Abstract:
:Itaconic acid, a C5-dicarboxylic acid, is a potential biobased building block for the polymer industry. It is obtained from the citric acid cycle by decarboxylation of cis-aconitic acid. This reaction is catalyzed by CadA in the native itaconic acid producer Aspergillus terreus. Recently, another enzyme encoded by the mammalian immunoresponsive gene 1 (irg1), was found to decarboxylate cis-aconitate to itaconate in vitro. We show that heterologous expression of irg1 enabled itaconate production in Escherichia coli with production titres up to 560 mg/L.
journal_name
Front Microbioljournal_title
Frontiers in microbiologyauthors
Vuoristo KS,Mars AE,van Loon S,Orsi E,Eggink G,Sanders JP,Weusthuis RAdoi
10.3389/fmicb.2015.00849subject
Has Abstractpub_date
2015-08-18 00:00:00pages
849issn
1664-302Xjournal_volume
6pub_type
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