Abstract:
:The present study was carried out to clarify the effects of an antianxiety drug and of personality characteristics on a psychomotor performance test. Forty-eight healthy women college students were chosen from 64 volunteers as having either high or low levels of trait anxiety, neuroticism, or extroversion. Subjects with high trait anxiety and/or neuroticism tended to show a decrease in both speed and accuracy of the mirror drawing test (MDT) in the initial nondrug trials. Bromazepam, 5 mg, a benzodiazepine derivative, decreased this decrement in highly anxious subjects but worsened the speed in less anxious subjects. The personality traits of subjects, as well as the degree to which a performance test will induce stress, must be considered when evaluating the effects of antianxiety drugs on the performance of normal volunteers. The clinical anxiety-reducing efficacy of drugs may be predicted by using the MDT in subjects with high levels of anxiety and/or neuroticism.
journal_name
J Clin Pharmacoljournal_title
Journal of clinical pharmacologyauthors
Nakano S,Ogawa N,Kawazu Y,Osato Edoi
10.1002/j.1552-4604.1978.tb02432.xsubject
Has Abstractpub_date
1978-02-01 00:00:00pages
125-30issue
2-3eissn
0091-2700issn
1552-4604journal_volume
18pub_type
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