Abstract:
:Monitoring drug levels in patients is standard practice in presentday critical care medicine. Clinical laboratories, however, are often unable to assay drug levels immediately following phlebotomy. This may result in blood samples being kept under a variety of storage conditions for nonuniform periods of time. The current study evaluated the stability of eight frequently monitored medications and one of their metabolities, in whole blood and plasma, at 4 degrees C or 25 degrees C, for up to 72 hours. The drugs included antibiotics, a bronchodilator, antiarrhythmics, and an anticonvulsant. Significant changes in drug levels were not identified at the time points studied. Our data suggests that meticulous postphlebotomy handling of blood samples may not be essential to obtain accurate levels of the drugs studied.
journal_name
J Clin Pharmacoljournal_title
Journal of clinical pharmacologyauthors
Colucci RD,Halpern NA,Levy E,McElhinney AJ,Greenstein RJdoi
10.1002/j.1552-4604.1988.tb03212.xsubject
Has Abstractpub_date
1988-08-01 00:00:00pages
762-6issue
8eissn
0091-2700issn
1552-4604journal_volume
28pub_type
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