Bi-directional changes in sham feeding in the rat produced by benzodiazepine receptor ligands.

Abstract:

:Both the real and sham intake of a 5% sucrose solution were increased by midazolam (3 mg/kg IP), a benzodiazepine agonist. In contrast, both the real and sham intakes of a 20% sucrose solution were reduced by Ro15-3505 (a benzodiazepine antagonist with weak inverse agonist properties) and by FG 7142 (a beta-carboline inverse agonist). These data demonstrate that drugs acting at benzodiazepine receptors can bi-directionally alter ingestional responses, probably by modulation of the oropharyngeal control of consumption.

journal_name

Physiol Behav

journal_title

Physiology & behavior

authors

Cooper SJ,van der Hoek G,Kirkham TC

doi

10.1016/0031-9384(88)90072-8

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

211-6

issue

3

eissn

0031-9384

issn

1873-507X

pii

0031-9384(88)90072-8

journal_volume

42

pub_type

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