Rhinovirus Biology, Antigenic Diversity, and Advancements in the Design of a Human Rhinovirus Vaccine.

Abstract:

:Human rhinovirus (HRV) remains a leading cause of several human diseases including the common cold. Despite considerable research over the last 60 years, development of an effective vaccine to HRV has been viewed by many as unfeasible due, in part, to the antigenic diversity of circulating HRVs in nature. Over 150 antigenically distinct types of HRV are currently known which span three species: HRV A, HRV B, and HRV C. Early attempts to develop a rhinovirus vaccine have shown that inactivated HRV is capable of serving as a strong immunogen and inducing neutralizing antibodies. Yet, limitations to virus preparation and recovery, continued identification of antigenic variants of HRV, and logistical challenges pertaining to preparing a polyvalent preparation of the magnitude required for true efficacy against circulating rhinoviruses continue to prove a daunting challenge. In this review, we describe HRV biology, antigenic diversity, and past and present advances in HRV vaccine design.

journal_name

Front Microbiol

authors

Stobart CC,Nosek JM,Moore ML

doi

10.3389/fmicb.2017.02412

subject

Has Abstract

pub_date

2017-12-05 00:00:00

pages

2412

issn

1664-302X

journal_volume

8

pub_type

杂志文章
  • Attachment Patterns of Human and Avian Influenza Viruses to Trachea and Colon of 26 Bird Species - Support for the Community Concept.

    abstract::Avian influenza A viruses (AIVs) have a broad host range, but are most intimately associated with waterfowl (Anseriformes) and, in the case of the H13 and H16 subtypes, gulls (Charadriiformes). Host associations are multifactorial, but a key factor is the ability of the virus to bind host cell receptors and thereby in...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00815

    authors: Eriksson P,Lindskog C,Lorente-Leal V,Waldenström J,González-Acuna D,Järhult JD,Lundkvist Å,Olsen B,Jourdain E,Ellström P

    更新日期:2019-04-18 00:00:00

  • Framework for Quantification of the Dynamics of Root Colonization by Pseudomonas fluorescens Isolate SBW25.

    abstract::Colonization of the root surface, or rhizoplane, is one of the first steps for soil-borne bacteria to become established in the plant microbiome. However, the relative contributions of processes, such as bacterial attachment and proliferation is not well characterized, and this limits our ability to comprehend the com...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.585443

    authors: Carroll D,Holden N,Gifford ML,Dupuy LX

    更新日期:2020-09-25 00:00:00

  • A PAS domain-containing regulator controls flagella-flagella interactions in Campylobacter jejuni.

    abstract::The bipolar flagella of the foodborne bacterial pathogen Campylobacter jejuni confer motility, which is essential for virulence. The flagella of C. jejuni are post-translationally modified, but how this process is controlled is not well understood. In this work, we have identified a novel PAS-domain containing regulat...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.00770

    authors: Reuter M,Periago PM,Mulholland F,Brown HL,van Vliet AH

    更新日期:2015-07-30 00:00:00

  • Constructing and Characterizing Bacteriophage Libraries for Phage Therapy of Human Infections.

    abstract::Phage therapy requires libraries of well-characterized phages. Here we describe the generation of phage libraries for three target species: Escherichia coli, Pseudomonas aeruginosa, and Enterobacter cloacae. The basic phage characteristics on the isolation host, sequence analysis, growth properties, and host range and...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.02537

    authors: Gibson SB,Green SI,Liu CG,Salazar KC,Clark JR,Terwilliger AL,Kaplan HB,Maresso AW,Trautner BW,Ramig RF

    更新日期:2019-11-12 00:00:00

  • Chalcone Attenuates Staphylococcus aureus Virulence by Targeting Sortase A and Alpha-Hemolysin.

    abstract::Staphylococcus aureus (S.aureus) resistance, considered a dilemma for the clinical treatment of this bacterial infection, is becoming increasingly intractable. Novel anti-virulence strategies will undoubtedly provide a path forward in combating these resistant bacterial infections. Sortase A (SrtA), an enzyme responsi...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.01715

    authors: Zhang B,Teng Z,Li X,Lu G,Deng X,Niu X,Wang J

    更新日期:2017-09-06 00:00:00

  • Diversity and Temporal Dynamics of the Epiphytic Bacterial Communities Associated with the Canopy-Forming Seaweed Cystoseira compressa (Esper) Gerloff and Nizamuddin.

    abstract::Canopy-forming seaweed species of the genus Cystoseira form diverse and productive habitats along temperate rocky coasts of the Mediterranean Sea. Despite numerous studies on the rich macrofauna and flora associated with Cystoseira spp., there is little knowledge about the epiphytic bacteria. We analyzed bacterial pop...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.00476

    authors: Mancuso FP,D'Hondt S,Willems A,Airoldi L,De Clerck O

    更新日期:2016-04-08 00:00:00

  • Insights Into the Evolution of Staphylococcus aureus Daptomycin Resistance From an in vitro Bioreactor Model.

    abstract::The extensive use of daptomycin for treating complex methicillin-resistant Staphylococcus aureus infections has led to the emergence of daptomycin-resistant strains. Although genomic studies have identified mutations associated with daptomycin resistance, they have not necessarily provided insight into the evolution a...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00345

    authors: Lasek-Nesselquist E,Lu J,Schneider R,Ma Z,Russo V,Mishra S,Pai MP,Pata JD,McDonough KA,Malik M

    更新日期:2019-02-28 00:00:00

  • 16S rRNA Gene Amplicon Based Metagenomic Signatures of Rhizobiome Community in Rice Field During Various Growth Stages.

    abstract::Rice is a major staple food across the globe. Its growth and productivity is highly dependent on the rhizobiome where crosstalk takes place between plant and the microbial community. Such interactions lead to selective enrichment of plant beneficial microbes which ultimately defines the crop health and productivity. I...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.02103

    authors: Imchen M,Kumavath R,Vaz ABM,Góes-Neto A,Barh D,Ghosh P,Kozyrovska N,Podolich O,Azevedo V

    更新日期:2019-09-20 00:00:00

  • Heavy metal driven co-selection of antibiotic resistance in soil and water bodies impacted by agriculture and aquaculture.

    abstract::The use of antibiotic agents as growth promoters was banned in animal husbandry to prevent the selection and spread of antibiotic resistance. However, in addition to antibiotic agents, heavy metals used in animal farming and aquaculture might promote the spread of antibiotic resistance via co-selection. To investigate...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2012.00399

    authors: Seiler C,Berendonk TU

    更新日期:2012-12-14 00:00:00

  • Antifungal Effect of Novel 2-Bromo-2-Chloro-2-(4-Chlorophenylsulfonyl)-1-Phenylethanone against Candida Strains.

    abstract::We investigated the antifungal activity of novel a 2-bromo-2-chloro-2-(4-chlorophenylsulfonyl)-1-phenylethanone (compound 4). The synthesis of compound 4 was commenced from sodium 4-chlorobenzene sulfinate and the final product was obtained by treatment of α-chloro-β-keto-sulfone with sodium hypobromite. The sensitivi...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.01309

    authors: Staniszewska M,Bondaryk M,Wieczorek M,Estrada-Mata E,Mora-Montes HM,Ochal Z

    更新日期:2016-08-25 00:00:00

  • Phosphorus Deficiency Inhibits Cell Division But Not Growth in the Dinoflagellate Amphidinium carterae.

    abstract::Phosphorus (P) is an essential nutrient element for the growth of phytoplankton. How P deficiency affects population growth and the cell division cycle in dinoflagellates has only been studied in some species, and how it affects photosynthesis and cell growth remains poorly understood. In the present study, we investi...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2016.00826

    authors: Li M,Shi X,Guo C,Lin S

    更新日期:2016-06-01 00:00:00

  • Anaerobic Degradation of the Plant Sugar Sulfoquinovose Concomitant With H2S Production: Escherichia coli K-12 and Desulfovibrio sp. Strain DF1 as Co-culture Model.

    abstract::Sulfoquinovose (SQ, 6-deoxy-6-sulfoglucose) is produced by plants and other phototrophs and its biodegradation is a relevant component of the biogeochemical carbon and sulfur cycles. SQ is known to be degraded by aerobic bacterial consortia in two tiers via C3-organosulfonates as transient intermediates to CO2, water ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02792

    authors: Burrichter A,Denger K,Franchini P,Huhn T,Müller N,Spiteller D,Schleheck D

    更新日期:2018-11-27 00:00:00

  • Corrigendum: Living at the Extremes: Extremophiles and the Limits of Life in a Planetary Context.

    abstract::[This corrects the article DOI: 10.3389/fmicb.2019.00780.]. ...

    journal_title:Frontiers in microbiology

    pub_type: 已发布勘误

    doi:10.3389/fmicb.2019.01785

    authors: Merino N,Aronson HS,Bojanova DP,Feyhl-Buska J,Wong ML,Zhang S,Giovannelli D

    更新日期:2019-08-13 00:00:00

  • Temporal changes in the diazotrophic bacterial communities associated with Caribbean sponges Ircinia stroblina and Mycale laxissima.

    abstract::Sponges that harbor microalgal or, cyanobacterial symbionts may benefit from photosynthetically derived carbohydrates, which are rich in carbon but devoid of nitrogen, and may therefore encounter nitrogen limitation. Diazotrophic communities associated with two Caribbean sponges, Ircinia strobilina and Mycale laxissim...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2014.00561

    authors: Zhang F,Vicente J,Hill RT

    更新日期:2014-10-28 00:00:00

  • Halophilic Archaea Mediate the Formation of Proto-Dolomite in Solutions With Various Sulfate Concentrations and Salinities.

    abstract::In the past several decades, sulfate concentration and salinity have been considered to be the two essential hydrochemical factors in the formation of dolomite, yet arguments against this hypothesis have existed simultaneously. To clarify the effects of sulfate concentration and salinity in the mineralization of dolom...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2019.00480

    authors: Qiu X,Yao Y,Wang H,Shen A,Zhang J

    更新日期:2019-03-12 00:00:00

  • Fungal and Bacterial Diversity Isolated from Aquilaria malaccensis Tree and Soil, Induces Agarospirol Formation within 3 Months after Artificial Infection.

    abstract::Aquilaria malaccensis Lam, commonly known as Agarwood, is a highly valuable species used in production of agar oil from its infected wood, which is utilized in pharmaceutical and perfumery industry. Agar oil formation in agarwood takes years through the natural process which is induced by natural or artificial injury ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.01286

    authors: Chhipa H,Kaushik N

    更新日期:2017-07-11 00:00:00

  • Adhesion Properties of Food-Associated Lactobacillus plantarum Strains on Human Intestinal Epithelial Cells and Modulation of IL-8 Release.

    abstract::Food-associated microbes can reach the gut as viable cells and interact with the human host providing potential health benefits. In this study, we evaluated the impact on cell viability and the adhesion ability of 22 Lactobacillus plantarum strains, mainly isolated from fermented foods, on a Normal-derived Colon Mucos...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.02392

    authors: Garcia-Gonzalez N,Prete R,Battista N,Corsetti A

    更新日期:2018-10-08 00:00:00

  • Characterization of saltern based Streptomyces sp. and statistical media optimization for its improved antibacterial activity.

    abstract::A moderately halotolerant Streptomyces strain, designated JAJ13 was characterized and a culture medium was statistically optimized to improve its antibacterial activity. Based on the phenotypic and molecular characteristics, strain JAJ13 was identified as a moderately halotolerant Streptomyces sp. JAJ13. Novelty of th...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2014.00753

    authors: Rajeswari P,Jose PA,Amiya R,Jebakumar SR

    更新日期:2015-01-21 00:00:00

  • An Extracellular Tetrathionate Hydrolase from the Thermoacidophilic Archaeon Acidianus Ambivalens with an Activity Optimum at pH 1.

    abstract:BACKGROUND:The thermoacidophilic and chemolithotrophic archaeon Acidianus ambivalens is routinely grown with sulfur and CO(2)-enriched air. We had described a membrane-bound, tetrathionate (TT) forming thiosulfate:quinone oxidoreductase. Here we describe the first TT hydrolase (TTH) from Archaea. RESULTS:A. ambivalens...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2011.00068

    authors: Protze J,Müller F,Lauber K,Naß B,Mentele R,Lottspeich F,Kletzin A

    更新日期:2011-04-25 00:00:00

  • Prion-Like Domains in Phagobiota.

    abstract::Prions are molecules characterized by self-propagation, which can undergo a conformational switch leading to the creation of new prions. Prion proteins have originally been associated with the development of mammalian pathologies; however, recently they have been shown to contribute to the environmental adaptation in ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.02239

    authors: Tetz G,Tetz V

    更新日期:2017-11-15 00:00:00

  • The Russian Doll Model: How Bacteria Shape Successful and Sustainable Inter-Kingdom Relationships.

    abstract::Successful inter-kingdom relationships are based upon a dynamic balance between defense and cooperation. A certain degree of competition is necessary to guarantee life spread and development. On the other hand, cooperation is a powerful tool to ensure a long lasting adaptation to changing environmental conditions and ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2020.573759

    authors: Pessione E

    更新日期:2020-10-20 00:00:00

  • Interactions Between Clostridioides difficile and Fecal Microbiota in in Vitro Batch Model: Growth, Sporulation, and Microbiota Changes.

    abstract::Disturbance in gut microbiota is crucial for the development of Clostridioides difficile infection (CDI). Different mechanisms through which gut microbiota influences C. difficile colonization are known. However, C. difficile could also affect gut microbiota balance as previously demonstrated by cultivation of fecal m...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2018.01633

    authors: Horvat S,Rupnik M

    更新日期:2018-07-24 00:00:00

  • Heterologous expression of Mus musculus immunoresponsive gene 1 (irg1) in Escherichia coli results in itaconate production.

    abstract::Itaconic acid, a C5-dicarboxylic acid, is a potential biobased building block for the polymer industry. It is obtained from the citric acid cycle by decarboxylation of cis-aconitic acid. This reaction is catalyzed by CadA in the native itaconic acid producer Aspergillus terreus. Recently, another enzyme encoded by the...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.00849

    authors: Vuoristo KS,Mars AE,van Loon S,Orsi E,Eggink G,Sanders JP,Weusthuis RA

    更新日期:2015-08-18 00:00:00

  • Sublethal Injury and Viable but Non-culturable (VBNC) State in Microorganisms During Preservation of Food and Biological Materials by Non-thermal Processes.

    abstract::The viable but non-culturable (VBNC) state, as well as sublethal injury of microorganisms pose a distinct threat to food safety, as the use of traditional, culture-based microbiological analyses might lead to an underestimation or a misinterpretation of the product's microbial status and recovery phenomena of microorg...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2018.02773

    authors: Schottroff F,Fröhling A,Zunabovic-Pichler M,Krottenthaler A,Schlüter O,Jäger H

    更新日期:2018-11-20 00:00:00

  • Characterizing Antimicrobial Resistant Escherichia coli and Associated Risk Factors in a Cross-Sectional Study of Pig Farms in Great Britain.

    abstract::Combatting antimicrobial resistant (AMR) using a One-Health approach is essential as various bacteria, including Escherichia coli, a common bacteria, are becoming increasingly resistant and livestock may be a reservoir. The AMR gene content of 492 E. coli, isolated from 56 pig farms across Great Britain in 2014-2015, ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2020.00861

    authors: AbuOun M,O'Connor HM,Stubberfield EJ,Nunez-Garcia J,Sayers E,Crook DW,Smith RP,Anjum MF

    更新日期:2020-05-25 00:00:00

  • Effects of Recombinant Toxoplasma gondii Citrate Synthase I on the Cellular Functions of Murine Macrophages In vitro.

    abstract::Toxoplasmosis, which is one of the most widespread zoonoses worldwide, has a high incidence and infection can result in severe disease in humans and livestock. Citrate synthase (CS) is a component of nearly all living cells that plays a vital role in the citric acid cycle, which is the central metabolic pathway of aer...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.01376

    authors: Liu X,Ma Q,Sun X,Lu M,Ehsan M,Hasan MW,Xu L,Yan R,Song X,Li X

    更新日期:2017-07-21 00:00:00

  • Experimental Evolution as an Underutilized Tool for Studying Beneficial Animal-Microbe Interactions.

    abstract::Microorganisms play a significant role in the evolution and functioning of the eukaryotes with which they interact. Much of our understanding of beneficial host-microbe interactions stems from studying already established associations; we often infer the genotypic and environmental conditions that led to the existing ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2016.01444

    authors: Hoang KL,Morran LT,Gerardo NM

    更新日期:2016-09-13 00:00:00

  • Programming Bacteria With Light-Sensors and Applications in Synthetic Biology.

    abstract::Photo-receptors are widely present in both prokaryotic and eukaryotic cells, which serves as the foundation of tuning cell behaviors with light. While practices in eukaryotic cells have been relatively established, trials in bacterial cells have only been emerging in the past few years. A number of light sensors have ...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章,评审

    doi:10.3389/fmicb.2018.02692

    authors: Liu Z,Zhang J,Jin J,Geng Z,Qi Q,Liang Q

    更新日期:2018-11-08 00:00:00

  • Ecogenomics and Taxonomy of Cyanobacteria Phylum.

    abstract::Cyanobacteria are major contributors to global biogeochemical cycles. The genetic diversity among Cyanobacteria enables them to thrive across many habitats, although only a few studies have analyzed the association of phylogenomic clades to specific environmental niches. In this study, we adopted an ecogenomics strate...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2017.02132

    authors: Walter JM,Coutinho FH,Dutilh BE,Swings J,Thompson FL,Thompson CC

    更新日期:2017-11-14 00:00:00

  • Methane Emission in a Specific Riparian-Zone Sediment Decreased with Bioelectrochemical Manipulation and Corresponded to the Microbial Community Dynamics.

    abstract::Dissimilatory metal-reducing bacteria are widespread in terrestrial ecosystems, especially in anaerobic soils and sediments. Thermodynamically, dissimilatory metal reduction is more favorable than sulfate reduction and methanogenesis but less favorable than denitrification and aerobic respiration. It is critical to un...

    journal_title:Frontiers in microbiology

    pub_type: 杂志文章

    doi:10.3389/fmicb.2015.01523

    authors: Friedman ES,McPhillips LE,Werner JJ,Poole AC,Ley RE,Walter MT,Angenent LT

    更新日期:2016-01-11 00:00:00