Abstract：
:This study was designed to measure the effect of the addition of zonisamide on phenytoin pharmacokinetics under steady-state conditions in patients with epilepsy. Nineteen patients stabilized under phenytoin monotherapy were included in a 3-center, open-label, 1-way drug interaction trial. Zonisamide was gradually increased to 400 mg/day, taken twice daily. Three pharmacokinetic profiles were performed: on days -7 and -1, to assess pharmacokinetic parameters of oral phenytoin administered alone, and on day 35, after 14 days of zonisamide treatment, to evaluate the effect of zonisamide on phenytoin pharmacokinetics and to characterize zonisamide pharmacokinetics in the presence of phenytoin. Fourteen patients completed the study; the coadministration of zonisamide and phenytoin was safe and well tolerated. Zonisamide did not significantly affect the mean C(min), C(max), AUC(0-12), and CL/F of phenytoin measured before and after zonisamide administration. The pharmacokinetic measures of zonisamide in the presence of phenytoin were consistent with previous reports of induction of zonisamide metabolism by phenytoin.
journal_name
J Clin Pharmacoljournal_title
Journal of clinical pharmacologyauthors
Levy RH,Ragueneau-Majlessi I,Garnett WR,Schmerler M,Rosenfeld W,Shah J,Pan WJdoi
10.1177/0091270004268045subject
Has Abstractpub_date
2004-11-01 00:00:00pages
1230-4issue
11eissn
0091-2700issn
1552-4604pii
44/11/1230journal_volume
44pub_type
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