Abstract:
:A decrease in dietary protein intake lowers the clearance of a number of substances excreted principally by the kidney including uric acid and oxypurinol, the major metabolite of allopurinol. We studied the kinetics of uric acid and oxypurinol in seven healthy volunteers on a normal protein diet (2600 calories; 100 g protein) followed by a 400 calorie, protein-free diet. A 600 mg dose of allopurinol was given orally after 6 days of the normal protein diet and again after 2 days of the 400 calorie, protein-free diet. Two major findings emerged: first, the renal clearance of oxypurinol was reduced from 21.2 +/- 1.9 ml/min during the normal protein diet to 12.3 +/- 1.2 ml/min (P less than .05) during the 400 calorie, protein-free diet, and second, there was a striking diurnal difference in oxypurinol renal clearance with a 41% decrease in the oxypurinol clearance at night (8 PM to 8 AM) versus day (8 AM to 8 PM) on the 400 calorie, protein-free diet.
journal_name
J Clin Pharmacoljournal_title
Journal of clinical pharmacologyauthors
Kitt TM,Park GD,Spector R,Tsalikian Edoi
10.1002/j.1552-4604.1989.tb03239.xsubject
Has Abstractpub_date
1989-01-01 00:00:00pages
65-71issue
1eissn
0091-2700issn
1552-4604journal_volume
29pub_type
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