Population Pharmacokinetics of an Intranasally Administered Combination of Oxymetazoline and Tetracaine in Healthy Volunteers.

abstract：:Many biologically active synthetic drugs contain chiral centers, although they are used as racemic mixtures. Enantiomers are hard to distinguish in the chemical laboratory but are readily discriminated in the body and differ in their biological activities and disposition. The pharmacokinetic profiles of enantiomers ca...

journal_title：Journal of clinical pharmacology

authors： Caldwell J

更新日期：1992-10-01 00:00:00

abstract：:This trial was conducted to evaluate the pharmacokinetics and safety of a sodium oxybate (gamma-hydroxybutyrate [GHB]) oral solution in narcoleptic patients after acute and chronic treatment. An open-label, two-period, two-treatment study design was used. Trial subjects included 13 patients with polysomnographically c...

journal_title：Journal of clinical pharmacology

authors： Borgen LA,Okerholm RA,Lai A,Scharf MB

更新日期：2004-03-01 00:00:00

abstract：:The effect of food on the pharmacokinetics of 15 mg oxybutynin XL was evaluated in a single-dose, randomized, crossover, open-label study in healthy volunteers. A validated, stereospecific, high-performance liquid chromatography assay was used to simultaneously determine the plasma concentrations of R- and S-oxybutyni...

journal_title：Journal of clinical pharmacology

authors： Sathyan G,Hu W,Gupta SK

更新日期：2001-02-01 00:00:00

abstract：:Fifteen healthy women participated in a study to determine the effect of multiple doses of troglitazone on the pharmacokinetics of Ortho-Novum 1/35 (35 micrograms ethinyl estradiol [EE] and 1 mg norethindrone [NE]). Participants received three cycles (21 days each of active drug followed by 7 days without medication) ...

journal_title：Journal of clinical pharmacology

authors： Loi CM,Stern R,Koup JR,Vassos AB,Knowlton P,Sedman AJ

更新日期：1999-04-01 00:00:00

abstract：:This multi-center, randomized, double-blind, multiple dose-escalation study was conducted to assess the pharmacokinetics and pharmacodynamics of a newly developed polyethylene glycol (PEG)-conjugated glucagon-like peptide-1 (GLP-1) receptor agonist, PEX168 once weekly in Chinese patients with type 2 diabetes (T2DM). F...

journal_title：Journal of clinical pharmacology

authors： Yang GR,Zhao XL,Jin F,Shi LH,Yang JK

更新日期：2015-02-01 00:00:00

abstract：:Eight healthy men received 100 mg oral doses of etretinate separated by two-week washout periods in an open, randomized, crossover study. Etretinate was administered during a complete fast, with a standard high fat breakfast, a standard high carbohydrate breakfast, and 16 ounces of whole milk. Plasma samples were obta...

journal_title：Journal of clinical pharmacology

authors： Colburn WA,Gibson DM,Rodriguez LC,Buggé CJ,Blumenthal HP

更新日期：1985-11-01 00:00:00

abstract：:Possible effects of multiple-dose administration of atorvastatin on the pharmacokinetics of single-dose antipyrine were evaluated in this drug-drug interaction study. Twelve healthy male volunteers received three 200-mg capsules of antipyrine on days 1 and 22, and two 40-mg atorvastatin tablets in the morning on days ...

journal_title：Journal of clinical pharmacology

authors： Yang BB,Hounslow NJ,Sedman AJ,Forgue ST

更新日期：1996-04-01 00:00:00

abstract：:Monitoring drug levels in patients is standard practice in presentday critical care medicine. Clinical laboratories, however, are often unable to assay drug levels immediately following phlebotomy. This may result in blood samples being kept under a variety of storage conditions for nonuniform periods of time. The cur...

journal_title：Journal of clinical pharmacology

authors： Colucci RD,Halpern NA,Levy E,McElhinney AJ,Greenstein RJ

更新日期：1988-08-01 00:00:00

abstract：:Beverage-drug interactions have remained an active area of research and have been the subject of extensive investigations in the past 2 decades. The known mechanisms of clinically relevant beverage-drug interactions include modulation of the activity of cytochrome P450 (CYP) 3A and organic anion-transporting polypepti...

journal_title：Journal of clinical pharmacology

authors： An G,Mukker JK,Derendorf H,Frye RF

更新日期：2015-12-01 00:00:00

abstract：:Several approaches are available to estimate the glomerular filtration rate (GFR) from the sinistrin clearance. To compare such approaches, GFR was estimated in six healthy volunteers, both after a bolus injection and a bolus dose followed by a 6-hour infusion. A recently developed high-performance liquid chromatograp...

journal_title：Journal of clinical pharmacology

authors： Buclin T,Pechère-Bertschi A,Séchaud R,Décosterd LA,Munafo A,Burnier M,Biollaz J

更新日期：1997-08-01 00:00:00

abstract：:Following oral administration of a single 500-mg dose of cefalexin, serum and urine levels of the antibiotic were determined comparatively in ten normal subjects, ten patients with renal impairment, and ten patients with chronic nephritis on maintenance hemodialysis. In normal subjects, mean serum peak levels (12.0 +/...

journal_title：Journal of clinical pharmacology

authors： Brogard JM,Pinget M,Dorner M,Lavillaureix J

更新日期：1975-10-01 00:00:00

abstract：:Interethnic variability in pharmacokinetics can cause unexpected outcomes such as therapeutic failure, adverse effects, and toxicity in subjects of different ethnic origin undergoing medical treatment. It is important to realize that both genetic and environmental factors can lead to these differences among ethnic gro...

journal_title：Journal of clinical pharmacology

authors： Kim K,Johnson JA,Derendorf H

更新日期：2004-10-01 00:00:00

abstract：:The pathophysiology of poliomyelitis and the recognition of the "post-polio syndrome" suggest that susceptibility to muscle relaxants of patients previously affected by this disease, may be altered. We compared the effects of d-tubocurarine (dTc), pancuronium (P), and gallamine (G) on two pediatric surgical patient gr...

journal_title：Journal of clinical pharmacology

authors： Gyermek L

更新日期：1990-02-01 00:00:00

abstract：:Gender and body weight influence the pharmacokinetics and pharmacodynamics of many drugs. This pooled analysis of 17 clinical studies evaluated the effect of gender, body mass index (BMI), body weight, and lean body weight (LBW) on the pharmacokinetics of the direct renin inhibitor aliskiren in healthy volunteers (n =...

journal_title：Journal of clinical pharmacology

authors： Jarugula V,Yeh CM,Howard D,Bush C,Keefe DL,Dole WP

更新日期：2010-12-01 00:00:00

abstract：:The rate of change of plasma procainamide concentration during 36 hours of constant-rate intravenous infusion was examined in five acute myocardial infarction patients. It was observed that a steady-state plasma concentration was established in about 16 hours, which is consistent with simulations of plasma concentrati...

journal_title：Journal of clinical pharmacology

authors： Lalka D,Wyman MG,Goldreyer BN,Ludden TM,Cannom DS

更新日期：1978-08-01 00:00:00

abstract：:Avibactam is a non-β-lactam β-lactamase inhibitor intended for use as a fixed-dose combination with ceftazidime for the treatment of certain serious Gram-negative infections. As avibactam is primarily excreted unchanged in the urine, renal impairment may affect its pharmacokinetics. This phase 1 study investigated the...

journal_title：Journal of clinical pharmacology

authors： Merdjan H,Tarral A,Das S,Li J

更新日期：2017-02-01 00:00:00

abstract：:The primary albumin binding site of indomethacin is remote from the bilirubin binding site. Indomethacin is, at most, a weak displacer of bilirubin at low serum drug concentrations. When administered at dosages less than 1 mg/kg, indomethacin would appear to be safe with respect to serum binding of bilirubin in premat...

journal_title：Journal of clinical pharmacology

authors： Rasmussen LF,Ahlfors CE,Wennberg RP

更新日期：1978-10-01 00:00:00

abstract：:Relationships between tocilizumab exposure and response were evaluated using data from 4 phase III studies. Increased tocilizumab exposure was associated with improvements in Disease Activity Score using 28 joints (DAS28) and American College of Rheumatology (ACR) criteria and with a decrease in inflammation markers. ...

journal_title：Journal of clinical pharmacology

authors： Levi M,Grange S,Frey N

更新日期：2013-02-01 00:00:00

abstract：:Ten years' experience with a system of modifying the scoring of examinations in pharmacology based on feedback comments from students on individual questions are analyzed. Each examination (3 per year for 10 years), approximately 100 items in length, was subjected to rigorous editing by a faculty committee and an inde...

journal_title：Journal of clinical pharmacology

authors： Smith CM

更新日期：1997-05-01 00:00:00

abstract：:Adverse reactions to sulfonamides occur at a higher frequency in patients infected with the human immunodeficiency virus (HIV) than noninfected patients. Some studies have suggested that patients with the slow acetylator phenotype are predisposed to these reactions, whereas other studies suggest that the slow acetylat...

journal_title：Journal of clinical pharmacology

authors： O'Neil WM,MacArthur RD,Farrough MJ,Doll MA,Fretland AJ,Hein DW,Crane LR,Svensson CK

更新日期：2002-06-01 00:00:00

abstract：:The effect of rosuvastatin on the pharmacokinetics of digoxin was assessed in 18 healthy male volunteers in this double-blind, randomized, two-way crossover trial. Volunteers were dosed with rosuvastatin (40 mg once daily) or placebo to steady state before being given a single dose of digoxin 0.5 mg. Blood and urine s...

journal_title：Journal of clinical pharmacology

authors： Martin PD,Kemp J,Dane AL,Warwick MJ,Schneck DW

更新日期：2002-12-01 00:00:00

abstract：:This study aimed to evaluate the safety and tolerability of intravenous (IV) levetiracetam (LEV) as a monotherapy in children aged 1 month-16 years and to explore the pharmacokinetics (PK) of IV LEV and the time to seizure after IV then oral administration of LEV in pediatric children with epilepsy. Children diagnosed...

journal_title：Journal of clinical pharmacology

authors： Kim MJ,Yum MS,Yeh HR,Ko TS,Lim HS

更新日期：2018-12-01 00:00:00

abstract：:Upadacitinib is a selective Janus kinase 1 inhibitor that was recently approved for treatment of rheumatoid arthritis and is currently being evaluated for treatment of several other autoimmune diseases, including atopic dermatitis (AD). The relationships between upadacitinib plasma exposure and efficacy (assessed as E...

journal_title：Journal of clinical pharmacology

authors： Mohamed MF,Gopalakrishnan S,Teixeira HD,Othman AA

更新日期：2020-11-06 00:00:00

abstract：:The overall response rate (ORR) is a largely adopted outcome measure in early-phase oncology trials. ORR is highly relevant in cancer drug development at the time of deciding whether to move to confirmatory phase 3 trials; moreover, ORR is gaining increasing relevance in fast-track registration procedures. No systemat...

journal_title：Journal of clinical pharmacology

authors： Dello Russo C,Cappoli N,Pilunni D,Navarra P

更新日期：2020-11-26 00:00:00

abstract：:The relative analgesic potency of oral and intramuscular oxymorphone was evaluated in a double-blind crossover comparison of graded single doses in patients with chronic pain due to cancer. When both duration and intensity of analgesia are considered (total effect), oral oxymorphone was 1/6 as potent as the intramuscu...

journal_title：Journal of clinical pharmacology

authors： Beaver WT,Wallenstein SL,Houde RW,Rogers A

更新日期：1977-04-01 00:00:00

abstract：:Anisotropine methyl bromide, an anticholinergic, 80 mg given orally at 8 P.M., suppresses gastric acid secretion through the night without significant side effects. Thirty patients with endoscopy-proved symptomatic duodenal ulcer disease completed a randomized, double-blind, placebo-controlled trial of nighttime aniso...

journal_title：Journal of clinical pharmacology

authors： Bowers JH,Forbes JA,Freston JW

更新日期：1978-07-01 00:00:00

abstract：:A drug-drug interaction study was conducted to determine whether ritonavir (200 mg; 4 doses over 2 days) alters the pharmacokinetic disposition of bupropion (75 mg; once) coadministered to 7 healthy volunteers in a placebo-controlled 2-way crossover study. Serum samples collected from 0 to 24 hours after bupropion adm...

journal_title：Journal of clinical pharmacology

authors： Hesse LM,Greenblatt DJ,von Moltke LL,Court MH

更新日期：2006-05-01 00:00:00

abstract：:The pharmacokinetics of a meloxicam suspension were studied in 18 children with juvenile rheumatoid arthritis. Children received a single 0.25-mg/kg dose up to a maximum of 15 mg. Pharmacokinetic parameters after the first dose were calculated by noncompartmental methods. Geometric mean (percent coefficient of variati...

journal_title：Journal of clinical pharmacology

authors： Burgos-Vargas R,Foeldvari I,Thon A,Linke R,Tuerck D

更新日期：2004-08-01 00:00:00

abstract：:Fifteen acute myocardial infarction patients (only one of whom had evidence of significant renal dysfunction) received a constant-rate intravenous infusion of procainamide at one rate for a least 24 hours. Steady-state plasma levels achieved during these infusions were used to calculate total body clearance (C/B). Lin...

journal_title：Journal of clinical pharmacology

authors： Wyman MG,Goldreyer BN,Cannon DS,Ludden TM,Lalka D

更新日期：1981-01-01 00:00:00

abstract：:To study the pharmacokinetics and pharmacodynamics of two intravenous nizatidine dosing regimens, serial plasma concentrations and continuous intragastric pH were monitored simultaneously in 10 subjects with a documented history of duodenal or gastric ulcers. A 24-hour gastric pH profile was characterized for a 300 mg...

journal_title：Journal of clinical pharmacology

authors： Danziger L,Furmaga KM,Rodvold KA,Bombeck CT,Fischer JH

更新日期：1989-10-01 00:00:00