Abstract:
:ATP binding cassette (ABC) transporters are involved in drug absorption, distribution and elimination. They also mediate multidrug resistance in cancer cells. Isoflavones, such as genistein (GNT), belong to a class of naturally-occurring compounds found at high concentrations in commonly consumed soya based-foods and dietary supplements. GNT and its metabolites interact with ABC transporters as substrates, inhibitors and/or modulators of their expression. This review compiles information about regulation of ABC transporters by GNT with special emphasis on the three major groups of ABC transporters involved in excretion of endo- and xenobiotics as follows: Pglycoprotein (MDR1, ABCB1), a group of multidrug resistance associated proteins (MRPs, ABCC subfamily) and ABCG2 (BCRP), an ABC half-transporter. The impact of these regulations on potential GNT-drug interactions is further considered.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Rigalli JP,Ciriaci N,Mottino AD,Catania VA,Ruiz MLdoi
10.2174/0929867323666160406120711subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1370-89issue
13eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-74822journal_volume
23pub_type
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