Abstract:
PURPOSE:To evaluate objectively and quantitatively human pupillary responses to a light stimulus under photopic conditions in individuals with non-blast-induced, chronic, mild traumatic brain injury (mTBI). METHODS:Seventeen individuals with chronic, non-blast-induced mTBI and 15 visually-normal (VN) controls were tested (aged 21-45 years). Pupillary responsivity to a brief step-input light stimulus was assessed objectively in each eye for 5 seconds using the Neuroptics PLR-200 monocular, hand-held pupillometer with its pre-set and automated eight parameter analysis. RESULTS:Five of the eight parameters assessed were significantly reduced (p ≤ 0.05) in the mTBI group as compared to the VN control group: maximum (or peak) constriction velocity, average constriction velocity, average dilation velocity, maximum diameter and amplitude of constriction. The remaining three parameters were similar in each group (p > 0.05): constriction latency, 75% dilation recovery time and minimum diameter. CONCLUSIONS:The slowed dilation dynamics and reduced maximum pupillary diameter in mTBI suggest deficiency primarily of the sympathetic control system. The reduced peak velocities and related amplitudes suggest subtle parasympathetic involvement.
journal_name
Brain Injjournal_title
Brain injuryauthors
Thiagarajan P,Ciuffreda KJdoi
10.3109/02699052.2015.1045029subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1420-5issue
12eissn
0269-9052issn
1362-301Xjournal_volume
29pub_type
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