Efficacy of acebutolol in chronic stable angina using single-blind and randomized double-blind protocol.

abstract：:This article describes the population pharmacokinetics (PK) of dalteparin in pediatric patients with venous thromboembolism (VTE). A prospective multicenter open-label study was conducted in children who required anticoagulation for the treatment of VTE. The study population included children with and without cancer. ...

journal_title：Journal of clinical pharmacology

authors： Damle B,Jen F,Sherman N,Jani D,Sweeney K

更新日期：2021-02-01 00:00:00

abstract：:Grapefruit is rich in flavonoids, which have been demonstrated to have a preventive influence on many chronic diseases, such as cancer and cardiovascular disease. However, since the early 1990s, the potential health benefits of grapefruit have been overshadowed by the possible risk of interactions between drugs and gr...

journal_title：Journal of clinical pharmacology

authors： Mertens-Talcott SU,Zadezensky I,De Castro WV,Derendorf H,Butterweck V

更新日期：2006-12-01 00:00:00

abstract：:The primary objective of the current investigation was to establish the pharmacokinetic characteristics of oxymetazoline and tetracaine's primary metabolite, para-butylaminobenzoic acid (PBBA), after the intranasal administration of oxymetazoline/tetracaine. Thirty-six subjects contributing a total of 1791 plasma conc...

journal_title：Journal of clinical pharmacology

authors： Cacek AT,Gobburu JV,Gopalakrishnan M

更新日期：2017-02-01 00:00:00

abstract：:Tissue pharmacokinetics and plasma protein binding of colistin have not been described in humans in vivo. Colistin concentrations in plasma, muscle, and subcutis of healthy volunteers were measured by microdialysis after a single dose of 2.5 million IU of colistin methanesulfonate. In vitro microdialysis experiments a...

journal_title：Journal of clinical pharmacology

authors： Matzneller P,Gobin P,Lackner E,Zeitlinger M

更新日期：2015-04-01 00:00:00

abstract：:Suvorexant is an orexin receptor antagonist for treating insomnia. The maximum approved dose in the United States and Japan is 20 mg. We evaluated suvorexant effects on respiration during sleep in a randomized, double-blind, 3-period crossover study of healthy adult men (n = 8) and women (n = 4) ≤ 50 years old who rec...

journal_title：Journal of clinical pharmacology

authors： Uemura N,McCrea J,Sun H,Donikyan M,Zammit G,Liu R,Louridas B,Marsilio S,Lines C,Troyer MD,Wagner J

更新日期：2015-10-01 00:00:00

abstract：:Two once-daily rivaroxaban dosing regimens were compared with warfarin for stroke prevention in patients with non-valvular atrial fibrillation in ROCKET AF: 20 mg for patients with normal/mildly impaired renal function and 15 mg for patients with moderate renal impairment. Rivaroxaban population pharmacokinetic (PK)/p...

journal_title：Journal of clinical pharmacology

authors： Girgis IG,Patel MR,Peters GR,Moore KT,Mahaffey KW,Nessel CC,Halperin JL,Califf RM,Fox KA,Becker RC

更新日期：2014-08-01 00:00:00

abstract：:Oral administration of docetaxel is an attractive alternative for conventional intravenous (IV) administration. The low bioavailability of docetaxel, however, hinders the application of oral docetaxel in the clinic. The aim of the current study was to develop a population pharmacokinetic (PK) model for docetaxel and r...

journal_title：Journal of clinical pharmacology

authors： Yu H,Janssen JM,Sawicki E,van Hasselt JGC,de Weger VA,Nuijen B,Schellens JHM,Beijnen JH,Huitema ADR

更新日期：2020-03-01 00:00:00

abstract：:A bioequivalence study of two oral formulations of 300 mg ranitidine was carried out in 16 healthy volunteers (8 men and 8 women), and the pharmacokinetics in both sexes were compared. There was bioequivalence of both formulations. The terminal half-life of ranitidine was 7% shorter and the oral apparent clearance 10....

journal_title：Journal of clinical pharmacology

authors： Abad-Santos F,Carcas AJ,Guerra P,Govantes C,Montuenga C,Gómez E,Fernández A,Frias J

更新日期：1996-08-01 00:00:00

abstract：:The present study was conducted to determine the absolute bioavailability of fimasartan (FMS; Kanarb(®) ) after the single oral administration of a 60-mg tablet or a single 30-mg intravenous (IV) infusion. This investigation was a randomized, single-dose, open-labeled, two-way crossover study of 16 healthy Korean male...

journal_title：Journal of clinical pharmacology

authors： Ghim JL,Paik SH,Hasanuzzaman M,Chi YH,Choi HK,Kim DH,Shin JG

更新日期：2016-05-01 00:00:00

abstract：:Traditionally, plasma or serum drug concentrations have been used for the assessment of bioavailability and bioequivalence. Since in the majority of cases the site of drug action is in the tissue rather than the blood, the use of corresponding free, unbound concentrations in the tissue is a much more meaningful approa...

journal_title：Journal of clinical pharmacology

authors： Schmidt S,Banks R,Kumar V,Rand KH,Derendorf H

更新日期：2008-03-01 00:00:00

abstract：:The electrocardiographic (ECG) effects of rivastigmine treatment were assessed in mild to moderately severe Alzheimer's disease (AD) by analysis of four 26-week, double-blind, multicenter, placebo-controlled, phase III clinical trials. Of an initial 2791 patients, 77% completed treatment. Seventy-one percent required ...

journal_title：Journal of clinical pharmacology

authors： Morganroth J,Graham S,Hartman R,Anand R

更新日期：2002-05-01 00:00:00

abstract：:The antipyretic activity of ibuprofen (Brufen) and paracetamol (Crocin) was compared in 22 children with pyrexia who received either ibuprofen or paracetamol in syrup form. Both axillary and rectal temperatures were recorded prior to drug administration and 1/2, 1, 2, 3, 4, 5, 6, 8, and 12 hours after dosing. Analysis...

journal_title：Journal of clinical pharmacology

authors： Sheth UK,Gupta K,Paul T,Pispati PK

更新日期：1980-11-01 00:00:00

abstract：:Twelve healthy subjects participated in a study to determine the effect of multiple doses of troglitazone on the steady-state pharmacokinetics of digoxin. Subjects received digoxin 0.25 mg orally once daily on days 1 through 20 and 400 mg of troglitazone orally once daily on days 11 through 20. Serial plasma samples a...

journal_title：Journal of clinical pharmacology

authors： Loi CM,Knowlton PW,Stern R,Randinitis EJ,Vassos AB,Koup JR,Sedman AJ

更新日期：1998-02-01 00:00:00

abstract：:Sleep disturbances and decrements of daytime performance have been attributed to HMG-CoA reductase inhibitors. As a rule, lipophilic compounds more readily cross the blood-brain barrier and are more likely to affect central nervous system function. The authors compared the effects of lovastatin (40 mg), a lipophilic c...

journal_title：Journal of clinical pharmacology

authors： Kostis JB,Rosen RC,Wilson AC

更新日期：1994-10-01 00:00:00

abstract：:The objective of this study was to investigate the influence of food on the pharmacokinetics of tolterodine, its active 5-hydroxymethyl metabolite (5-HM), and exposure to the active moiety (sum of unbound tolterodine + 5-HM) in healthy volunteers. Serum concentrations of tolterodine and 5-HM were measured for up to 12...

journal_title：Journal of clinical pharmacology

authors： Olsson B,Brynne N,Johansson C,Arnberg H

更新日期：2001-03-01 00:00:00

abstract：:The contribution of renal and non-renal clearance toward targeted concentrations and/or effects of therapeutic proteins in nephrotic patients are unknown. This study dissected the contribution of clearance pathways to adalimumab elimination in patients with focal segmental glomerulosclerosis (FSGS). Urine was collecte...

journal_title：Journal of clinical pharmacology

authors： Roberts BV,Susano I,Gipson DS,Trachtman H,Joy MS

更新日期：2013-09-01 00:00:00

abstract：:This randomized crossover study in healthy participants assessed pharmacokinetic interactions between telavancin, aztreonam, and piperacillin/tazobactam. Part 1: 11 participants received telavancin 10 mg/kg, aztreonam 2 g, or a combination of telavancin 10 mg/kg+aztreonam 2 g intravenously on 3 separate days. Part 2: ...

journal_title：Journal of clinical pharmacology

authors： Wong SL,Sörgel F,Kinzig M,Goldberg MR,Kitt MM,Barriere SL

更新日期：2009-07-01 00:00:00

abstract：:Pain is considered the most common complaint worldwide for which patients seek treatment. Conventional analgesic agents play an important role in modern pain therapy, but they cause several adverse effects. Therefore, newer and better analgesics continue to be investigated. In this controlled clinical trial, the autho...

journal_title：Journal of clinical pharmacology

authors： Yuan CS,Mehendale SR,Wang CZ,Aung HH,Jiang T,Guan X,Shoyama Y

更新日期：2004-11-01 00:00:00

abstract：:The effect of desipramine on chronic ventricular ectopic depolarizations (VEDs) was studied in 10 patients with at least 30 VEDs per hour. A single-blind, placebo-controlled, dose-ranging protocol was followed. Efficacy was defined as a decrease in VED frequency of at least 75%, base on three 24 hour ambulatory ECGs o...

journal_title：Journal of clinical pharmacology

authors： Fenster PE,Bressler R,Kipps J

更新日期：1989-02-01 00:00:00

abstract：:Chiral inversion of R(-)- to S(+)-ibuprofen in children with cystic fibrosis was investigated. Children with cystic fibrosis (n = 38, ages 2-13 years) were administered a single oral dose of racemic ibuprofen (20 mg/kg), and the pharmacokinetics of ibuprofen was found to be stereoselective. Mean Cmax, AUC, apparent CL...

journal_title：Journal of clinical pharmacology

authors： Dong JQ,Ni L,Scott CS,Retsch-Bogart GZ,Smith PC

更新日期：2000-08-01 00:00:00

abstract：:The objective of this study was to characterize the population pharmacokinetics of enfuvirtide in HIV-1-infected children and adolescents. HIV-infected patients received combination antiretroviral therapy, including enfuvirtide 2.0 mg/kg subcutaneously, twice daily. Serial and trough blood samples were collected up to...

journal_title：Journal of clinical pharmacology

authors： Zhang X,Lin T,Bertasso A,Evans C,Dorr A,Kolis SJ,Salgo M,Patel I,T20-310\/NV16056 Study Group.

更新日期：2007-04-01 00:00:00

abstract：:Aprepitant, a neurokinin antagonist, is an effective antiemetic agent in chemotherapy for delayed nausea and vomiting. The study objective was to evaluate the pharmacokinetics of aprepitant and concurrent cyclophosphamide (CY), often a component of hematopoietic stem cell transplant (HSCT) conditioning regimen, in can...

journal_title：Journal of clinical pharmacology

authors： Bubalo JS,Cherala G,McCune JS,Munar MY,Tse S,Maziarz R

更新日期：2012-04-01 00:00:00

abstract：:The plasma and red blood cell pharmacokinetics and bioavailability of the natural source (RRR, d) and all racemic (all rac, dl) stereoisomers of alpha-tocopherol were studied in 12 men in a double-blind randomized crossover study. Subjects were administered two 400-mg soft-gelatin capsules of either RRR or all rac alp...

journal_title：Journal of clinical pharmacology

authors： Ferslew KE,Acuff RV,Daigneault EA,Woolley TW,Stanton PE Jr

更新日期：1993-01-01 00:00:00

abstract：:The antihypertensive effect of a new beta-adrenergic receptor blocker, l-bunolol, was evaluated in 11 hospitalized hypertensive patients of whom four belonged to the high-renin, five to the normal-renin, and two to the low-renin subgroup. There was a significant decrease in blood pressure in most patients, often to no...

journal_title：Journal of clinical pharmacology

authors： Gavras H,Gavras I,Brunner HR,Laragh JH

更新日期：1977-05-01 00:00:00

abstract：:This study was designed to determine the pharmacokinetics and dose proportionality of clentiazem (CLZ) after single doses (SD) of 20, 40, and 80 mg and multiple dose administration (SS) of 40, 80, and 160 mg/day for 5 days. The study was an open-label, randomized four-period complete crossover design. Twenty-four heal...

journal_title：Journal of clinical pharmacology

authors： Bhargava VO,Shah AK,Weir SJ,Nordbrock EE,Giesing DH

更新日期：1993-05-01 00:00:00

abstract：:The analgesic activity of buprenorphine was monitored versus that of morphine in a double-blind, randomized, multiple-dose, parallel-design study involving 97 postsurgical patients. Patients could receive intramuscular injections of either buprenorphine (0.3, o.45, or 0.6 mg) or morphine (10, 15, or 20 mg) every 3 or ...

journal_title：Journal of clinical pharmacology

authors： Ouellette RD

更新日期：1982-04-01 00:00:00

abstract：:The effect of food on the oral bioavailability of sustained-release morphine sulfate tablets (ORAMORPH SR; Roxane Laboratories, Inc., Columbus, OH; OSR) was examined in an open-label, randomized, two-period crossover study. Healthy male volunteers received a 30-mg OSR tablet orally every 12 hours for seven doses durin...

journal_title：Journal of clinical pharmacology

authors： Bass J,Shepard KV,Lee JW,Hulse J

更新日期：1992-11-01 00:00:00

abstract：:Recent initiatives calling for changes in medical education, such as the General Professional Education of the Physician and Robert Wood Johnson Reports, have recommended alternative teaching approaches to the lecture format. The Patient-Oriented Problem-Solving (POPS) exercises, sponsored by the Upjohn Company (Kalam...

journal_title：Journal of clinical pharmacology

authors： Ingenito AJ,Wooles WR

更新日期：1995-02-01 00:00:00

abstract：:The objective of this randomized clinical trial was to compare steady-state gestational RBC and plasma folate concentrations in pregnant women supplementing daily with 1.1 mg (regular dose) vs. 5 mg (high dose) folic acid. Thirty-seven pregnant women, who were not previously taking folic acid, were enrolled in this op...

journal_title：Journal of clinical pharmacology

authors： Shere M,Nguyen P,Tam C,Stern S,Kapur B,O'Connor DL,Koren G

更新日期：2015-02-01 00:00:00

abstract：:Comparative pharmacokinetics of vitamin K epoxide reductase antagonists tecarfarin and warfarin were assessed before and after coadministration for 21 days of the CYP450 inhibitor fluconazole in a randomized, open-label, single-center drug interaction study. Twenty healthy adult participants were randomized 1:1 to rec...

journal_title：Journal of clinical pharmacology

authors： Bavisotto LM,Ellis DJ,Milner PG,Combs DL,Irwin I,Canafax DM

更新日期：2011-04-01 00:00:00