Prognostic models for prediction of outcomes after traumatic brain injury based on patients admission characteristics.

Abstract:

OBJECTIVE:To identify the best performing prognostic model using admission characteristics to predict mortality at 30 days and functioning outcome at 6-months post-admission in patients with moderate or severe brain injury. METHODS:Using a retrospective database (n = 1466 patients) of a tertiary trauma care centre, three different models were developed using logistic regression methods for predicting mortality and functioning outcome. The performance of the models was assessed in terms of discrimination and calibration. The models were validated using split sample method. For facilitating clinical usefulness, score charts were derived from the regression models. RESULTS:The variables motor score, hypotension, pupillary reactivity, age, creatinine level, limb movement (hemiparesis), and tSAH/IVH were found to be the most predictive independent prognostic factors of both mortality and functioning outcome. For both the outcomes, discriminative ability of the three prognostic models was excellent in the development dataset (AUC = 0.845--0.905) as well as the validation data set (AUC = 0.836-0.880). Calibration in the validation data set for model-2 was good (H-L test p-value > 0.05); however, for model-1 and model-3, it was poor (H-L test p-value < 0.05). CONCLUSION:For clinical decision-making, model-2 is recommended on the basis of good performance in predicting outcomes in patients with moderate or severe TBI in India and other similar countries.

journal_name

Brain Inj

journal_title

Brain injury

authors

Kamal VK,Agrawal D,Pandey RM

doi

10.3109/02699052.2015.1113568

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

393-406

issue

4

eissn

0269-9052

issn

1362-301X

journal_volume

30

pub_type

杂志文章
  • Course of neuropsychological recovery from moderate-to-severe head injury: a 2-year follow-up.

    abstract::Neuropsychological outcome and recovery of a group of 91 patients with moderate-to-severe head injuries were prospectively investigated over a 2 year period, with evaluations at acute hospital discharge at 6 months and 2 years post-injury. A group of 39 trauma patients with injuries to parts of the body other than the...

    journal_title:Brain injury

    pub_type: 临床试验,杂志文章

    doi:

    authors: Lannoo E,Colardyn F,Jannes C,de Soete G

    更新日期:2001-01-01 00:00:00

  • Children and young adults in a prolonged unconscious state after severe brain injury: long-term functional outcome as measured by the DRS and the GOSE after early intensive neurorehabilitation.

    abstract:OBJECTIVE:To investigate the long-term (2-15 years) functional outcome of children and young adults who received an early intensive neurorehabilitation programme (EINP) after a prolonged period of unconsciousness due to severe brain injury; to differentiate between traumatic brain injury (TBI) and non-traumatic brain i...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050601151795

    authors: Eilander HJ,Timmerman RB,Scheirs JG,Van Heugten CM,De Kort PL,Prevo AJ

    更新日期:2007-01-01 00:00:00

  • The development of the therapeutic working alliance, patients' awareness and their compliance during the process of brain injury rehabilitation.

    abstract:PURPOSE:To examine the development and interaction of the therapeutic alliance, patients' compliance and awareness during the process of brain injury rehabilitation and the role of demographic and injury related variables in this process. Subjects were 86 patients who underwent a holistic neuropsychological outpatient ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050600664772

    authors: Schönberger M,Humle F,Teasdale TW

    更新日期:2006-04-01 00:00:00

  • PTSD and TBI co-morbidity: scope, clinical presentation and treatment options.

    abstract:PRIMARY OBJECTIVE:To summarize the literature on post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI) and their co-morbidity, focusing on diagnosis, clinical symptoms and treatment issues relevant to the clinician. RESEARCH DESIGN:Review of the literature. METHODS AND PROCEDURES:Pubmed searches were...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699052.2013.873821

    authors: Tanev KS,Pentel KZ,Kredlow MA,Charney ME

    更新日期:2014-01-01 00:00:00

  • Analysis of serum cortisol to predict recovery in paediatric sport-related concussion.

    abstract:OBJECTIVE:To study the relationship between acute serum cortisol following pediatric sport-related concussion (SRC) and clinical outcome measures of symptom burden and length to return to sport (RTS) Methods: Prospective observational study of ice hockey players ages 11-12 recruited prior to the hockey season. Players ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2018.1429662

    authors: Ritchie EV,Emery C,Debert CT

    更新日期:2018-01-01 00:00:00

  • Effects of CC-chemokine receptor 5 on ROCK2 and P-MLC2 expression after focal cerebral ischaemia-reperfusion injury in rats.

    abstract:OBJECTIVE:CC-chemokine receptor 5 (CCR5) plays a pivotal role in reperfusion after stroke. This study assessed and confirmed the effects of CCR5 in experimental stroke via regulation of ROCK/P-MLC pathway. METHODS:Male Sprague Dawley (SD) rats were randomly divided into sham group, ischaemia-reperfusion group (I/R gro...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2015.1129557

    authors: Li L,Zhi D,Shen Y,Liu K,Li H,Chen J

    更新日期:2016-01-01 00:00:00

  • Sleep Disturbances in Young Adults with Childhood Traumatic Brain Injury: Relationship with Fatigue, Depression, and Quality of Life.

    abstract:OBJECTIVE:This study assessed the consequences of childhood traumatic brain injury (TBI) on sleep, fatigue, depression, and quality of life (QoL) outcomes and explored the relationships between these variables at 20 years following childhood TBI. PARTICIPANTS:We followed up 54 young adults with mild, moderate, and sev...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2020.1832704

    authors: Botchway EN,Godfrey C,Ryan NP,Hearps S,Nicholas CL,Anderson VA,Catroppa C

    更新日期:2020-10-14 00:00:00

  • Spasticity after stroke: physiology, assessment and treatment.

    abstract:BACKGROUND:Spasticity following a stroke occurs in about 30% of patients. The mechanisms underlying this disorder, however, are not well understood. METHOD:This review aims to define spasticity, describe hypotheses explaining its development after a stroke, give an overview of related neuroimaging studies as well as a...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699052.2013.804202

    authors: Thibaut A,Chatelle C,Ziegler E,Bruno MA,Laureys S,Gosseries O

    更新日期:2013-01-01 00:00:00

  • Assessment of thalamic perfusion in patients with mild traumatic brain injury by true FISP arterial spin labelling MR imaging at 3T.

    abstract:OBJECTIVE:To assess cerebral blood flow (CBF) changes in patients with mild traumatic brain injury (MTBI) using an arterial spin labelling (ASL) perfusion MRI and to investigate the severity of neuropsychological functional impairment with respect to haemodynamic changes. MATERIALS AND METHODS:Twenty-one patients with...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050903014899

    authors: Ge Y,Patel MB,Chen Q,Grossman EJ,Zhang K,Miles L,Babb JS,Reaume J,Grossman RI

    更新日期:2009-07-01 00:00:00

  • 'We are the forgotten victims': Perspectives of adult siblings of persons with traumatic brain injury.

    abstract:PRIMARY OBJECTIVE:This study determined how the lives of a cross-national sample of adult siblings had changed since their brothers and sisters incurred a traumatic brain injury. RESEARCH DESIGN:A total of 272 participants provided responses to the question, 'How is your life different since your sibling had a TBI?' R...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2010.514317

    authors: Degeneffe CE,Olney MF

    更新日期:2010-01-01 00:00:00

  • Biased responding: a case series demonstrating a relationship between somatic symptoms and impaired recognition memory performance for traumatic brain injured individuals.

    abstract::Biased responding on the Sternberg Recognition Memory Test was observed in four patients with traumatic brain injury. None of these individuals met the Diagnostic and Statistical Manual's (DSM-IV) criteria for malingering. Individual recognition memory scores were high shortly after injury, declined to chance or below...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050010013671

    authors: Bierley RA,Drake AI,Ahmed S,Date ES,Rosner M,Warden D,Salazar AM,Defense and Veterans Head Injury Program (DVHIP) Study Group.

    更新日期:2001-08-01 00:00:00

  • Return to work after rehabilitation following traumatic brain injury.

    abstract::The relationship of medical variables and discharge functional status to vocational and educational outcomes was examined in 79 closed head-injured patients who were consecutively admitted to an inpatient rehabilitation hospital during a two-year period. A follow-up study, conducted after hospital discharge (median, 1...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059009026148

    authors: Rao N,Rosenthal M,Cronin-Stubbs D,Lambert R,Barnes P,Swanson B

    更新日期:1990-01-01 00:00:00

  • Factor analysis of the adolescent version of the behavioural assessment screening tool (BAST-A) in adolescents with concussion.

    abstract::Objective: Develop and validate the Behavioral Assessment Screening Tool for Adolescents with brain injury. Setting: Concussion clinics Participants: Adolescents with mild traumatic brain injury 3 months after initial concussion clinic visit (n = 138). Design: Assessment development and validation (cross-sectional coh...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2020.1857838

    authors: B Juengst S,Kajankova M,Wright B,Terhorst L

    更新日期:2020-12-29 00:00:00

  • The effects of motivating interventions on rehabilitation outcomes in children and youth with acquired brain injuries: a systematic review.

    abstract:PRIMARY OBJECTIVE:To systematically review the evidence of the effects of motivating rehabilitation interventions on outcomes in children with acquired brain injury (ABI). METHODS:A literature search of six databases was conducted to identify intervention studies published until July 2013. The American Academy for Cer...

    journal_title:Brain injury

    pub_type: 杂志文章,评审

    doi:10.3109/02699052.2014.890747

    authors: Tatla SK,Sauve K,Jarus T,Virji-Babul N,Holsti L

    更新日期:2014-01-01 00:00:00

  • Caregiver burden in Danish family members of patients with severe brain injury: The chronic phase.

    abstract:OBJECTIVE:To investigate caregiver burden and factors associated with caregiver burden among family members of patients with severe brain injury in the chronic phase. Additionally, the study aimed at investigating differences in burden between parents and spouses. METHODS:Forty-four Danish caregivers of patients with ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2015.1114143

    authors: Doser K,Norup A

    更新日期:2016-01-01 00:00:00

  • Anoxic encephalopathy: a neurobehavioural study in rehabilitation.

    abstract::This study examined an operational conditioning paradigm designed to train procedural learning channels in a patient with anoxic encephalopathy. Prior to treatment the patient had been incontinent to bowel and bladder incontinent, minimally participant in daily activities and aggressive toward staff and residents for ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990597123115

    authors: Goldberg KB,Ellis DW

    更新日期:1997-10-01 00:00:00

  • Articulatory function following traumatic brain injury in childhood: a perceptual and instrumental analysis.

    abstract:PRIMARY OBJECTIVE:To investigate the articulatory function of a group of children with traumatic brain injury (TBI), using both perceptual and instrumental techniques. RESEARCH DESIGN:The performance of 24 children with TBI was assessed on a battery of perceptual (Frenchay Dysarthria Assessment, Assessment of Intellig...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050410001719961

    authors: Cahill LM,Murdoch BE,Theodoros DG

    更新日期:2005-01-01 00:00:00

  • A neurophysiological and clinical study of Brunnstrom recovery stages in the upper limb following stroke.

    abstract:PRIMARY OBJECTIVE:To determine the extent to which the Brunnstrom recovery stages of upper limb in hemiparetic stroke patients are correlated to neurophysiological measures and the spasticity measure of Modified Modified Ashworth Scale (MMAS). RESEARCH DESIGN:A concurrent criterion-related validity study. INTERVENTIO...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2010.506860

    authors: Naghdi S,Ansari NN,Mansouri K,Hasson S

    更新日期:2010-01-01 00:00:00

  • Seeing minds in patients with disorders of consciousness.

    abstract::Objective: To explore the ways in which health care professionals and families understand terms and concepts associated with disorders of consciousness.Methods: Open-ended, semi-structured interviews were conducted with 20 health care professionals and 18 family caregivers affiliated with a disorders of consciousness ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2019.1706000

    authors: Peterson A,Kostick KM,O'Brien KA,Blumenthal-Barby J

    更新日期:2020-02-23 00:00:00

  • The use of bupropion in the treatment of restlessness after a traumatic brain injury.

    abstract::The occurrence of restlessness after a traumatic brain injury (TBI) is common. Severe restlessness can be a barrier in the multidisciplinary treatment of patients with TBI. The following case describes a patient with restlessness after a head-on motor vehicle accident. The patient was tachycardic, diaphoretic, demonst...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050010005931

    authors: Teng CJ,Bhalerao S,Lee Z,Farber J,Morris H,Foran T,Tucker W

    更新日期:2001-05-01 00:00:00

  • Reading assessment post head injury: how valid is it?

    abstract::The purpose of this study was to identify the passage dependency for three reading tests applied to the closed head injured (CHI) population and to determine whether reading the passage resulted in improved accuracy in responding to passage-related questions. Based on the performance of 10 CHI adults, passage dependen...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059009026160

    authors: Rand MB,Trudeau MD,Nelson LK

    更新日期:1990-04-01 00:00:00

  • Semantic memory impairments following non-progressive brain injury: a study of four cases.

    abstract::Four brain-injured subjects with semantic memory impairments are described. Two had sustained traumatic head injury and two had herpes simplex virus encephalitis. The study seeks to determine (a) whether subjects with non-progressive brain injury and impaired semantic memory perform similarly to patients with progress...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990597123566

    authors: Wilson BA

    更新日期:1997-04-01 00:00:00

  • Longitudinal changes in brain morphology from 4 weeks to 12 months after mild traumatic brain injury: Associations with cognitive functions and clinical variables.

    abstract:OBJECTIVE:To investigate longitudinal changes in cortical and subcortical volumes in patients with mild traumatic brain injury (MTBI) and to evaluate whether such changes were associated with self-reported post-concussive symptoms, global functional outcomes and neuropsychological functioning. METHODS:This was a prosp...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2017.1283537

    authors: Hellstrøm T,Westlye LT,Sigurdardottir S,Brunborg C,Soberg HL,Holthe Ø,Server A,Lund MJ,Andreassen OA,Andelic N

    更新日期:2017-01-01 00:00:00

  • Effectiveness of valproic acid on destructive and aggressive behaviours in patients with acquired brain injury.

    abstract::Valproic acid, a primary anticonvulsant drug, has recently been studied for purported effectiveness in disparate disorders of mood and behaviour. The psychopharmacological treatment of patients with acquired brain injury frequently includes numerous trials of psychotherapeutic drugs such as antipsychotics, benzodiazep...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990597123791

    authors: Wroblewski BA,Joseph AB,Kupfer J,Kalliel K

    更新日期:1997-01-01 00:00:00

  • Assessment after extremely severe head injury in a case of life or death: further support for McMillan.

    abstract::This paper is a sequel to that of McMillan (1997) and describes further assessment of an extremely severely head injured patient. A combination of direct observations, structured interviews with staff, simple cognitive tests and questions with yes/no answers were used to assess communication and cognitive function in ...

    journal_title:Brain injury

    pub_type: 评论,杂志文章

    doi:10.1080/026990598122043

    authors: Shiel A,Wilson BA

    更新日期:1998-10-01 00:00:00

  • The truth effect in relation to neuropsychological functioning in traumatic brain injury.

    abstract:OBJECTIVES:Individuals with traumatic brain injury may have difficulty accepting other viewpoints, but there is not yet a clinical test to measure the readiness with which one accepts new information as true. This study examined the truth effect-the tendency to rate previously seen material as being 'more true' than ne...

    journal_title:Brain injury

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/02699052.2010.506856

    authors: Ladowsky-Brooks RL

    更新日期:2010-01-01 00:00:00

  • Histochemical characterization of skeletal muscles in rats with photochemically-induced stroke.

    abstract:PRIMARY OBJECTIVE:The aim of this study was to assess skeletal muscle showing a complete functional recovery after induction of pan-necrotic lesions in the right sensorimotor cortex in rats. RESEARCH DESIGN AND METHODS:A focal lesion of the right sensorimotor cortex was induced photochemically. Rats were divided into ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050410001672305

    authors: Abo M,Miyano S,Eun SS,Yamauchi H

    更新日期:2004-10-01 00:00:00

  • Functional and cognitive progress in aphasic patients with traumatic brain injury during post-acute phase.

    abstract:OBJECTIVES:To investigate the relationship between language functions and cognitive and functional outcome and to evaluate the effects of a conventional language rehabilitation programme on aphasic adult patients in the post-acute stage of traumatic brain injury (TBI). DESIGN:Non-concurrent prospective study. Patients...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050601081844

    authors: Demir SO,Altinok N,Aydin G,Köseoğlu F

    更新日期:2006-12-01 00:00:00

  • The combined use of amantadine and l-dopa/carbidopa in the treatment of chronic brain injury.

    abstract::The frontal lobes are particularly vulnerable to injury during trauma. The syndrome commonly attributed to frontal lobe dysfunction includes problems with impulsivity, perseveration, disinhibition, amotivation, attention, planning, and problem solving. These symptoms can respond to certain pharmacologic interventions,...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990597123430

    authors: Kraus MF,Maki P

    更新日期:1997-06-01 00:00:00

  • Pupillary responses to light in chronic non-blast-induced mTBI.

    abstract:PURPOSE:To evaluate objectively and quantitatively human pupillary responses to a light stimulus under photopic conditions in individuals with non-blast-induced, chronic, mild traumatic brain injury (mTBI). METHODS:Seventeen individuals with chronic, non-blast-induced mTBI and 15 visually-normal (VN) controls were tes...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2015.1045029

    authors: Thiagarajan P,Ciuffreda KJ

    更新日期:2015-01-01 00:00:00