Pharmacokinetic interactions between sirolimus and microemulsion cyclosporine when orally administered jointly and 4 hours apart in healthy volunteers.

abstract：:To determine if ordinary doses of nitrates produce a significant increase in methemoglobin, methemoglobin levels were measured in 59 randomly selected patients with coronary artery disease and unstable angina pectoris who were receiving organic nitrate therapy. Patients were taking isosorbide dinitrate, 2% nitroglycer...

journal_title：Journal of clinical pharmacology

authors： Arsura E,Lichstein E,Guadagnino V,Nicchi V,Sanders M,Hollander G,Greengart A

更新日期：1984-04-01 00:00:00

abstract：:This study was designed to investigate the multiple-dose pharmacokinetics, safety, and tolerability of the selective α4β2 nicotinic acetylcholine partial agonist, varenicline, in elderly (65-85 years old) nonsmokers. Fifty male and female subjects with normal renal function for their age were randomized to receive var...

journal_title：Journal of clinical pharmacology

authors： Zhao Q,Schwam E,Fullerton T,O'Gorman M,Burstein AH

更新日期：2011-04-01 00:00:00

abstract：:This study evaluated the pharmacodynamics and pharmacokinetics of once-daily dosing of warfarin at steady state when taken concomitantly with once-daily doses of duloxetine. Healthy subjects with a stable international normalized ratio (INR) of 1.5 to 2.0 on an individualized fixed dose of warfarin (2-9 mg) in period ...

journal_title：Journal of clinical pharmacology

authors： Chappell J,He J,Knadler MP,Mitchell M,Lee D,Lobo E

更新日期：2009-12-01 00:00:00

abstract：:The purpose of this study was to evaluate the pharmacokinetics of sulindac, a purported "renal sparing" nonsteroidal anti-inflammatory drug, and its effects on renal function and prostaglandin excretion in patients with reduced glomerular filtration rate. Twelve female patients (glomerular filtration rate 37 +/- 4 mL/...

journal_title：Journal of clinical pharmacology

authors： Klassen DK,Stout RL,Spilman PS,Whelton A

更新日期：1989-11-01 00:00:00

abstract：:This study determined the pharmacokinetics (PK) of figitumumab and its effects on insulin-like growth factor (IGF) axis-related biomarkers, following a single intravenous dose (10 [n = 16] and 20 [n = 12] mg/kg) in healthy adults. Serial blood sampling for PK and biomarkers was conducted up to 84 days postdose. A dose...

journal_title：Journal of clinical pharmacology

authors： Yin D,Sleight B,Alvey C,Hansson AG,Bello A

更新日期：2013-01-01 00:00:00

abstract：:This study was conducted to evaluate whether the allometric approach can be used to predict maximum tolerated dose (MTD) in humans from animal data. Twenty-five anticancer drugs were taken from the literature and used in this analysis. The results of the study indicate that MTD can be predicted with reasonable accurac...

journal_title：Journal of clinical pharmacology

authors： Mahmood I

更新日期：2001-01-01 00:00:00

abstract：:Nine patients with resistant hypertension received captopril for 12 months. Five received captopril alone, four required additional therapy. In the former, mean blood pressure fell from 109 +/- 4.2 mm Hg to 84 +/- 7.5 mm Hg (P less than 0.025) after seven days. A rise to 101 +/- 19 mm Hg was noted at six and 12 months...

journal_title：Journal of clinical pharmacology

authors： Sullivan JM,Taylor JC,Patrick DR,Johnson JG,Ratts TE,Muirhead EE

更新日期：1982-10-01 00:00:00

abstract：:A total of 175 physicians were surveyed by questionnaire before a Clinical Pharmacology Consult Service was started. Of those that responded, 72% thought the service would be helpful, although 40% said they would use the service no more than once a month. Most physicians (75%) preferred self-initiated consultations to...

journal_title：Journal of clinical pharmacology

authors： Casner PR,Dillon KR

更新日期：1988-01-01 00:00:00

abstract：:Golimumab is a fully human antitumor necrosis factor alpha (TNF-alpha) monoclonal antibody that is being developed for intravenous and subcutaneous administration. To assess the pharmacokinetics and safety of the intravenous formulation of golimumab, 36 adult subjects with rheumatoid arthritis were randomly assigned t...

journal_title：Journal of clinical pharmacology

authors： Zhou H,Jang H,Fleischmann RM,Bouman-Thio E,Xu Z,Marini JC,Pendley C,Jiao Q,Shankar G,Marciniak SJ,Cohen SB,Rahman MU,Baker D,Mascelli MA,Davis HM,Everitt DE

更新日期：2007-03-01 00:00:00

abstract：:Clinical pharmacologists are all dedicated to improving the use of medications and decreasing medication errors and adverse drug reactions. However, quality improvement requires that some significant parameters of quality be categorized, measured, and tracked to provide benchmarks to which future data (performance) ca...

journal_title：Journal of clinical pharmacology

authors： Benjamin DM,Pendrak RF

更新日期：2003-07-01 00:00:00

abstract：:Using a sensitive and specific radioimmunoassay the pharmacokinetic disposition of clonidine was determined in hypertensive patients after a single dose and then after 5, 28 and 56 days of chronic dosing with 75 micrograms bd. Following a single dose of clonidine maximal plasma concentrations of 0.34 +/- 0.06 ng/ml we...

journal_title：Journal of clinical pharmacology

authors： Anavekar SN,Howes LG,Jarrott B,Syrjanen M,Conway EL,Louis WJ

更新日期：1989-04-01 00:00:00

abstract：:This was a preliminary feasibility study to assess the pharmacokinetics and acute safety of a single dose of orally inhaled testosterone via the AERx system, a novel handheld aerosol delivery system in postmenopausal women. Twelve postmenopausal women stabilized on oral estrogen therapy were treated with a single dose...

journal_title：Journal of clinical pharmacology

authors： Davison S,Thipphawong J,Blanchard J,Liu K,Morishige R,Gonda I,Okikawa J,Adams J,Evans A,Otulana B,Davis S

更新日期：2005-02-01 00:00:00

abstract：:Experiments were performed on humans to study the blunting on the diuretic action of furosemide by prostaglandin synthetase inhibitors. Maximal water diuresis was instituted. At the peak of urine flow, clearance periods were performed during baseline conditions and repeated after the injection of aspirin and, subseque...

journal_title：Journal of clinical pharmacology

authors： Bartoli E,Arras S,Faedda R,Soggia G,Satta A,Olmeo NA

更新日期：1980-07-01 00:00:00

abstract：:Fosamprenavir (FPV) is the phosphate ester prodrug of the HIV-1 protease inhibitor amprenavir (APV). A pediatric population pharmacokinetic model for APV was developed and simulation was used to identify dosing regimens for pediatric patients receiving FPV in combination with ritonavir (RTV) which resulted in concentr...

journal_title：Journal of clinical pharmacology

authors： Barbour AM,Gibiansky L,Wire MB

更新日期：2014-02-01 00:00:00

abstract：:In 14 patients with congestive heart failure (CHF) of various grade (NYHA class 2-4) the effects of zofenopril calcium (SQ 26,991) on blood pressure and forearm circulation were studied by venous occlusion plethysmography. Changes in plasma renin activity (PRA), aldosterone, Atrial natriuretic factor (ANF) and arginin...

journal_title：Journal of clinical pharmacology

authors： Borghi C,Magelli C,Boschi S,Costa FV,Capelli M,Varani E,Magnani B,Ambrosioni E

更新日期：1989-12-01 00:00:00

abstract：:Cyclosporine (CsA) dosing is based on CsA plasma or blood concentrations measured 12 to 24 hours after drug administration (trough levels). This study evaluated the relationship between the timing of CsA concentrations and subsequent pharmacokinetic parameters to predict an optimal sampling period. Plasma samples were...

journal_title：Journal of clinical pharmacology

authors： Regazzi MB,Rondanelli R,Gastaldi L,Martinelli L,Viganò M

更新日期：1992-11-01 00:00:00

abstract：:For many years, effective therapy for the management of asthma has been available. Issues of adverse side effects and questionable patient compliance with current therapies have been seen as deterrents for proven beneficial agents such as the anti-inflammatory corticosteroids and the bronchodilating beta 2-agonists. A...

journal_title：Journal of clinical pharmacology

authors： O'Byrne PM

更新日期：1999-03-01 00:00:00

abstract：:Current dosing recommendations for rivaroxaban advocate dosage reduction in patients with moderate to severe renal impairment and avoidance of concomitant strong inhibitors of CYP3A or P-glycoprotein. However, rivaroxaban dosing in patients with mild renal impairment taking concomitant moderate inhibitors of CYP3A and...

journal_title：Journal of clinical pharmacology

authors： Ismail M,Lee VH,Chow CR,Rubino CM

更新日期：2018-04-01 00:00:00

abstract：:In ten patients (age: 47-59 yr) with moderately severe essential hypertension, the humoral and hemodynamic effects of a 4-day therapy with 2 x 75 micrograms clonidine, 2 x 20 mg nifedipine (slow-release), and their combination were investigated and compared with baseline values. The following measurements were observe...

journal_title：Journal of clinical pharmacology

authors： Mitrovic V,Patyna W,von Bruchhausen V,Hüting J,Schlepper M

更新日期：1991-06-01 00:00:00

abstract：:The efficacy and tolerability of aminoglutethimide for the treatment of Cushing's syndrome was assessed in 66 cases three of which are described in the present paper. Aminoglutethimide provided palliation from the signs and symptoms of hypercorticism in 13 of 21 patients with metastatic adrenocortical carcinoma and fo...

journal_title：Journal of clinical pharmacology

authors： Misbin RI,Canary J,Willard D

更新日期：1976-11-01 00:00:00

abstract：:Approximately equianalgesic oral doses of codeine, an oxycodone compound resembling Percodan, and pentazocine were compared for adverse effects in a double-blind, randomized study of four doses of each drug given over two days to 247 postsurgical patients with pain. Placebo and parenteral morphine were also treated as...

journal_title：Journal of clinical pharmacology

authors： Kantor TG,Hopper M,Laska E

更新日期：1981-01-01 00:00:00

abstract：:The angiotensin-converting enzyme (ACE) gene is a candidate genetic locus for coronary artery disease (CAD). Studies investigating the relationship between the ACE-insertion/deletion (I/D) gene polymorphism and myocardial infarction (MI) have been inconsistent. The authors hypothesized that age may be an important mod...

journal_title：Journal of clinical pharmacology

authors： Hamelin BA,Zakrzewski-Jakubiak M,Robitaille NM,Bogaty P,Labbé L,Turgeon J

更新日期：2011-09-01 00:00:00

abstract：:The role of dopaminergic receptors on renal function has been extensively studied. Recently dopaminergic receptor has been classified in two subtypes D1 and D2, which seem to have different modulatory function. However, the role of dopaminergic receptors on cardiovascular function and more specifically the potential r...

journal_title：Journal of clinical pharmacology

authors： Luchsinger A,Velasco M,Urbina A,Morillo J,Romero E,Alvarez R,Pieretti OH

更新日期：1992-01-01 00:00:00

abstract：:Ball-and-stick mechanical models, typically associated with chemists, have been helpful in understanding structural problems and the relationship between structure and biologic activity. With progress in computer speed, graphics performance, and software innovation, molecules of biological interest can be subjected to...

journal_title：Journal of clinical pharmacology

authors： Bowen JP,Charifson PS,Fox PC,Kontoyianni M,Miller AB,Schnur D,Stewart EL,Van Dyke C

更新日期：1993-12-01 00:00:00

abstract：:Four protease inhibitor antiviral agents (ritonavir, indinavir, nelfinavir, saquinavir) were evaluated as in vitro inhibitors of the activity of six human cytochromes using an in vitro model based on human liver microsomes. Ritonavir was a highly potent inhibitor of P450-3A activity (triazolam hydroxylation), having i...

journal_title：Journal of clinical pharmacology

authors： von Moltke LL,Greenblatt DJ,Grassi JM,Granda BW,Duan SX,Fogelman SM,Daily JP,Harmatz JS,Shader RI

更新日期：1998-02-01 00:00:00

abstract：:Current guidelines for hypercholesterolemia treatment emphasize lifestyle modification and lipid-modifying therapy to reduce the risk for cardiovascular disease. Statins are the primary class of agents used for the treatment of hypercholesterolemia. Although statins are effective for many patients, they fail to achiev...

journal_title：Journal of clinical pharmacology

authors： Ito MK,Santos RD

更新日期：2017-01-01 00:00:00

abstract：:Procaterol, a new beta-adrenergic agonist, was tested in two different doses in patients with reversible airway obstruction. Single oral doses of 0.05 or 0.1 mg produce an increase in measured expiratory flow rates, and the peak and duration of action are both dose related. Side effects reported during this one-day st...

journal_title：Journal of clinical pharmacology

authors： Zanetti CL,Rotman HH,Dresner AJ

更新日期：1982-05-01 00:00:00

abstract：:Floctafenin (FFn), 2,3-dihydroxypropyl--N--(8--trifluoromethyl--4--quinolyl) anthranilate, a new nonnarcotic analgesic drug, was studied in man, mice, and the isolated perfused rat liver. In all species the drug is rapidly hydrolyzed to floctafenic acid (FFa). In seven volunteer subjects who each received a single ora...

journal_title：Journal of clinical pharmacology

authors： Lynn RK,Holm R,Swanson BN,Smith R,Gerber N

更新日期：1979-01-01 00:00:00

abstract：:Universally present but overlooked cavities or pockets in long-lived biopharmaceuticals, such as monoclonal antibodies (mAbs), are capable of binding small drugs. Such direct interactions can alter the pharmacokinetics of drugs and potentially affect clinical outcome. The extreme differences in the pharmacokinetic pro...

journal_title：Journal of clinical pharmacology

authors： Panayotatos N

更新日期：2008-10-01 00:00:00

abstract：:Although physiologic modeling has not gained the widespread acceptance that was originally projected, it may serve as the basis for future PK/PD modeling approaches. In addition, with more effort applied to developing in vitro and animal-to-human predictions, physiologic modeling may assume a higher position in the ph...

journal_title：Journal of clinical pharmacology

authors： Colburn WA

更新日期：1988-08-01 00:00:00