Effect of nighttime anisotropine methyl bromide of duodenal ulcer healing and pain: a double-blind controlled trial.

abstract：:The decrease in renal blood flow (RBF) observed in patients with hypertension can be increased with converting enzyme inhibition (CEI). It is unknown whether the decrease in RBF observed with age can also be increased with CEI. This study compared the short- and long-term effects of captopril monotherapy in young (les...

journal_title：Journal of clinical pharmacology

authors： Penner SB,Mitenko PA,Aoki FY,Sitar DS,Smyth DD,McKenzie JK

更新日期：1991-01-01 00:00:00

abstract：:Varenicline is a novel selective α4β2 nicotinic acetylcholine partial agonist developed for smoking cessation. Single- and multiple dose studies were conducted to investigate pharmacokinetics, safety, and tolerability of varenicline in healthy male Japanese smokers. The single-dose study was conducted as a double-blin...

journal_title：Journal of clinical pharmacology

authors： Kikkawa H,Maruyama N,Fujimoto Y,Hasunuma T

更新日期：2011-04-01 00:00:00

abstract：:Two populations of critical care patients were studied using indices of renal tubular damage (beta 2-microglobulin, enzymes, casts) and indices of glomerular filtration (creatinine, creatinine clearance). The purpose of these studies had been initially to elucidate the type of renal failure typical of the critically i...

journal_title：Journal of clinical pharmacology

authors： Schentag JJ

更新日期：1983-10-01 00:00:00

abstract：:Lofexidine, an antihypertensive imidazoline derivative, was given to ten hypertensives on both a twice-daily and once-daily regimen, using routine blood pressure measurements and 24-hour Remler recording. Plasma renin activity and catecholamines were measured. After a dose titration with twice-daily doses, the total t...

journal_title：Journal of clinical pharmacology

authors： Garrett BN,Kaplan NM

更新日期：1981-04-01 00:00:00

abstract：:Ciramadol, a new analgesic with mixed narcotic agonist-antagonist actions, was compared with codeine and placebo in a double-blind study in 343 patients with postoperative pain. The patients received a single oral dose of either 30 or 60 mg of ciramadol, 60 mg of codeine, or placebo. As indicated by three efficacy mea...

journal_title：Journal of clinical pharmacology

authors： Graf DF,Pandit SK,Kothary SP,Freeland GR

更新日期：1985-11-01 00:00:00

abstract：:The study evaluated whether a liquid suspension of adefovir dipivoxil (ADV) is effective and safe when dose adjusted based on varying degrees of renal impairment in patients with chronic hepatitis B. Patients had stable mild, moderate, or severe renal impairment or end-stage renal disease. Twenty-eight patients were e...

journal_title：Journal of clinical pharmacology

authors： Shiffman ML,Pol S,Rostaing L,Schiff E,Thabut D,Zeuzem S,Zong J,Frederick D,Rousseau F

更新日期：2011-09-01 00:00:00

abstract：:The analgesic activity of buprenorphine was monitored versus that of morphine in a double-blind, randomized, multiple-dose, parallel-design study involving 97 postsurgical patients. Patients could receive intramuscular injections of either buprenorphine (0.3, o.45, or 0.6 mg) or morphine (10, 15, or 20 mg) every 3 or ...

journal_title：Journal of clinical pharmacology

authors： Ouellette RD

更新日期：1982-04-01 00:00:00

abstract：:Avibactam is a non-β-lactam β-lactamase inhibitor intended for use as a fixed-dose combination with ceftazidime for the treatment of certain serious Gram-negative infections. As avibactam is primarily excreted unchanged in the urine, renal impairment may affect its pharmacokinetics. This phase 1 study investigated the...

journal_title：Journal of clinical pharmacology

authors： Merdjan H,Tarral A,Das S,Li J

更新日期：2017-02-01 00:00:00

abstract：:The present study was carried out to clarify the effects of an antianxiety drug and of personality characteristics on a psychomotor performance test. Forty-eight healthy women college students were chosen from 64 volunteers as having either high or low levels of trait anxiety, neuroticism, or extroversion. Subjects wi...

journal_title：Journal of clinical pharmacology

authors： Nakano S,Ogawa N,Kawazu Y,Osato E

更新日期：1978-02-01 00:00:00

abstract：:Relationships between tocilizumab exposure and response were evaluated using data from 4 phase III studies. Increased tocilizumab exposure was associated with improvements in Disease Activity Score using 28 joints (DAS28) and American College of Rheumatology (ACR) criteria and with a decrease in inflammation markers. ...

journal_title：Journal of clinical pharmacology

authors： Levi M,Grange S,Frey N

更新日期：2013-02-01 00:00:00

abstract：:Twelve patients chronically maintained on warfarin were administered 80 mg atorvastatin for 2 weeks. Mean prothrombin times decreased slightly, but only for the first few days of the two-week treatment period. Thus atorvastatin had no consistent effect on the anticoagulant activity of warfarin and adjustment in warfar...

journal_title：Journal of clinical pharmacology

authors： Stern R,Abel R,Gibson GL,Besserer J

更新日期：1997-11-01 00:00:00

abstract：:The efficacy of intravenously administered metoprolol, a cardioselective beta-adrenergic blocking agent, was evaluated in the treatment of supraventricular tachyarrhythmias in 16 patients. The arrhythmias that were treated were atrial fibrillation (11 patients), atrial flutter (2 patients), supraventricular tachycardi...

journal_title：Journal of clinical pharmacology

authors： Amsterdam EA,Kulcyski J,Ridgeway MG

更新日期：1991-08-01 00:00:00

abstract：:ABT-761 is a second-generation 5-lipoxygenase inhibitor in clinical development for the treatment of asthma. The effects of ABT-761 on the pharmacokinetics of an oral contraceptive were assessed in 21 female adult volunteers in a phase I, multiple-dose, open-label study. Subjects received a single dose of oral contrac...

journal_title：Journal of clinical pharmacology

authors： Wong SL,O'Dea RF,Dube LM,Awni WM

更新日期：1998-07-01 00:00:00

abstract：:This study was designed to measure the effect of the addition of zonisamide on phenytoin pharmacokinetics under steady-state conditions in patients with epilepsy. Nineteen patients stabilized under phenytoin monotherapy were included in a 3-center, open-label, 1-way drug interaction trial. Zonisamide was gradually inc...

journal_title：Journal of clinical pharmacology

authors： Levy RH,Ragueneau-Majlessi I,Garnett WR,Schmerler M,Rosenfeld W,Shah J,Pan WJ

更新日期：2004-11-01 00:00:00

abstract：:The effects on the upper gastrointestinal tract of five different preparations of KCl were compared in 90 healthy subjects treated with glycopyrrolate. The KCl preparations studied were wax-matrix KCl, microencapsulated KCl, liquid KCl, experimental extended-release capsules, experimental extended-release tablets,and ...

journal_title：Journal of clinical pharmacology

authors： Alsop WR,Moore JG,Rollins DE,Tolman KG

更新日期：1984-05-01 00:00:00

abstract：:The objective of this study was to evaluate the effect of the acute administration of marijuana (MJ) on cardiovascular (CV) function and CNS pharmacokinetics (PK) of [(15)O]water in occasional (O) versus chronic (C) MJ users. Each subject received four injections of [(15)O]water (one prior and three postsmoking) on tw...

journal_title：Journal of clinical pharmacology

authors： Ponto LL,O'Leary DS,Koeppel J,Block RI,Watkins GL,Richmond JC,Ward CA,Clermont DA,Schmitt BA,Hichwa RD

更新日期：2004-07-01 00:00:00

abstract：:The primary objective was to determine the pharmacokinetics of single oral and intravenous doses of pantoprazole in children 2 to 16 years of age. The secondary objective was to assess the safety and tolerability of these doses. Male and female hospitalized and nonhospitalized patients from ages 5 to 16 years received...

journal_title：Journal of clinical pharmacology

authors： Kearns GL,Blumer J,Schexnayder S,James LP,Adcock KG,Reed MD,Daniel JF,Gaedigk A,Paul J

更新日期：2008-11-01 00:00:00

abstract：:The in vitro plasma protein binding of warfarin was evaluated by ultrafiltration in plasma from seven normal subjects and seven patients with varying degrees of renal dysfunction. The unbound, or free, warfarin fraction was twice as high in the plasma samples withdrawn from patients with renal impairment than in the s...

journal_title：Journal of clinical pharmacology

authors： Bachmann K,Shapiro R,Mackiewicz J

更新日期：1976-10-01 00:00:00

abstract：:A randomized, single-blind, placebo-controlled, parallel-group study was conducted to assess the effect of age and gender on the pharmacokinetics and pharmacodynamics of rivaroxaban - an oral, direct Factor Xa inhibitor. Subjects (n = 34) were enrolled into four groups: young males or females (aged 18-45 years) and el...

journal_title：Journal of clinical pharmacology

authors： Kubitza D,Becka M,Roth A,Mueck W

更新日期：2013-03-01 00:00:00

abstract：:After space-flights of less than ten days, orthostatic hypotension upon reentry is characterized by plasma volume depletion that may lead to activation of the Bezold-Jarisch reflex which is also considered to be the mechanism of vasovagal (neurocardiogenic) syncope. For space-flight of longer duration, loss of cardiov...

journal_title：Journal of clinical pharmacology

authors： Piwinski SE,Jankovic J,McElligott MA

更新日期：1994-05-01 00:00:00

abstract：:Twenty-three normal volunteers who received morphine sulphate (MS Contin) with naltrexone completed this randomized, analytically blinded, two-way crossover comparison of the bioavailability of one 200-mg oral controlled-release morphine sulfate tablet with two 100-mg MSC tablets. Morphine effects were blocked by thre...

journal_title：Journal of clinical pharmacology

authors： Kaiko RF,Grandy RP,Reder RF,Goldenheim PD,Sackler RS

更新日期：1995-05-01 00:00:00

abstract：:The aim of this study was to test the usefulness of the metabolite/caffeine ratio for the evaluation of hepatic dysfunction. Subjects with liver cirrhosis and chronic hepatitis, as well as healthy volunteers, were given the oral dose of 300 mg caffeine. Blood samples were collected after 4, 8, and 12 hours. Concentrat...

journal_title：Journal of clinical pharmacology

authors： Jodynis-Liebert J,Flieger J,Matuszewska A,Juszczyk J

更新日期：2004-04-01 00:00:00

abstract：:Sustained-release (SR) bupropion (Zyban) is approved as a smoking cessation aid for adults. Since smoking often begins in adolescence, we determined the single-dose pharmacokinetics of bupropion SR in 75 adolescent subjects ranging from 13 to 18 years old. Subjects self-reported their smoking status. Urinary cotinine ...

journal_title：Journal of clinical pharmacology

authors： Stewart JJ,Berkel HJ,Parish RC,Simar MR,Syed A,Bocchini JA Jr,Wilson JT,Manno JE

更新日期：2001-07-01 00:00:00

abstract：:There is an increasing interest in the simultaneous administration of several probe substrates to characterize the activity of multiple drug-metabolizing enzymes, the so-called "cocktail" approach. However, this method remains controversial and is being investigated more extensively. No general consensus has emerged o...

journal_title：Journal of clinical pharmacology

authors： Zhou H,Tong Z,McLeod JF

更新日期：2004-02-01 00:00:00

abstract：:The purpose of this open-label, parallel-group study was to investigate the effect of severe renal impairment on the pharmacokinetics (PK), tolerability, and safety of clazosentan, an intravenous endothelin receptor antagonist. Clazosentan was administered as a continuous intravenous infusion of 1 mg/h for a period of...

journal_title：Journal of clinical pharmacology

authors： Bruderer S,Sasu B,Tsvitbaum N,Dingemanse J

更新日期：2011-03-01 00:00:00

abstract：:Continuous Holter recordings are often used in thorough QT studies (TQTS), with multiple 10-second electrocardiograms (ECGs) visually selected around predesignated time points. The authors hypothesized that computer-automated ECG selection would reduce within-subject variability, improve study data precision, and incr...

journal_title：Journal of clinical pharmacology

authors： George S,Rodriguez I,Ipe D,Sager PT,Gussak I,Vajdic B

更新日期：2012-12-01 00:00:00

abstract：:CGS 13080, a selective thromboxane synthetase inhibitor, was given intravenously (0.6 mg/kg over 6 hours) to eight hypertensive (diastolic 95-115 mm Hg) euvolemic caucasian females on their customary salt intake (24 hour urine Na: 142.9 +/- 14.8 meq). No change occurred in blood pressure or glomerular filtration rate ...

journal_title：Journal of clinical pharmacology

authors： Weir MR,Klassen DK,Hoover N,Douglas FL

更新日期：1989-12-01 00:00:00

abstract：:The disposition of nalmefene, an opioid antagonist intended for the reversal of opioid-induced respiratory depression, and its primary metabolite nalmefene glucuronide, were characterized in adult volunteers with normal renal function and in patients with end-stage renal disease (ESRD). The effect of hemodialysis on t...

journal_title：Journal of clinical pharmacology

authors： Matzke GR,Frye RF,Alexander AC,Reynolds R,Dixon R,Johnston J,Rault RM

更新日期：1996-02-01 00:00:00

abstract：:Udenafil, a cyclic guanosine monophosphate-specific phosphodiesterase type 5 inhibitor, has been developed to treat erectile dysfunction. We evaluated the effect of age on the pharmacokinetics and tolerability of udenafil. A single-center, open-label, parallel-group phase 1 study was conducted in healthy adult subject...

journal_title：Journal of clinical pharmacology

authors： Choi HK,Jung JA,Shon J,Bahng MY,Cho DY,Yeo CW,Kim EY,Shin JG

更新日期：2016-11-01 00:00:00

abstract：:We compared the pharmacokinetic (PK) exposure parameters of efavirenz (EFV) and its major inactive metabolite, 8-hydroxy-efavirenz (8-OH-EFV), in an open-label, single-sequence, and parallel design of HIV-infected and tuberculosis (TB)-HIV-coinfected Ethiopian patients in the HIV-TB Pharmagene study with 20 and 33 pat...

journal_title：Journal of clinical pharmacology

authors： Habtewold A,Aklillu E,Makonnen E,Amogne W,Yimer G,Aderaye G,Bertilsson L,Owen JS,Burhenne J

更新日期：2016-12-01 00:00:00