Abstract:
OBJECTIVES:This study aimed at evaluating the biological response of titanium implants coated with UV-irradiated 7-dehydrocholesterol (7-DHC) and vitamin E (VitE) in vivo and analyzing the effects of aging on their stability and bioactivity in vitro. MATERIAL AND METHODS:Titanium surfaces were coated with 7-DHC and VitE, UV-irradiated and incubated for 48 h at 23°C to allow cholecalciferol synthesis. The in vivo biological response was tested using a rabbit tibia model after 8 weeks of healing by analyzing the wound fluid and the mRNA levels of several markers at the bone-implant interface (N = 8). The stability of the coating after storage up to 12 weeks was determined using HPLC analysis, and the bioactivity of the stored modified implants was studied by an in vitro study with MC3T3-E1 cells (N = 6). RESULTS:A significant increase in gene expression levels of osteocalcin was found in the bone tissue attached to implants coated with the low dose of 7-DHC and VitE, together with a higher ALP activity in the wound fluid. Implants treated with the high dose of 7-DHC and VitE showed increased tissue necrosis and inflammation. Regarding the aging effects, coated implants were stable and bioactive up to 12 weeks when stored at 4°C and avoiding oxygen, light and moisture. CONCLUSION:This study demonstrates that Ti implants coated with UV-irradiated 7-DHC and VitE promote in vivo gene expression of bone formation markers and ALP activity, while they keep their osteopromotive potential in vitro and composition when stored up to 12 weeks at 4°C.
journal_name
Clin Oral Implants Resjournal_title
Clinical oral implants researchauthors
Satué M,Monjo M,Ronold HJ,Lyngstadaas SP,Ramis JMdoi
10.1111/clr.12815subject
Has Abstractpub_date
2017-04-01 00:00:00pages
424-431issue
4eissn
0905-7161issn
1600-0501journal_volume
28pub_type
杂志文章abstract:OBJECTIVE:To review systematically whether supportive implant treatment during a follow-up of at least 10 years after functional loading is effective in prevention of biological complications and fixture loss. METHODS:A MEDLINE search was conducted for the period of 1965 to April 2006 of longitudinal clinical studies ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,评审
doi:10.1111/j.1600-0501.2007.01447.x
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVES:Alumina toughening enhances the mechanical properties of zirconia ceramics but the biocompatibility of this material has rarely been addressed. In this study, we examined the osteoblast response to alumina-toughened zirconia (ATZ) with different surface topographies. MATERIAL AND METHODS:Human osteoblasts i...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2009.01735.x
更新日期:2009-11-01 00:00:00
abstract::The aim of the present study was to compare three different systems for preparing platelet concentrates: two commercially available bed-side techniques (Curasan system and PCCS) and a procedure used routinely in transfusion medicine. Platelet concentrates were prepared from venous blood of 12 healthy male volunteers u...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2002.130512.x
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate hard and soft tissues around implants placed in posterior mandible 1 year after vertical ridge augmentation (VRA). MATERIALS AND METHODS:40 patients with vertical defects were enrolled and treated according to the study protocol. Patients were randomly divided into two ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.13673
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:To compare ear, nose, and throat (ENT) specialists and dentists assessing health or pathology of maxillary sinuses using cone beam computed tomography (CBCT). MATERIAL AND METHODS:Two ENT specialists and two oral surgeons assessed 100 CBCT datasets of healthy patients referred for dental implant placement i...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13582
更新日期:2020-05-01 00:00:00
abstract::In the present multi-center study, non-submerged ITI implants were prospectively followed to evaluate their long-term prognosis in fully and partially edentulous patients. In a total of 1003 patients, 2359 implants were consecutively inserted. Following a healing period of 3-6 months, the successfully integrated impla...
journal_title:Clinical oral implants research
pub_type: 杂志文章,多中心研究
doi:10.1034/j.1600-0501.1997.080302.x
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVES:The present study aimed at evaluating the marginal bone resorption and the peri-implant tissue conditions around Narrow-Neck ITI implants in the implant-prosthetic treatment of the agenesis of maxillary lateral incisors. MATERIAL AND METHODS:Thirty patients affected by monolateral or bilateral agenesis of t...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章
doi:10.1111/j.1600-0501.2005.01188.x
更新日期:2006-02-01 00:00:00
abstract::The purpose of this study was to investigate the possibility of antimicrobial treatment of peri-implant infections associated with a periodontitis-like subgingival microbiota. Nine partially or fully edentulous patients with titanium hollow cylinder implants were selected which showed loss of bone and probing depths >...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1992.030402.x
更新日期:1992-12-01 00:00:00
abstract::In a prospective study, 20 patients who underwent harvesting of chin grafts as outpatients, were followed up for 12 months (3 further patients with incomplete follow-up data were excluded from the study). Preoperatively and 7 days, 1, 3, 6 and 12 months postoperatively, follow-up data were assessed. Evaluation of the ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.2001.120510.x
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:A systematic review and meta-analysis are carried out to assess the scientific evidence that bisphosphonate therapy can decrease the success rate of dental implants. MATERIAL AND METHODS:The PubMed (Medline) database was used to search for articles published up until February 22, 2014. The meta-analysis was ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,meta分析,评审
doi:10.1111/clr.12526
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:The aim of this work was to evaluate the biofilm formation of Porphyromonas gingivalis on disks of titanium (Ti) grade 4 (G4) and Ti-6Al-4V alloy grade 5 (G5) with different surface topographies. MATERIALS AND METHODS:Porphyromonas gingivalis ATCC 33277 was used to develop an in vitro mature biofilm on a tot...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12659
更新日期:2016-07-01 00:00:00
abstract::The aim of this controlled, parallel design clinical study was to compare the effectiveness of an Er:YAG laser (ERL) to that of mechanical debridement using plastic curettes and antiseptic therapy for nonsurgical treatment of peri-implantitis. Twenty patients with moderate to advanced peri-implantitis lesions were ran...
journal_title:Clinical oral implants research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1600-0501.2004.01051.x
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to examine the microbial composition of early (after 3 days, D3) and mature biofilms (after 31 days, D31) on materials typically used in implant/abutment buildups. Implant/abutment materials with different surface roughness values (Ra ) were compared to detect differences in the qua...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13656
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:Short implants are increasingly used, but there is doubt about their performance being similar to that of regular implants. The aim of this study was to compare the mechanical stability of short implants vs. regular implants placed in the edentulous posterior mandible. MATERIAL AND METHODS:Twenty-three patie...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12394
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVES:The aim of the present superiority study was to determine the effect of systemic antibiotics primarily on patient-reported outcome measures (PROMs) and post-surgical complications in patients undergoing oral implant therapy with simultaneous guided bone regeneration (GBR). MATERIALS AND METHODS:A total of 2...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.13580
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:To appraise whether adverse biological events following oral implant placement may be associated with perioperative use of non-steroidal anti-inflammatory drugs (NSAIDs). METHODS:All patients treated in a university faculty postgraduate dental clinic between 1979 and 2012 that had experienced a failing and s...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12493
更新日期:2016-02-01 00:00:00
abstract:AIM:The aim of this prospective study was to evaluate the outcome of computer-guided flapless placement and immediate loading of four conical screw-type implants in the interforaminal region. PATIENTS AND METHODS:From May to August 2003, 25 consecutive patients (m : f=16 : 9) with edentulous mandibles were included in...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2007.01370.x
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVES:To evaluate implant survival, peri-implant marginal bone loss, technical, and biological complications as well as aesthetic outcomes of zirconia implants in clinical studies. MATERIAL AND METHODS:Electronic (Medline, Embase) and hand searches were performed to identify clinical studies published between Jan...
journal_title:Clinical oral implants research
pub_type: 杂志文章,meta分析
doi:10.1111/clr.13352
更新日期:2018-10-01 00:00:00
abstract::The effect of bioactive glass (BG) and calcium carbonate (CC) granules on bone formation around titanium and BG implants projecting into the medullary space of rabbit tibia was studied. The bone marrow tissue was removed and the medullary space was filled either with BG or CC (Biocoral) granules (phi 630-800 microns)....
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1997.080204.x
更新日期:1997-04-01 00:00:00
abstract::Breakdown of bone around oral implants following occlusal overload or plaque accumulation was evaluated in monkeys. 5 screw-type implants of pure titanium (Astra Tech) were inserted in the mandible of 4 monkeys (Macaca Fascicularis). 6 months after insertion of the implants a fixed partial prosthesis was mounted on th...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.1997.tb00001.x
更新日期:1997-02-01 00:00:00
abstract::It has been documented that the long-term clinical outcome of the Brånemark system is very favourable. However, failures do occur before and after loading. This study examined the differences in marginal bone loss between standard and self-tapping fixtures and attempted to explain excessive marginal bone loss or loss ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1992.030302.x
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVES:Compare clinical outcomes of two types of dental implants with non-matching implant-abutment junctions loaded with fixed implant-borne reconstructions at 5 years of loading. MATERIALS AND METHODS:In 64 patients, one of two implant systems (S1, S2) was randomly used to support fixed dental prostheses (FDP). ...
journal_title:Clinical oral implants research
pub_type: 杂志文章,随机对照试验
doi:10.1111/clr.13526
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:To compare clinical and radiographic outcomes between transcrestal sinus floor elevation (TSFE) and lateral sinus floor elevation (LSFE) approaches of simultaneous implant placement in atrophic maxilla. MATERIALS AND METHODS:Patients with a residual bone height (RBH) ≤6 mm were enrolled and randomly assigne...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.13688
更新日期:2020-11-21 00:00:00
abstract:BACKGROUND:In the replacement of missing teeth, a paradigm shift is currently observed with immediate implant placement and/or restoration, particularly in the aesthetic zone. In molar sites, however, anatomical, occlusal and biomechanical considerations remain deterrent factors influencing the outcome of this treatmen...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2011.02415.x
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:Primary implant stability is related to local bone density. After insertion of an implant, implant stability is subject to changes due to bone remodeling. In patients who have undergone radiotherapy in the head and neck region, implant stability is impaired because irradiation reduces bone vitality. The curr...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/j.1600-0501.2007.01457.x
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the preference of a patients' population, according to the index of willingness to pay (WTP), against two treatments to restore a single-tooth gap: the implant-supported crown (ISC) and the 3-unit fixed partial denture prosthesis (FPDP) on natural teeth. MATERIALS ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12264
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Minimizing crestal bone loss following immediate implant placement is considered the most challenging aspect in implant therapy. Implant surface topography and chemical modifications have been shown to influence the success of Osseointegration. The Straumann Bone Level implant, featuring SLActive surface, ha...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12388
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVES:Retrospective evaluation of the biological and technical complications in implant-supported single-tooth molar restorations performed in a private practice after functional periods of ≥4 years. MATERIAL AND METHODS:Sixty-five patients (34 females, age 51.7 ± 10.6 years) with 112 implants received annual fol...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12382
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVES:The aim of this study is twofold: to assess the esthetic outcome of single dental implant restorations in the anterior maxillary area after up to 3 years of function, and to evaluate the relationship between the esthetic outcome and oral health-related quality of life. MATERIALS AND METHODS:Twenty patients ...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1111/clr.12922
更新日期:2017-09-01 00:00:00
abstract::The 15 patients included in this study each had 2-6 permucosal Branemark osseointegrated implants that had functioned successfully for 18 months or more. They were given a full oral examination which included measurements of probing depth and gingival, bleeding and plaque indices around the implants. Marginal bone red...
journal_title:Clinical oral implants research
pub_type: 杂志文章
doi:10.1034/j.1600-0501.1991.020203.x
更新日期:1991-04-01 00:00:00