Abstract:
:Mannose-modified lectin-binding peptides were obtained from an α-helical-designed peptide phage library. Concanavalin A (ConA) was used as a representative target protein for the lectin family. The identified glycopeptides could selectively bind to ConA with micromolar affinity. With these results, the methodologies described in this study will enhance the selection of saccharide-modified ligands through the synergistic effects of sugar and peptide units, with better specificity and affinity towards lectin proteins.
journal_name
Mol Biosystjournal_title
Molecular bioSystemsauthors
Ven Chang I,Tsutsumi H,Mihara Hdoi
10.1039/c7mb00495hsubject
Has Abstractpub_date
2017-10-24 00:00:00pages
2222-2225issue
11eissn
1742-206Xissn
1742-2051journal_volume
13pub_type
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