result in blood samples being kept under a variety of storage conditions for nonuniform periods of time. The cur...

journal_title：Journal of clinical pharmacology

authors： Colucci RD,Halpern NA,Levy E,McElhinney AJ,Greenstein RJ

更新日期：1988-08-01 00:00:00

abstract：:The study was undertaken to develop a pharmacokinetic-pharmacodynamic model to characterize efavirenz-induced neuropsychologic impairment, given preexistent impairment, which can be used for the optimization of efavirenz therapy via Monte Carlo simulations. The modeling was performed with NONMEM 7.2. A 1-compartment p...

journal_title：Journal of clinical pharmacology

authors： Bisaso KR,Mukonzo JK,Ette EI

更新日期：2015-11-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a major cause of disability and death globally. Despite significant progress in neuromonitoring and neuroprotection, pharmacological interventions have failed to generate favorable results. We examined the effect of memantine on serum levels of neuron-specific enolase (NSE), a marker of...

journal_title：Journal of clinical pharmacology

authors： Mokhtari M,Nayeb-Aghaei H,Kouchek M,Miri MM,Goharani R,Amoozandeh A,Akhavan Salamat S,Sistanizad M

更新日期：2018-01-01 00:00:00

abstract：:Antibacterial drugs are among the most common medications used by pregnant women. While medical literature generally defines nitrofurantoin as an antibiotic that is safe for use during the first trimester of pregnancy, new concerns about a possible association between congenital malformations following exposure to nit...

journal_title：Journal of clinical pharmacology

authors： Goldberg O,Koren G,Landau D,Lunenfeld E,Matok I,Levy A

更新日期：2013-09-01 00:00:00

abstract：:Armodafinil, the longer lasting R-isomer of racemic modafinil, improves wakefulness in patients with excessive sleepiness associated with shift work disorder (SWD). Pharmacokinetic studies suggest that armodafinil achieves higher plasma concentrations than modafinil late in a dose interval following equal oral doses. ...

journal_title：Journal of clinical pharmacology

authors： Darwish M,Bond M,Ezzet F

更新日期：2012-09-01 00:00:00

abstract：:L- and T-type voltage-dependent transmembrane calcium channels are important for normal functioning of the cardiovascular system. T-type channels are a heterogeneous group, and have physiologic and pathophysiologic relevance in a number of organ systems, including the heart and central nervous system. They appear to b...

journal_title：Journal of clinical pharmacology

authors： Glasser SP

更新日期：1998-08-01 00:00:00

abstract：:Based on the discussion of NMS, certain conclusions may be reached in regard to this patient. In the psychiatric setting, agitation and confusion alone are not suggestive of NMS. However in this patient, the symptoms of agitation, the rapid development of EPS symptoms unresponsive to anticholinergic therapy, autonomic...

journal_title：Journal of clinical pharmacology

authors： Schneiderhan ME,Marken PA

更新日期：1994-04-01 00:00:00

abstract：:Renal electrolyte excretion patterns were determined in nonedematous healthy volunteers following bumetanide and furosemide in two separate clinical studies. In study 1, intravenous bumetanide was administered to 24 subjects at four dose levels. In study 2, bumetanide (1 or 2 mg) or furosemide (40 or 80 mg) was admini...

journal_title：Journal of clinical pharmacology

authors： Hutcheon DE,Vincent ME,Sandhu RS

更新日期：1981-11-01 00:00:00

abstract：:Varenicline is a novel selective α4β2 nicotinic acetylcholine partial agonist developed for smoking cessation. Single- and multiple dose studies were conducted to investigate pharmacokinetics, safety, and tolerability of varenicline in healthy male Japanese smokers. The single-dose study was conducted as a double-blin...

journal_title：Journal of clinical pharmacology

authors： Kikkawa H,Maruyama N,Fujimoto Y,Hasunuma T

更新日期：2011-04-01 00:00:00

abstract：:A general objective of drug-drug interaction (DDI) studies is to determine whether potential interactions of new molecular entities with concomitantly administered other drugs exist and, if DDIs occur, whether dosage adjustments are required. A typical end point for DDI evaluations is the ratio of area under the plasm...

journal_title：Journal of clinical pharmacology

authors： Yamazaki S

更新日期：2018-08-01 00:00:00

abstract：:Because of the key role blood viscosity plays in the regulation of blood pressure (BP) and the hemorheological effects of pentoxifylline (PTX), this study was conducted to evaluate whether PTX can reduce BP when added to captopril in patients with stage 1 hypertension. In this randomized clinical trial 62 patients wit...

journal_title：Journal of clinical pharmacology

authors： Namdar H,Khani E,Pourrashid MH,Entezari-Maleki T

更新日期：2020-02-01 00:00:00

abstract：:Two populations of critical care patients were studied using indices of renal tubular damage (beta 2-microglobulin, enzymes, casts) and indices of glomerular filtration (creatinine, creatinine clearance). The purpose of these studies had been initially to elucidate the type of renal failure typical of the critically i...

journal_title：Journal of clinical pharmacology

authors： Schentag JJ

更新日期：1983-10-01 00:00:00

abstract：:A double-blind, crossover study was carried out to compare the antihypertensive efficacy of the long-acting ACE inhibitor trandolapril 1 mg administered once daily and 0.5 mg twice daily in 31 patients with mild to moderate essential hypertension. After randomization, patients entered a single-blind placebo period of ...

journal_title：Journal of clinical pharmacology

authors： Poirier L,Bourgeois J,Lacourcière Y

更新日期：1993-09-01 00:00:00

abstract：:While sulindac failed to affect significantly warfarin-induced hypoprothrombinemia in normal male volunteers, it markedly prolonged prothrombin time in a patient with a renal tubular defect who had been anticoagulated with warfarin. This difference in individual response with respect to a drug interaction illustrates ...

journal_title：Journal of clinical pharmacology

authors： Loftin JP,Vesell ES

更新日期：1979-11-01 00:00:00

abstract：:Tafenoquine is being developed for relapse prevention in Plasmodium vivax malaria. This Phase I, single-blind, randomized, placebo- and active-controlled parallel group study investigated whether tafenoquine at supratherapeutic and therapeutic concentrations prolonged cardiac repolarization in healthy volunteers. Subj...

journal_title：Journal of clinical pharmacology

authors： Green JA,Patel AK,Patel BR,Hussaini A,Harrell EJ,McDonald MJ,Carter N,Mohamed K,Duparc S,Miller AK

更新日期：2014-09-01 00:00:00

abstract：:To determine the impact of gastric hypoacidity and acidic beverages on delavirdine mesylate pharmacokinetics in HIV-infected subjects, matched subjects with (n = 11) and without (n = 10) gastric hypoacidity received delavirdine 400 mg tid with either water or an acidic beverage (usually orange juice). The pharmacokine...

journal_title：Journal of clinical pharmacology

authors： Shelton MJ,Hewitt RG,Adams JM,Cox SR,Chambers JH,Morse GD

更新日期：2003-02-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitors are effective at reducing blood pressure, whereas statins decrease plasma cholesterol impeding atherosclerosis. It is hypothesized that these medications may improve blood pressure and serum cholesterol by modifying the antioxidative status and energy metabolism of erythrocytes...

journal_title：Journal of clinical pharmacology

authors： Kaminsky Y,Suslikov A,Kosenko E

更新日期：2010-02-01 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics of intravenous famotidine were evaluated in 10 infants ranging from 5 to 19 days of age who had a therapeutic indication for the prophylactic treatment of stress ulceration. After a 0.5-mg/kg infusion of famotidine, timed serum (n = 6), urine (24-hour collection), and repeated...

journal_title：Journal of clinical pharmacology

authors： James LP,Marotti T,Stowe CD,Farrar HC,Taylor BJ,Kearns GL

更新日期：1998-12-01 00:00:00

abstract：:Esmolol hydrochloride was administered by constant-rate continuous infusion to 10 patients undergoing hypothermic cardiopulmonary bypass for coronary artery revascularization surgery. After a suitable loading dose, the esmolol infusion was started approximately 30 minutes before bypass and was stopped 10 minutes after...

journal_title：Journal of clinical pharmacology

authors： Jacobs JR,Croughwell ND,Goodman DK,White WD,Reves JG

更新日期：1993-04-01 00:00:00

abstract：:Pharmacokinetic studies of i.v. and oral racemic verapamil and 14C-erythromycin breath tests (ERBT) were performed in 84 healthy men (n = 42) and women (n = 42). Verapamil was measured by HPLC, concentration versus time data were analyzed by noncompartmental models, protein binding was measured by equilibrium dialysis...

journal_title：Journal of clinical pharmacology

authors： Krecic-Shepard ME,Barnas CR,Slimko J,Jones MP,Schwartz JB

更新日期：2000-03-01 00:00:00

abstract：:Sustained-release (SR) bupropion (Zyban) is approved as a smoking cessation aid for adults. Since smoking often begins in adolescence, we determined the single-dose pharmacokinetics of bupropion SR in 75 adolescent subjects ranging from 13 to 18 years old. Subjects self-reported their smoking status. Urinary cotinine ...

journal_title：Journal of clinical pharmacology

authors： Stewart JJ,Berkel HJ,Parish RC,Simar MR,Syed A,Bocchini JA Jr,Wilson JT,Manno JE

更新日期：2001-07-01 00:00:00

abstract：:The pharmacokinetics, safety, and preliminary efficacy of FTY720, a novel immunomodulator, were examined in de novo renal transplant patients. Both noncompartmental and population methods were used to estimate pharmacokinetic estimates in the patients. The steady-state plasma concentrations of FTY720 increased in acco...

journal_title：Journal of clinical pharmacology

authors： Skerjanec A,Tedesco H,Neumayer HH,Cole E,Budde K,Hsu CH,Schmouder R

更新日期：2005-11-01 00:00:00

abstract：:The efficacy and safety of esmolol, a titratable intravenous beta-adrenergic blocking agent with a short elimination half-life (t 1/2 = 9.0 min) was evaluated in a multicenter open-label study for the treatment of supraventricular tachyarrhythmias (heart rate greater than 100 bpm). The study also investigated the feas...

journal_title：Journal of clinical pharmacology

authors： Das G,Tschida V,Gray R,Dhurandhar R,Lester R,McGrew F,Askenazi J,Kaplan K,Emanuele M,Turlapaty P

更新日期：1988-08-01 00:00:00

abstract：:The safety, tolerability, and pharmacokinetics of orally administered enzastaurin were evaluated in 2 placebo-controlled, dose escalation studies in healthy subjects. In the first human dose study, single doses (2-400 mg) were evaluated, with 22 subjects receiving enzastaurin. The mean half-lives of enzastaurin and it...

journal_title：Journal of clinical pharmacology

authors： Welch PA,Sinha VP,Cleverly AL,Darstein C,Flanagan SD,Musib LC

更新日期：2007-09-01 00:00:00

abstract：:Intravenous administration of acetaminophen is an alternative to the oral and rectal routes, which may be contraindicated in particular clinical settings. This randomized, placebo-controlled study of intravenous acetaminophen (Ofirmev, Mallinckrodt Pharmaceuticals, Bedminster, New Jersey) in neonate and infant patient...

journal_title：Journal of clinical pharmacology

authors： Hammer GB,Maxwell LG,Taicher BM,Visoiu M,Cooper DS,Szmuk P,Pheng LH,Gosselin NH,Lu J,Devarakonda K

更新日期：2020-01-01 00:00:00

abstract：:This study investigated the steady-state pharmacokinetic interaction between the HIV protease inhibitor, darunavir (TMC114), administered with low-dose ritonavir (darunavir/ritonavir), and clarithromycin in HIV-negative healthy volunteers. In a 3-way crossover study, 18 individuals received darunavir/ritonavir 400/100...

journal_title：Journal of clinical pharmacology

authors： Sekar VJ,Spinosa-Guzman S,De Paepe E,De Pauw M,Vangeneugden T,Lefebvre E,Hoetelmans RM

更新日期：2008-01-01 00:00:00

abstract：:This study examined warfarin usage for elderly Medicare beneficiaries with atrial fibrillation (AF) who suffered traumatic brain injury (TBI), hip fracture, or torso injuries. Using the 5% Chronic Condition Data Warehouse administrative claims data, this study included fee-for-service Medicare beneficiaries who had a ...

journal_title：Journal of clinical pharmacology

authors： Liu X,Baumgarten M,Smith G,Gambert S,Gottlieb S,Rattinger G,Albrecht J,Langenberg P,Zuckerman I

更新日期：2015-01-01 00:00:00