Abstract：
BACKGROUND:The relatively little resistance to quinine globally has led to an increase in its use in P. falciparum malaria especially in multi-drug resistant strains. OBJECTIVE:To evaluate the physicochemical and equivalency of three brands of quinine sulphate tablets available in South Western region of Nigeria. METHODS:The pharmaceutical and chemical equivalence of three brands of quinine sulphate tablets were assessed through the evaluation of some biopharmaceutical parameters and active drug content. RESULTS:All the brands complied with the official specification for uniformity of weight. Two of the brands (A & B) gave similar crushing strengths while the third brand (C) gave a much lower value. Similarly all the brands complied with the official specification of disintegration test but the obtained values were statistically different (p<0.05). The T(70) obtained from the dissolution rate profile was less than 45 minutes for the three brands, although A and B were not statistically different but C was statistically from A and B. The quinine content of brands B and C are within the official specification however brand A with percentage content of 110±1.3%w/w, is above the specification while it is statistically different from the other brands. CONCLUSION:Brands B and C could be regarded as chemical equivalent, but they are not biopharmaceutical equivalents, on the other hand, brands A and B may be regarded as biopharmaceutical equivalents but not chemical equivalent.
journal_name
Afr Health Scijournal_title
African health sciencesauthors
Adegbite A,Adegbolagun OMsubject
Has Abstractpub_date
2011-06-01 00:00:00pages
197-203issue
2eissn
1680-6905issn
1729-0503journal_volume
11pub_type
杂志文章abstract：BACKGROUND:Day case surgery services are increasing all over the world. The prevalence of postoperative pain after day surgery is found to be high. Little is known about the prevalence of postoperative pain, in Kenya, after day case surgeries. OBJECTIVE:To investigate the prevalence of postoperative pain after day sur...
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pub_type： 杂志文章
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journal_title：African health sciences
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journal_title：African health sciences
pub_type： 杂志文章
doi：
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journal_title：African health sciences
pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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更新日期：2010-06-01 00:00:00
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更新日期：2010-12-01 00:00:00
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journal_title：African health sciences
pub_type： 杂志文章
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更新日期：2011-09-01 00:00:00
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更新日期：2011-03-01 00:00:00
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journal_title：African health sciences
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doi：
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pub_type： 杂志文章,meta分析
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