Efficacy and pharmacokinetics of adefovir dipivoxil liquid suspension in patients with chronic hepatitis B and renal impairment.

abstract：:A randomized, double-blind, within-patient, crossover study was carried out after bilateral "identical" surgical procedures using local anesthesia only. A 3-day tablet regime of racemic ketoprofen 75 mg or acetaminophen 1000 mg qid (x 4) was given starting 3 hours after surgery. Ketoprofen reduced objectively measured...

journal_title：Journal of clinical pharmacology

authors： Bjørnsson GA,Haanaes HR,Skoglund LA

更新日期：2003-03-01 00:00:00

abstract：:Half-life is a standard result reported with analysis of pharmacokinetic data. Different definitions such as noncompartmental half-life, terminal half-life, effective half-life, and context-sensitive half-life can yield substantially different estimates of the quantity "half-life." Time to attainment of steady-state c...

journal_title：Journal of clinical pharmacology

authors： Krause A,Lott D,Dingemanse J

更新日期：2021-01-01 00:00:00

abstract：:Lofexidine, an antihypertensive imidazoline derivative, was given to ten hypertensives on both a twice-daily and once-daily regimen, using routine blood pressure measurements and 24-hour Remler recording. Plasma renin activity and catecholamines were measured. After a dose titration with twice-daily doses, the total t...

journal_title：Journal of clinical pharmacology

authors： Garrett BN,Kaplan NM

更新日期：1981-04-01 00:00:00

abstract：:Nine patients with resistant hypertension received captopril for 12 months. Five received captopril alone, four required additional therapy. In the former, mean blood pressure fell from 109 +/- 4.2 mm Hg to 84 +/- 7.5 mm Hg (P less than 0.025) after seven days. A rise to 101 +/- 19 mm Hg was noted at six and 12 months...

journal_title：Journal of clinical pharmacology

authors： Sullivan JM,Taylor JC,Patrick DR,Johnson JG,Ratts TE,Muirhead EE

更新日期：1982-10-01 00:00:00

abstract：:In patients with renal insufficiency, dose adjustments based on creatinine clearance and body weight have been a component of imipenem dosage instructions. The objective of the current analysis was to provide revised dosing recommendations by evaluating the impact of creatinine clearance and body weight on the pharmac...

journal_title：Journal of clinical pharmacology

authors： Lala M,Brown M,Kantesaria B,Walker B,Paschke A,Rizk ML

更新日期：2019-05-01 00:00:00

abstract：:To determine if ordinary doses of nitrates produce a significant increase in methemoglobin, methemoglobin levels were measured in 59 randomly selected patients with coronary artery disease and unstable angina pectoris who were receiving organic nitrate therapy. Patients were taking isosorbide dinitrate, 2% nitroglycer...

journal_title：Journal of clinical pharmacology

authors： Arsura E,Lichstein E,Guadagnino V,Nicchi V,Sanders M,Hollander G,Greengart A

更新日期：1984-04-01 00:00:00

abstract：:A single blind crossover study with washout phases showed that pyrazinoylguanidine (PZG) reduced elevated serum concentrations of urea, triglycerides, and cholesterol in patients with renal insufficiency. Pyrazinoylguanidine was saluretic, without affecting serum potassium or glucose concentrations. The onset of PZG's...

journal_title：Journal of clinical pharmacology

authors： Beyer KH Jr,Ward TD,Vary JE,Gelarden RT,Knutson DW,Vesell ES

更新日期：1993-06-01 00:00:00

abstract：:Two phase I open-label studies were conducted to investigate the pharmacokinetics (PK), safety, and tolerability of single oral doses of selumetinib in subjects with end-stage renal disease (ESRD) undergoing hemodialysis and subjects with varying degrees of hepatic impairment; both studies included a matched control g...

journal_title：Journal of clinical pharmacology

authors： Dymond AW,Martin P,So K,Huang Y,Severin P,Holmes V,Mariani G,Marbury T

更新日期：2017-05-01 00:00:00

abstract：:The pharmacokinetic profile of solifenacin succinate (YM905; Vesicare), a new once-daily bladder-selective muscarinic receptor antagonist, was examined in 2 controlled trials of healthy young men. A single-dose study evaluated 5-, 10-, 20-, 40-, 60-, 80-, and 100-mg doses. A multidose study evaluated 5-, 10-, 20-, and...

journal_title：Journal of clinical pharmacology

authors： Smulders RA,Krauwinkel WJ,Swart PJ,Huang M

更新日期：2004-09-01 00:00:00

abstract：:The onset and offset of the electropharmacologic effect of procainamide was studied in nine patients with ventricular arrhythmias. Procainamide was given at a constant infusion rate of 0.27 +/- 0.05 mg/kg/min for 50 to 60 minutes to an average total dose of 15.5 +/- 4.4 mg/kg. The QRS interval (used as an index of ele...

journal_title：Journal of clinical pharmacology

authors： Liem LB,Yee YG,Swerdlow CD,Kates RE

更新日期：1988-11-01 00:00:00

abstract：:This was a double-blind, placebo-controlled, randomized, parallel, dose-escalation study to assess the pharmacokinetics, platelet response, safety, and tolerability of supratherapeutic doses of eltrombopag (100 mg, 150 mg, and 200 mg once daily) administered for 5 days to 33 healthy adult volunteers. Plasma eltrombopa...

journal_title：Journal of clinical pharmacology

authors： Matthys G,Park JW,McGuire S,Wire MB,Bowen C,Williams D,Jenkins J,Peng B

更新日期：2011-03-01 00:00:00

abstract：:The influence of food on the bioavailability of trimoprostil , a new antiulcer prostaglandin E2 derivative, was investigated in healthy male volunteers in four separate studies. Doses of 0.75, 1.5, and 3.0 mg were administered orally in both the presence and absence of food followed by serial blood sampling through 24...

journal_title：Journal of clinical pharmacology

authors： Wills RJ

更新日期：1984-04-01 00:00:00

abstract：:A single-dose, randomized, double-blind study of parallel design was conducted to determine the analgesic efficacy and safety of ketorolac tromethamine in patients who experience moderate or severe pain after the surgical removal of three or more third molars, one of which was a bony-impacted mandibular molar. Meperid...

journal_title：Journal of clinical pharmacology

authors： Fricke JR Jr,Angelocci D,Fox K,McHugh D,Bynum L,Yee JP

更新日期：1992-04-01 00:00:00

abstract：:The pharmacokinetics and safety of a single oral dose of 200-mg plant-derived pharmaceutical formulation of highly purified cannabidiol (CBD) in oral solution (Epidiolex in the United States; 100 mg/mL) were assessed in subjects with mild to severe hepatic impairment (n =  8 each for mild and moderate, n = 6 for sever...

journal_title：Journal of clinical pharmacology

authors： Taylor L,Crockett J,Tayo B,Morrison G

更新日期：2019-08-01 00:00:00

abstract：:Gestational diabetes mellitus (GDM) has affected a great number of pregnant women worldwide. Artemisia extracts have been found to exhibit a potent antidiabetic effect in the treatment of type 2 diabetes mellitus. We aimed to examine the effects of Artemisia extract on insulin resistance and lipid profiles in pregnant...

journal_title：Journal of clinical pharmacology

authors： Sun X,Sun H,Zhang J,Ji X

更新日期：2016-12-01 00:00:00

abstract：:Nintedanib, a triple angiokinase inhibitor, has undergone clinical investigation for the treatment of solid tumors and idiopathic pulmonary fibrosis. Nintedanib (Vargatef® ) plus docetaxel is approved in the EU for the treatment of patients with adenocarcinoma non-small cell lung cancer (NSCLC) after first-line chemot...

journal_title：Journal of clinical pharmacology

authors： Dallinger C,Trommeshauser D,Marzin K,Liesener A,Kaiser R,Stopfer P

更新日期：2016-11-01 00:00:00

abstract：:Abetimus sodium is an oligonucleotide-based investigational drug designed to treat patients with lupus nephritis by specifically reducing anti-double-stranded DNA antibody levels. The safety and pharmacokinetics of abetimus were evaluated in 24 healthy volunteers at intravenous doses of 600 mg, 1200 mg, and 2400 mg. T...

journal_title：Journal of clinical pharmacology

authors： Linnik MD,O'Rourke AM,Crowther MA

更新日期：2008-08-01 00:00:00

abstract：:Sirolimus (RAPA) and cyclosporine (CsA) are immunosuppressive compounds that are being used concomitantly in renal transplant patients. Both drugs are dosed orally, have common intestinal and hepatic metabolism and intestinal transport mechanisms, and thus offer potential for pharmacokinetic drug interactions. A singl...

journal_title：Journal of clinical pharmacology

authors： Zimmerman JJ,Harper D,Getsy J,Jusko WJ

更新日期：2003-10-01 00:00:00

abstract：:Concentrations in breast milk of medications used during general anesthesia were measured to determine whether interruption of breast-feeding was indicated. Breast milk and maternal blood samples were obtained from nine women undergoing tubal sterilization under general anesthesia. Concentrations of methohexital, mepe...

journal_title：Journal of clinical pharmacology

authors： Borgatta L,Jenny RW,Gruss L,Ong C,Barad D

更新日期：1997-03-01 00:00:00

abstract：:To assess the efficacy and time-dependent effects of once-daily moexipril, a nonsulfhydryl ester prodrug of the angiotensin-converting enzyme (ACE) inhibitor, moexiprilat, we conducted a multicenter, double-blind, placebo-controlled trial in 51 hypertensive patients using both clinic and ambulatory blood pressure (BP)...

journal_title：Journal of clinical pharmacology

authors： White WB,Whelton A,Fox AA,Stimpel M,Kaihlanen PM

更新日期：1995-03-01 00:00:00

abstract：:To explore the clinical relevance of inhibition of multidrug resistance transporter 1 and organic anion transporting polypeptide transporter, a drug-drug interaction study was conducted using aliskiren and cyclosporine. This was an open-label, single-sequence, parallel-group, single-dose study in healthy subjects. Sub...

journal_title：Journal of clinical pharmacology

authors： Rebello S,Compain S,Feng A,Hariry S,Dieterich HA,Jarugula V

更新日期：2011-11-01 00:00:00

abstract：:Sixteen healthy male volunteers received a single oral dose of 25 mg doxylamine succinate. Doxylamine concentrations in plasma were measured by a newly developed gas chromatographic methodology, utilizing direct alkaline extraction into hexane:isoamyl alcohol followed by concentration and autoinjection. Doxylamine kin...

journal_title：Journal of clinical pharmacology

authors： Friedman H,Greenblatt DJ

更新日期：1985-09-01 00:00:00

abstract：:Although people living with human immunodeficiency virus and other comorbidities are expected to experience more grievous consequences with corona virus disease 2019 (COVID-19), recent cohort studies did not indicate this. Antiretrovirals (ARVs) might have a prophylactic role in these patients. The purpose of this stu...

journal_title：Journal of clinical pharmacology

authors： Alavian G,Kolahdouzan K,Mortezazadeh M,Torabi ZS

更新日期：2020-11-20 00:00:00

abstract：:The safety, antiretroviral activity, and pharmacokinetic profile of nelfinavir, a potent and specific inhibitor of human immunodeficiency virus (HIV) protease, were assessed in a small open-label phase I/II dose-ranging study in protease inhibitor-naive HIV-positive men. A total of 22 patients with baseline plasma HIV...

journal_title：Journal of clinical pharmacology

authors： Moyle GJ,Youle M,Higgs C,Monaghan J,Prince W,Chapman S,Clendeninn N,Nelson MR

更新日期：1998-08-01 00:00:00

abstract：:This study aimed to investigate a food effect on the bio-availability of modified-release (MR) trimetazidine tablets in 36 healthy volunteers. Trimetazidine, an anti-ischemic drug, protects the myocardial cell from the harmful effects of ischemia. The authors investigated the effect of being under a fasting or fed sta...

journal_title：Journal of clinical pharmacology

authors： Ozbay L,Unal DO,Erol D

更新日期：2012-10-01 00:00:00

abstract：:Inflammatory conditions, such as rheumatoid arthritis, reduce response to calcium channel and beta-adrenergic antagonists but not the angiotensin II type 1 receptor (AT(1)R) antagonist valsartan. Inflammation also reduces clearance of some drugs or active metabolite, thereby reducing response. Active (n = 14) and cont...

journal_title：Journal of clinical pharmacology

authors： Daneshtalab N,Lewanczuk RZ,Russell AS,Jamali F

更新日期：2006-11-01 00:00:00

abstract：:The in vitro plasma protein binding of warfarin was evaluated by ultrafiltration in plasma from seven normal subjects and seven patients with varying degrees of renal dysfunction. The unbound, or free, warfarin fraction was twice as high in the plasma samples withdrawn from patients with renal impairment than in the s...

journal_title：Journal of clinical pharmacology

authors： Bachmann K,Shapiro R,Mackiewicz J

更新日期：1976-10-01 00:00:00

abstract：:The efficacy and safety of esmolol, a titratable intravenous beta-adrenergic blocking agent with a short elimination half-life (t 1/2 = 9.0 min) was evaluated in a multicenter open-label study for the treatment of supraventricular tachyarrhythmias (heart rate greater than 100 bpm). The study also investigated the feas...

journal_title：Journal of clinical pharmacology

authors： Das G,Tschida V,Gray R,Dhurandhar R,Lester R,McGrew F,Askenazi J,Kaplan K,Emanuele M,Turlapaty P

更新日期：1988-08-01 00:00:00

abstract：:Universally present but overlooked cavities or pockets in long-lived biopharmaceuticals, such as monoclonal antibodies (mAbs), are capable of binding small drugs. Such direct interactions can alter the pharmacokinetics of drugs and potentially affect clinical outcome. The extreme differences in the pharmacokinetic pro...

journal_title：Journal of clinical pharmacology

authors： Panayotatos N

更新日期：2008-10-01 00:00:00

abstract：:Glasdegib is approved for treating acute myeloid leukemia in elderly patients at 100 mg once daily in combination with low-dose cytarabine. Exposure-efficacy analysis showed that the survival benefit of glasdegib was not glasdegib exposure-dependent. The relationship between glasdegib exposure and adverse event (AE) c...

journal_title：Journal of clinical pharmacology

authors： Ruiz-Garcia A,Shaik N,Lin S,Jamieson C,Heuser M,Chan G

更新日期：2021-03-01 00:00:00