Impulsive-aggressive traits, serotonin function, and alcohol-enhanced aggression.

abstract：:Twenty young (45 years or younger) and 20 older (55 years or older) adult patients with mild hypertension were enrolled in this study to compare the hemodynamic effects of labetalol versus placebo in two age groups. Ten patients in each group were randomly assigned to receive either a single oral dose of labetalol (20...

journal_title：Journal of clinical pharmacology

authors： Buell JC,Eliot RS,Plachetka JR,Little MR

更新日期：1988-04-01 00:00:00

abstract：:The effects on the upper gastrointestinal tract of five different preparations of KCl were compared in 90 healthy subjects treated with glycopyrrolate. The KCl preparations studied were wax-matrix KCl, microencapsulated KCl, liquid KCl, experimental extended-release capsules, experimental extended-release tablets,and ...

journal_title：Journal of clinical pharmacology

authors： Alsop WR,Moore JG,Rollins DE,Tolman KG

更新日期：1984-05-01 00:00:00

abstract：:The pharmacokinetic properties of dezocine were examined in 15 patients with acute or chronic pain. In 3 groups of 5 patients each, serum levels were determined at various intervals after single intravenous doses of 5, 10, and 20 mg. After these single doses, dezocine was very rapidly distributed (mean t1/2 alpha less...

journal_title：Journal of clinical pharmacology

authors： Wilson JM,Cohen RI,Kezer EA,Schange SJ,Smith ER

更新日期：1995-04-01 00:00:00

abstract：:Although population studies have demonstrated a relationship between casual office blood pressures and target organ events, the variability of these blood pressure measurements for individual patients has generated an interest in the role of ambulatory blood pressure monitoring for defining the presence of hypertensio...

journal_title：Journal of clinical pharmacology

authors： Prisant LM,Bottini PB,Carr AA

更新日期：1992-07-01 00:00:00

abstract：:This study was conducted to evaluate whether the allometric approach can be used to predict maximum tolerated dose (MTD) in humans from animal data. Twenty-five anticancer drugs were taken from the literature and used in this analysis. The results of the study indicate that MTD can be predicted with reasonable accurac...

journal_title：Journal of clinical pharmacology

authors： Mahmood I

更新日期：2001-01-01 00:00:00

abstract：:The objective of this study was to measure the steady-state cerebrospinal fluid (CSF) concentration of LY450108 and LY451395 (positive modulators of AMPA receptors) in healthy subjects after the administration of 1 mg and 5 mg. Secondary objectives included the evaluation of safety, pharmacokinetics, and steady-state ...

journal_title：Journal of clinical pharmacology

authors： Jhee SS,Chappell AS,Zarotsky V,Moran SV,Rosenthal M,Kim E,Chalon S,Toublanc N,Brandt J,Coutant DE,Ereshefsky L

更新日期：2006-04-01 00:00:00

abstract：:This open-label study evaluated apixaban pharmacokinetics, pharmacodynamics, and safety in subjects with mild, moderate, or severe renal impairment and in healthy subjects following a single 10-mg oral dose. The primary analysis determined the relationship between apixaban AUC∞ and 24-hour creatinine clearance (CLcr )...

journal_title：Journal of clinical pharmacology

authors： Chang M,Yu Z,Shenker A,Wang J,Pursley J,Byon W,Boyd RA,LaCreta F,Frost CE

更新日期：2016-05-01 00:00:00

abstract：:This study investigated the potential pharmacokinetic interaction between the direct renin inhibitor aliskiren and modulators of P-glycoprotein and cytochrome P450 3A4 (CYP3A4). Aliskiren stimulated in vitro P-glycoprotein ATPase activity in recombinant baculovirus-infected Sf9 cells with high affinity (K(m) 2.1 micro...

journal_title：Journal of clinical pharmacology

authors： Vaidyanathan S,Camenisch G,Schuetz H,Reynolds C,Yeh CM,Bizot MN,Dieterich HA,Howard D,Dole WP

更新日期：2008-11-01 00:00:00

abstract：:Sustained-release (SR) bupropion (Zyban) is approved as a smoking cessation aid for adults. Since smoking often begins in adolescence, we determined the single-dose pharmacokinetics of bupropion SR in 75 adolescent subjects ranging from 13 to 18 years old. Subjects self-reported their smoking status. Urinary cotinine ...

journal_title：Journal of clinical pharmacology

authors： Stewart JJ,Berkel HJ,Parish RC,Simar MR,Syed A,Bocchini JA Jr,Wilson JT,Manno JE

更新日期：2001-07-01 00:00:00

abstract：:CGS 13080, a selective thromboxane synthetase inhibitor, was given intravenously (0.6 mg/kg over 6 hours) to eight hypertensive (diastolic 95-115 mm Hg) euvolemic caucasian females on their customary salt intake (24 hour urine Na: 142.9 +/- 14.8 meq). No change occurred in blood pressure or glomerular filtration rate ...

journal_title：Journal of clinical pharmacology

authors： Weir MR,Klassen DK,Hoover N,Douglas FL

更新日期：1989-12-01 00:00:00

abstract：:This study determined the pharmacokinetics (PK) of figitumumab and its effects on insulin-like growth factor (IGF) axis-related biomarkers, following a single intravenous dose (10 [n = 16] and 20 [n = 12] mg/kg) in healthy adults. Serial blood sampling for PK and biomarkers was conducted up to 84 days postdose. A dose...

journal_title：Journal of clinical pharmacology

authors： Yin D,Sleight B,Alvey C,Hansson AG,Bello A

更新日期：2013-01-01 00:00:00

abstract：:The integrated glucose-insulin (IGI) model is a previously published semimechanistic model that describes plasma glucose and insulin concentrations after glucose challenges. The aim of this work was to use knowledge of physiology to improve the IGI model's description of glucose absorption and gastric emptying after t...

journal_title：Journal of clinical pharmacology

authors： Alskär O,Bagger JI,Røge RM,Knop FK,Karlsson MO,Vilsbøll T,Kjellsson MC

更新日期：2016-03-01 00:00:00

abstract：:Twelve patients chronically maintained on warfarin were administered 80 mg atorvastatin for 2 weeks. Mean prothrombin times decreased slightly, but only for the first few days of the two-week treatment period. Thus atorvastatin had no consistent effect on the anticoagulant activity of warfarin and adjustment in warfar...

journal_title：Journal of clinical pharmacology

authors： Stern R,Abel R,Gibson GL,Besserer J

更新日期：1997-11-01 00:00:00

abstract：:Pharmacokinetic studies of i.v. and oral racemic verapamil and 14C-erythromycin breath tests (ERBT) were performed in 84 healthy men (n = 42) and women (n = 42). Verapamil was measured by HPLC, concentration versus time data were analyzed by noncompartmental models, protein binding was measured by equilibrium dialysis...

journal_title：Journal of clinical pharmacology

authors： Krecic-Shepard ME,Barnas CR,Slimko J,Jones MP,Schwartz JB

更新日期：2000-03-01 00:00:00

abstract：:Atazanavir, a potent protease inhibitor of human immunodeficiency virus (HIV), exhibits pH-dependent solubility. Previous studies have indicated that coadministration with omeprazole 40 mg once daily significantly decreased atazanavir exposure by approximately 75%. Concomitant use of omeprazole and atazanavir is curre...

journal_title：Journal of clinical pharmacology

authors： Zhu L,Persson A,Mahnke L,Eley T,Li T,Xu X,Agarwala S,Dragone J,Bertz R

更新日期：2011-03-01 00:00:00

abstract：:This study evaluated the pharmacodynamics and pharmacokinetics of once-daily dosing of warfarin at steady state when taken concomitantly with once-daily doses of duloxetine. Healthy subjects with a stable international normalized ratio (INR) of 1.5 to 2.0 on an individualized fixed dose of warfarin (2-9 mg) in period ...

journal_title：Journal of clinical pharmacology

authors： Chappell J,He J,Knadler MP,Mitchell M,Lee D,Lobo E

更新日期：2009-12-01 00:00:00

abstract：:Aprepitant, a neurokinin antagonist, is an effective antiemetic agent in chemotherapy for delayed nausea and vomiting. The study objective was to evaluate the pharmacokinetics of aprepitant and concurrent cyclophosphamide (CY), often a component of hematopoietic stem cell transplant (HSCT) conditioning regimen, in can...

journal_title：Journal of clinical pharmacology

authors： Bubalo JS,Cherala G,McCune JS,Munar MY,Tse S,Maziarz R

更新日期：2012-04-01 00:00:00

abstract：:This study was designed to investigate the multiple-dose pharmacokinetics, safety, and tolerability of the selective α4β2 nicotinic acetylcholine partial agonist, varenicline, in elderly (65-85 years old) nonsmokers. Fifty male and female subjects with normal renal function for their age were randomized to receive var...

journal_title：Journal of clinical pharmacology

authors： Zhao Q,Schwam E,Fullerton T,O'Gorman M,Burstein AH

更新日期：2011-04-01 00:00:00

abstract：:The aim of this study was to determine the relationship, precision, and bias of a propofol target-controlled infusion (TCI) system during prolonged infusion in neurosurgical patients. We retrospectively included patients undergoing general anesthesia for elective neurosurgical removal of brain tumors and postoperative...

journal_title：Journal of clinical pharmacology

authors： Cortegiani A,Pavan A,Azzeri F,Accurso G,Vitale F,Gregoretti C

更新日期：2018-05-01 00:00:00

abstract：:Nintedanib is an intracellular inhibitor of tyrosine kinases used in the treatment of non-small cell lung cancer and idiopathic pulmonary fibrosis (IPF). This phase 1 open-label study investigated the influence of mild and moderate hepatic impairment on the pharmacokinetics (PK), safety, and tolerability of nintedanib...

journal_title：Journal of clinical pharmacology

authors： Marzin K,Kretschmar G,Luedtke D,Kraemer S,Kuelzer R,Schlenker-Herceg R,Schmid U,Schnell D,Dallinger C

更新日期：2018-03-01 00:00:00

abstract：:Hypertensive emergency is a condition in which there is elevation of both systolic and diastolic blood pressure with the presence of acute target organ disease. Hypertensive urgency is a condition where the blood pressure is elevated (diastolic > 120 mmHg) with the absence of acute target organ disease. Hypertensive e...

journal_title：Journal of clinical pharmacology

authors： Abdelwahab W,Frishman W,Landau A

更新日期：1995-08-01 00:00:00

abstract：:Amikacin was administered to 51 patients with serious Gram-negative infections. A favorable clinical outcome was observed in 32 patients (62 per cent). No major untoward effects were noted. The severity of the underlying disease and the site of the infection were important for the outcome. Urinary tract infections res...

journal_title：Journal of clinical pharmacology

authors： Klastersky J,Van Beerse D,Schoutens E,De Temmerman P,Yourassowsky E

更新日期：1976-04-01 00:00:00

abstract：:The decrease in renal blood flow (RBF) observed in patients with hypertension can be increased with converting enzyme inhibition (CEI). It is unknown whether the decrease in RBF observed with age can also be increased with CEI. This study compared the short- and long-term effects of captopril monotherapy in young (les...

journal_title：Journal of clinical pharmacology

authors： Penner SB,Mitenko PA,Aoki FY,Sitar DS,Smyth DD,McKenzie JK

更新日期：1991-01-01 00:00:00

abstract：:GS-9667, a new selective, partial agonist of the A(1) adenosine receptor (AR), may represent an effective therapy for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA). The objectives of the studies were to evaluate the effects of single and multiple doses of GS-9667 on plasma FFA concentr...

journal_title：Journal of clinical pharmacology

authors： Staehr PM,Dhalla AK,Zack J,Wang X,Ho YL,Bingham J,Belardinelli L

更新日期：2013-04-01 00:00:00

abstract：:The most thorough and clinically relevant approach to hypnotic drug evaluation is one that balances the strengths and weaknesses of clinical trials and sleep laboratory evaluations. Advantages of clinical trials include the ability to evaluate large numbers of subjects and specific target groups and to thoroughly asse...

journal_title：Journal of clinical pharmacology

authors： Kales A,Scharf MB,Soldatos CR,Bixler EO

更新日期：1979-07-01 00:00:00

abstract：:The objective of this study was to evaluate the effect of the antireflux barrier formed by Na alginate on pH-metry-defined acid reflux events in preterms. Four times/day, 1 mL/kg of Na alginate was administered as an intervention to the preterm infants whose gastroesophageal reflux disease was confirmed by 24-hour pH ...

journal_title：Journal of clinical pharmacology

authors： Atasay B,Erdeve O,Arsan S,Türmen T

更新日期：2010-11-01 00:00:00

abstract：:Due to the prevalence of both gastrointestinal and cardiovascular diseases, it is likely that patients may be coprescribed gastric parietal cell proton pump inhibitors and beta-adrenergic antagonists. Therefore, the objectives of this phase I study were to assess the potential effects of the coadministration of lansop...

journal_title：Journal of clinical pharmacology

authors： Karol MD,Locke CS,Cavanaugh JH

更新日期：2000-03-01 00:00:00

abstract：:The objective of this study was to determine the effects of double-strength grapefruit juice on gastric pH and systemic bioavailability of indinavir in HIV-infected subjects receiving indinavir. Fourteen HIV-infected subjects took 800 mg of indinavir with 6 ounces (180 ml) of water or double-strength grapefruit juice....

journal_title：Journal of clinical pharmacology

authors： Shelton MJ,Wynn HE,Hewitt RG,DiFrancesco R

更新日期：2001-04-01 00:00:00

abstract：:Clinical pharmacologists, neurologists, internists, and all health care givers must consider the efficacy, safety, and side effect profile of a given antiepileptic drug (AED) when determining which drug is best for a given patient. The first purpose of this paper is to address whether the "new" AEDs have advantages ov...

journal_title：Journal of clinical pharmacology

authors： Lathers CM,Schraeder PL,Claycamp HG

更新日期：2003-05-01 00:00:00

abstract：:Sinbaglustat (ACT-519276), a brain-penetrating inhibitor of glucosylceramide synthase and nonlysosomal glucosylceramidase, is developed as a new therapy for lysosomal storage disorders. In the first-in-human study, sinbaglustat was primarily excreted unchanged in urine. This study was conducted to evaluate the effect ...

journal_title：Journal of clinical pharmacology

authors： Melchior M,Dingemanse J,Alatrach A,Feldkamp T,Sidharta PN,Géhin M

更新日期：2020-12-23 00:00:00