Abstract:
BACKGROUND:Globally, and particularly in developing countries, the menace of anti-microbial resistance is an accelerating problem. In Nigeria, increase in bacterial resistance has been phenotypically established but due to high cost, few molecular studies have been reported. OBJECTIVES:This study screened for presence of transferable resistance genes and mobile genetic elements (MGEs) such as integron among multi-drug resistant (MDR) P. mirabilis. METHODS:A total of 108 P. mirabilis strains collected from five tertiary hospitals in SouthWest Nigeria were subjected to antibiotic susceptibility study using disc-diffusion method. Transferable resistance genes and MGEs were amplified using Polymerase chain reaction (PCR) analysis and amplicons sequenced. RESULTS:Varied resistance was observed against all the antibiotics tested. About 56% of the isolates were MDR including those from 0-12 years old children. PCR analysis revealed the presence of aac(6')-Ib (33.3%), plasmid mediated quinolone resistance (PMQR) genes [qnrA (36.7%), acc(6')-Ib-cr (5%)], TEM (48.3%), CTX-M (6.7%) and integrons class 1 (58.3%) and class 2 (26.7%). Sequencing analysis revealed blaTEM-1, blaCTX-M-15 associated with ISEcp1 and eight different arrays of gene cassettes: aadA1, aadA1-qacH, aadB-aadA2, aadA5, dfrA7, dfrA15, dfrA17, dfrA17-aadA5. CONCLUSION:Transferable resistance genes in association with MGEs are present in Nigerian P. mirabilis thus their potential in disseminating resistance.
journal_name
Afr Health Scijournal_title
African health sciencesauthors
Alabi OS,Mendonça N,Adeleke OE,da Silva GJdoi
10.4314/ahs.v17i2.9subject
Has Abstractpub_date
2017-06-01 00:00:00pages
356-365issue
2eissn
1680-6905issn
1729-0503pii
jAFHS.v17.i2.pg356journal_volume
17pub_type
杂志文章abstract:BACKGROUND:Pain, swelling and trismus are common complications associated with third molar surgery. These complications have been reported to have an adverse effect on the quality of life of patients undergoing third molar surgery. OBJECTIVE:To review the different modalities of minimizing inflammatory complications i...
journal_title:African health sciences
pub_type: 杂志文章,评审
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更新日期:2011-03-01 00:00:00
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更新日期:2010-09-01 00:00:00
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更新日期:2020-09-01 00:00:00
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更新日期:2008-12-01 00:00:00
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更新日期:2009-12-01 00:00:00
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journal_title:African health sciences
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更新日期:2011-06-01 00:00:00
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journal_title:African health sciences
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doi:
更新日期:2011-09-01 00:00:00
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更新日期:2009-09-01 00:00:00
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更新日期:2018-12-01 00:00:00