Low (40 mg) versus high (80 mg) dose methadone in a 180-day heroin detoxification program.

Abstract:

:Methadone Transition Treatment (MTT) is a treatment program for opioid-addicted individuals that takes advantage of a 1989 change in federal guidelines permitting the establishment of 180-day detoxification programs. Thirty-eight subjects were assigned to either high-dose (80 mg) or low-dose (40 mg) methadone in a double-blind design. Both conditions showed initial dramatic decreases in illicit drug use and distress symptoms (opioid craving, withdrawal symptoms, and dysphoria). The high-dose condition showed a nonsignificant trend toward less frequent illicit drug use during the period of stable methadone dosing. We speculate that intensive psychosocial treatment, including weekly individual counseling and three-times a week group therapy, may have dampened outcome differences between high- and low-dose methadone conditions. Treatment retention was high for both dosage conditions.

journal_name

J Subst Abuse Treat

authors

Banys P,Tusel DJ,Sees KL,Reilly PM,Delucchi KL

doi

10.1016/0740-5472(94)90079-5

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

225-32

issue

3

eissn

0740-5472

issn

1873-6483

journal_volume

11

pub_type

临床试验,杂志文章,随机对照试验
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