The use of bupropion in the treatment of restlessness after a traumatic brain injury.

Abstract:

:The occurrence of restlessness after a traumatic brain injury (TBI) is common. Severe restlessness can be a barrier in the multidisciplinary treatment of patients with TBI. The following case describes a patient with restlessness after a head-on motor vehicle accident. The patient was tachycardic, diaphoretic, demonstrating decerebrate posturing and a Rancho Los Amigos Stage II--III. Significant left lower leg restlessness was severe enough to cause bruising and ulceration. A multidisciplinary look was taken at the effects of using different neurotransmitter modulators in the treatment of restlessness after a TBI. Current biology treatment options include the use of medications that either modulate dopamine or noradrenaline alone. Bupropion effects both the dopaminergic and noradrenergic pathways. In the following case, the patient's restlessness was resistant to almost every medication employed. The only medication that proved to be effective in significantly reducing the patient's restlessness was bupropion. The evidence for the use of bupropion in the treatment of restlessness after a TBI has never been discussed previously, aside from anecdotal accounts. It is hoped that this case will prove insight into another treatment option for patients who have severe restlessness.

journal_name

Brain Inj

journal_title

Brain injury

authors

Teng CJ,Bhalerao S,Lee Z,Farber J,Morris H,Foran T,Tucker W

doi

10.1080/02699050010005931

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

463-7

issue

5

eissn

0269-9052

issn

1362-301X

journal_volume

15

pub_type

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