Single- and multiple-dose pharmacokinetics of dezocine in patients with acute or chronic pain.


:The pharmacokinetic properties of dezocine were examined in 15 patients with acute or chronic pain. In 3 groups of 5 patients each, serum levels were determined at various intervals after single intravenous doses of 5, 10, and 20 mg. After these single doses, dezocine was very rapidly distributed (mean t1/2 alpha less than 2 minutes), and then rather rapidly eliminated (mean t1/2 beta about 4 hours); the apparent volume of distribution was large (mean Vz beta about 6 L/kg) as was the total clearance (mean CL about 1.5 L/h/kg). In 2 groups of 5 patients each, serum levels were determined after the first and third of 3 intravenous doses of 5 or 20 mg given at 3-hour intervals. The pharmacokinetic parameters after these multiple doses were consistent with those after the single doses. Although some observations were suggestive, there was no unequivocal evidence that the pharmacokinetics were dose-related. In 7 serum samples containing dezocine at concentrations ranging from 12.8 to 522 ng/mL, the mean (+/- SE) proportion of dezocine bound to protein was 91.6 +/- 0.8%.


J Clin Pharmacol


Wilson JM,Cohen RI,Kezer EA,Schange SJ,Smith ER




Has Abstract


1995-04-01 00:00:00












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    abstract::The population pharmacokinetic (PK) profile of oral clonidine was characterized in newborns with neonatal abstinence syndrome, and significant covariates affecting its PK parameters were identified. Plasma clonidine concentration data were obtained from a clinical trial in which 36 newborns, aged 1 to 25 days (postnat...

    journal_title:Journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Xie HG,Cao YJ,Gauda EB,Agthe AG,Hendrix CW,Lee H

    更新日期:2011-04-01 00:00:00

  • A Randomized Controlled Exploratory Pilot Study to Evaluate the Effect of Rotigotine Transdermal Patch on Parkinson's Disease-Associated Chronic Pain.

    abstract::Pain is a troublesome nonmotor symptom of Parkinson's disease (PD). This double-blind exploratory pilot study (NCT01744496) was the first to specifically investigate the effect of a dopamine agonist on PD-associated pain as primary outcome. Patients with advanced PD (ie, receiving levodopa) and at least moderate PD-as...

    journal_title:Journal of clinical pharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Rascol O,Zesiewicz T,Chaudhuri KR,Asgharnejad M,Surmann E,Dohin E,Nilius S,Bauer L

    更新日期:2016-07-01 00:00:00

  • A multivariable analysis of factors governing the steady-state pharmacokinetics of valproic acid in 52 young epileptics.

    abstract::A number of factors have been implicated in the interpatient variability of valproic acid (VPA) pharmacokinetics. These include patient age, concurrent anticonvulsant therapy, and dosage of VPA. In the clinical setting, it is important to determine which of these variables exert a major effect on the observed differen...

    journal_title:Journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Hall K,Otten N,Johnston B,Irvine-Meek J,Leroux M,Seshia S

    更新日期:1985-05-01 00:00:00

  • Population pharmacokinetics of cyclophosphamide and metabolites in children with neuroblastoma: a report from the Children's Oncology Group.

    abstract::Cyclophosphamide-based regimens are front-line treatment for numerous pediatric malignancies; however, current dosing methods result in considerable interpatient variability in tumor response and toxicity. In this pediatric population, the authors' objectives were (1) to quantify and explain the pharmacokinetic variab...

    journal_title:Journal of clinical pharmacology

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    authors: McCune JS,Salinger DH,Vicini P,Oglesby C,Blough DK,Park JR

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    journal_title:Journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Vernikos J,Dallman MF,Van Loon G,Keil LC

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  • Application of Individualized PBPK Modeling of Rate Data (iPBPK-R) to Evaluate the Effect of Hemodialysis On Nonrenal Clearance Pathways.

    abstract::The aim of this study was to apply individualized, physiologically-based pharmacokinetic (iPBPK-R) modeling of 14 CO2 production rates measured by the erythromycin breath test (ERMBT) to characterize the effect of hemodialysis on the function of nonrenal clearance pathways in patients with end-stage renal disease (ESR...

    journal_title:Journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Franchetti Y,Nolin TD

    更新日期:2021-01-18 00:00:00

  • Bioavailability of sublingual buprenorphine.

    abstract::Buprenorphine administered sublingually is a promising treatment for opiate dependence. Utilizing a new, sensitive, and specific gas chromatographic electron-capture detector assay, the absolute bioavailability of sublingual buprenorphine was determined in six healthy volunteers by comparing plasma concentrations afte...

    journal_title:Journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Mendelson J,Upton RA,Everhart ET,Jacob P 3rd,Jones RT

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  • Changes in Health-Related Quality of Life in People With Intellectual Disabilities Who Discontinue Long-Term Used Antipsychotic Drugs for Challenging Behaviors.

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    journal_title:Journal of clinical pharmacology

    pub_type: 杂志文章


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    journal_title:Journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Malone RP,Bennett DS,Delaney MA,Choudhury MS,Luebbert JF,Cater J

    更新日期:2006-09-01 00:00:00

  • Safety, pharmacokinetics, and antiretroviral activity of the potent, specific human immunodeficiency virus protease inhibitor nelfinavir: results of a phase I/II trial and extended follow-up in patients infected with human immunodeficiency virus.

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    journal_title:Journal of clinical pharmacology

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    authors: Moyle GJ,Youle M,Higgs C,Monaghan J,Prince W,Chapman S,Clendeninn N,Nelson MR

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    journal_title:Journal of clinical pharmacology

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    authors: Malati CY,Robertson SM,Hunt JD,Chairez C,Alfaro RM,Kovacs JA,Penzak SR

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  • Pharmacokinetic and pharmacodynamic profiles of CS-518, a selective, long-lasting thromboxane synthase inhibitor, after single and multiple oral administration to healthy volunteers.

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    journal_title:Journal of clinical pharmacology

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    authors: Uematsu T,Nagashima S,Inaba H,Mizuno A,Kosuge K,Nakashima M

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  • Population Pharmacokinetic Analysis of Dalteparin in Pediatric Patients With Venous Thromboembolism.

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    journal_title:Journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Damle B,Jen F,Sherman N,Jani D,Sweeney K

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  • Clinical and bacteriological evaluation of amikacin in severe gram-negative infections.

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    journal_title:Journal of clinical pharmacology

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    authors: Klastersky J,Van Beerse D,Schoutens E,De Temmerman P,Yourassowsky E

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  • Cyclosporine absorption following orthotopic liver transplantation.

    abstract::Blood concentrations of cyclosporine were determined in adult and pediatric patients following orthotopic liver transplantation to quantitate cyclosporine blood clearance and oral absorption. Seventeen bioavailability studies were performed following transplantation surgery in nine children and seven adults. The intra...

    journal_title:Journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Burckart GJ,Venkataramanan R,Ptachcinski RJ,Starzl TE,Gartner JC Jr,Zitelli BJ,Malatack JJ,Shaw BW,Iwatsuki S,Van Thiel DH

    更新日期:1986-11-01 00:00:00

  • Pharmacokinetics of retinoids in women after meal consumption or vitamin A supplementation.

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    journal_title:Journal of clinical pharmacology

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    authors: Chen C,Mistry G,Jensen B,Heizmann P,Timm U,van Brummelen P,Rakhit AK

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  • First-in-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of an Oral Formulation of DS-1040, an Inhibitor of the Activated Form of Thrombin-Activatable Fibrinolysis Inhibitor, in Healthy Subjects.

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    journal_title:Journal of clinical pharmacology

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  • Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance.

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    journal_title:Journal of clinical pharmacology

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    authors: Loi CM,Stern R,Koup JR,Vassos AB,Knowlton P,Sedman AJ

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    authors: May K,Westphal K,Giessmann T,Wegner D,Adam U,Lerch MM,Oertel R,Warzok RW,Weitschies W,Braeter M,Siegmund W

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    pub_type: 杂志文章


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    journal_title:Journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Schnelle K,Klein G,Schinz A

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    journal_title:Journal of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Bowen JP,Charifson PS,Fox PC,Kontoyianni M,Miller AB,Schnur D,Stewart EL,Van Dyke C

    更新日期:1993-12-01 00:00:00

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    journal_title:Journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Ankrom W,Xu J,Vallee MH,Dockendorf MF,Armas D,Boinpally R,Min KC

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    journal_title:Journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kovarik JM,Kalbag J,Figueiredo J,Rouilly M,Frazier OL,Rordorf C

    更新日期:2002-01-01 00:00:00