Abstract：
BACKGROUND:Chronic opioid misuse is associated with reduced sensitivity to natural rewards and social motivation deficits that include impaired caregiving. The neurobiological mechanisms underlying these deficits and their response to treatment are not well understood. Baby schema (Kindchenschema) is a set of juvenile physical features, which is perceived as "cute" and triggers motivation for caregiving. Recent studies suggest that the "baby schema effect" is mediated by the brain "reward" network. We studied the impact of opioid antagonist treatment on the baby schema response in patients with opioid use disorder. METHODS:Forty-seven (24 F) recently detoxified patients with opioid use disorder underwent functional magnetic resonance imaging (fMRI) while viewing infant portraits that were parametrically manipulated for baby schema content and rating them for cuteness, at baseline and during treatment with the injectable extended release opioid antagonist naltrexone (XRNTX). The study was not placebo-controlled. RESULTS:The behavioral effect of baby schema, indexed by "cuteness" ratings, was present and unaffected by XRNTX. The brain response to baby schema was absent at baseline, but present in the bilateral ventral striatum after two weeks of XRNTX treatment. The decline in self-reported craving for opioids was positively correlated with the brain fMRI response to baby schema in the bilateral ventral striatum. CONCLUSIONS:Opioid antagonist treatment modulated the brain reward system response to a marker of caregiving motivation in patients with opioid use disorder. Neural response to baby schema may offer a novel probe of social motivation and affiliative behaviors in this population.
journal_name
J Subst Abuse Treatjournal_title
Journal of substance abuse treatmentauthors
Wang AL,Lowen SB,Elman I,Shi Z,Fairchild VP,Bouril A,Gur RC,Langleben DDdoi
10.1016/j.jsat.2017.10.007subject
Has Abstractpub_date
2018-02-01 00:00:00pages
70-77eissn
0740-5472issn
1873-6483pii
S0740-5472(16)30469-Xjournal_volume
85pub_type
杂志文章abstract：:Although there have been supply-side efforts in response to the opioid crisis (e.g., prescription drug monitoring programs), little information exists on demand-side approaches related to patient cost sharing that may affect utilization of and adherence to pharmacotherapy by individuals with opioid use disorder. Among...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2019.08.001
更新日期：2019-11-01 00:00:00
abstract：:We examined the role of sexual gender, age, working status, education, cigarettes per day, Fagerström test, age of onset, pharmacologic intervention (bupropion or varenicline), 10 sessions of cognitive-behavioral group counseling therapy (GCT) conducted over 6 weeks, and level of attendance of the counseling program a...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2012.12.004
更新日期：2013-05-01 00:00:00
abstract：:Widespread adoption of empirically-supported treatment innovations has the potential to improve effectiveness of treatment received by individuals with substance use disorders. However, the process of disseminating such innovations has been complex, slow, and difficult. We empirically describe the dissemination and ad...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2015.04.003
更新日期：2015-10-01 00:00:00
abstract：:Sudden gains (SGs) are defined as abrupt and significant improvements in mental health symptoms that occur between two psychotherapy sessions. Preliminary evidence suggests that SGs may be an important pattern of symptom reduction in the treatment of alcohol use disorder (AUD) (i.e., a steep between-session reduction ...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jsat.2017.09.014
更新日期：2017-12-01 00:00:00
abstract：:Methadone Transition Treatment (MTT) is a treatment program for opioid-addicted individuals that takes advantage of a 1989 change in federal guidelines permitting the establishment of 180-day detoxification programs. Thirty-eight subjects were assigned to either high-dose (80 mg) or low-dose (40 mg) methadone in a dou...
journal_title：Journal of substance abuse treatment
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0740-5472(94)90079-5
更新日期：1994-05-01 00:00:00
abstract：:Methadone maintenance therapy has been found to be an effective harm reduction treatment for opioid use disorder. However evidence of its benefits over a longer duration of treatment is limited as most studies focus on its short term benefits. As methadone maintenance therapy reaches a decade since its implementation ...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2016.07.006
更新日期：2016-10-01 00:00:00
abstract：:Gratitude is a central component of addiction recovery for many, yet it has received scant attention in addiction research. In a sample of 67 individuals entering abstinence-based alcohol-use-disorder treatment, this study employed gratitude and abstinence variables from sequential assessments (baseline, 6months, 12mo...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2017.04.013
更新日期：2017-07-01 00:00:00
abstract：:Adolescence is a period of rapid biological, psychological, and social development in the human life cycle. Drug and alcohol misuse during this critical period poses substantial problems for individual and public health, yet is highly prevalent in the United States and elsewhere. The screening, brief interventions, an...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章,评审
doi：10.1016/j.jsat.2012.11.005
更新日期：2013-05-01 00:00:00
abstract：:Runaway/homeless shelters document high levels of substance abuse among runaway youth, at least double that of school youth. These youth present a constellation of problems and research suggests that this population may be unique in the range and intensity of associated problems. Most studies to date have collected se...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/s0740-5472(00)00100-8
更新日期：2000-10-01 00:00:00
abstract：:This paper describes a short-term approach developed at a time of numerous drug-related incidents occurring at a large VA Hospital to help staff manage psychiatric patients abusing alcohol or drugs during hospitalization. This was accomplished through the development of a decision tree designed to improve the clinical...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/0740-5472(92)90063-t
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Hepatitis C Virus (HCV) risk is elevated for individuals with an opioid use disorder (OUD). Routine HCV testing is recommended for high-risk individuals, including those with an injection drug use history. HCV antibody testing addresses the first step in the HCV treatment care cascade, with uptake and comple...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2017.01.017
更新日期：2017-05-01 00:00:00
abstract：:Data from three outpatient studies of treatment of marijuana dependence were used to test whether behavior change parallels stage movement in the transtheoretical model of change (TMC). This study examined one putative assumption of the TMC: individuals remaining in the preaction stages of change (i.e., precontemplati...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2008.03.004
更新日期：2008-12-01 00:00:00
abstract：:Persons who abuse or are dependent on opioids are at elevated risk for arrest. Co-occurring behavioral health problems may exacerbate that risk, although the extent of any such increase has not been described. This study examines such risk factors among 40,238 individuals with a diagnosis of opioid abuse or dependence...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2014.05.002
更新日期：2014-09-01 00:00:00
abstract：:This study measured substance use disorder clinicians' perceptions regarding the implementation extensiveness of the Office of Alcohol and Substance Abuse Services (OASAS) tobacco-free regulation, passed in New York State in July of 2008, at three time-points and across organizations with varying characteristics. Repe...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2013.01.001
更新日期：2013-07-01 00:00:00
abstract：:Medication-assisted treatment (MAT) with methadone or buprenorphine has been shown to be more effective at reducing the use of illicit opioids, the risk of drug-related overdose, and overall healthcare costs, on average, compared to abstinence-based addiction treatments for individuals with an opioid use disorder (OUD...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2019.05.015
更新日期：2019-09-01 00:00:00
abstract：:Parents who use opioids and are involved in the child welfare system are less likely to retain custody of their children than parents who use other drugs. No previous studies have described medication-assisted treatment (MAT) utilization and child permanency outcomes for this population. The Sobriety Treatment and Rec...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2016.09.006
更新日期：2016-12-01 00:00:00
abstract：:Although it has been well documented that narcotic addicts derive the bulk of their income from criminal activities and that there are major differences between black and white addicts, interview data presented in this paper show little difference between the two races with respect to the degree of dependence on crimi...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/0740-5472(85)90035-2
更新日期：1985-01-01 00:00:00
abstract：:This pilot study evaluated the use of smartphone ecological momentary assessments (EMA) for self-monitoring to optimize treatment outcomes among gay and bisexual men enrolled in an outpatient methamphetamine abuse treatment service program. Participants (N = 34) received EMA prompts five times daily to self-monitor th...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jsat.2018.06.005
更新日期：2018-09-01 00:00:00
abstract：:Substance use among adolescents with one or more psychiatric disorders is a significant public health concern. In this study, 151 psychiatrically hospitalized adolescents, ages 13-17 with comorbid psychiatric and substance use disorders, were randomized to a two-session Motivational Interviewing intervention to reduce...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jsat.2015.06.016
更新日期：2015-12-01 00:00:00
abstract：:The incidence of conditioned high, craving, and withdrawal in methadone-maintained patients was compared across three settings: an artificial laboratory setting, clinic extinction sessions, and in self-reports from the natural home environment. A significant proportion of methadone patients showed increased craving an...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/0740-5472(86)90018-8
更新日期：1986-01-01 00:00:00
abstract：:Alprazolam appears to have an abuse liability among opiate addicts, and detoxification can be prolonged. The authors describe experience with five methadone maintenance patients who were polysubstance abusers and were admitted specifically for detoxification from alprazolam dependence. Phenobarbital in tapering doses ...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/0740-5472(90)90036-p
更新日期：1990-01-01 00:00:00
abstract：:The association of physical and sexual abuse with substance abuse has frequently been noted among chemically dependent women. Without diagnosis and treatment of the trauma, female substance abusers are vulnerable to relapse and/or revictimization. This paper describes a model for education and preliminary treatment of...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/0740-5472(90)90003-9
更新日期：1990-01-01 00:00:00
abstract：:Focus groups were conducted to identify ways persons in recovery from chemical dependence think they have benefited from their struggles with addiction. Categories of positive by-products were identified independently by two sets of readers. Several of the positive by-products discussed by the focus group participants...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章,多中心研究
doi：10.1016/s0740-5472(00)00151-3
更新日期：2001-01-01 00:00:00
abstract：:Alcohol use, both short-term intoxication and longer-term use, is a notable risk factor for suicide. Despite the strong relationship between alcohol use and suicidal thoughts and behaviors, providers typically treat these two problems independently. In particular, acute psychiatric care hospitalizations for adolescent...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jsat.2018.08.013
更新日期：2018-11-01 00:00:00
abstract：:The continued need for advancement in evidence-based SUD treatment, as well as increases in treatment expense and decline in support from insurance providers, suggest that brief, innovative, and affordable treatments are needed. Meditation, spirituality, and adherence to medication-assisted treatments have all been sh...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2018.10.012
更新日期：2019-01-01 00:00:00
abstract：:To determine how the city-run New Haven syringe exchange program (SEP) expedited requests, for entry into treatment, records of the SEP's drug treatment coordinator were analyzed. During the study period, a majority of those requesting treatment did not use the SEP to obtain sterile syringes. Comparisons between the p...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/s0740-5472(97)00220-1
更新日期：1998-05-01 00:00:00
abstract：:This study examines the impact of comprehensive services on treatment outcomes for women and men. The study uses data collected from 1992 to 1997 for the National Treatment Improvement Evaluation Study, a prospective, cohort study of substance abuse treatment programs and their clients. The analytic sample consists of...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2004.08.004
更新日期：2004-12-01 00:00:00
abstract：:Attaining altered states of consciousness is described as a basic human motive. The substance dependent population is distinguished from other populations because they pursue these states destructively by inappropriate use of alcohol and drugs. Despite a body of literature supporting the benefits of altered states of ...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章,评审
doi：10.1016/0740-5472(91)90030-e
更新日期：1991-01-01 00:00:00
abstract：:Opioid use disorder (OUD) has been declared a national crisis, as prevalence of OUD has increased remarkably over the past decade (Jones, 2017). While Medication Assisted Treatment (MAT) is the standard of care for OUDs, several key barriers to implementation have been noted throughout the clinical and research litera...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章
doi：10.1016/j.jsat.2019.06.006
更新日期：2020-01-01 00:00:00
abstract：:Brief, effective interventions are needed to reduce the risk of an alcohol-exposed pregnancy in women who drink and do not use effective contraception. The Healthy Choices study compared telephone and in-person administration of a brief intervention. In addition to indicators of alcohol use and effective contraception...
journal_title：Journal of substance abuse treatment
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jsat.2013.06.006
更新日期：2013-11-01 00:00:00
