Early and mature biofilm on four different dental implant materials: An in vivo human study.


OBJECTIVES:The aim of this study was to examine the microbial composition of early (after 3 days, D3) and mature biofilms (after 31 days, D31) on materials typically used in implant/abutment buildups. Implant/abutment materials with different surface roughness values (Ra ) were compared to detect differences in the quantity and quality of bacterial composition. MATERIAL AND METHODS:Four different materials were investigated: rough implant surface (sand-blasted acid-etched titanium, Ti-p), implant collar (machined titanium, Ti-m), titanium abutment (Ti6Al4V), and zirconium dioxide abutment (ZrO2 ). Fourteen periodontally healthy subjects received mandibular acrylic devices with four disks (one for each material) facing the anterior lingual area. The total bacterial count was analyzed using RT-qPCR. Both presence and proliferation of 20 selected bacterial species were assessed with microarrays. RESULTS:The highest mean total cell counts (x108  ± standard deviation) were detected at D3 on ZrO2 (5.63 ± 4.83; Ra  = 0.74 µm), followed by Ti-p (4.53 ± 5.00; Ra  = 1.87), Ti-m (4.43 ± 9.38; Ra  = 0.18 µm), and Ti6Al4V (3.83 ± 3.13; Ra  = 0.16 µm). ZrO2 showed significantly higher total bacterial cell counts than Ti-p and Ti-m (p < .05) for both time intervals. The microarrays detected 16 (D3) and 17 (D31) bacterial species; those associated with healthy oral microbiotas, but also bacteria of the red complex (Tannerella forsythia, Treponema denticola), were found on all materials. CONCLUSIONS:Biofilms on ZrO2 harbored a higher total number of bacterial cells compared with those formed on titanium surfaces with much lower roughness values. Putative periodontopathogens were detected on all materials after both time intervals. Implant/abutment materials with a low surface roughness showed less biofilm accumulation.


Clin Oral Implants Res


Herrmann H,Kern JS,Kern T,Lautensack J,Conrads G,Wolfart S




Has Abstract


2020-11-01 00:00:00












  • Is the use of digital technologies for the fabrication of implant-supported reconstructions more efficient and/or more effective than conventional techniques: A systematic review.

    abstract:OBJECTIVE:To identify clinical studies evaluating efficiency and/or effectiveness of digital technologies as compared to conventional manufacturing procedures for the fabrication of implant-supported reconstructions. MATERIALS AND METHODS:A systematic search from 1990 through July 2017 was performed using the online d...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Mühlemann S,Kraus RD,Hämmerle CHF,Thoma DS

    更新日期:2018-10-01 00:00:00

  • Attempts to obtain re-osseointegration following experimental peri-implantitis in dogs.

    abstract::The purpose of this study was to examine the healing potential and re-osseointegration in peri-implant infection defects adjacent to various implant surfaces. In 7 female Beagle dogs, a total of 41 titanium oral implants (ITI, Straumann, Waldenburg; Switzerland) with a sink depth of 6 mm (diameter 2.8 mm) were placed ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Wetzel AC,Vlassis J,Caffesse RG,Hämmerle CH,Lang NP

    更新日期:1999-04-01 00:00:00

  • The comparative evaluation of transcrestal and lateral sinus floor elevation in sites with residual bone height ≤6 mm: A two-year prospective randomized study.

    abstract:OBJECTIVES:To compare clinical and radiographic outcomes between transcrestal sinus floor elevation (TSFE) and lateral sinus floor elevation (LSFE) approaches of simultaneous implant placement in atrophic maxilla. MATERIALS AND METHODS:Patients with a residual bone height (RBH) ≤6 mm were enrolled and randomly assigne...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Zhou Y,Shi Y,Si M,Wu M,Xie Z

    更新日期:2020-11-21 00:00:00

  • Prognostic parameters contributing to palatal implant failures: a long-term survival analysis of 239 patients.

    abstract:OBJECTIVE:To evaluate the demographic, radiological and therapeutic parameters that influence the overall clinical performance of palatal implants subjected to orthodontic loading. PATIENTS AND METHODS:The data of all patients who had received an orthodontic palatal implant for skeletal anchorage between January 1998 ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章,多中心研究


    authors: Jung BA,Kunkel M,Göllner P,Liechti T,Wagner W,Wehrbein H

    更新日期:2012-06-01 00:00:00

  • Implant treatment in immunosuppressed renal transplant patients: A prospective case-controlled study.

    abstract:OBJECTIVES:The aim of this clinical study was to evaluate long-term outcomes of implant therapy in a cohort of immunosuppressed renal transplant patients compared with a matched control group. MATERIAL AND METHODS:Pharmacologically immunosuppressed renal transplant patients received dental implant treatment between 20...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Hernández G,Paredes V,López-Pintor RM,de Andrés A,de Vicente JC,Sanz M

    更新日期:2019-06-01 00:00:00

  • A 7-year life table analysis from a prospective study on ITI implants with special emphasis on the use of short implants. Results from a private practice.

    abstract::This paper reports on a 7-year life table analysis on ITI titanium plasma-sprayed (TPS) and sandblasted and etched (SLA) implants placed in a private practice and loaded for at least 1 year. In 236 patients, 528 (264 TPS and 264 SLA) implants were placed, 351 (66.5%) implants rehabilitated the posterior region and 71....

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Nedir R,Bischof M,Briaux JM,Beyer S,Szmukler-Moncler S,Bernard JP

    更新日期:2004-04-01 00:00:00

  • Augmentation of the rat jaw with autogeneic cortico-cancellous bone grafts and guided tissue regeneration.

    abstract::The aim of the present study was to evaluate the effect of augmenting the maxillary alveolar ridge and the lateral aspect of the mandible with onlay autogeneic cortico-cancellous bone grafts that were covered with e-PTFE membranes. The experiment was carried out in 51 rats. In 15 rats, the edentulous maxillary jaw bet...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Donos N,Kostopoulos L,Karring T

    更新日期:2002-04-01 00:00:00

  • Implant periapical lesion--a review and a case report with histological evaluation.

    abstract:OBJECTIVE:Information of implant periapical lesion(IPL) is insufficient by now. The aim of this review is to analyze the possible causes of IPL and to find out the proper treatment protocol. MATERIAL AND METHODS:A systematic literature search was carried out (up to June 2012) using relevant search terms in PUBMED. And...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章,评审


    authors: Qu C,Meng H,Han J

    更新日期:2014-09-01 00:00:00

  • Computer-guided implant therapy and soft- and hard-tissue aspects. The Third EAO Consensus Conference 2012.

    abstract:INTRODUCTION:The objectives of this working group were to update the existing knowledge base in computer-guided implant treatment (accuracy and clinical advantages), to search for scientific evidence on the need for keratinized tissue around implants, and to review recent literature in the search for new insights into ...

    journal_title:Clinical oral implants research

    pub_type: 共识发展会议,杂志文章,评审


    authors: Sicilia A,Botticelli D,Working Group 3.

    更新日期:2012-10-01 00:00:00

  • Influence of residual alveolar bone height on implant stability in the maxilla: an experimental animal study.

    abstract:AIMS/BACKGROUND:Empirically, for implant placement associated with sinus floor augmentation, a minimum of five mm of residual crestal bone height has been recommended in order to achieve sufficient initial implant stability. It has been the aim of the study to test this assumption in an experimental animal trial. MATE...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Fenner M,Vairaktaris E,Stockmann P,Schlegel KA,Neukam FW,Nkenke E

    更新日期:2009-08-01 00:00:00

  • Immunohistochemical, tomographic and histological study on onlay iliac grafts remodeling.

    abstract::The information concerning the molecular events taking place in onlay bone grafts are still incipient. The objective of the present study is to correlate the effects of perforation of resident bone bed on (1) the timing of onlay autogenous graft revascularization; (2) the maintenance of volume/density of the graft (as...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Faria PE,Okamoto R,Bonilha-Neto RM,Xavier SP,Santos AC,Salata LA

    更新日期:2008-04-01 00:00:00

  • Electromyography evaluation of masseter and temporalis, bite force, and quality of life in elderly patients during the adaptation of mandibular implant-supported overdentures.

    abstract:OBJECTIVES:The aim of this study was to investigate the outcomes of the installation of two implant-supported overdentures until such treatment is complete. Although this treatment is well established in the literature, there are no studies comparing what happens to muscles and the quality of life (QoL) of patients dur...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Sônego MV,Goiato MC,Dos Santos DM

    更新日期:2017-10-01 00:00:00

  • Endoscopically controlled sinus floor augmentation. A preliminary report.

    abstract::Sinus augmentation has been advocated to be a surgical technique with predictable results in peri-implant surgery. Endoscopic surgery of the maxillary sinus so far has been used as diagnostic procedure. In this paper, the use of endoscopy is described as a low invasive adjunctive technique in sinus floor augmentation....

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Engelke W,Deckwer I

    更新日期:1997-12-01 00:00:00

  • Porous titanium granules promote bone healing and growth in rabbit tibia peri-implant osseous defects.

    abstract:OBJECTIVES:The aim of this study was to investigate the osteoconductive properties and biological performance of porous titanium granules used in osseous defects adjacent to titanium implants. MATERIAL AND METHODS:In this animal experimental study, calibrated defects were prepared in the tibias of 24 New Zealand rabbi...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Wohlfahrt JC,Monjo M,Rønold HJ,Aass AM,Ellingsen JE,Lyngstadaas SP

    更新日期:2010-02-01 00:00:00

  • Critical horizontal dimensions of interproximal and buccal bone around implants for optimal aesthetic outcomes: a systematic review.

    abstract:OBJECTIVE:This systematic review was initiated to explore the critical horizontal interproximal and buccal bone dimensions around implants for an optimal aesthetic outcome. MATERIALS AND METHODS:Pubmed, the Cochrane and the ISI web of Science databases were searched to identify eligible human studies that reflect on t...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章,评审


    authors: Teughels W,Merheb J,Quirynen M

    更新日期:2009-09-01 00:00:00

  • Does residual cement around implant-supported restorations cause peri-implant disease? A retrospective case analysis.

    abstract:OBJECTIVES:The purpose of this study was to determine the relationship between patients with a history of periodontitis and development of cement-related peri-implant disease. MATERIALS AND METHODS:Seventy-seven patients with 129 implants for this retrospective analysis were selected from completed implant cases that ...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Linkevicius T,Puisys A,Vindasiute E,Linkeviciene L,Apse P

    更新日期:2013-11-01 00:00:00

  • Alveolar ridge dimensional changes following ridge preservation procedure with novel devices: Part 1--CBCT linear analysis in non-human primate model.

    abstract:AIM:This study sought to investigate dimensional changes to the alveolar bone following extraction and application of novel devices used for obturation of socket orifice (socket cap) and space maintenance in sockets with facial dehiscence (socket cage). MATERIAL AND METHODS:Six Macaca fascicularis had six teeth each r...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Min S,Liu Y,Tang J,Xie Y,Xiong J,You HK,Zadeh HH

    更新日期:2016-01-01 00:00:00

  • In vivo evaluation of bioactive glass-based coatings on dental implants in a dog implantation model.

    abstract:OBJECTIVES:Although titanium is commonly used as a favorable bone implant material due to its mechanical properties, its bioactive and osteoconductive capacity is relatively low. Calcium phosphate ceramics, predominantly hydroxyapatite (HA), have been frequently used for coating purposes to improve the bioactive proper...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: van Oirschot BA,Alghamdi HS,Närhi TO,Anil S,Al Farraj Aldosari A,van den Beucken JJ,Jansen JA

    更新日期:2014-01-01 00:00:00

  • Implant surface roughness alterations induced by different prophylactic procedures: an in vitro study.

    abstract:AIM:To evaluate surface roughness alterations at the smooth neck of dental implants after the use of eight different prophylactic procedures. MATERIALS AND METHODS:50 tissue level implants (Institut Straumann AG, Basel, Switzerland) were used for the present investigation. The smooth collar of each implant was divided...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Cafiero C,Aglietta M,Iorio-Siciliano V,Salvi GE,Blasi A,Matarasso S

    更新日期:2017-07-01 00:00:00

  • Peri-implant tissue response to TiO2 surface modified implants.

    abstract:OBJECTIVES:The objective of this study was to evaluate peri-implant soft tissue attachment and alveolar bone height on nanoporous TiO(2) thin film on commercial titanium dental implants compared with unmodified standard implants. MATERIAL AND METHODS:In six adult beagle dogs, the mandibular premolars P2-P4 were extrac...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Rossi S,Tirri T,Paldan H,Kuntsi-Vaattovaara H,Tulamo R,Närhi T

    更新日期:2008-04-01 00:00:00

  • In vitro cleaning potential of three implant debridement methods. Simulation of the non-surgical approach.

    abstract:OBJECTIVES:To assess the cleaning potential of commonly used implant debridement methods, simulating non-surgical peri-implantitis therapy in vitro. MATERIALS AND METHODS:One-hundred-and-eighty dental implants were ink-stained and mounted in combined soft and hard tissue models, representing peri-implantitis defects w...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Ronay V,Merlini A,Attin T,Schmidlin PR,Sahrmann P

    更新日期:2017-02-01 00:00:00

  • Radiographic evaluation of marginal bone levels during healing period, adjacent to parallel-screw cylinder implants inserted in the posterior zone of the jaws, placed with flapless surgery.

    abstract:OBJECTIVE:The purpose of this study was to compare changes at the marginal bone level adjacent to implants placed with flapless surgery and flap surgery during a stress-free healing period. MATERIAL AND METHODS:Seven hundred and eighty-five implants were placed in 417 patients with a flapless approach and 459 implants...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Nickenig HJ,Wichmann M,Schlegel KA,Nkenke E,Eitner S

    更新日期:2010-12-01 00:00:00

  • A new optical method to evaluate three-dimensional volume changes of alveolar contours: a methodological in vitro study.

    abstract:OBJECTIVES:The aim of this study was to evaluate the reproducibility and the accuracy of volumetric measurements of specimens imitating localized alveolar ridge defects using an optical three-dimensional (3D) system. MATERIAL AND METHODS:Eight pairs of specimens (five with a cuboid and three with a geometrically compl...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Windisch SI,Jung RE,Sailer I,Studer SP,Ender A,Hämmerle CH

    更新日期:2007-10-01 00:00:00

  • Ceramic hydroxyapatite coating on titanium implants drives selective bone marrow stromal cell adhesion.

    abstract::The aim of this study was to determine the cell characteristics that regulate implant osseointegration. The heterogeneity of bone marrow stromal cells obtained from 11 donors was assessed by measuring the expression of a large panel of adhesion molecules. Large differences in expression of adhesion molecules were dete...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Torensma R,ter Brugge PJ,Jansen JA,Figdor CG

    更新日期:2003-10-01 00:00:00

  • Topographic characterization of multispecies biofilms growing on dental implant surfaces: An in vitro model.

    abstract:OBJECTIVES:To describe the early biofilm formation over whole dental implants with its micro- and macrostructure, using an in vitro multispecies biofilm model. MATERIAL AND METHODS:Six bacterial strains (Streptococcus oralis, Actinomyces naeslundii, Veillonella parvula, Fusobacterium nucleatum, Porphyromonas gingivali...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Bermejo P,Sánchez MC,Llama-Palacios A,Figuero E,Herrera D,Sanz M

    更新日期:2019-03-01 00:00:00

  • A 10-year prospective clinical and radiographic study of one-stage dental implants.

    abstract:OBJECTIVE:The purpose of this prospective study was to evaluate one-stage dental implants clinically and radiographically after 10 years in function. MATERIAL AND METHODS:Twenty-five patients with a total of 68 implants [46 hollow screws (HS) and 22 hollow cylinders (HC)] who previously participated in 5-year prospect...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Kim DM,Badovinac RL,Lorenz RL,Fiorellini JP,Weber HP

    更新日期:2008-03-01 00:00:00

  • Influence of presence or absence of teeth adjacent to implants installed immediately into extraction sockets on peri-implant hard tissue levels: an experimental study in the dog.

    abstract:AIM:To evaluate the influence of the presence or absence of adjacent teeth on the level of the mesial and distal alveolar bony crest following healing at sites where implants were installed immediately into extraction sockets. MATERIAL AND METHODS:Six Labrador dogs were used. In the right side of the mandible, full-th...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Favero G,Botticelli D,Rea M,Pantani F,León IG,Lang NP

    更新日期:2013-03-01 00:00:00

  • Bioactive glass and calcium carbonate granules as filler material around titanium and bioactive glass implants in the medullar space of the rabbit tibia.

    abstract::The effect of bioactive glass (BG) and calcium carbonate (CC) granules on bone formation around titanium and BG implants projecting into the medullary space of rabbit tibia was studied. The bone marrow tissue was removed and the medullary space was filled either with BG or CC (Biocoral) granules (phi 630-800 microns)....

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Turunen T,Peltola J,Helenius H,Yli-Urpo A,Happonen RP

    更新日期:1997-04-01 00:00:00

  • The effect of SLActive surface in guided bone formation in osteoporotic-like conditions.

    abstract:OBJECTIVES:The aim of the study was to evaluate new bone formation under etched titanium (SLA) and modified-etched hydrophilic titanium (modSLA) domes placed on the calvarium of healthy, osteoporotic and osteoporotic treated with bisphosphonates rabbits. METHODS:Experimental osteoporosis was induced by ovariectomy (OV...

    journal_title:Clinical oral implants research

    pub_type: 杂志文章


    authors: Mardas N,Schwarz F,Petrie A,Hakimi AR,Donos N

    更新日期:2011-04-01 00:00:00

  • Clinical evaluation of an Er:YAG laser for nonsurgical treatment of peri-implantitis: a pilot study.

    abstract::The aim of this controlled, parallel design clinical study was to compare the effectiveness of an Er:YAG laser (ERL) to that of mechanical debridement using plastic curettes and antiseptic therapy for nonsurgical treatment of peri-implantitis. Twenty patients with moderate to advanced peri-implantitis lesions were ran...

    journal_title:Clinical oral implants research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Schwarz F,Sculean A,Rothamel D,Schwenzer K,Georg T,Becker J

    更新日期:2005-02-01 00:00:00