Abstract：
OBJECTIVE:To appraise whether adverse biological events following oral implant placement may be associated with perioperative use of non-steroidal anti-inflammatory drugs (NSAIDs). METHODS:All patients treated in a university faculty postgraduate dental clinic between 1979 and 2012 that had experienced a failing and surgically removed dental implant (292 implants in 168 patients) were contacted to solicit additional information about their present dental and medical status and frequency of current and past use of NSAIDs. Potential associations between perioperative NSAIDs use and the occurrence of adverse biological events were explored by the use of 2 × 2 tables and two-tailed Fisher's exact tests. RESULTS:One hundred and four patients with initially 468 implants had experienced 238 implant failures, of which 197 were due to failing osseointegration (42%). Sixty of the participants, initially with 273 implants, had used NSAIDs perioperatively and experienced 44% implant failures, versus 38% in the non-NSAID cohort. The NSAID cohort experienced 3.2 times more cases of radiographic bone loss greater than 30% of the vertical height of their remaining implants and 1.9 times more cases of cluster failures, defined as failure of 50% or more of the implant(s) placed. CONCLUSIONS:Notwithstanding that a retrospective study design is open to potential bias, the current data indicate that dental implant osseointegration may be affected negatively by an inhibitory effect of NSAIDs on bone healing in vulnerable patients. Future and better clinical studies than the current should be designed to appraise more precisely the potential effects of NSAIDs on implant osseointegration in study populations that are not limited by stringent medical inclusion and exclusion criteria.
journal_name
Clin Oral Implants Resjournal_title
Clinical oral implants researchauthors
Winnett B,Tenenbaum HC,Ganss B,Jokstad Adoi
10.1111/clr.12493subject
Has Abstractpub_date
2016-02-01 00:00:00pages
e1-7issue
2eissn
0905-7161issn
1600-0501journal_volume
27pub_type
杂志文章abstract：:Microbial plaque accumulation on titanium dental implant surfaces can result in an inflammatory condition of the surrounding tissues. Cleaning of such a contaminated surface, in vivo, by means of a solution of amino-alcohol, following surgical exposure, has been proposed. However, the tissue healing following treatmen...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1034/j.1600-0501.1999.100303.x
更新日期：1999-06-01 00:00:00
abstract：OBJECTIVES:Although implants with a roughened surface are widely used today, little is known about the long-term effect of a roughened surface compared with the conventional machined surface on clinical and radiographic parameters. The purpose of this study is to investigate the long-term differences between moderately...
journal_title：Clinical oral implants research
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1600-0501.2009.01768.x
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVES:To analyze the relationships between peri-implant conditions and periodontal conditions in Chinese patients with dental implants in place for at least 1 year. MATERIAL AND METHODS:Seventy-six patients (mean age, 41 ± 10 years; range, 21-69 years) who received placement of 120 dental implants (Straumann(®) )...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/clr.12114
更新日期：2014-03-01 00:00:00
abstract：:Currently, 3 treatment options are available for patients with denture complaints and an edentulous mandible with a height of at least 15 mm: meticulous construction of a new set of dentures (CD), construction of a new set of dentures following preprosthetic surgery to enlarge the denture-bearing area (PPS), and const...
journal_title：Clinical oral implants research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1034/j.1600-0501.2000.011003195.x
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVE:This study histologically analyzed the healing of fresh frozen bone allograft (FFBA) with or without platelet-rich plasma (PRP) in bony defects surgically created in the mandible of dogs. MATERIAL AND METHODS:Bilateral resection defects were surgically created on the inferior border of the mandible in 10 dog...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/clr.12008
更新日期：2013-12-01 00:00:00
abstract：:Well integrated and clinically functional titanium dental implants retrieved in humans after 14 and 40 months of settlement were used for the characterization of the interfacial area between the plasma-sprayed coating and the surrounding mineralized bone. Electron microscopic studies were performed from undecalcified ...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1034/j.1600-0501.2000.011004279.x
更新日期：2000-08-01 00:00:00
abstract：:The placement of implants immediately after tooth extraction has become a relatively common event. This approach has gained popularity because it reduces the time between tooth extraction and placement of the final prosthetic restoration. One problem that remains unresolved with this procedure, however, is that there ...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1034/j.1600-0501.2002.130611.x
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the synergistic effect of bone morphogenetic protein 2 (BMP-2) and vascular endothelial growth factor (VEGF) on the repair of bone defects around dental implants. MATERIAL AND METHODS:Five groups of scaffold were fabricated by a freeze-drying method, including pure chitosan/collagen scaffold; sca...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2011.02164.x
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To evaluate how bone-level implants maintain crestal bone stability after thickening of thin mucosal tissues with allogenic membrane. MATERIALS AND METHODS:Ninety-seven bone-level implants of 4.1 mm diameter (Institute Straumann AG, Switzerland) were evaluated in 97 patients (28 men and 69 women, mean age 47...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/clr.12301
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVES:To assess the relationship between smooth and roughened implant surfaces of straight and narrow configurations with respect to microdamage of the bone surface during placement of dental implants. MATERIALS AND METHODS:Straight and tapered, rough and smooth surface Nobel Biocare implants were placed into she...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2010.02024.x
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVES:The objective of this study was to evaluate peri-implant soft tissue attachment and alveolar bone height on nanoporous TiO(2) thin film on commercial titanium dental implants compared with unmodified standard implants. MATERIAL AND METHODS:In six adult beagle dogs, the mandibular premolars P2-P4 were extrac...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2007.01478.x
更新日期：2008-04-01 00:00:00
abstract：:The purpose of this study was to determine the peri-implant soft tissue dimension (PSD) and peri-implant bone level (BL) of dental implants with different designs and surface modifications after functional loading without oral hygiene. Three types of dental implants were placed in the posterior jaws of adult baboons, ...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2005.01217.x
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVES:(1) To assess whether there is evidence of an association between the number of peri-implant tissue complications and patient characteristics such as gender, diabetes status, smoking status, and bite force; (2) To assess whether there is evidence of an association between the number of peri-implant tissue co...
journal_title：Clinical oral implants research
pub_type： 杂志文章,随机对照试验
doi：10.1111/clr.12484
更新日期：2015-12-01 00:00:00
abstract：AIM:This study compared the effects of Escherichia-coli-produced recombinant human bone morphogenetic protein 2 (ErhBMP-2) with a biphasic calcium phosphate (BCP) carrier to those of deproteinized bovine bone in human maxillary sinus floor augmentation. MATERIAL AND METHODS:Screening for this clinical trial selected 5...
journal_title：Clinical oral implants research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/clr.12471
更新日期：2015-12-01 00:00:00
abstract：:The aim of the present study was to evaluate the soft tissue response to intra-orally exposed and contaminated titanium surfaces (machined, blasted or polished) after being chemically and/or mechanically cleaned. Eight adult Sprague-Dawley rats were used for histomorphometrical and histological analyses. A total of 44...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1034/j.1600-0501.2000.011004370.x
更新日期：2000-08-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to evaluate the preference of a patients' population, according to the index of willingness to pay (WTP), against two treatments to restore a single-tooth gap: the implant-supported crown (ISC) and the 3-unit fixed partial denture prosthesis (FPDP) on natural teeth. MATERIALS ...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/clr.12264
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVES:The aim of the present superiority study was to determine the effect of systemic antibiotics primarily on patient-reported outcome measures (PROMs) and post-surgical complications in patients undergoing oral implant therapy with simultaneous guided bone regeneration (GBR). MATERIALS AND METHODS:A total of 2...
journal_title：Clinical oral implants research
pub_type： 杂志文章,随机对照试验
doi：10.1111/clr.13580
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVES:The aim of this prospective cohort trial was to perform a cost/time analysis for implant-supported single-unit reconstructions in the digital workflow compared to the conventional pathway. MATERIALS AND METHODS:A total of 20 patients were included for rehabilitation with 2 × 20 implant crowns in a crossover...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/clr.12476
更新日期：2015-12-01 00:00:00
abstract：:The aim of the study was to evaluate two bioresorbable polylactic acid (PLA) filler materials in a guided bone regeneration (GBR) model system. The first was Polyfibre, a fibrous PLA filler material. Polyfoam, the second material tested, consisted of a spongy PLA filler material. In each group there were eight rabbits...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1046/j.0905-7161.2003.00930.x
更新日期：2003-12-01 00:00:00
abstract：:It has been postulated that the wound healing in a closed submerged location is one of the prerequisites for osseointegration of dental implants. The purpose of the present study was to evaluate the tissue integration of intentionally non-submerged titanium implants inserted by a one-stage surgical procedure. 100 ITI ...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1034/j.1600-0501.1990.010105.x
更新日期：1990-12-01 00:00:00
abstract：OBJECTIVES:To evaluate implant survival rate, any complications, and changes in residual alveolar bone height (RABH) using saline or platelet-rich fibrin (PRF) filling after hydraulic transcrestal sinus lifting. METHODS:Dental implants were placed after hydraulic transcrestal sinus lifting and the filling of saline (2...
journal_title：Clinical oral implants research
pub_type： 杂志文章,随机对照试验
doi：10.1111/clr.13655
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:To assess the influence of complete maxillary sinus volume on the dimensional changes of different grafts used in maxillary sinus lift. MATERIALS AND METHODS:Analysis of 50 surgical procedures of maxillary sinus lift performed on 43 subjects using different grafting materials: fresh frozen allogenic particulat...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/clr.12488
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVES:To compare the effectiveness of free-handed (FH), pilot-drill guided (PG) and fully guided (FG) implant surgery by means of the apical global deviation (AGD) in relation to the additional financial cost and time spent. MATERIALS AND METHODS:Thirty-three partially edentulous patients in need of ≥2 implants i...
journal_title：Clinical oral implants research
pub_type： 杂志文章,随机对照试验
doi：10.1111/clr.13399
更新日期：2019-02-01 00:00:00
abstract：:The aim of this study is to evaluate a surgical protocol for vertical ridge augmentation in the maxilla and mandible using autogenous onlay bone graft associated with a titanium mesh. A group of 18 partially edentulous patients, presenting the need for vertical bone augmentation of at least 4 mm, were treated before i...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2004.00998.x
更新日期：2004-02-01 00:00:00
abstract：OBJECTIVES:Although titanium is commonly used as a favorable bone implant material due to its mechanical properties, its bioactive and osteoconductive capacity is relatively low. Calcium phosphate ceramics, predominantly hydroxyapatite (HA), have been frequently used for coating purposes to improve the bioactive proper...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/clr.12060
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to investigate the effects of a nanostructured calcium coating on the surfaces of blasted Ti implants on peri-implant bone formation in the rabbit tibiae. MATERIAL AND METHODS:Threaded implants (3.75 mm in diameter, 6 mm in length) were roughened by hydroxyapatite (HA) blasting ...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2006.01323.x
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVE:A precise and scientifically established method for the evaluation of the bone quality/primary stability is the measure of the insertion torque (IT). The aim of this study was a comparison between the IT values and the bone-implant contact percentage (BIC) of human implants retrieved after a 4/8-week healing ...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2008.01599.x
更新日期：2009-08-01 00:00:00
abstract：AIM:The aim of this prospective study was to evaluate the outcome of computer-guided flapless placement and immediate loading of four conical screw-type implants in the interforaminal region. PATIENTS AND METHODS:From May to August 2003, 25 consecutive patients (m : f=16 : 9) with edentulous mandibles were included in...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2007.01370.x
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVES:To evaluate the effect of vertical and periosteal-releasing incisions (PRI) on the extension of the buccal flap in a trapezoidal flap design. MATERIAL AND METHODS:Thirty patients scheduled for implant surgery accompanied by bone augmentation were recruited. The amount of flap extension pulled with a minimal...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/j.1600-0501.2011.02244.x
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to investigate whether bone marrow aspirates (BMA) and concentrates (BMAC) influence the grafts' stability when added to deproteinized bovine bone mineral (DBBM) within the first 6 months after maxillary sinus augmentation. MATERIAL AND METHODS:26 CT data of 13 patients undergoing b...
journal_title：Clinical oral implants research
pub_type： 杂志文章
doi：10.1111/clr.12101
更新日期：2014-02-01 00:00:00
