Bumetanide: a new diuretic. Results of clinical efficacy and safety in patients with congestive heart failure.

abstract：:Vitamin B6 has been known to possess antiemetic effects since 1942. This water soluble compound has several forms in the circulation including pyridoxine, pyridoxal, and pyridoxal phosphate. The active antiemetic form of vitamin B6 is unknown. This was a pre-specified substudy of a randomized, placebo-controlled trial...

journal_title：Journal of clinical pharmacology

authors： Matok I,Clark S,Caritis S,Miodovnik M,Umans JG,Hankins G,Mattison DR,Koren G

更新日期：2014-12-01 00:00:00

abstract：:With increasing interest in enrolling adolescent patients in adult trials, a question often arises: when can pediatric patients use adult dosages? For currently approved therapeutic monoclonal antibodies (mAbs) with equivalent adult and pediatric indications, body weight thresholds for pediatric patients to receive ad...

journal_title：Journal of clinical pharmacology

authors： Yang N,Xu MC,Yao Z

更新日期：2019-10-01 00:00:00

abstract：:Although alcohol consumption is involved in most acts of violence, most people do not become violent when they drink. Individuals also respond differently to alcohol on laboratory measures of aggression. The objective of this study was to determine whether individual differences in the effects of alcohol on a laborato...

journal_title：Journal of clinical pharmacology

authors： Fulwiler C,Eckstine J,Kalsy S

更新日期：2005-01-01 00:00:00

abstract：:Argatroban, a direct thrombin inhibitor, is metabolized in vitro by CYP3A4/5 and therefore may be susceptible to clinically relevant CYP3A drug interactions. The effect of erythromycin, a potent CYP3A4/5 inhibitor, on the pharmacokinetics and pharmacodynamics of argatroban was evaluated in 14 healthy male volunteers i...

journal_title：Journal of clinical pharmacology

authors： Tran JQ,Di Cicco RA,Sheth SB,Tucci M,Peng L,Jorkasky DK,Hursting MJ,Benincosa LJ

更新日期：1999-05-01 00:00:00

abstract：:The present study was carried out to clarify the effects of an antianxiety drug and of personality characteristics on a psychomotor performance test. Forty-eight healthy women college students were chosen from 64 volunteers as having either high or low levels of trait anxiety, neuroticism, or extroversion. Subjects wi...

journal_title：Journal of clinical pharmacology

authors： Nakano S,Ogawa N,Kawazu Y,Osato E

更新日期：1978-02-01 00:00:00

abstract：:The efficacy and tolerability of aminoglutethimide for the treatment of Cushing's syndrome was assessed in 66 cases three of which are described in the present paper. Aminoglutethimide provided palliation from the signs and symptoms of hypercorticism in 13 of 21 patients with metastatic adrenocortical carcinoma and fo...

journal_title：Journal of clinical pharmacology

authors： Misbin RI,Canary J,Willard D

更新日期：1976-11-01 00:00:00

abstract：:Nateglinide (Starlix, SDZ DJN 608 or A-4166), a new insulinotropic agent, is intended to be administered prior to a meal in order to improve early insulin release in non-insulin-dependent diabetes mellitus patients. The effects of a meal on the oral bioavailability and pharmacodynamic actions of nateglinide were inves...

journal_title：Journal of clinical pharmacology

authors： Karara AH,Dunning BE,McLeod JF

更新日期：1999-02-01 00:00:00

abstract：:Ixekizumab (LY2439821), a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody that selectively binds and neutralizes interleukin (IL) 17A has demonstrated efficacy in the treatment of psoriasis. A population pharmacokinetics-pharmacodynamics model was developed using NONMEM 7.2 to describe the temporal re...

journal_title：Journal of clinical pharmacology

authors： Tham LS,Tang CC,Choi SL,Satterwhite JH,Cameron GS,Banerjee S

更新日期：2014-10-01 00:00:00

abstract：:Monitoring drug levels in patients is standard practice in presentday critical care medicine. Clinical laboratories, however, are often unable to assay drug levels immediately following phlebotomy. This may result in blood samples being kept under a variety of storage conditions for nonuniform periods of time. The cur...

journal_title：Journal of clinical pharmacology

authors： Colucci RD,Halpern NA,Levy E,McElhinney AJ,Greenstein RJ

更新日期：1988-08-01 00:00:00

abstract：:Upadacitinib is a selective Janus kinase 1 inhibitor that was recently approved for treatment of rheumatoid arthritis and is currently being evaluated for treatment of several other autoimmune diseases, including atopic dermatitis (AD). The relationships between upadacitinib plasma exposure and efficacy (assessed as E...

journal_title：Journal of clinical pharmacology

authors： Mohamed MF,Gopalakrishnan S,Teixeira HD,Othman AA

更新日期：2020-11-06 00:00:00

abstract：:Current guidelines for hypercholesterolemia treatment emphasize lifestyle modification and lipid-modifying therapy to reduce the risk for cardiovascular disease. Statins are the primary class of agents used for the treatment of hypercholesterolemia. Although statins are effective for many patients, they fail to achiev...

journal_title：Journal of clinical pharmacology

authors： Ito MK,Santos RD

更新日期：2017-01-01 00:00:00

abstract：:This study assessed the efficacy and safety of ketoprofen patch compared with placebo in patients who had rheumatoid arthritis and persistent wrist pain. Patients (N = 676)who had achieved systemic disease control with a disease-modifying antirheumatic drug and/or systemic corticosteroid, but still had persistent wris...

journal_title：Journal of clinical pharmacology

authors： Kawai S,Uchida E,Kondo M,Ohno S,Obata J,Nawata Y,Sugimoto K,Oribe M,Nagaya I

更新日期：2010-10-01 00:00:00

abstract：:To investigate the impact of cytochrome P450 (CYP) genetic polymorphisms CYP2B6, CYP2C19, and CYP3A5 on mRNA expression, cyclophosphamide/4-hydroxycyclophosphamide pharmacokinetics, and treatment outcomes of the R-CHOP regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) in Chinese patients ...

journal_title：Journal of clinical pharmacology

authors： Shu W,Chen L,Hu X,Zhang M,Chen W,Ma L,Liu X,Huang J,Pang T,Li J,Zhang Y

更新日期：2017-07-01 00:00:00

abstract：:For more than a decade, first responders and the general public have been able to treat suspected opioid overdoses using an improvised nasal naloxone device (INND) constructed from a prefilled syringe containing 2 mg of naloxone (1 mg/mL) attached to a mucosal atomization device. In recent years, the U.S. Food and Dru...

journal_title：Journal of clinical pharmacology

authors： Krieter PA,Chiang CN,Gyaw S,McCann DJ

更新日期：2019-08-01 00:00:00

abstract：:The clinical effects of a cardioselective beta-adrenergic blocking drug, acebutolol, were studied in 25 patients with chronic stable angina, using a seven-week single-blind placebo leads to acebutolol (mean dose 913 mg/day) phase followed by 12-week randomized double-blind placebo leads to acebutolol (mean dose 968 mg...

journal_title：Journal of clinical pharmacology

authors： Lee G,DeMaria AN,Favrot L,Hermanovich J,Kozina J,Krieg P,Kimchi A,Laddu A,Mason DT

更新日期：1982-08-01 00:00:00

abstract：:The objective of this study was to evaluate the effect of the acute administration of marijuana (MJ) on cardiovascular (CV) function and CNS pharmacokinetics (PK) of [(15)O]water in occasional (O) versus chronic (C) MJ users. Each subject received four injections of [(15)O]water (one prior and three postsmoking) on tw...

journal_title：Journal of clinical pharmacology

authors： Ponto LL,O'Leary DS,Koeppel J,Block RI,Watkins GL,Richmond JC,Ward CA,Clermont DA,Schmitt BA,Hichwa RD

更新日期：2004-07-01 00:00:00

abstract：:There has been a considerable revolution in the field of hypertension therapy. We have gone through an era in which patients with severe hypertension and those with accelerated hypertension had a very short life expectancy. Currently blood pressure can be readily controlled with a marked improvement in longevity. We h...

journal_title：Journal of clinical pharmacology

authors： Somberg J,Ehrenpreis S,Shroff G,Khosla S

更新日期：1993-03-01 00:00:00

abstract：:The plasma and red blood cell pharmacokinetics and bioavailability of the natural source (RRR, d) and all racemic (all rac, dl) stereoisomers of alpha-tocopherol were studied in 12 men in a double-blind randomized crossover study. Subjects were administered two 400-mg soft-gelatin capsules of either RRR or all rac alp...

journal_title：Journal of clinical pharmacology

authors： Ferslew KE,Acuff RV,Daigneault EA,Woolley TW,Stanton PE Jr

更新日期：1993-01-01 00:00:00

abstract：:A method of estimating the elimination half-life of a drug at any selected serum concentration when the Km and Vmax of that drug are known is described. The method was validated in six patients by determining their Km and Vmax values for phenytoin, using data obtained at two serum concentrations and then using the Km ...

journal_title：Journal of clinical pharmacology

authors： Browne TR,Greenblatt DJ,Evans JE,Szabo GK,Evans BA,Schumacher GE

更新日期：1987-04-01 00:00:00

abstract：:A clinical study was performed on 41 asthmatic patients. After complete physical and spirometric examinations, they received capsules containing 200 mg anhydrous theophylline per capsule t.i.d. for three weeks. All other antiasthmatic medications were omitted during this study. The results showed that these capsules (...

journal_title：Journal of clinical pharmacology

authors： Miller J,Salem H

更新日期：1976-07-01 00:00:00

abstract：:The relative analgesic potency of oral and intramuscular oxymorphone was evaluated in a double-blind crossover comparison of graded single doses in patients with chronic pain due to cancer. When both duration and intensity of analgesia are considered (total effect), oral oxymorphone was 1/6 as potent as the intramuscu...

journal_title：Journal of clinical pharmacology

authors： Beaver WT,Wallenstein SL,Houde RW,Rogers A

更新日期：1977-04-01 00:00:00

abstract：:Transporters play an important role in drug absorption, disposition, and drug action. The evaluation of drug transporters requires a comprehensive understanding of transporter biology and pharmacology. Physiologically based pharmacokinetic (PBPK) models may offer an integrative platform to quantitatively evaluate the ...

journal_title：Journal of clinical pharmacology

authors： Pan Y,Hsu V,Grimstein M,Zhang L,Arya V,Sinha V,Grillo JA,Zhao P

更新日期：2016-07-01 00:00:00

abstract：:T Cell Modulatory Peptide (TCMP-80), L-lysine-L-serine, is a synthetic dipeptide structurally related to a selected amino acid sequence in human immunoglobulin G. Based on in vitro and preclinical in vivo testing, TCMP-80 has immunomodulatory properties. This report describes the first administration of TCMP-80 to man...

journal_title：Journal of clinical pharmacology

authors： Eldon MA,Smith RA,Leese PT,Daigle AE,Katz DV,Richieri SP

更新日期：1990-04-01 00:00:00

abstract：:Atrial fibrillation is very common in the United States. After a search of Medline, EMBASE, and CINAHL, 4 trials evaluating inhibitors of the renin-angiotensin system were identified for prevention of new-onset atrial fibrillation, facilitation of electrical cardioversion of atrial fibrillation, and prevention of atri...

journal_title：Journal of clinical pharmacology

authors： Kalus JS,Coleman CI,White CM

更新日期：2006-01-01 00:00:00

abstract：:Tinidazole is a potent nitroimidazole compound active against, and used to treat, Trichomonas vaginalis infections in males and females. Speculation exists in the literature that observed differences in tinidazole plasma concentrations between males and females may be due to sex-mediated pharmacokinetic differences. T...

journal_title：Journal of clinical pharmacology

authors： Chaikin P,Alton KB,Sampson C,Weintraub HS

更新日期：1982-11-01 00:00:00

abstract：:The efficacy and safety of esmolol, a titratable intravenous beta-adrenergic blocking agent with a short elimination half-life (t 1/2 = 9.0 min) was evaluated in a multicenter open-label study for the treatment of supraventricular tachyarrhythmias (heart rate greater than 100 bpm). The study also investigated the feas...

journal_title：Journal of clinical pharmacology

authors： Das G,Tschida V,Gray R,Dhurandhar R,Lester R,McGrew F,Askenazi J,Kaplan K,Emanuele M,Turlapaty P

更新日期：1988-08-01 00:00:00

abstract：:The pharmacokinetics of codeine, codeine glucuronide, morphine, and morphine glucuronide were assessed after single- (60 mg) and multiple-dose (60 mg every six hours for nine doses) oral administration of codeine sulfate to six normal volunteers. Multiple blood and urine samples were collected after administration of ...

journal_title：Journal of clinical pharmacology

authors： Guay DR,Awni WM,Halstenson CE,Findlay JW,Opsahl JA,Abraham PA,Jones EC,Matzke GR

更新日期：1987-12-01 00:00:00

abstract：:Twelve healthy volunteers received single oral doses of propranolol (80 mg), metoprolol (100 mg), L-bunolol (2 mg), and placebo in a four-way crossover study. Blood pressure, ventricular rate, and echocardiographically determined ejection fraction, ejection time, and mean rate of circumferential fiber shortening (mVcf...

journal_title：Journal of clinical pharmacology

authors： Ochs HR,Bahrmann H,Greenblatt DJ,Labedzki L

更新日期：1988-12-01 00:00:00

abstract：:Magnesium sulfate is the anticonvulsant of choice for eclampsia prophylaxis and treatment; however, the recommended dosing regimens are costly and cumbersome and can be administered only by skilled health professionals. The objectives of this study were to develop a robust exposure-response model for the relationship ...

journal_title：Journal of clinical pharmacology

authors： Du L,Wenning LA,Carvalho B,Duley L,Brookfield KF,Witjes H,de Greef R,Lumbiganon P,Titapant V,Kongwattanakul K,Long Q,Sangkomkamhang US,Gülmezoglu AM,Oladapo OT

更新日期：2019-11-01 00:00:00

abstract：:The availability of poisoning information from the pharmaceutical industry was evaluated. Manufacturers of the top 50 drugs were surveyed. Information that was received was classified by established criteria for evaluation. Compendia on poisoning information was evaluated based on 11 components ranging from toxicity i...

journal_title：Journal of clinical pharmacology

authors： Bolger PB,Shimomura SK,Cupit GC,Davis LJ,McCart GM

更新日期：1979-02-01 00:00:00